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- Title
- Effects of Resistance and Aerobic Training on IGF-1 and BDNF Expression in a Murine Model of Alzheimer’s Disease.
- Creator
- Pena, Gabriel S., Whitehurst, Michael, Florida Atlantic University, College of Education, Department of Exercise Science and Health Promotion
- Abstract/Description
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The primary purpose of this study was to investigate the effects of aerobic and resistance training on BDNF and IGF-I expression in a 3xTg-AD mouse model of Alzheimer’s disease. Twenty-four 3xTg-AD mice were randomly assigned to either an aerobic (AT, n=8), resistance (RT, n=8), or control (CNT, n=8) group. Intervention groups underwent 9 weeks of exercise training. Motor behavior and grip strength were measured pre- and post- intervention. Our results showed a significant increase in...
Show moreThe primary purpose of this study was to investigate the effects of aerobic and resistance training on BDNF and IGF-I expression in a 3xTg-AD mouse model of Alzheimer’s disease. Twenty-four 3xTg-AD mice were randomly assigned to either an aerobic (AT, n=8), resistance (RT, n=8), or control (CNT, n=8) group. Intervention groups underwent 9 weeks of exercise training. Motor behavior and grip strength were measured pre- and post- intervention. Our results showed a significant increase in hippocampal BDNF expression in AT mice after a 9-week intervention. Further, AT mice were found to have higher concentrations of IGF-I, and improved motor behavior when compared to RT and CNT. No significant differences were observed in IGF-I concentration between RT and other groups. RT improved grip strength after nine weeks of training. These findings support the use of AT and RT as a tool to improve comorbidities found in Alzheimer’s disease.
Show less - Date Issued
- 2018
- PURL
- http://purl.flvc.org/fau/fd/FA00013094
- Subject Headings
- Alzheimer's disease., Insulin-Like Growth Factor I., Brain-Derived Neurotrophic Factor, Aerobic exercises., Resistance Training.
- Format
- Document (PDF)
- Title
- The Effect of Maximal Aerobic Exercise on Plasma BDNF and BDNF Expression in PBMCs in Obese and Non-Obese Individuals.
- Creator
- Maharaj, Arun, Whitehurst, Michael, Florida Atlantic University, College of Education, Department of Exercise Science and Health Promotion
- Abstract/Description
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The purpose of this study was to determine if maximal aerobic exercise promotes BDNF expression in obese individuals. Plasma levels and the expression of BDNF in PBMCs were examined. 22 participants (10 obese, 12 non-obese) completed a V02max treadmill test and blood was obtained pre, post, and 1 and 2 hours into exercise recovery. Plasma and PBMCs were isolated and analyzed for BDNF via ELISA and Western blot techniques. A significant effect for time was observed for plasma BDNF (P=
Show moreThe purpose of this study was to determine if maximal aerobic exercise promotes BDNF expression in obese individuals. Plasma levels and the expression of BDNF in PBMCs were examined. 22 participants (10 obese, 12 non-obese) completed a V02max treadmill test and blood was obtained pre, post, and 1 and 2 hours into exercise recovery. Plasma and PBMCs were isolated and analyzed for BDNF via ELISA and Western blot techniques. A significant effect for time was observed for plasma BDNF (P= <0.00 1 ). Additionally, A significant group-by-time interaction was found from pre-to-RIH for BDNF expression in PBMCs (P= 0.046). Further, significant correlations were found between BMI and waist circumference (r= .91, P< 0.001), WHR (r= .51, P= 0.002) and Pre-to-RlH ratio (r=0.58, P=0.008). Young obese subject's BDNF response to maximal exercise was consistent with previous studies. Post-exercise BDNF expressed in PBMCs were significantly higher than rest suggesting immunological-neuroprotective interactions in the CNS.
Show less - Date Issued
- 2016
- PURL
- http://purl.flvc.org/fau/fd/FA00004664, http://purl.flvc.org/fau/fd/FA00004664
- Subject Headings
- Biochemical markers, Blood lipoproteins, Blood plasma -- Physiology, Exercise -- Physiological aspects, Obesity -- Exercise therapy
- Format
- Document (PDF)
- Title
- The Impact of Obesity on Plasma Calprotectin in Response to Acute Aerobic Exercise.
- Creator
- Fico, Brandon G., Slusher, Aaron L., Whitehurst, Michael, Maharaj, Arun, Huang, Chun-Jung, College of Education
- Abstract/Description
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The secular issue of obesity has been linked to increased inflammatory mediators, such as calprotectin (S100A8/A9). This study examined the effect of acute aerobic exercise on plasma calprotectin response in obese and normal-weight subjects and its relationship with inflammatory cytokine (IL-6). All subjects (11 obese and 10 normal-weight) performed 30 minutes of treadmill exercise at 75% maximal oxygen consumption (VO2max). Blood samples were collected prior to, immediately following...
Show moreThe secular issue of obesity has been linked to increased inflammatory mediators, such as calprotectin (S100A8/A9). This study examined the effect of acute aerobic exercise on plasma calprotectin response in obese and normal-weight subjects and its relationship with inflammatory cytokine (IL-6). All subjects (11 obese and 10 normal-weight) performed 30 minutes of treadmill exercise at 75% maximal oxygen consumption (VO2max). Blood samples were collected prior to, immediately following exercise, and one hour after exercise. Our results showed higher baseline levels of calprotectin in obese subjects than normal-weight subjects. While acute aerobic exercise increased an elevation in calprotectin and IL-6, no difference was found between two groups. Furthermore, a positive relationship was observed between calprotectin area-under-the curve “with respect to increase” (AUCi) and IL-6 AUCi, even after controlling for cardiorespiratory fitness (VO2max). Our results support previous finding that IL-6 may potentially regulate calprotectin expression in skeletal muscle during exercise.
Show less - Date Issued
- 2015
- PURL
- http://purl.flvc.org/fau/fd/FA00005187
- Subject Headings
- College students --Research --United States.
- Format
- Document (PDF)
- Title
- Effect of compression stockings on cycling performance and post exercise muscle soreness in moderately trained females.
- Creator
- Kilsdonk, Korey, Whitehurst, Michael, College of Education, Department of Exercise Science and Health Promotion
- Abstract/Description
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Purpose: Determine effect of below knee compression stockings on metabolic and perceptual responses to cycling (i.e., BLa, HR, VO2, and RPE) in moderately-trained female cyclists. Methods: Subjects (n=12) performed a graded exercise test (GXT) on a cycle-ergometer to assess VO2peak. Subsequently, and on different days, two graded tests were administered (with, without stockings) with 5 minute warm-up at 50 W followed by 5 minute stages at 60 %, 70%, and 80% of max power output. Following the...
Show morePurpose: Determine effect of below knee compression stockings on metabolic and perceptual responses to cycling (i.e., BLa, HR, VO2, and RPE) in moderately-trained female cyclists. Methods: Subjects (n=12) performed a graded exercise test (GXT) on a cycle-ergometer to assess VO2peak. Subsequently, and on different days, two graded tests were administered (with, without stockings) with 5 minute warm-up at 50 W followed by 5 minute stages at 60 %, 70%, and 80% of max power output. Following the last sub-maximal stage, participants performed 3 - 5 supramaximal trials. Each lasted 30 seconds at 200% of her peak power output with HR, RPE, and BLa measured at the end of each trial. Results: No significant difference was observed between conditions for any metabolic or perceptual measure across workloads while perceived muscle soreness at 24 hours trended towards significance (p=.067). Conclusion: Compression socks did not significantly alter metabolic or perceptual responses to cycling.
Show less - Date Issued
- 2012
- PURL
- http://purl.flvc.org/fau/fd/FA00004254
- Format
- Document (PDF)
- Title
- The effect of acute moderate-intensity continuous and high intensity interval exercise on serum brain-derived neurotrophic factor in recreationally trained males.
- Creator
- Mock, Thomas J., Whitehurst, Michael, Florida Atlantic University, College of Education, Department of Exercise Science and Health Promotion
- Abstract/Description
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BDNF is a neurotrophin that enhances neural health and is increased by exercise. PURPOSE: To compare moderate continuous (MCE) and high-intensity interval exercise (HIE) effects on serum BDNF levels, and examine the relationship between BDNF and lactate. METHODS: Seven males completed a VO2peak test and two protocols on separate days, (MCE) 28 min at 60% Workrate max (WRmax) and (HIE) 28 min of intervals at 90%WRmax (10- 1 min intervals separated by 2 min of rest). Serum BDNF and lactate were...
Show moreBDNF is a neurotrophin that enhances neural health and is increased by exercise. PURPOSE: To compare moderate continuous (MCE) and high-intensity interval exercise (HIE) effects on serum BDNF levels, and examine the relationship between BDNF and lactate. METHODS: Seven males completed a VO2peak test and two protocols on separate days, (MCE) 28 min at 60% Workrate max (WRmax) and (HIE) 28 min of intervals at 90%WRmax (10- 1 min intervals separated by 2 min of rest). Serum BDNF and lactate were determined prior, during, and following both protocols. RESULTS: BDNF levels (pg/mL) increased from baseline during HIE and MCE (p<.05). The BDNF response to HIE correlated with lactate for area under the curve (AUC) (r=0.901; P<0.05). CONCLUSION: HIE is an effective alternative to MCE at increasing BDNF. Additionally, lactate may act as a measure of intensity or a mediator of the BDNF response to exercise.
Show less - Date Issued
- 2014
- PURL
- http://purl.flvc.org/fau/fd/FA00004219, http://purl.flvc.org/fau/fd/FA00004219
- Subject Headings
- Biochemical markers., Neurons--Physiology., Cell aging--Physiology., Neurotrophic function., Metabolic syndrome--Pathophysiology.
- Format
- Document (PDF)
