Current Search: info:fedora/islandora:personCModel (x) » Miami (Fla.) (x) » text (x) » Marine natural products (x)
Pages
-
-
Title
-
8-hydroxymanzamine A, a β-Carboline alkaoid from a sponge, Pachypellina sp.
-
Creator
-
Ichiba, T., Corgiat, J. M., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
-
Date Issued
-
1994
-
PURL
-
http://purl.flvc.org/FCLA/DT/3318972
-
Subject Headings
-
Sponges --Research, Marine natural products
-
Format
-
Document (PDF)
-
-
Title
-
A brominated (aminoimidazolinyl) indole from the sponge Discodermia polydiscus.
-
Creator
-
Sun, H. H., Sakemi, S., Harbor Branch Oceanographic Institute
-
Date Issued
-
1991
-
PURL
-
http://purl.flvc.org/FCLA/DT/3332982
-
Subject Headings
-
Sponges, Indoles, Marine natural products
-
Format
-
Document (PDF)
-
-
Title
-
A new bastadin from the sponge Psammaplysilla purpurea.
-
Creator
-
Carney, J. R., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
-
Date Issued
-
1993
-
PURL
-
http://purl.flvc.org/FCLA/DT/3318955
-
Subject Headings
-
Sponges --Research, Marine metabolites, Marine natural products
-
Format
-
Document (PDF)
-
-
Title
-
A new bis-(indole) alkaloid from a deep-water marine sponge of the genus Spongosorites.
-
Creator
-
Wright, Amy E., Pomponi, Shirley A., Cross, S. S., McCarthy, Peter J.
-
Date Issued
-
1992
-
PURL
-
http://purl.flvc.org/FCLA/DT/3333002
-
Subject Headings
-
Sponges, Indole alkaloids, Marine natural products
-
Format
-
Document (PDF)
-
-
Title
-
A new cytotoxic sterol methoxymethyl ether from a deep water marine sponge Scleritoderma sp. cf. paccardi.
-
Creator
-
Gunasekera, Sarath P., Kelly-Borges, M., Longley, Ross E., Harbor Branch Oceanographic Institute
-
Date Issued
-
1996
-
PURL
-
http://purl.flvc.org/FCLA/DT/3319090
-
Subject Headings
-
Sponges --Research, Sterols, Marine natural products, NMR spectroscopy
-
Format
-
Document (PDF)
-
-
Title
-
A new sesterterpene, Sch 599473, from a marine sponge, Ircinia sp.
-
Creator
-
Yang, Shu-Wei, Chan, Tze-Ming, Pomponi, Shirley A., Gonsiorek, W., Chen, Guodong, Wright, Amy E., Hipkin, W., Patel, Mahesh, Gullo, Vincent, Pramanik, B., Zavodny, P., Chu, Min
-
Date Issued
-
2003
-
PURL
-
http://purl.flvc.org/FCLA/DT/3351980
-
Subject Headings
-
Sponges, Sesterterpenes, Marine natural products
-
Format
-
Document (PDF)
-
-
Title
-
A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis.
-
Creator
-
Guzman, Esther A., Johnson, J. D., Linley, P. A., Wright, Amy E., Gunasekera, Sarath P.
-
Date Issued
-
2010
-
PURL
-
http://purl.flvc.org/FCLA/DT/3318907
-
Subject Headings
-
Pancreas--Cancer, Apoptosis, Sponges--Research, Marine natural products, Drug Discovery
-
Format
-
Document (PDF)
-
-
Title
-
A SHOTGUN METAGENOMIC APPROACH TO THE BIOSYNTHESIS OF MARINE NATURAL PRODUCTS.
-
Creator
-
Miller-Xavier, René Kathleen, Mincer, Tracy, Florida Atlantic University, Department of Biological Sciences, Charles E. Schmidt College of Science
-
Abstract/Description
-
Genomics has been revolutionized by improved sequencing technologies, allowing for the detailed exploration of microbial dark matter and complex microscopic ecosystems. The bottleneck in genomic workflows has shifted from high-throughput sequencing to data analysis. This dissertation developed the Florida Center for Coastal and Human Health Shotgun Metagenomics Workflow (FCHsm) that is easy to use and tailor to unique datasets. This work acts as the beta-testing for the workflow, as it...
Show moreGenomics has been revolutionized by improved sequencing technologies, allowing for the detailed exploration of microbial dark matter and complex microscopic ecosystems. The bottleneck in genomic workflows has shifted from high-throughput sequencing to data analysis. This dissertation developed the Florida Center for Coastal and Human Health Shotgun Metagenomics Workflow (FCHsm) that is easy to use and tailor to unique datasets. This work acts as the beta-testing for the workflow, as it analyzes disparate biomes (environmental and host microbiomes) at varying sequencing depths (shallow and deep). FCHsm was used to resolve molecular dynamics and mine trans-kingdom metagenomes for secondary metabolic biosynthetic gene clusters (BGCs) in two marine environments— Indian River Lagoon toxic harmful algal blooms (IRL HABs) and the medicinal Leiodermatium sponge holobiont. First, an in silico mock dataset was analyzed to benchmark the FCHsm workflow. Sourmash, coupled with the Genome Taxonomy Database, outcompeted the other taxonomic profilers by accurately predicting the size of the mock metagenome (450 genomes) and recalling the highest number of species (82 %) and strains (44 %). Nonpareil calculated the sequencing effort needed for 100 % coverage for all the datasets and correctly estimated the 75 Gbp of sequencing needed for almost 100 % coverage of the mock metagenomes (99.5 %). Next, the trans-kingdom metagenomes of the IRL were explored, and potential HAB biomarkers were identified.
Show less
-
Date Issued
-
2023
-
PURL
-
http://purl.flvc.org/fau/fd/FA00014186
-
Subject Headings
-
Marine natural products, Metagenomics
-
Format
-
Document (PDF)
-
-
Title
-
Acetylated analogues of the microtubule stabilizing agent Discodermolide: preparation and biological activity.
-
Creator
-
Gunasekera, Sarath P., Longley, Ross E., Isbrucker, Richard A., Harbor Branch Oceanographic Institute
-
Date Issued
-
2001
-
PURL
-
http://purl.flvc.org/FCLA/DT/3319101
-
Subject Headings
-
Sponges --Research, Marine natural products, Cytotoxin, Acetylation
-
Format
-
Document (PDF)
-
-
Title
-
An antiviral sesquiterpene hydroquinone from the marine sponge Strongylophora hartmani.
-
Creator
-
Wright, Amy E., Rueth, S. A., Cross, S. S.
-
Date Issued
-
1991
-
PURL
-
http://purl.flvc.org/FCLA/DT/3332987
-
Subject Headings
-
Sponges, Sesquiterpenes, Marine natural products, Spectroscopy
-
Format
-
Document (PDF)
-
-
Title
-
Analogs of the marine immunosuppressant microcolin A: Preparation and biological activity.
-
Creator
-
Koehn, F. E., Longley, Ross E., Sennett, Susan H., Reed, John K.
-
Date Issued
-
1994
-
PURL
-
http://purl.flvc.org/FCLA/DT/3331884
-
Subject Headings
-
Immunosuppressive agents, Immunosuppressive agents--Mechanism of action, Immunosuppressive agents--Testing, Marine natural products
-
Format
-
Document (PDF)
-
-
Title
-
Antifungal activity of meridine, a natural product from the marine sponge Corticium sp.
-
Creator
-
McCarthy, Peter J., Pitts, Tara P., Gunawardana, G. P., Kelly-Borges, M., Pomponi, Shirley A.
-
Date Issued
-
1992
-
PURL
-
http://purl.flvc.org/FCLA/DT/3333005
-
Subject Headings
-
Sponges, Alkaloids, Marine natural products, Antifungal agents
-
Format
-
Document (PDF)
-
-
Title
-
Antitumor activity and biochemical effects of topsentin.
-
Creator
-
Burres, N. S., Barber, D. A., Gunasekera, Sarath P., Clement, J. J., Shen, L. L.
-
Date Issued
-
1991
-
PURL
-
http://purl.flvc.org/FCLA/DT/3355144
-
Subject Headings
-
Marine natural products, Antitumor agents
-
Format
-
Document (PDF)
-
-
Title
-
Antitumor activity and nucleic acid binding properties of Dercitin, a new acridinealkaloid isolated from a marine dercitus species sponge.
-
Creator
-
Burres, N. S., Sazesh, S., Gunawardana, G. P., Clement, J. J., Harbor Branch Oceanographic Institute
-
Date Issued
-
1989
-
PURL
-
http://purl.flvc.org/fau/fd/FA00007199
-
Subject Headings
-
Alkaloids, Acridines, Sponges, Antineoplastic agents, Cytotoxins, Marine natural products
-
Format
-
Document (PDF)
-
-
Title
-
Antitumor macrodiolides isolated from a marine sponge Theonella sp.: structure revision of misakinolide A.
-
Creator
-
Kato, Y., Fusetani, N., Matsunaga, S., Hashimoto, K., Sakai, R., Higa, T., Kashman, Y., Harbor Branch Oceanographic Institute
-
Date Issued
-
1987
-
PURL
-
http://purl.flvc.org/FCLA/DT/3353820
-
Subject Headings
-
Sponges, Antineoplastic agents, Macrolides, Chemical structure, Marine natural products
-
Format
-
Document (PDF)
-
-
Title
-
Antitumoractivity and mechanism of action of the novel marine natural products mycalamide-A and -B andonnamide.
-
Creator
-
Burres, N. S., Clement, J. J., Harbor Branch Oceanographic Institute
-
Date Issued
-
1989
-
PURL
-
http://purl.flvc.org/fau/fd/FA00007377
-
Subject Headings
-
Marine natural products, Pyrans, Marine Toxins, Antineoplastic agents
-
Format
-
Document (PDF)
-
-
Title
-
Aplysillin A, a thrombin receptor antagonist from the marine sponge, Aplysina fistularis fulva.
-
Creator
-
Gulavita, N. K., Pomponi, Shirley A., Wright, Amy E., Garay, M., Sills, Matthew A.
-
Date Issued
-
1995
-
PURL
-
http://purl.flvc.org/FCLA/DT/3319084
-
Subject Headings
-
Sponges --Research, Marine natural products, Receptors, Thrombin, Aplysillin A, Antagonists, Enzyme, Marine pharmacology
-
Format
-
Document (PDF)
-
-
Title
-
Bioactivity of marine organisms: relationships with taxonomy, geography and depth.
-
Creator
-
Reed, John K., Sennett, Susan H., McCarthy, Peter J., Pitts, Tara P., Wright, Amy E., Pomponi, Shirley A.
-
Date Issued
-
1998
-
PURL
-
http://purl.flvc.org/fau/fd/FA00007421
-
Subject Headings
-
Marine organisms, Bioactive compounds, Marine natural products
-
Format
-
Document (PDF)
-
-
Title
-
Biogenetically diverse, bioactive constituents of a sponge, order Verongida: bromotyramines and sesquiterpene-shikimate derived metabolites.
-
Creator
-
Hamann, Mark T., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
-
Date Issued
-
1993
-
PURL
-
http://purl.flvc.org/FCLA/DT/3318968
-
Subject Headings
-
Sponges --Research, Marine metabolites, Sesquiterpenes, Marine natural products
-
Format
-
Document (PDF)
-
-
Title
-
Biomedical research in the sea, a search for drugs and novel compounds.
-
Creator
-
Reed, John K., Pomponi, Shirley A.
-
Date Issued
-
1989
-
PURL
-
http://purl.flvc.org/FCLA/DT/3351938
-
Subject Headings
-
Biomedical Research, Marine natural products, Bioactive compounds, Drugs
-
Format
-
Document (PDF)
Pages