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The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells.
New cytotoxic acridine alkaloids from two deep water marine sponges of the family Pachastrellidae
Isometachromin, a new cytotoxic sesquiterpenoid from a deep water sponge of the family Spongiidae
Cytotoxic peptides from marine sponges
Antitumor activity and nucleic acid binding properties of Dercitin, a new acridinealkaloid isolated from a marine dercitus species sponge