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GFAP-based gene therapy for treatment of retinal diseases
Title
GFAP-based gene therapy for treatment of retinal diseases.
Creator
Dorey, C. Kathleen, Blanks, Janet C., Prentice, Howard, Florida Atlantic University
Date Issued
2005-11
PURL
http://purl.flvc.org/fcla/dt/15800
Format
Document (PDF)
GFAP-Based Gene Therapy for Treatment of Retinal Diseases, 2008
Title
GFAP-Based Gene Therapy for Treatment of Retinal Diseases, 2008.
Creator
Dorey, C. Kathleen, Blanks, Janet C., Florida Atlantic University, Prentice, Howard
Abstract/Description
Compositions and methods for reducing neovascularization. Purified nucleic acid constructs and vectors encoding an antiangiogenic protein operably linked to a GFAP promoter. Vectors can include at least one hypoxia regulated element, enhancer element and silencer element. Gene therapy methods for reducing, delaying or preventing neovascularization based on the nucleic acid constructs and vectors.
Date Issued
2008
PURL
http://purl.flvc.org/fau/fd/FAUIR000259
Format
Document (PDF)
Materials and Methods for the Treatment of Pathological Neovascularization in the Eye, 2012
Title
Materials and Methods for the Treatment of Pathological Neovascularization in the Eye, 2012.
Creator
Blanks, Janet C., Prentice, Howard M., Florida Atlantic University, Dorey, C. Kathleen
Abstract/Description
The subject invention provides materials and methods useful in safely and effectively preventing pathological proliferation of blood vessels. The prevention of the over-proliferation of blood vessels according to the subject invention is particularly advantageous for treatment of certain ocular conditions including age-related macular degeneration (AMD), retinopathy of prematurity (ROP) and diabetic retinopathy. In preferred embodiments, the subject invention provides materials and methods...
Show moreThe subject invention provides materials and methods useful in safely and effectively preventing pathological proliferation of blood vessels. The prevention of the over-proliferation of blood vessels according to the subject invention is particularly advantageous for treatment of certain ocular conditions including age-related macular degeneration (AMD), retinopathy of prematurity (ROP) and diabetic retinopathy. In preferred embodiments, the subject invention provides materials and methods for effective treatment of pathological ocular neovascularization using gene therapy. In a specific embodiment the materials and methods of the subject invention can be used to treat AMD.
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Date Issued
2012
PURL
http://purl.flvc.org/fau/fd/FAUIR000245
Format
Document (PDF)