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THE ROLE OF ENDOTHELIAL C-MYC IN CARDIAC DYSFUNCTION

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Date Issued:
2024
Abstract/Description:
Cardiovascular disease is a broad term that encompasses a variety of disorders in which the heart and its associated blood vessels lose the capacity to deliver blood efficiently and effectively throughout the body. Cardiac endothelial cells play a vital role in maintaining the homeostatic balance of cardiac physiology. Research into c-Myc, a master regulator involved in the transcription of a large set of genes that regulate inflammation, has been the focus of new therapeutics aimed at treating or lessening the deleterious effects of cardiovascular disease. This project serves to explore how endothelial loss of c-Myc impacts cardiac function under normal and stress conditions, using ultrasound echocardiography image analysis to determine the key differences between all models.
Title: THE ROLE OF ENDOTHELIAL C-MYC IN CARDIAC DYSFUNCTION.
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Name(s): Rahbar, Homan, author
Rodrigues, Claudia , Thesis advisor
Florida Atlantic University, Degree grantor
Department of Biomedical Science
Charles E. Schmidt College of Medicine
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Date Created: 2024
Date Issued: 2024
Publisher: Florida Atlantic University
Place of Publication: Boca Raton, Fla.
Physical Form: application/pdf
Extent: 46 p.
Language(s): English
Abstract/Description: Cardiovascular disease is a broad term that encompasses a variety of disorders in which the heart and its associated blood vessels lose the capacity to deliver blood efficiently and effectively throughout the body. Cardiac endothelial cells play a vital role in maintaining the homeostatic balance of cardiac physiology. Research into c-Myc, a master regulator involved in the transcription of a large set of genes that regulate inflammation, has been the focus of new therapeutics aimed at treating or lessening the deleterious effects of cardiovascular disease. This project serves to explore how endothelial loss of c-Myc impacts cardiac function under normal and stress conditions, using ultrasound echocardiography image analysis to determine the key differences between all models.
Identifier: FA00014488 (IID)
Degree granted: Thesis (MS)--Florida Atlantic University, 2024.
Collection: FAU Electronic Theses and Dissertations Collection
Note(s): Includes bibliography.
Subject(s): Cardiovascular Diseases
Transcription factors
Endothelial Cells
Echocardiography
Persistent Link to This Record: http://purl.flvc.org/fau/fd/FA00014488
Use and Reproduction: Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Use and Reproduction: http://rightsstatements.org/vocab/InC/1.0/
Host Institution: FAU