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Isolation and biosynthesis of terpenes in Pseudopterogorgia elisabethae and Leptogorgia minimata
| Title: | Isolation and biosynthesis of terpenes in Pseudopterogorgia elisabethae and Leptogorgia minimata. |
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| Name(s): |
von Saalfeld, Silke. Florida Atlantic University, Degree grantor Kerr, Russell G., Thesis advisor |
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| Type of Resource: | text | |
| Genre: | Electronic Thesis Or Dissertation | |
| Issuance: | monographic | |
| Date Issued: | 2006 | |
| Publisher: | Florida Atlantic University | |
| Place of Publication: | Boca Raton, Fla. | |
| Physical Form: | application/pdf | |
| Extent: | 97 p. | |
| Language(s): | English | |
| Summary: | The marine environment has proven to be an extremely rich source of novel natural products with activities in a variety of biological assays. The field of marine natural products chemistry has enjoyed an explosion of growth over the past 40 years and currently there are marine-derived metabolites in clinical trials for cancer, analgesia, allergy and cognitive diseases. Even with this tremendous development, it is clear that chemists and pharmacologists are only beginning to scratch the surface of the biomedical potential of marine organisms. One problem with this source of new pharmaceuticals is that the supply of such compounds can be problematic. The thesis describes projects directed at fundamental biosynthetic questions regarding terpenes from marine corals. In a general sense, these projects are directed as addressing the supply issue identified above. One project examined the origin of terpene building blocks in the coral Pseudopterogorgia elisabethae. A second project focused on the characterization of terpenes from Leptogorgia minimata. Here, a new cembranoid diterpene was isolated. Experiments were also conducted to identify a microbial source of terpene biosynthesis in this system. Data strongly supported a bacterial origin of these compounds. | |
| Identifier: | 9780542566370 (isbn), 13325 (digitool), FADT13325 (IID), fau:10175 (fedora) | |
| Collection: | FAU Electronic Theses and Dissertations Collection | |
| Note(s): |
Thesis (M.S.)--Florida Atlantic University, 2006. Charles E. Schmidt College of Science |
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| Subject(s): |
Natural products--Synthesis Marine pharmacology Aquaculture Terpenes Marine chemical ecology |
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| Held by: | Florida Atlantic University Libraries | |
| Persistent Link to This Record: | http://purl.flvc.org/fcla/dt/13325 | |
| Sublocation: | Digital Library | |
| Use and Reproduction: | Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder. | |
| Use and Reproduction: | http://rightsstatements.org/vocab/InC/1.0/ | |
| Host Institution: | FAU | |
| Is Part of Series: | Florida Atlantic University Digital Library Collections. |
