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- Title
- Xestamines A, B, and C, three new long-chain methoxylamine pyridines from the sponge Xestospongia wiedenmayeri.
- Creator
- Sakemi, S., Totton, L. E., Sun, H. H., Harbor Branch Oceanographic Institute
- Date Issued
- 1990
- PURL
- http://purl.flvc.org/FCLA/DT/3332968
- Subject Headings
- Sponges, Pyridines, Alkaloids, Haplosclerida
- Format
- Document (PDF)
- Title
- Wiedendiol-A and -B, Cholesteryl ester transfer protein inhibitors from the marine sponge Xestospongia wiedenmayeri.
- Creator
- Coval, S. J., Conover, M. A., Mierzwa, Ronald, King, Arthur, Puar, M. S., Phife, D. W., Pai, J.-K., Burrier, R. E., Ahn, H.-S., Boykow, G. C., Patel, Mahesh, Pomponi, Shirley A.
- Date Issued
- 1995
- PURL
- http://purl.flvc.org/FCLA/DT/3331891
- Subject Headings
- Sponges, Sesquiterpenes, Cholesterol Ester Transfer Proteins, Marine natural products
- Format
- Document (PDF)
- Title
- Two new bioactive cyclic peroxides from the marine sponge Plakortis angulospiculatus.
- Creator
- Gunasekera, Sarath P., Gunasekera, M., Gunawardana, G. P., McCarthy, Peter J., Burres, N. S.
- Date Issued
- 1990
- PURL
- http://purl.flvc.org/FCLA/DT/3332965
- Subject Headings
- Sponges, Peroxides, Bioactive compounds, Antifungal agents, Cytotoxin, Marine metabolites
- Format
- Document (PDF)
- Title
- Two cytotoxic 3, 6-epidoxy fatty acids from an Indonesian sponge, Plakortis sp.
- Creator
- Ichiba, T., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
- Date Issued
- 1995
- PURL
- http://purl.flvc.org/FCLA/DT/3331902
- Subject Headings
- Sponges, Fatty acids, Cytotoxin, Marine natural products
- Format
- Document (PDF)
- Title
- Tsukamurella spongiae sp. nov., a novel actinomycete isolated from a deep-water marinesponge.
- Creator
- Olson, Julie B., Harmody, Dedra K., Bej, A. K., McCarthy, Peter J.
- Date Issued
- 2007
- PURL
- http://purl.flvc.org/fau/fd/FA00007117
- Subject Headings
- Curaçao, Sponges, Actinobacteria, Actinomycetes, RNA, Ribosomal, 16S
- Format
- Document (PDF)
- Title
- Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide.
- Creator
- Paterson, Ian, Naylor, G. J., Wright, Amy E.
- Date Issued
- 2008
- PURL
- http://purl.flvc.org/fau/fd/FA00007062
- Subject Headings
- Antineoplastic agents, Macrolides, Polyketides, Tubulin Modulators, Marine natural products, Sponges
- Format
- Document (PDF)
- Title
- Therapeutic potential, mechanism of action, and ecology of novel marine natural products.
- Creator
- Winder, Priscilla L., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
- Abstract/Description
-
The projects described in this dissertation are focused on compounds derived from the marine environment. Chapter 1 gives an introduction to the study of marine natural products to treat human ailments and a thorough review on compounds from lithistid sponges that have been isolated or synthesized since 2000. Chapter 2 describes the isolation and structure elucidation of two sesquiterpene substituted benzoquinone derivatives, petrosiquinones A and B, from a deep-water marine sponge from the...
Show moreThe projects described in this dissertation are focused on compounds derived from the marine environment. Chapter 1 gives an introduction to the study of marine natural products to treat human ailments and a thorough review on compounds from lithistid sponges that have been isolated or synthesized since 2000. Chapter 2 describes the isolation and structure elucidation of two sesquiterpene substituted benzoquinone derivatives, petrosiquinones A and B, from a deep-water marine sponge from the Family Petrosiidae. Although initially purified following activity in a (Sb(B-catenin/Tcf4 assay they were later followed using tumor cell line cytotoxicity assays. Petrosiquinone A was the more active of the two compounds with moderate cytotoxicity in the DLD-1, PANC-1, and AsPC-1 cell lines. In Chapter 3, the isolation and structure elucidation of two new marine-derived macrolides, madeirolide A and B, isolated from a deep-water lithistid sponge of the genus Leiodermatium is described., They were isolated using numerous chromatographic techniques and the structures were elucidated on the basis of 1D and 2D NMR spectra coupled with high resolution-mass spectrometry (HR-MS) data. Madeirolide A and B inhibited the growth of the fungal pathogen Candida albicans with minimum inhibitory concentrations (MIC) of 12.5 and 25 (So(Bg/mL, respectively, but were not cytotoxic in tumor cell assays under the conditions tested. Chapter 4 describes work performed to determine the molecular target of lasonolide A using affinity chromatography. The target of lasonolide A is of interest since lasonolide A is known to kill cancer cells in vitro through a unique mechanism., This chapter highlights the research performed to create an affinity matrix with immobilized lasonolide. A target has not been confirmed but there are a number of interesting hits that are being pursued. In Chapter 5, a liquid chromatography-mass spectrometry (LC-MS) screening method was established in order to rapidly identify the metabolites from numerous collections of Lyngbya spp. obtained from Broward and Lee County, Florida sites that may help marine ecologists assess the effects of Lyngbya spp. blooms on the environment. A link between the metabolites produced and nutrients from both the algal tissue and water column was also explored.
Show less - Date Issued
- 2009
- PURL
- http://purl.flvc.org/FAU/369392
- Subject Headings
- Natural products, Therapeutic use, Sponges, Ecology, Marine resources, Research, Marine biotechnology
- Format
- Document (PDF)
- Title
- Theopederins K and L. Highly Potent Cytotoxic Metabolites from a Marine Sponge Discodermia Species.
- Creator
- Paul, Gopal K., Gunasekera, Sarath P., Longley, Ross E., Pomponi, Shirley A.
- Date Issued
- 2002
- PURL
- http://purl.flvc.org/FCLA/DT/3164097
- Subject Headings
- Sponges, Marine metabolites, Bioactive compounds, Natural products, Cytotoxicity, Immunologic
- Format
- Document (PDF)
- Title
- The sponges of the tropicalisland region of Oceania: a taxonomic status review.
- Creator
- Kelly-Borges, M., Valentine, C., Harbor Branch Oceanographic Institute
- Date Issued
- 1995
- PURL
- http://purl.flvc.org/fau/fd/FA00007340
- Subject Headings
- Oceania, Sponges, Sponges--Classification
- Format
- Document (PDF)
- Title
- The microtubule-stabilizing agent discodermolide competitively inhibits the binding of paclitaxel (Taxol) to tubulin polymers, enhances tubulin nucleation reactions more potently than paclitaxel, and inhibits the growth of paclitaxel-resistant cells.
- Creator
- Kowalski, R. J., Giannakakou, P., Gunasekera, Sarath P., Longley, Ross E., Day, B. W., Hamel, E., Harbor Branch Oceanographic Institute
- Date Issued
- 1997
- PURL
- http://purl.flvc.org/fau/fd/FA00007052
- Subject Headings
- Marine natural products, Cytotoxins, Tubulin Modulators, Paclitaxel, Lactones, Sponges
- Format
- Document (PDF)
- Title
- The Lithistida: important sources of compounds useful in biomedical research.
- Creator
- Wright, Amy E.
- Date Issued
- 2010
- PURL
- http://purl.flvc.org/FCLA/DT/3331940
- Subject Headings
- Sponges, Biomedical research, Marine natural products, Bioactive compounds
- Format
- Document (PDF)
- Title
- The ecology of the western Atlantic athecate hydroid, Solanderia gracilis.
- Creator
- Larson, R. J., Harbor Branch Oceanographic Institute
- Date Issued
- 1987
- PURL
- http://purl.flvc.org/FCLA/DT/3172773
- Subject Headings
- Hydroida, Polyps, Algae, Ecology, Sponges
- Format
- Document (PDF)
- Title
- The discovery and characterization of an interleukin 6 cytokine familyantagonist protein from a marine sponge, Callyspongia sp.
- Creator
- Peppard, J. V., Loo, P., Sills, Matthew A., Wennogle, L., Wright, Amy E., Pomponi, Shirley A., Cueto, M.
- Date Issued
- 2001
- PURL
- http://purl.flvc.org/fau/fd/FA00007313
- Subject Headings
- Sponges, Interleukin-6, Cytokines--antagonists & inhibitors, Proteins--chemistry
- Format
- Document (PDF)
- Title
- The comparative structure of two western Atlantic reef-fish assemblages.
- Creator
- Alevizon, W. S., Brooks, M. G., Harbor Branch Oceanographic Institute
- Date Issued
- 1975
- PURL
- http://purl.flvc.org/FCLA/DT/3174428
- Subject Headings
- Coral reef fishes, Fish populations, Species diversity, Coral reef ecology, Sponges
- Format
- Document (PDF)
- Title
- The chemistry and biological activity of five marine sponges of the genus Aplysina.
- Creator
- Gunasekera, Sarath P., Cross, S. S., Longley, Ross E., Pomponi, Shirley A.
- Date Issued
- 1991
- PURL
- http://purl.flvc.org/fau/fd/FA00007303
- Subject Headings
- Sponges, Antiviral agents, Immunosuppressive agents, Bioactive compounds, Marine natural products
- Format
- Document (PDF)
- Title
- The cellular basis of photobehavior in the tufted parenchymella larva of demosponges.
- Creator
- Maldonado, Manuel, Durfort, M., McCarthy, A., Young, Craig M., Harbor Branch Oceanographic Institute
- Date Issued
- 2003
- PURL
- http://purl.flvc.org/FCLA/DT/2795622
- Subject Headings
- Sponges, Demospongiae, Marine animals --Effect of light on, Transmission electron microscopy, Cytology --Research
- Format
- Document (PDF)
- Title
- Sulfircin: a new sesterterpene sulfate from a deep-water sponge of the genus Ircinia.
- Creator
- Wright, Amy E., McCarthy, Peter J., Schulte, G. K.
- Date Issued
- 1989
- PURL
- http://purl.flvc.org/FCLA/DT/3332962
- Subject Headings
- Sponges, Sulfates, Sesterterpenes, Antifungal agents, Marine natural products
- Format
- Document (PDF)
- Title
- Strategies for flow cytometric analysis of marine microalgae and sponge cells.
- Creator
- Yentsch, C. M., Pomponi, Shirley A.
- Date Issued
- 1994
- PURL
- http://purl.flvc.org/FCLA/DT/3353886
- Subject Headings
- Microalgae, Sponges, Cytometric cellular analysis
- Format
- Document (PDF)
- Title
- Stochastic events and dynamics of a mangrove root epifaunal community.
- Creator
- Bingham, Brian L., Young, Craig M., Harbor Branch Oceanographic Institute
- Date Issued
- 1995
- PURL
- http://purl.flvc.org/fau/fd/FA00007233
- Subject Headings
- Mangroves, Ascidians, Sponges, Stability
- Format
- Document (PDF)
- Title
- Sterols of the marine sponge Petrosia weinbergi: implications for the absolute configurations of the antiviral orthoesterols and weinbersterols.
- Creator
- Giner, José-Luis, Gunasekera, Sarath P., Pomponi, Shirley A.
- Date Issued
- 1999
- PURL
- http://purl.flvc.org/FCLA/DT/3158771
- Subject Headings
- Sponges, Sterols --Analysis, Steroids, Biosynthesis, Marine metabolites
- Format
- Document (PDF)