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Effects of anoxia on methionine sulfoxide reductase (Msr) deficient drosophila
Title
Effects of anoxia on methionine sulfoxide reductase (Msr) deficient drosophila.
Creator
Howard, Danielle, Binninger, David
Date Issued
2013-04-05
PURL
http://purl.flvc.org/fcla/dt/3361093
Subject Headings
Anoxia, Drosophila, Reactive Oxygen Species
Format
Document (PDF)
The role of methionine sulfoxide reductase in thermal stress response
Title
The role of methionine sulfoxide reductase in thermal stress response.
Creator
Martin, James, Bruce, Lindsay, Schey, Karin, Binninger, David
Date Issued
2013-04-05
PURL
http://purl.flvc.org/fcla/dt/3361149
Subject Headings
Hyperthermia, Heat shock proteins, Methionine, Oxidative stress
Format
Document (PDF)
Effects of MsrA and MsrB During Anoxic Stress in Drosophila melanogaster
Title
Effects of MsrA and MsrB During Anoxic Stress in Drosophila melanogaster.
Creator
Suthakaran, Nirthieca, Binninger, David
Abstract/Description
Drosophila melanogaster can withstand hours of oxygen deprivation (anoxia) by entering a protective coma called spreading depression. When oxygen is reintroduced to the cells, a burst of reactive oxygen species (ROS) causes oxidative damage. Methionine is susceptible to oxidation to form methionine sulfoxide. This oxidation is reversible where methionine sulfoxide reductase (Msr) A and B reduce the S and R enantiomers, respectively. In this study, MsrA and MsrB single deletion lines were...
Show moreDrosophila melanogaster can withstand hours of oxygen deprivation (anoxia) by entering a protective coma called spreading depression. When oxygen is reintroduced to the cells, a burst of reactive oxygen species (ROS) causes oxidative damage. Methionine is susceptible to oxidation to form methionine sulfoxide. This oxidation is reversible where methionine sulfoxide reductase (Msr) A and B reduce the S and R enantiomers, respectively. In this study, MsrA and MsrB single deletion lines were exposed to one hour of anoxia and the Drosophila Activity Monitor (DAM) recorded their recovery times. RNA interference (RNAi) lines were used to mimic the effect of these deletion lines by ubiquitously knocking down their expression. My current data indicates that MsrA loss-of-function strains recover significantly faster than the MsrB loss-of-function lines with increasing age. Insight into the roles of Msr genes under anoxic stress could lead to a better understanding of how these genes contribute to aging.
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Date Issued
2014
PURL
http://purl.flvc.org/fau/fd/FA0005037
Subject Headings
College students --Research --United States.
Format
Document (PDF)