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Comparison of hypothalamic-pituitary-adrenal responses to maternal deprivation and chronic variable stress in pre-weanling rats

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Date Issued:
2005
Summary:
This paradigm evaluated a novel chronic stressor paradigm that could be as effective as 24 hr of maternal deprivation (24-MD), yet be intrinsically capable of examination over numerous days in pre-weanling pups. It was hypothesized that a 19 hr chronic variable stressor paradigm (19-CVS) would be equally or more effective in eliciting a corticosterone (CORT) response than 24-MD and that 19-CVS would have elevated recovery CORT levels over 24-MD. The results indicated that (1) 19-CVS elicited a significantly greater CORT response than 24-MD immediately after stressor exposure and (2) 19-CVS had significantly elevated recovery CORT in comparison to 24-MD. These results demonstrate that 19-CVS early in development is capable of robustly activating the hypothalamic-pituitary-adrenal (HPA)-axis immediately after exposure and may prove useful as an early life stressor. However, additional work is necessary to clarify how these two distinct stressors differ in termination of their respective HPA response.
Title: Comparison of hypothalamic-pituitary-adrenal responses to maternal deprivation and chronic variable stress in pre-weanling rats.
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Name(s): Blandino, Peter, Jr.
Florida Atlantic University, Degree grantor
Terry, Leslie M., Thesis advisor
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Issuance: monographic
Date Issued: 2005
Publisher: Florida Atlantic University
Place of Publication: Boca Raton, Fla.
Physical Form: application/pdf
Extent: 77 p.
Language(s): English
Summary: This paradigm evaluated a novel chronic stressor paradigm that could be as effective as 24 hr of maternal deprivation (24-MD), yet be intrinsically capable of examination over numerous days in pre-weanling pups. It was hypothesized that a 19 hr chronic variable stressor paradigm (19-CVS) would be equally or more effective in eliciting a corticosterone (CORT) response than 24-MD and that 19-CVS would have elevated recovery CORT levels over 24-MD. The results indicated that (1) 19-CVS elicited a significantly greater CORT response than 24-MD immediately after stressor exposure and (2) 19-CVS had significantly elevated recovery CORT in comparison to 24-MD. These results demonstrate that 19-CVS early in development is capable of robustly activating the hypothalamic-pituitary-adrenal (HPA)-axis immediately after exposure and may prove useful as an early life stressor. However, additional work is necessary to clarify how these two distinct stressors differ in termination of their respective HPA response.
Identifier: 9780542418938 (isbn), 13302 (digitool), FADT13302 (IID), fau:10154 (fedora)
Collection: FAU Electronic Theses and Dissertations Collection
Note(s): Charles E. Schmidt College of Science
Thesis (M.A.)--Florida Atlantic University, 2005.
Subject(s): Hypothalamic-pituitary-adrenal axis
Rats as laboratory animals
Neuropharmacology
Maternal deprivation
Held by: Florida Atlantic University Libraries
Persistent Link to This Record: http://purl.flvc.org/fcla/dt/13302
Sublocation: Digital Library
Use and Reproduction: Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
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Host Institution: FAU
Is Part of Series: Florida Atlantic University Digital Library Collections.