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CELL-TYPE-SPECIFIC CONSOLIDATION OF LEARNED MOTOR MEMORIES IN THE NEOCORTEX

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Date Issued:
2024
Abstract/Description:
Motor learning is crucial for diverse behaviors, yet the neural mechanisms that consolidate the learning remain poorly understood. A recent study (Majumder et al., 2023) found that inhibiting Calcium/calmodulin-dependent protein kinase II (CaMKII) in pyramidal tract (PT) neurons, but not Intratelencephalic (IT) neurons, in the Anterior Lateral Motor cortex (ALM) disrupt motor learning. This suggests a cell-type-specific reliance on CaMKII for inducing synaptic plasticity during motor skill acquisition. This project aims to explore how the brain consolidates the acquired motor skill as a long-term memory. We hypothesize that following motor learning, CaMKII in PT, but not IT, cells activates the expression of immediate early genes (IEGs) arc and cfos, which may play a critical role in the storage of motor memories. Understanding the cell-specific roles in the ALM could provide insights into motor memory neural circuitry and diseases.
Title: CELL-TYPE-SPECIFIC CONSOLIDATION OF LEARNED MOTOR MEMORIES IN THE NEOCORTEX.
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Name(s): DiCicco, Rebecca , author
Young, Erica, Thesis advisor
Harriet L. Wilkes Honors College
Florida Atlantic University, Degree grantor
Type of Resource: text
Genre: Thesis
Date Created: 2024
Date Issued: 2024
Publisher: Florida Atlantic University
Place of Publication: Jupiter, FL
Physical Form: application/pdf
Extent: 39 p.
Language(s): English
Abstract/Description: Motor learning is crucial for diverse behaviors, yet the neural mechanisms that consolidate the learning remain poorly understood. A recent study (Majumder et al., 2023) found that inhibiting Calcium/calmodulin-dependent protein kinase II (CaMKII) in pyramidal tract (PT) neurons, but not Intratelencephalic (IT) neurons, in the Anterior Lateral Motor cortex (ALM) disrupt motor learning. This suggests a cell-type-specific reliance on CaMKII for inducing synaptic plasticity during motor skill acquisition. This project aims to explore how the brain consolidates the acquired motor skill as a long-term memory. We hypothesize that following motor learning, CaMKII in PT, but not IT, cells activates the expression of immediate early genes (IEGs) arc and cfos, which may play a critical role in the storage of motor memories. Understanding the cell-specific roles in the ALM could provide insights into motor memory neural circuitry and diseases.
Identifier: FAUHT00296 (IID)
Degree granted: Thesis (B.S.)--Florida Atlantic University, Harriet L. Wilkes Honors College, 2024
Persistent Link to This Record: http://purl.flvc.org/fau/fd/FAUHT00296
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Host Institution: FAU
Is Part of Series: Florida Atlantic University Digital Library Collections.

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