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- Title
- Charge Regulation of a Surface Immersed in an Electrolyte Solution.
- Creator
- Acharya, Pramod, Lau, Andy W. C., Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
- Abstract/Description
-
In this thesis, we investigate theoretically a new model of charge regulation of a single charged planar surface immersed in an aqueous electrolyte solution. Assuming that the adsorbed ions are mobile in the charged plane, we formulate a field theory of charge regulation where the numbers of adsorbed ions can be determined consistently by equating the chemical potentials of the adsorbed ions to that of the ions in the bulk. We analyze the mean-field treatment of the model for electrolyte of...
Show moreIn this thesis, we investigate theoretically a new model of charge regulation of a single charged planar surface immersed in an aqueous electrolyte solution. Assuming that the adsorbed ions are mobile in the charged plane, we formulate a field theory of charge regulation where the numbers of adsorbed ions can be determined consistently by equating the chemical potentials of the adsorbed ions to that of the ions in the bulk. We analyze the mean-field treatment of the model for electrolyte of arbitrary valences, and then beyond, where correlation effects are systematically taken into account in a loop expansion. In particular, we compute exactly various one-loop quantities, including electrostatic potentials, ion distributions, and chemical potentials, not only for symmetric (1, 1) electrolyte but also for asymmetric (2, 1) electrolyte, and make use of these quantities to address charge regulation at the one-loop level. We find that correlation effects give rise to various phase transitions in the adsorption of ions, and present phase diagrams for (1, 1) and (2, 1) electrolytes, whose distinct behaviors suggest that charge regulation, at the one-loop level, is no longer universal but depends crucially on the valency of the ions.
Show less - Date Issued
- 2016
- PURL
- http://purl.flvc.org/fau/fd/FA00004560, http://purl.flvc.org/fau/fd/FA00004560
- Subject Headings
- Surface chemistry., Intermolecular forces., Electrodynamics., Quantum field theory.
- Format
- Document (PDF)
- Title
- Subjecting the CHIMERA supernova code to two hydrodynamic test problems, (i) Riemann problem and (ii) Point blast explosion.
- Creator
- Ahsan, Abu Salah M., Charles E. Schmidt College of Science, Department of Physics
- Abstract/Description
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A Shock wave as represented by the Riemann problem and a Point-blast explosion are two key phenomena involved in a supernova explosion. Any hydrocode used to simulate supernovae should be subjected to tests consisting of the Riemann problem and the Point-blast explosion. L. I. Sedov's solution of Point-blast explosion and Gary A. Sod's solution of a Riemann problem have been re-derived here from one dimensional fluid dynamics equations . Both these problems have been solved by using the idea...
Show moreA Shock wave as represented by the Riemann problem and a Point-blast explosion are two key phenomena involved in a supernova explosion. Any hydrocode used to simulate supernovae should be subjected to tests consisting of the Riemann problem and the Point-blast explosion. L. I. Sedov's solution of Point-blast explosion and Gary A. Sod's solution of a Riemann problem have been re-derived here from one dimensional fluid dynamics equations . Both these problems have been solved by using the idea of Self-similarity and Dimensional analysis. The main focus of my research was to subject the CHIMERA supernova code to these two hydrodynamic tests. Results of CHIMERA code for both the blast wave and Riemann problem have then been tested by comparing with the results of the analytic solution.
Show less - Date Issued
- 2008
- PURL
- http://purl.flvc.org/FAU/172665
- Subject Headings
- Mathematical physics, Continuum mechanics, Number theory, Supernovae, Data processing, Shock waves, Fluid dynamics
- Format
- Document (PDF)
- Title
- INCREASING THE ACCURACY OF BINARY NEUTRON STARSIMULATIONS WITH AN IMPROVED VACUUM TREATMENT.
- Creator
- Amit Poudel, Tichy, Wolfgang, Florida Atlantic University, Department of Physics, Charles E. Schmidt College of Science
- Abstract/Description
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The main purpose of this dissertation is to study the inspiral and merger of binary neutron stars. The inspiral, in such a system, is caused by the loss of energy and angular momentum that is carried away by the emitted gravitational waves. Newly-formed neutron stars, after supernova explosions, are very hot. They cool down during the hundreds of millions of years, which is needed to bring the two stars in a neutron star binary close enough together to start investigating them with numerical...
Show moreThe main purpose of this dissertation is to study the inspiral and merger of binary neutron stars. The inspiral, in such a system, is caused by the loss of energy and angular momentum that is carried away by the emitted gravitational waves. Newly-formed neutron stars, after supernova explosions, are very hot. They cool down during the hundreds of millions of years, which is needed to bring the two stars in a neutron star binary close enough together to start investigating them with numerical relativity simulations. Thus, they can be considered as fluids at zero temperature to very high accuracy, when we start numerical simulations. In this description, the stars also have a well-defined star surface, beyond which there is a true vacuum. This vacuum, outside the stars, will persist until the stars get so close that mass can be ejected due to tidal forces, and later, when they come into contact and eject streams of hot matter. To date, all current numerical relativity programs use an artificial atmosphere from the very beginning. They do this, to avoid numerical problems arising from the sharp transition of the matter region to the vacuum outside the stars. To be more precise, they take the initial data and fill all the vacuum regions with a very low-density zero velocity atmosphere. While this atmosphere is not physical and used only for numerical reasons, it can still influence the results of the simulations. For example, studies of merger dynamics, merger remnant, disk mass, ejecta mass, and kinetic energy of ejecta, are hampered by the presence of the artificial zero velocity low-density material. To avoid this problem, we have developed a new method to evolve the neutron star systems, without the need for an artificial atmosphere. We describe this method, which we call vacuum method, we present tests with it, and compare it to the conventional atmosphere method. For these tests, we first consider the evolution of stable, oscillating, and collapsing single neutron stars. We also study simulations of the inspiral and merger of binaries using both methods. We find better mass conservation in low-density regions and near refinement boundaries, as well as better ejecta material conservation for the new method. However, the gravitational wave predictions produced by our simulations are almost identical for both methods, since they are mainly due to the bulk motion of the stars which is not strongly affected by the presence or absence of an artificial atmosphere.
Show less - Date Issued
- 2019
- PURL
- http://purl.flvc.org/fau/fd/FA00013403
- Subject Headings
- Neutron stars, Double stars, Simulations, Gravitational waves, Vacuum
- Format
- Document (PDF)
- Title
- First-principles study of metastable phases and structural anomalies of Fe, Al, Zn, and Cd under pressure.
- Creator
- Apostol, Florin., Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
- Abstract/Description
-
Stable and metastable phases of Fe and Al and structural anomalies of Zn and Cd have been studied by epitaxial Bain path (EBP) and minimum path (MNP) first-principles procedures, based on finding equilibrium structures from minimizing the Gibbs free energy G with respect to structure at a given hydrostatic pressure p and temperature T . The main accomplishments are as follows. (1) This dissertation illustrates the effectiveness of the MNP procedure for finding stable and metastable phases of...
Show moreStable and metastable phases of Fe and Al and structural anomalies of Zn and Cd have been studied by epitaxial Bain path (EBP) and minimum path (MNP) first-principles procedures, based on finding equilibrium structures from minimizing the Gibbs free energy G with respect to structure at a given hydrostatic pressure p and temperature T . The main accomplishments are as follows. (1) This dissertation illustrates the effectiveness of the MNP procedure for finding stable and metastable phases of an element by studying four Bravais phases of Fe including body-centered tetragonal (bct), body-centered cubic (bcc), face-centered cubic (fcc) and rhombohedral (rh) phases. The determination of absolute stability using MNP is new; MNP finds all the elastic constants cjj of a given state and the eigenvalues of the elastic constants matrix, which determine the absolute stability of the state., (2) We have extended our search for stable and metastable phases from zero temperature to finite temperature, which requires the calculations of the Debye temperature Od from cjj in the case of no symmetry. The Debye theory is modified by introducing a parameter B2 that gives the fraction of the full Debye zero-point energy possessed by the actual dispersive mode frequencies. The value of the lattice parameter of fcc Al at low temperatures,a(T) , is shown to be accurately determined by the modified Debye theory of lattice vibrations and first-principles total energy band calculations with the MNP procedure. (3) The existence of structural anomalies in hcp Zn and Cd has been shown from first-principles total-energy calculations using WIEN2k with the EBP procedure., Evaluation of the pressure dependence of various elastic quantities which are much more sensitive to the anomaly shows that the anomalies in hcp Zn and hcp Cd exist over a considerable range of pressure; several abrupt changes in the electron distribution are thereby indicated in that pressure range. (4) Calculations on the zone-center transverse optical phonon frequencies Vto(p) of hcp Zn, which found oscillatory behavior of Vto(p) in the pressure range of the anomalies, support the conclusions made in (3) on the structural anomalies. Based on this dissertation research four papers have been published in refereed journals.
Show less - Date Issued
- 2008
- PURL
- http://purl.flvc.org/FAU/186334
- Subject Headings
- Epitaxy, Mathematical physics, Metals, Electric properties, Phase transformation (Statistical physics)
- Format
- Document (PDF)
- Title
- Liver Cancer Risk Quantification through an Artificial Neural Network based on Personal Health Data.
- Creator
- Ataei, Afrouz, Muhammad, Wazir, Florida Atlantic University, Department of Physics, Charles E. Schmidt College of Science
- Abstract/Description
-
Liver cancer is the sixth most common type of cancer worldwide and is the third leading cause of cancer related mortality. Several types of cancer can form in the liver. Hepatocellular carcinoma (HCC) makes up 75%-85% of all primary liver cancers and it is a malignant disease with limited therapeutic options due to its aggressive progression. While the exact cause of liver cancer may not be known, habits/lifestyle may increase the risk of developing the disease. Several risk prediction models...
Show moreLiver cancer is the sixth most common type of cancer worldwide and is the third leading cause of cancer related mortality. Several types of cancer can form in the liver. Hepatocellular carcinoma (HCC) makes up 75%-85% of all primary liver cancers and it is a malignant disease with limited therapeutic options due to its aggressive progression. While the exact cause of liver cancer may not be known, habits/lifestyle may increase the risk of developing the disease. Several risk prediction models for HCC are available for individuals with hepatitis B and C virus infections who are at high risk but not for general population. To address this challenge, an artificial neural network (ANN) was developed, trained, and tested using the health data to predict liver cancer risk. Our results indicate that our ANN can be used to predict liver cancer risk with changes with lifestyle and may provide a novel approach to identify patients at higher risk and can be bene ted from early diagnosis.
Show less - Date Issued
- 2021
- PURL
- http://purl.flvc.org/fau/fd/FA00013742
- Subject Headings
- Liver--Cancer, Artificial neural networks, Neural networks (Computer science), Cancer--Risk assessment
- Format
- Document (PDF)
- Title
- NOVEL RHEOTAXIS-BASED MICROFLUIDIC DEVICES FOR SORTING HUMAN SPERM.
- Creator
- Ataei, Afrouz, Lau, Andy W.C., Florida Atlantic University, Department of Physics, Charles E. Schmidt College of Science
- Abstract/Description
-
The ultimate challenge for assisted reproductive technologies (ARTs) is to select the most competent sperm population from a semen sample in an efficient way. In this thesis, we report on an effective sperm sorting microfluidic device that exploits the rheotaxis of sperm and investigates the sperm quality sorted under various flow conditions. Rheotaxis is the ability of a sperm cell to orient itself in the direction of the flow and swim against it. We developed a novel passively driven...
Show moreThe ultimate challenge for assisted reproductive technologies (ARTs) is to select the most competent sperm population from a semen sample in an efficient way. In this thesis, we report on an effective sperm sorting microfluidic device that exploits the rheotaxis of sperm and investigates the sperm quality sorted under various flow conditions. Rheotaxis is the ability of a sperm cell to orient itself in the direction of the flow and swim against it. We developed a novel passively driven pumping system that provides a steady flow rate while it requires no external power source. We have also developed another rheotaxis-based microfluidic device that washes out the raw semen sample from any dead or less motile sperm. The device consists of a collection and waste chamber. To evaluate the effect of the shape and height of the collection chamber, we measured the sperm motility and velocity parameters after sorting using varying the shape and height of the collection chamber. We demonstrated that sperm selected with all devices have higher motility, normal morphology, and a fewer degree of DNA fragmentation compared to a control group.
Show less - Date Issued
- 2022
- PURL
- http://purl.flvc.org/fau/fd/FA00013971
- Subject Headings
- Microfluidic devices, Rheotaxis, Spermatozoa, Reproductive Techniques, Assisted
- Format
- Document (PDF)
- Title
- Measurements of output factors for small photon fields up to 10 cm x 10 cm.
- Creator
- Bacala, Angelina, Pella, Silvia, Charles E. Schmidt College of Science, Department of Physics
- Abstract/Description
-
Field output factors (OF) for photon beams from a 6 MV medical accelerator were measured using five different detectors in a scanning water phantom. The measurements were taken for square field sizes of integral widths ranging from 1 cm to 10 cm for two reference source-to-surface distances (SSD) and depths in water. For the diode detectors, square field widths as small as 2.5 mm were also studied. The photon beams were collimated by using either the jaws or the multileaf collimators....
Show moreField output factors (OF) for photon beams from a 6 MV medical accelerator were measured using five different detectors in a scanning water phantom. The measurements were taken for square field sizes of integral widths ranging from 1 cm to 10 cm for two reference source-to-surface distances (SSD) and depths in water. For the diode detectors, square field widths as small as 2.5 mm were also studied. The photon beams were collimated by using either the jaws or the multileaf collimators. Measured OFs are found to depend upon the field size, SSD, depth and also upon the type of beam collimation, size and type of detector used. For field sizes larger than 3 cm x 3 cm, the OF measurements agree to within 1% or less. The largest variation in OF occurs for jawsshaped field of size 1 cm x 1cm, where a difference of more than 18% is observed.
Show less - Date Issued
- 2013
- PURL
- http://purl.flvc.org/fau/fd/FA0004003
- Subject Headings
- Integrated circuits, Photonics, Quantum electrodynamics, Quantum theory
- Format
- Document (PDF)
- Title
- Nuclear Halo Effect and Field Size Factor for Pencil-Beam Scanning Proton Therapy.
- Creator
- Beqiri, Atdhe, Shang, Charles, Muhammad, Wazir, Florida Atlantic University, Department of Physics, Charles E. Schmidt College of Science
- Abstract/Description
-
In proton therapy systems with pencil-beam scanning, output of Halo effect is not necessarily included in Treatment Planning System (TPS). Halo effect (low-intensity tail) can significantly affect a patient’s dose distribution. The output of this dose depends on the field size being irradiated. Although much research has been made to investigate such relation to the field size, the number of reports on dose calculations including the halo effect is small. In this work we have investigated the...
Show moreIn proton therapy systems with pencil-beam scanning, output of Halo effect is not necessarily included in Treatment Planning System (TPS). Halo effect (low-intensity tail) can significantly affect a patient’s dose distribution. The output of this dose depends on the field size being irradiated. Although much research has been made to investigate such relation to the field size, the number of reports on dose calculations including the halo effect is small. In this work we have investigated the Halo effect, including field size factor, target depth factor, and air gaps with a range shifter for a Varian ProBeam. Dose calculations created on the Eclipse Treatment Planning System (vs15.6 TPS) are compared with plane-parallel ionization chambers (PTW Octavius 1500) measurements using PCS and AcurosPT MC model in different isocenters: 5cm, 10cm, and 20cm. We find that in AcurosPT algorithm deviations range between -7.53% (for 2cm field in 25cm air gap with range shifter) up to +7.40% (for 20cm field in 15cm air gap with range shifter). Whereas, in PCS algorithm the deviations are -2.07% (for 20x20cm field in open conditions) to -6.29% (for 20x20cm field in 25cm air gap with range shifter).
Show less - Date Issued
- 2021
- PURL
- http://purl.flvc.org/fau/fd/FA00013788
- Subject Headings
- Proton Therapy, Proton beams, Radiotherapy
- Format
- Document (PDF)
- Title
- Theoretical study of binary alloy thin film growth.
- Creator
- Bouwens, Mark R., Charles E. Schmidt College of Science, Department of Physics
- Abstract/Description
-
Computer simulations of the growth of binary alloy thin films in two and three dimensions were performed using an extension of the Solid on Solid model. Snapshots for a range of interactions and diffusion rates are presented and critically compared to experiment. A wide variety of distinct phases is identified and their growth conditions analyzed. These findings are summarized in a phase diagram. In addition, a fractal analysis of the domains is performed. It is found that for negative...
Show moreComputer simulations of the growth of binary alloy thin films in two and three dimensions were performed using an extension of the Solid on Solid model. Snapshots for a range of interactions and diffusion rates are presented and critically compared to experiment. A wide variety of distinct phases is identified and their growth conditions analyzed. These findings are summarized in a phase diagram. In addition, a fractal analysis of the domains is performed. It is found that for negative interactions the islands are two-dimensional, while for positive interactions, regardless of diffusion rate, a fractal dimension of 1.78 is obtained.
Show less - Date Issued
- 2011
- PURL
- http://purl.flvc.org/FAU/3174504
- Subject Headings
- Binary systems (Metallurgy), Mathematical models, Thermal diffusivity, Phase diagrams, Phase transformations (Statistical physics)
- Format
- Document (PDF)
- Title
- Biogenic gas dynamics in peat soil blocks using ground penetrating radar: a comparative study in the laboratory between peat soils from the Everglades and from two northern peatlands in Minnesota and Maine.
- Creator
- Cabolova, Anastasija., Charles E. Schmidt College of Science, Department of Physics
- Abstract/Description
-
Peatlands cover a total area of approximately 3 million square kilometers and are one of the largest natural sources of atmospheric methane (CH4) and carbon dioxide (CO2). Most traditional methods used to estimate biogenic gas dynamics are invasive and provide little or no information about lateral distribution of gas. In contrast, Ground Penetrating Radar (GPR) is an emerging technique for non-invasive investigation of gas dynamics in peat soils. This thesis establishes a direct comparison...
Show morePeatlands cover a total area of approximately 3 million square kilometers and are one of the largest natural sources of atmospheric methane (CH4) and carbon dioxide (CO2). Most traditional methods used to estimate biogenic gas dynamics are invasive and provide little or no information about lateral distribution of gas. In contrast, Ground Penetrating Radar (GPR) is an emerging technique for non-invasive investigation of gas dynamics in peat soils. This thesis establishes a direct comparison between gas dynamics (i.e. build-up and release) of four different types of peat soil using GPR. Peat soil blocks were collected at peatlands with contrasting latitudes, including the Everglades, Maine and Minnesota. A unique two-antenna GPR setup was used to monitor biogenic gas buildup and ebullition events over a period of 4.5 months, constraining GPR data with surface deformation measurements and direct CH4 and CO2 concentration measurements. The effect of atmospheric pressure was also investigated. This study has implications for better understanding global gas dynamics and carbon cycling in peat soils and its role in climate change.
Show less - Date Issued
- 2010
- PURL
- http://purl.flvc.org/FAU/2974433
- Subject Headings
- Wetland ecology, Wetland ecology, Wetland ecology, Gas dynamics, Soil permeability, Ground penetrating radar, Porous materials, Fluid dynamics
- Format
- Document (PDF)
- Title
- Spin-foam dynamics of general relativity.
- Creator
- Chaharsough Shirazi, Atousa, Engle, Jonathan S., Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
- Abstract/Description
-
In this dissertation the dynamics of general relativity is studied via the spin-foam approach to quantum gravity. Spin-foams are a proposal to compute a transition amplitude from a triangulated space-time manifold for the evolution of quantum 3d geometry via path integral. Any path integral formulation of a quantum theory has two important parts, the measure factor and a phase part. The correct measure factor is obtained by careful canonical analysis at the continuum level. The basic...
Show moreIn this dissertation the dynamics of general relativity is studied via the spin-foam approach to quantum gravity. Spin-foams are a proposal to compute a transition amplitude from a triangulated space-time manifold for the evolution of quantum 3d geometry via path integral. Any path integral formulation of a quantum theory has two important parts, the measure factor and a phase part. The correct measure factor is obtained by careful canonical analysis at the continuum level. The basic variables in the Plebanski-Holst formulation of gravity from which spin-foam is derived are a Lorentz connection and a Lorentz-algebra valued two-form, called the Plebanski two-form. However, in the final spin-foam sum, one usually sums over only spins and intertwiners, which label eigenstates of the Plebanski two-form alone. The spin-foam sum is therefore a discretized version of a Plebanski-Holst path integral in which only the Plebanski two-form appears, and in which the conne ction degrees of freedom have been integrated out. Calculating the measure factor for Plebanksi Holst formulation without the connection degrees of freedom is one of the aims of this dissertation. This analysis is at the continuum level and in order to be implemented in spin-foams one needs to properly discretize and quantize this measure factor. The correct phase is determined by semi-classical behavior. In asymptotic analysis of the Engle-Pereira-Rovelli-Livine spin-foam model, due to the inclusion of more than the usual gravitational sector, more than the usual Regge term appears in the asymptotics of the vertex amplitude. As a consequence, solutions to the classical equations of motion of GR fail to dominate in the semi-classical limit. One solution to this problem has been proposed in which one quantum mechanically imposes restriction to a single gravitational sector, yielding what has been called the “proper” spin-foam model. However, this revised model of quantum gravity, like any proposal for a theory of quantum gravity, must pass certain tests. In the regime of small curvature, one expects a given model of quantum gravity to reproduce the predictions of the linearized theory. As a consistency check we calculate the graviton two-point function predicted by the Lorentzian proper vertex and examine its semiclassical limit.
Show less - Date Issued
- 2015
- PURL
- http://purl.flvc.org/fau/fd/FA00004488, http://purl.flvc.org/fau/fd/FA00004488
- Subject Headings
- General relativity (Physics), Gravitation, Mass (Physics), Mathematical physics, Quantum gravity, Quantum theory
- Format
- Document (PDF)
- Title
- Investigation of Rotational Deviations on Single Fiducial Tumor Tracking with Simulated Respiratory Motion using Synchrony® Respiratory Motion Tracking for Cyberknife® Treatment.
- Creator
- Christ, Zachary A., Shang, Charles, Leventouri, Theodora, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
- Abstract/Description
-
It is hypothesized that the uncertainty of the Synchrony® model from the rotation of a geometrically asymmetrical single fiducial shall be non-zero during the motion tracking. To validate this hypothesis, the uncertainty was measured for a Synchrony® model built for a respiratory motion phantom oriented at different yaw angles on a Cyberknife® treatment table. A Mini-ball Cube with three cylindrical GoldMark™ (1mmx5mm Au) numbered fiducials was placed inside a respiratory phantom and used for...
Show moreIt is hypothesized that the uncertainty of the Synchrony® model from the rotation of a geometrically asymmetrical single fiducial shall be non-zero during the motion tracking. To validate this hypothesis, the uncertainty was measured for a Synchrony® model built for a respiratory motion phantom oriented at different yaw angles on a Cyberknife® treatment table. A Mini-ball Cube with three cylindrical GoldMark™ (1mmx5mm Au) numbered fiducials was placed inside a respiratory phantom and used for all tests. The fiducial with the least artifact interference was selected for the motion tracking. A 2cm periodic, longitudinal, linear motion of the Mini-ball cube was executed and tested for yaw rotational angles, 0° – 90°. The test was repeated over 3 nonconsecutive days. The uncertainty increased with the yaw angle with the most noticeable changes seen between20° and 60° yaw, where uncertainty increased from 23.5% to 57.9%. A similar test was performed using a spherical Gold Anchor™ fiducial. The uncertainties found when using the Gold Anchor™ were statistically lower than those found when using the GoldMark™ fiducial for all angles of rotation. For the first time, it is found that Synchrony® model uncertainty depends on fiducial geometry. In addition, this research has shown that tracking target rotation using a single fiducial can be accomplished with the Synchrony® model uncertainty as it is displayed on the treatment console. The results of this research could lead to decreased acute toxicity effects related to multiple fiducials.
Show less - Date Issued
- 2018
- PURL
- http://purl.flvc.org/fau/fd/FA00013041
- Subject Headings
- Fiducial Markers, Radiosurgery--Quality control, Robotic radiosurgery
- Format
- Document (PDF)
- Title
- Dosimetric Consequences of the Parotid Glands Using CT-To-CBCT Deformable Registration During IMRT For Late Stage Head And Neck Cancers.
- Creator
- Conill, Annette L., Selvaraj, Raj, Kalantzis, Georgios, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
- Abstract/Description
-
Patients receiving Intensity Modulated Radiation Therapy (IMRT) for late stage head and neck (HN) cancer often experience anatomical changes due to weight loss, tumor regression, and positional changes of normal anatomy (1). As a result, the actual dose delivered may vary from the original treatment plan. The purpose of this study was (a) to evaluate the dosimetric consequences of the parotid glands during the course of treatment, and (b) to determine if there would be an optimal timeframe...
Show morePatients receiving Intensity Modulated Radiation Therapy (IMRT) for late stage head and neck (HN) cancer often experience anatomical changes due to weight loss, tumor regression, and positional changes of normal anatomy (1). As a result, the actual dose delivered may vary from the original treatment plan. The purpose of this study was (a) to evaluate the dosimetric consequences of the parotid glands during the course of treatment, and (b) to determine if there would be an optimal timeframe for replanning. Nineteen locally advanced HN cancer patients underwent definitive IMRT. Each patient received an initial computerized tomography simulation (CT-SIM) scan and weekly cone beam computerized tomography (CBCT) scans. A Deformable Image Registration (DIR) was performed between the CT-SIM and CBCT of the parotid glands and Planning Target Volumes (PTVs) using the Eclipse treatment planning system (TPS) and the Velocity deformation software. A recalculation of the dose was performed on the weekly CBCTs using the original monitor units. The parameters for evaluation of our method were: the changes in volume of the PTVs and parotid glands, the dose coverage of the PTVs, the lateral displacement in the Center of Mass (COM), the mean dose, and Normal Tissue Complication Probability (NTCP) of the parotid glands. The studies showed a reduction of the volume in the PTVs and parotids, a medial displacement in COM, and alterations of the mean dose to the parotid glands as compared to the initial plans. Differences were observed for the dose volume coverage of the PTVs and NTCP of the parotid gland values between the initial plan and our proposed method utilizing deformable registration-based dose calculations.
Show less - Date Issued
- 2015
- PURL
- http://purl.flvc.org/fau/fd/FA00004491
- Subject Headings
- Cancer -- Radiation therapy, Head -- Cancer -- Treatment, Medical physics, Neck -- Cancer -- Treatment, Radiation dosimetry
- Format
- Document (PDF)
- Title
- A dosimetric study of a heterogeneous phantom for lung stereotactic body radiation therapy comparing Monte Carlo and pencil beam calculations to dose distributions measured with a 2-d diode array.
- Creator
- Curley, Casey Michael, Ouhib, Zoubir, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
- Abstract/Description
-
Monte Carlo (MC) and Pencil Beam (PB) calculations are compared to their measured planar dose distributions using a 2-D diode array for lung Stereotactic Body Radiation Therapy (SBRT). The planar dose distributions were studied for two different phantom types: an in-house heterogeneous phantom and a homogeneous phantom. The motivation is to mimic the human anatomy during a lung SBRT treatment and incorporate heterogeneities into the pre-treatment Quality Assurance process, where measured and...
Show moreMonte Carlo (MC) and Pencil Beam (PB) calculations are compared to their measured planar dose distributions using a 2-D diode array for lung Stereotactic Body Radiation Therapy (SBRT). The planar dose distributions were studied for two different phantom types: an in-house heterogeneous phantom and a homogeneous phantom. The motivation is to mimic the human anatomy during a lung SBRT treatment and incorporate heterogeneities into the pre-treatment Quality Assurance process, where measured and calculated planar dose distributions are compared before the radiation treatment. Individual and combined field dosimetry has been performed for both fixed gantry angle (anterior to posterior) and planned gantry angle delivery. A gamma analysis has been performed for all beam arrangements. The measurements were obtained using the 2-D diode array MapCHECK 2™.
Show less - Date Issued
- 2015
- PURL
- http://purl.flvc.org/fau/fd/FA00004360
- Subject Headings
- Cancer -- Radiotherapy, Drug development -- Computer simulation, Image guided radiation therapy, Ion bombardment, Lung cancer -- Treatment, Medical physics, Monte Carlo method, Proton beams
- Format
- Document (PDF)
- Title
- Phantom Study Incorporating A Diode Array Into The Treatment Planning System For Patient-Specific Quality Assurance.
- Creator
- Curley, Casey Michael, Leventouri, Theodora, Ouhib, Zoubir, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
- Abstract/Description
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The purpose of this research is to accurately match the calculation environment, i.e. the treatment planning system (TPS) with the measurement environment (using a 2-D diode array) for lung Stereotactic Body Radiation Therapy (SBRT) patient-specific quality assurance (QA). Furthermore, a new phantom was studied in which the 2-D array and heterogeneities were incorporated into the patient-specific QA process for lung SBRT. Dual source dual energy computerized tomography (DSCT) and single...
Show moreThe purpose of this research is to accurately match the calculation environment, i.e. the treatment planning system (TPS) with the measurement environment (using a 2-D diode array) for lung Stereotactic Body Radiation Therapy (SBRT) patient-specific quality assurance (QA). Furthermore, a new phantom was studied in which the 2-D array and heterogeneities were incorporated into the patient-specific QA process for lung SBRT. Dual source dual energy computerized tomography (DSCT) and single energy computerized tomography (SECT) were used to model phantoms incorporating a 2-D diode array into the TPS. A water-equivalent and a heterogeneous phantom (simulating the thoracic region of a patient) were studied. Monte Carlo and pencil beam dose distributions were compared to the measured distributions. Composite and individual fields were analyzed for normally incident and planned gantry angle deliveries. The distributions were compared using γ-analysis for criteria 3% 3mm, 2% 2mm, and 1% 1mm. The Monte Carlo calculations for the DSCT modeled phantoms (incorporating the array) showed an increase in the passing percentage magnitude for 46.4 % of the fields at 3% 3mm, 85.7% at 2% 2mm, and 92.9% at 1% 1mm. The Monte Carlo calculations gave no agreement for the same γ-analysis criteria using the SECT. Pencil beam calculations resulted in lower passing percentages when the diode array was incorporated in the TPS. The DSCT modeled phantoms (incorporating the array) exhibited decrease in the passing percentage magnitude for 85.7% of the fields at 3% 3mm, 82.1% at 2% 2mm, and 71.4% at 1% 1mm. In SECT modeled phantoms (incorporating the array), a decrease in passing percentage magnitude were found for 92.9% of the fields at 3% 3mm, 89.3% at 2% 2mm, and 82.1% at 1% 1mm. In conclusion, this study demonstrates that including the diode array in the TPS results in increased passing percentages when using a DSCT system with a Monte Carlo algorithm for patient-specific lung SBRT QA. Furthermore, as recommended by task groups (e.g. TG 65, TG 101, TG 244) of the American Association of Physicists in Medicine (AAPM), pencil beam algorithms should be avoided in the presence of heterogeneous materials, including a diode array.
Show less - Date Issued
- 2016
- PURL
- http://purl.flvc.org/fau/fd/FA00004744, http://purl.flvc.org/fau/fd/FA00004744
- Subject Headings
- Cancer--Radiotherapy., Lungs--Cancer--Treatment., Monte Carlo method., Proton beams., Image-guided radiation therapy., Ion bombardment., Medical physics.
- Format
- Document (PDF)
- Title
- Empirical beam angle optimization for lung cancer intensity modulated radiation therapy.
- Creator
- Doozan, Brian, Pella, Silvia, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
- Abstract/Description
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Empirical methods of beam angle optimization (BAO) are tested against the BAO that is currently employed in Eclipse treatment planning software. Creating an improved BAO can decrease the amount of time a dosimetrist spends on making a treatment plan, improve the treatment quality and enhance the tools an inexperienced dosimetrist can use to develop planning techniques. Using empirical data created by experienced dosimetrists from 69 patients treated for lung cancer, the most frequently used...
Show moreEmpirical methods of beam angle optimization (BAO) are tested against the BAO that is currently employed in Eclipse treatment planning software. Creating an improved BAO can decrease the amount of time a dosimetrist spends on making a treatment plan, improve the treatment quality and enhance the tools an inexperienced dosimetrist can use to develop planning techniques. Using empirical data created by experienced dosimetrists from 69 patients treated for lung cancer, the most frequently used gantry angles were applied to four different regions in each lung to gather an optimal set of fields that could be used to treat future lung cancer patients. This method, given the moniker FAU BAO, is compared in 7 plans created with the Eclipse BAO choosing 5 fields and 9 fields. The results show that the conformality index improved by 30% or 3% when using the 5 and 9 fields. The conformation number was better by 12% from the 5 fields and 9% from the 9 fields. The organs at risk (OAR) were overall more protected to produce fewer nonstochastic effects from the radiation treatment with the FAU BAO.
Show less - Date Issued
- 2014
- PURL
- http://purl.flvc.org/fau/fd/FA00004280, http://purl.flvc.org/fau/fd/FA00004280
- Subject Headings
- Cancer -- Radiotherapy, Image guided radiation therapy, Lung cancer -- Treatment, Medical physics, Medical radiology -- Data processing, Medicine -- Mathematical models
- Format
- Document (PDF)
- Title
- The Advantages of Collimator Optimization for Intensity Modulated Radiation Therapy.
- Creator
- Doozan, Brian, Leventouri, Theodora, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
- Abstract/Description
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The goal of this study was to improve dosimetry for pelvic, lung, head and neck, and other cancers sites with aspherical planning target volumes (PTV) using a new algorithm for collimator optimization for intensity modulated radiation therapy (IMRT) that minimizes the x-jaw gap (CAX) and the area of the jaws (CAA) for each treatment field. A retroactive study on the effects of collimator optimization of 20 patients was performed by comparing metric results for new collimator optimization...
Show moreThe goal of this study was to improve dosimetry for pelvic, lung, head and neck, and other cancers sites with aspherical planning target volumes (PTV) using a new algorithm for collimator optimization for intensity modulated radiation therapy (IMRT) that minimizes the x-jaw gap (CAX) and the area of the jaws (CAA) for each treatment field. A retroactive study on the effects of collimator optimization of 20 patients was performed by comparing metric results for new collimator optimization techniques in Eclipse version 11.0. Keeping all other parameters equal, multiple plans are created using four collimator techniques: CA0, all fields have collimators set to 0°, CAE, using the Eclipse collimator optimization, CAA, minimizing the area of the jaws around the PTV, and CAX, minimizing the x-jaw gap. The minimum area and the minimum x-jaw angles are found by evaluating each field beam’s eye view of the PTV with ImageJ and finding the desired parameters with a custom script. The evaluation of the plans included the monitor units (MU), the maximum dose of the plan, the maximum dose to organs at risk (OAR), the conformity index (CI) and the number of fields that are calculated to split. Compared to the CA0 plans, the monitor units decreased on average by 6% for the CAX method with a p-value of 0.01 from an ANOVA test. The average maximum dose remained within 1.1% difference between all four methods with the lowest given by CAX. The maximum dose to the most at risk organ was best spared by the CAA method, which decreased by 0.62% compared to the CA0. Minimizing the x-jaws significantly reduced the number of split fields from 61 to 37. In every metric tested the CAX optimization produced comparable or superior results compared to the other three techniques. For aspherical PTVs, CAX on average reduced the number of split fields, lowered the maximum dose, minimized the dose to the surrounding OAR, and decreased the monitor units. This is achieved while maintaining the same control of the PTV.
Show less - Date Issued
- 2017
- PURL
- http://purl.flvc.org/fau/fd/FA00004804, http://purl.flvc.org/fau/fd/FA00004804
- Subject Headings
- Radiation--Dosage., Optical engineering., Medical physics., Image-guided radiation therapy., Cancer--Radiotherapy., Medical radiology--Data processing., Medicine--Mathematical models.
- Format
- Document (PDF)
- Title
- COMMISSIONING AND ACCEPTANCE TESTING OF A TRUEBEAM LINEAR ACCELERATOR.
- Creator
- Dumitru, Nicolae, Pella, Silvia, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
- Abstract/Description
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Due to the difficulty of a complex commissioning technique for a multi energetic, multi-modality linear accelerator, I perform all the commissioning and acceptance testing for a TrueBeam linear accelerator with 4 megavoltage (MV) energies of which 2 are flattening filter-free (FFF) and 6 electron energies varying from 6 MeV to 20 MeV. A 2 dimensional (2D) water tank was used for scanning all the required field sizes for all the energies. The one dimensional (1D) water tank was used to collect...
Show moreDue to the difficulty of a complex commissioning technique for a multi energetic, multi-modality linear accelerator, I perform all the commissioning and acceptance testing for a TrueBeam linear accelerator with 4 megavoltage (MV) energies of which 2 are flattening filter-free (FFF) and 6 electron energies varying from 6 MeV to 20 MeV. A 2 dimensional (2D) water tank was used for scanning all the required field sizes for all the energies. The one dimensional (1D) water tank was used to collect all the output factors for all the photon fields sizes small to medium electron field sizes. For the large electron fields sizes, we had to use the 2D water tank. All the collected data was converted into a file type accepted by the planning system (Eclipse) and subsequently imported there. Treatment plans were generated using multiple forms of planning to verify the viability and quality of the beam data commissioned.
Show less - Date Issued
- 2019
- PURL
- http://purl.flvc.org/fau/fd/FA00013301
- Subject Headings
- Linear accelerators, Cancer--Treatment, Radiation dosimetry
- Format
- Document (PDF)
- Title
- Validation of a Monte Carlo dose calculation algorithm for clinical electron beams in the presence of phantoms with complex heterogeneities.
- Creator
- Enright, Shayla Landfair, Pella, Silvia, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
- Abstract/Description
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The purpose of this thesis is to validate the Monte Carlo algorithm for electron radiotherapy in the Eclipse™ treatment planning system (TPS), and to compare the accuracy of the Electron Monte Carlo algorithm (eMC) to the Pencil Beam algorithm (PB) in Eclipse™. Dose distributions from GafChromic™ EBT3 film measurements were compared to dose distributions from eMC and PB treatment plans. Measurements were obtained with 6MeV, 9MeV, and 12MeV electron beams at various depths. A 1 cm thick solid...
Show moreThe purpose of this thesis is to validate the Monte Carlo algorithm for electron radiotherapy in the Eclipse™ treatment planning system (TPS), and to compare the accuracy of the Electron Monte Carlo algorithm (eMC) to the Pencil Beam algorithm (PB) in Eclipse™. Dose distributions from GafChromic™ EBT3 film measurements were compared to dose distributions from eMC and PB treatment plans. Measurements were obtained with 6MeV, 9MeV, and 12MeV electron beams at various depths. A 1 cm thick solid water template with holes for bone-like and lung-like plugs was used to create assorted configurations and heterogeneities. Dose distributions from eMC plans agreed better with the film measurements based on gamma analysis. Gamma values for eMC were between 83%-99%, whereas gamma values for PB treatment plans were as low as 38.66%. Our results show that using the eMC algorithm will improve dose accuracy in regions with heterogeneities and should be considered over PB.
Show less - Date Issued
- 2014
- PURL
- http://purl.flvc.org/fau/fd/FA00004192
- Subject Headings
- Electron beams -- Therapeutic use, Image guided radiotherapy, Monte Carlo method, Proton beams -- Therapeutic use, Radiation dosimetry, Radiotherapy, High energy
- Format
- Document (PDF)
- Title
- Improving In Vivo Two Photon Microscopy Without Adaptive Optics.
- Creator
- Estrada, Gerardo, Beetle, Christopher, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
- Abstract/Description
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Two photon microscopy is one of the fastest growing methods of in-vivo imaging of the brain. It has the capability of imaging structures on the scale of 1μm. At this scale the wavelength of the imaging field (usually near infra-red), is comparable to the size of the structures being imaged, which makes the use of ray optics invalid. A better understanding is needed to predict the result of introducing different media into the light path. We use Wolf's integral, which is capable of fulfilling...
Show moreTwo photon microscopy is one of the fastest growing methods of in-vivo imaging of the brain. It has the capability of imaging structures on the scale of 1μm. At this scale the wavelength of the imaging field (usually near infra-red), is comparable to the size of the structures being imaged, which makes the use of ray optics invalid. A better understanding is needed to predict the result of introducing different media into the light path. We use Wolf's integral, which is capable of fulfilling these needs without the shortcomings of ray optics. We predict the effects of aberrating media introduced into the light path like glass cover-slips and then correct the aberration using the same method. We also create a method to predict aberrations when the interfaces of the media in the light-path are not aligned with the propagation direction of the wavefront.
Show less - Date Issued
- 2015
- PURL
- http://purl.flvc.org/fau/fd/FA00004495
- Subject Headings
- Cellular signal transmission -- Measurement, Image analysis, Imaging systems in medicine, Membranes (Biology) -- Imaging, Neurons -- Imaging, Optics, Adaptive
- Format
- Document (PDF)