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Diterpene biosynthesis in early ontogenetic stages of Pseudopterogorgia elisabethae and Pseudopterogorgia bipinnata

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Date Issued:
2005
Summary:
There is growing evidence that secondary metabolites isolated from some marine invertebrates may actually be produced by a symbiont. The capacity of early ontogenetic stages of Pseudopterogorgia elisabethae and Pseudopterogorgia bipinnata to biosynthesize biologically active and pharmaceutically important diterpenes was examined. These early life stages lack the algal symbionts found in adult colonies of the species, thus removing one level of complexity. The larvae and polyps of these two species produced high concentrations of the diterpenoid secondary metabolites, one of which proved to significantly deter fish-feeding in in situ feeding assays. Additionally, a novel cembrenoid diterpene was isolated from P. bipinnata. The structure of this compound, bipinnatolide L (40) was solved using 1D and 2D NMR experiments.
Title: Diterpene biosynthesis in early ontogenetic stages of Pseudopterogorgia elisabethae and Pseudopterogorgia bipinnata.
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Name(s): Mukherjee, Maia Stapleton
Florida Atlantic University, Degree Grantor
Charles E. Schmidt College of Science
Department of Chemistry and Biochemistry
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Issuance: monographic
Date Issued: 2005
Publisher: Florida Atlantic University
Place of Publication: Boca Raton, Fla.
Physical Form: application/pdf
Extent: 97 p.
Language(s): English
Summary: There is growing evidence that secondary metabolites isolated from some marine invertebrates may actually be produced by a symbiont. The capacity of early ontogenetic stages of Pseudopterogorgia elisabethae and Pseudopterogorgia bipinnata to biosynthesize biologically active and pharmaceutically important diterpenes was examined. These early life stages lack the algal symbionts found in adult colonies of the species, thus removing one level of complexity. The larvae and polyps of these two species produced high concentrations of the diterpenoid secondary metabolites, one of which proved to significantly deter fish-feeding in in situ feeding assays. Additionally, a novel cembrenoid diterpene was isolated from P. bipinnata. The structure of this compound, bipinnatolide L (40) was solved using 1D and 2D NMR experiments.
Identifier: 9780542407031 (isbn), 13297 (digitool), FADT13297 (IID), fau:10149 (fedora)
Collection: FAU Electronic Thesis or Dissertation Collection
Note(s): Adviser: Russell Kerr.
Thesis (M.S.)--Florida Atlantic University, 2005.
Subject(s): Chemistry, Biochemistry
Held by: Florida Atlantic University Libraries
Persistent Link to This Record: http://purl.flvc.org/fcla/dt/13297
Sublocation: Digital Library
Use and Reproduction: Copyright © is held by Maia Stapleton Mukherjee, the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Use and Reproduction: http://rightsstatements.org/vocab/InC/1.0/
Host Institution: FAU
Is Part of Series: FAU Digital Library Collections.