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Title: Study on pharmacokinetics and periodic drug dosing.
Creator: Taraskevich, Peter, Division of Academic Affairs, Florida Atlantic University
Date Issued: 2012-04-06
PURL: http://purl.flvc.org/fcla/dt/3351214
Subject Headings: Pharmacokinetics, Periodic drug dosing, Maximum tolerated dose, Fixed steady state
Format: Document (PDF)

Title: Synthesis and Sensing Studies of Erbium MOF Based on 2-2’-bithiophene- 5,5’-dicarboxylic acid.
Creator: Ortega, Raul E., Einkauf, Jeffrey D., De Lill, Daniel T., Mathivathanan, Logesh, Office of Undergraduate Research and Inquiry
Abstract/Description: Metal-organic frameworks (MOFs), are a unique class of materials in which metal clusters are linked together by organic moieties forming porous 1-D, 2-D, and 3-D structures. MOFs have many applications resulting from not only the overall structure, but also the metal center, organic “linker”, or a combination thereof. The high surface areas and porosity of these materials have found use in heterogeneous catalysis, display technologies, semiconducting materials, and biomedicine. These...
Show moreMetal-organic frameworks (MOFs), are a unique class of materials in which metal clusters are linked together by organic moieties forming porous 1-D, 2-D, and 3-D structures. MOFs have many applications resulting from not only the overall structure, but also the metal center, organic “linker”, or a combination thereof. The high surface areas and porosity of these materials have found use in heterogeneous catalysis, display technologies, semiconducting materials, and biomedicine. These materials are also currently being developed as a new sensor technology for detection of potentially harmful chemicals. Nitroaromatics are key components in the fabrication of explosives, however, current detection methods are time consuming and expensive. Considering this, our interest lies in synthesizing MOFs that can be used as a sensor for nitroaromatic compounds. To this end, our lab has developed a new Er(III) MOF based on the linker 2-2’-bithiophene-5,5’-dicarboxylic acid (DTDC). Herein, synthesis and nitroaromatic sensing studies will be discussed.
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Date Issued: 2017
PURL: http://purl.flvc.org/fau/fd/FA00005632
Subject Headings: College students --Research --United States.
Format: Document (PDF)

Title: Synthesis of Complex Polycyclic Scaffolds Incorporating α-Amino Esters.
Creator: Zorc, Stephen A., Samanta, Shyam S., Roche, Stéphane P., Charles E. Schmidt College of Science
Abstract/Description: In order to keep up with the high demand for biologically active molecules, chemists devised several synthetic strategies to access novel chemical spaces. The two main strategies to construct new scaffolds are to revisit underexploited or forgotten reactions or to devise new transformations. We are exploring a unique and underexploited reaction, the Himbert–Henn cycloaddition, to produce complex molecular scaffolds in a single step (strategy 1). In a second novel approach, we are modifying...
Show moreIn order to keep up with the high demand for biologically active molecules, chemists devised several synthetic strategies to access novel chemical spaces. The two main strategies to construct new scaffolds are to revisit underexploited or forgotten reactions or to devise new transformations. We are exploring a unique and underexploited reaction, the Himbert–Henn cycloaddition, to produce complex molecular scaffolds in a single step (strategy 1). In a second novel approach, we are modifying the Hantzsch 4-component reaction (4CR) by incorporating an α-amino ester residue to construct new molecules (strategy 2). Both of these reactions have great potential to synthesize novel and chiral molecules from proteinogenic α-amino esters. These unprecedented and complex polycyclic molecules have potential application in medicinal chemistry and natural product synthesis. 4-aza-podophyllotoxins obtained by the Hantzsch-4CR have been proven to be potent as anti-leukemia, anti-colon cancer, and vascular disrupting agents (with nanomolar activity).
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Date Issued: 2015
PURL: http://purl.flvc.org/fau/fd/FA00005218
Subject Headings: College students --Research --United States.
Format: Document (PDF)

Title: Synthesis of Podophyllotoxin Derivatives.
Creator: Flint, Madison, Roche, Stéphane P.
Abstract/Description: Podophyllotoxin is a natural aryltetralin lignan compound isolated from plants within the genus Podophyllum. Podophyllotoxin has been under extensive biochemical investigation since the discovery of its biological activity as a strong microtubule destabilizing mitotic agent. Although these antineoplastic compounds have shown significant activity as cancerous cell growth inhibitors, they lack selectivity and are thus extremely toxic to healthy cells. This has led to a recent interest in the...
Show morePodophyllotoxin is a natural aryltetralin lignan compound isolated from plants within the genus Podophyllum. Podophyllotoxin has been under extensive biochemical investigation since the discovery of its biological activity as a strong microtubule destabilizing mitotic agent. Although these antineoplastic compounds have shown significant activity as cancerous cell growth inhibitors, they lack selectivity and are thus extremely toxic to healthy cells. This has led to a recent interest in the synthesis of Podophyllotoxin analogues in hopes of optimizing the biological selectivity and potency of these semi-synthetic derivatives. The objective of my research in the Roche group is to generate a library of these derivatives for subsequent biological assays to determine their potential as chemotherapeutic agents. In total I have synthesized 22 Podophyllotoxin analogues. Of these 22 derivatives, 14 have been biologically evaluated and 4 were observed to possess promising anti-cancer activity and are currently undergoing further evaluation.
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Date Issued: 2014
PURL: http://purl.flvc.org/fau/fd/FA0005014
Subject Headings: College students --Research --United States.
Format: Document (PDF)

Title: T.O.S.S ( The Official Shredding System).
Creator: Vanande, Katryna, Horowitz, Arielle, Smith, Jo Mei, Zingman, Shana
Abstract/Description: In the past 24 years, the United States Postal Service (USPS) has decommissioned over 218,064 mail drop-off collection boxes due to lack of usage. The mail collection at these mailboxes is projected to drop even more in the coming years. This project's objective is to repurpose the decommissioned mailboxes into The Official Shredding System (TOSS). TOSS will be a publicly accessible shredding service located at official USPS locations to ensure security. TOSS will allow people to destroy...
Show moreIn the past 24 years, the United States Postal Service (USPS) has decommissioned over 218,064 mail drop-off collection boxes due to lack of usage. The mail collection at these mailboxes is projected to drop even more in the coming years. This project's objective is to repurpose the decommissioned mailboxes into The Official Shredding System (TOSS). TOSS will be a publicly accessible shredding service located at official USPS locations to ensure security. TOSS will allow people to destroy sensitive documents and mail with personal information in a secure setting. The shredded documents will ultimately be recycled through the current USPS recycling system. The goal and research of the project is to demonstrate how interdisciplinary studies of graphic design and engineering can work together to address and solve social problems. The result of this project will be communicated in a concept manual.
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Date Issued: 2014
PURL: http://purl.flvc.org/fau/fd/FA0005039
Subject Headings: College students --Research --United States.
Format: Document (PDF)

Title: Taking a Brain Break.
Creator: Burton, Christiania, Dassa, Lori, Office of Undergraduate Research and Inquiry
Abstract/Description: The purpose of the project was to see if giving students a structured physical activity break after a lesson and before the intended summative assessment would increase their scores academically and/ or decrease their test anxiety. The idea was acquired from spending over 1,000 hours in elementary school classrooms ranging from kindergarten to fifth grade. It was observed that after a 30-minute math lesson, the students were expected to take an assessment based on the content of the lesson....
Show moreThe purpose of the project was to see if giving students a structured physical activity break after a lesson and before the intended summative assessment would increase their scores academically and/ or decrease their test anxiety. The idea was acquired from spending over 1,000 hours in elementary school classrooms ranging from kindergarten to fifth grade. It was observed that after a 30-minute math lesson, the students were expected to take an assessment based on the content of the lesson. It seemed as if students were having a difficult time focusing on the test and were getting wiggly in their seats. The students seemed nervous to take a test directly after instruction and some of the scores were not as high as intended. This was the basis behind conducting this research. There had to be a solution to this problem and the researcher was determined to find one.
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Date Issued: 2017
PURL: http://purl.flvc.org/fau/fd/FA00005616
Subject Headings: College students --Research --United States.
Format: Document (PDF)

Title: Taxation and the Separation of Church and State.
Creator: Roman, Abel, Arflin, Cheryl, Office of Undergraduate Research and Inquiry
Abstract/Description: The separation of church and state was passed under the First Amendment in 1791. However, Since its inception the United States has not followed through with this philosophy. Since colonial times, churches have been privileged with tax exemptions. Nine out of the thirteen colonies had some form of tax relief to aid their churches. This right was granted to all religious organizations with the expectation that they would contribute to their communities by providing aid to the poor. Through...
Show moreThe separation of church and state was passed under the First Amendment in 1791. However, Since its inception the United States has not followed through with this philosophy. Since colonial times, churches have been privileged with tax exemptions. Nine out of the thirteen colonies had some form of tax relief to aid their churches. This right was granted to all religious organizations with the expectation that they would contribute to their communities by providing aid to the poor. Through their constant reformation, tax laws have achieved a more rigorous stance on religious tax exemptions, yet lack the integrity needed to prevent religious organizations from taking advantage of the current tax laws. The objective of this project is to analyze how the church went from being humble, to a corporation that exploits the current tax exemptions law, and how we need reconstruct the current tax exemptions on religious organization.
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Date Issued: 2016
PURL: http://purl.flvc.org/fau/fd/FA00005602
Subject Headings: College students --Research --United States.
Format: Document (PDF)

Title: Tea masters as master builders: the predecessors of the architectural profession in Japan.
Creator: Brodeur, Angelica, Kulic, Vladimir
Date Issued: 2012-04-06
PURL: http://purl.flvc.org/fcla/dt/3350932
Subject Headings: Japanese tea masters, Architecture --Japan, Tearooms --Japan, Sen no Rikyu
Format: Document (PDF)

Title: Technology and Design of a Fuel Cell - Photo-Voltaic Powered Vehicle with an Energy Storage System.
Creator: Augustin, Windy, Carvalho Dias, Thiago, Flit, Mike, Bennett, Thomas, Zilouchian, Ali
Abstract/Description: FAU's Office of Undergraduate Research and Inquiry hosts an annual symposium where students engaged in undergraduate research may present their findings either through a poster presentation or an oral presentation.
Date Issued: 2011
PURL: http://purl.flvc.org/fau/fd/FA00005427
Format: Document (PDF)

Title: Temporal Ontogeny of Epileptogenesis in a Model of Adult-onset, Spontaneous Seizures.
Creator: Melanie Gil, Rachel St. Clair, Ceylan Isgor
Date Issued: 2017
PURL: http://purl.flvc.org/fau/fd/FAU_SR00000010
Subject Headings: College students --Research --United States.
Format: Document (PDF)

Title: Testing Links Between Cognition and Stress Responsiveness in a Songbird.
Creator: Jenny Applebaum, Rindy Anderson
Date Issued: 2017
PURL: http://purl.flvc.org/fau/fd/FAU_SR00000001
Subject Headings: College students --Research --United States.
Format: Document (PDF)

Title: The American Family…As Seen on TV?.
Creator: Weisler, Joseph, Carreno-Lukasik, Gina, Office of Undergraduate Research and Inquiry
Abstract/Description: The public sphere has been long- saturated with the spectacle. Among the most prominent form of the spectacle on television is noted through infamous family sitcoms that work to explain the dynamics of family life. Sociologists have long questioned the role of the family, working to define it as an evolving institution. This qualitative deductive research study seeks to examine American family life and how it is sociologically interpreted on the screen. Using the sitcoms “Full House” to...
Show moreThe public sphere has been long- saturated with the spectacle. Among the most prominent form of the spectacle on television is noted through infamous family sitcoms that work to explain the dynamics of family life. Sociologists have long questioned the role of the family, working to define it as an evolving institution. This qualitative deductive research study seeks to examine American family life and how it is sociologically interpreted on the screen. Using the sitcoms “Full House” to examine the role of fathers in the family; “Step By Step” to evaluate the dynamic of step-family life; “George Lopez” and “One Day at a Time” to observe Latino-American life; “Black-ish” to understand the realities of Black-American life, and “Boy Meets World” to determine the ways in which education is responsible for shaping identity; this study works to embed and question the depictions of sitcoms into an analysis of American family life.
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Date Issued: 2017
PURL: http://purl.flvc.org/fau/fd/FA00005639
Subject Headings: College students --Research --United States.
Format: Document (PDF)

Title: The bidirectional interaction of oxytocin and cortisol levels in mother-infant dyads: a pilot study.
Creator: McDole, Brittnee, Hardin, Jillian, Jones, Nancy Aaron, Mize, Krystal D.
Date Issued: 2013-04-05
PURL: http://purl.flvc.org/fcla/dt/3361151
Subject Headings: Oxytocin, Cortisol, Infants--Development, Infants--Growth, Mother and infant
Format: Document (PDF)

Title: The construction of metal-organic hybrid materials based on benzophenone-4,4'-dicarboxylic acid.
Creator: Zribi, Dan, Torres, Melissa, De Lill, Daniel T.
Date Issued: 2013-04-05
PURL: http://purl.flvc.org/fcla/dt/3361243
Subject Headings: Dicarboxylic acids, Benzophenones, Lanthanides, Transition metals
Format: Document (PDF)

Title: The Determinants of Democratic Consolidation in Eastern Europe and the Former USSR.
Creator: Dolun, Deniz, Shaykhutdinov, Renat, Dorothy F. Schmidt College of Arts and Letters
Abstract/Description: The process of democratization still remains an ongoing process in the majority of the Eastern Bloc nations. A quarter century after the dissolution of the USSR and her satellite states, only eight of twenty-eight transitioning states have been able to fully democratize. Several of these anocratic states are today characterized by routine human rights violations, state repressions of civil society, and incarcerations of political opposition. There is limited cohesive research on how the Post...
Show moreThe process of democratization still remains an ongoing process in the majority of the Eastern Bloc nations. A quarter century after the dissolution of the USSR and her satellite states, only eight of twenty-eight transitioning states have been able to fully democratize. Several of these anocratic states are today characterized by routine human rights violations, state repressions of civil society, and incarcerations of political opposition. There is limited cohesive research on how the Post-Communist formation of oligarchs across Eurasia and increases in democratic transitioning period have influenced democratization. In this study, I research, test, and explain the effects of Post-Communist oligarchies and the periods of democratic transitions on current levels of democratic consolidation in twenty-eight former socialist states through publicly available statistics and primary sources. I find that while oligarchical influence on democratization is limited, shorter democratic transitions produce significantly higher levels of democratic consolidation than their prolonged counterparts.
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Date Issued: 2015
PURL: http://purl.flvc.org/fau/fd/FA00005183
Subject Headings: College students --Research --United States.
Format: Document (PDF)

Title: The development of parvalbumin-positive neurons in ferret visual cortex.
Creator: Casciato, Dominick Joseph
Abstract/Description: Experience plays a critical role in maturation of cortical circuits. In visual cortex, experience-dependent development has been linked to the maturation of inhibitory interneurons. Parvalbumin-containing (PV+) interneurons, a subtype of GABAergic interneurons, play an important role in cortical circuit function; however, it remains unknown how visual experience shapes their organization. We used immunohistochemistry to observe the organization of PV+ expression in visual cortex through...
Show moreExperience plays a critical role in maturation of cortical circuits. In visual cortex, experience-dependent development has been linked to the maturation of inhibitory interneurons. Parvalbumin-containing (PV+) interneurons, a subtype of GABAergic interneurons, play an important role in cortical circuit function; however, it remains unknown how visual experience shapes their organization. We used immunohistochemistry to observe the organization of PV+ expression in visual cortex through visual maturity. Before visual experience, PV+ cell bodies and processes are most pronounced in layer 5, less in layer 2/3, and generally lacking in layer 4. Within 3 days of the onset of visual experience, PV+ organization undergoes a major shift, with PV+ expression found throughout layers 2-6. We performed dark rearing which determined these morphological changes are due to visual experience. This rapid change in parvalbumin organization may play a role in functional changes associated with the onset of visual experience.
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Date Issued: 2014
PURL: http://purl.flvc.org/fau/fd/FA0005007
Subject Headings: College students --Research --United States.
Format: Document (PDF)

Title: The Effect of Inactivation of the Nucleus Reuniens on Spatial Working Memory.
Creator: Martinez Rey, Macarena, Minnerly, Christopher, Vertes, Robert P., Office of Undergraduate Research and Inquiry
Abstract/Description: The Nucleus Reuniens (RE) of the ventral midline thalamus has been shown to have extensive reciprocal innervations with the medial prefrontal cortex (mPFC) and the hippocampus (HF) in the brain of the rat. Both structures are essential for encoding, retrieval, and delayed spatial working memory. The (RE) is believed to play a vital role in facilitating cognitive function and affective behavior and has been shown to be critical for a variety of working memory tasks. In this study we tested...
Show moreThe Nucleus Reuniens (RE) of the ventral midline thalamus has been shown to have extensive reciprocal innervations with the medial prefrontal cortex (mPFC) and the hippocampus (HF) in the brain of the rat. Both structures are essential for encoding, retrieval, and delayed spatial working memory. The (RE) is believed to play a vital role in facilitating cognitive function and affective behavior and has been shown to be critical for a variety of working memory tasks. In this study we tested Long Evan rats using a T-maze. For each trial the rats were required to alternate between the left and right goal arms with a delay period in between randomized intervals of 30s, 60s, or 120s. After two consecutive testing days of 80% the rats were infused with muscimol procaine, and saline. We expect that the effect of reversible inactivation of RE will demonstrate a significant decline in performance of the task.
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Date Issued: 2016
PURL: http://purl.flvc.org/fau/fd/FA00005588
Subject Headings: College students --Research --United States.
Format: Document (PDF)

Title: The effect of medical labels on perceptions of illnesses and sufferers.
Creator: Lasaga, Jessica, Lanning, Kevin
Date Issued: 2012-04-06
PURL: http://purl.flvc.org/fcla/dt/3350916
Subject Headings: Medical labels, Concept formation, Attitude to health, Patients --psychology
Format: Document (PDF)

Title: The effect of mutated aconitase on yeast longevity.
Creator: Kwan, Melissa “CJ”, Kirchman, Paul
Date Issued: 2012-04-06
PURL: http://purl.flvc.org/fcla/dt/3350911
Subject Headings: Mitochondrial Proteins, Citric Acid Cycle, Aconitate Hydratase, ACO2 protein, human, Saccharomyces cerevisiae, Oxidative Stress, Yeast Longevity
Format: Document (PDF)

Title: The Effect of Time on Visual Search Patterns.
Creator: Tamir, Daniel, Higgen, Bonnie, Paredes, Luis, Taner, Utku, Office of Undergraduate Research and Inquiry
Abstract/Description: Spatial intelligence is the ability to conceptualize and comprehend complicated visual scenes. Previous studies have shown that scanning patterns change based on the content and the layout viewed. For example, subjects will scan a webpage differently when imagery is present as opposed to reading text-only pages. This study proposes the question: Does the element of time have a crucial effect on scanning patterns and the degree of comprehension? With the aid of eye-tracking technology, this...
Show moreSpatial intelligence is the ability to conceptualize and comprehend complicated visual scenes. Previous studies have shown that scanning patterns change based on the content and the layout viewed. For example, subjects will scan a webpage differently when imagery is present as opposed to reading text-only pages. This study proposes the question: Does the element of time have a crucial effect on scanning patterns and the degree of comprehension? With the aid of eye-tracking technology, this paper will explore subjects’ fixation durations and saccade patterns in a timed environment. The results may potentially influence methods for administering timed evaluations in the educational system.
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Date Issued: 2016
PURL: http://purl.flvc.org/fau/fd/FA00005575
Subject Headings: College students --Research --United States.
Format: Document (PDF)

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