Current Search: info:fedora/fau:CurrentETDs (x) » Songs and music (x) » Wright, Amy E. (x)
Pages
-
-
Title
-
Use of real-time qPCR to quantify members of the unculturable heterotrophic bacterial community in a deep sea marine sponge, Vetulina sp.
-
Creator
-
Cassler, M., Peterson, C. L., Ledger, Angela, Pomponi, Shirley A., Wright, Amy E., Winegar, R., McCarthy, Peter J., Lopez, Jose V.
-
Date Issued
-
2008
-
PURL
-
http://purl.flvc.org/FCLA/DT/2708323
-
Subject Headings
-
Microbiology --Research, Sponges --Microbiology, Marine biology --Caribbean Area
-
Format
-
Document (PDF)
-
-
Title
-
Two New Cytotoxic Linderazulenes from a Deep-Sea Gorgonian of the Genus Paramuricea.
-
Creator
-
Reddy, N. Srinivasa, Reed, John K., Longley, Ross E., Wright, Amy E.
-
Date Issued
-
2005
-
PURL
-
http://purl.flvc.org/FCLA/DT/3164111
-
Subject Headings
-
Paramuricea placomus, Deep-sea ecology, Cnidaria, Azulene, Spectrum analysis
-
Format
-
Document (PDF)
-
-
Title
-
Tubulin polymerizing activity of dictyostatin-1, a polyketide of marine sponge origin.
-
Creator
-
Isbrucker, Richard A., Cummins, Jennifer, Pomponi, Shirley A., Longley, Ross E., Wright, Amy E.
-
Date Issued
-
2003
-
PURL
-
http://purl.flvc.org/FCLA/DT/2848313
-
Subject Headings
-
Tubulins, Cytotaxonomy, Antimitotic agents, Polyketides, Cells
-
Format
-
Document (PDF)
-
-
Title
-
Tubercidin, A Cytotoxic Agent from the Marine Sponge Caulospongia biflabellata.
-
Creator
-
Biabani, Misbah F., Gunasekera, Sarath P., Longley, Ross E., Wright, Amy E., Pomponi, Shirley A.
-
Date Issued
-
2002
-
PURL
-
http://purl.flvc.org/FCLA/DT/2795916
-
Subject Headings
-
Demospongiae, Nucleosides --chemistry, Cytotoxins --biosynthesis --congresses, Streptomyces, Antitumor antibiotics
-
Format
-
Document (PDF)
-
-
Title
-
Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide.
-
Creator
-
Paterson, Ian, Naylor, G. J., Wright, Amy E.
-
Date Issued
-
2008
-
PURL
-
http://purl.flvc.org/fau/fd/FA00007062
-
Subject Headings
-
Antineoplastic agents, Macrolides, Polyketides, Tubulin Modulators, Marine natural products, Sponges
-
Format
-
Document (PDF)
-
-
Title
-
Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin.
-
Creator
-
Paterson, Ian, Naylor, G. J., Fujita, T., Guzman, Esther A., Wright, Amy E.
-
Date Issued
-
2010
-
PURL
-
http://purl.flvc.org/fau/fd/FA00007065
-
Subject Headings
-
Antineoplastic agents, Paclitaxel, Polyketides, Microtubules, Tubulin Modulators, Marine natural products
-
Format
-
Document (PDF)
-
-
Title
-
Total synthesis and biological evaluation of potent analogues of dictyostatin: modification of the C2-C6 dienoate region.
-
Creator
-
Paterson, Ian, Gardner, Nicola M., Guzman, Esther A., Wright, Amy E.
-
Date Issued
-
2008-12-01
-
PURL
-
http://purl.flvc.org/FCLA/DT/1591053
-
Subject Headings
-
Bioorganic chemistry, Cancer--Research
-
Format
-
Document (PDF)
-
-
Title
-
Total synthesis and biological evaluation of novel C2–C6 region analogues of dictyostatin.
-
Creator
-
Paterson, Ian, Gardner, Nicola M., Guzman, Esther A., Wright, Amy E.
-
Date Issued
-
2009-03-15
-
PURL
-
http://purl.flvc.org/FCLA/DT/1745595
-
Subject Headings
-
Bioorganic chemistry, Cancer--Research
-
Format
-
Document (PDF)
-
-
Title
-
Total synthesis and biological evaluation of aseries of macrocyclic hybrids and analogues of the antimitotic natural products Dictyostatin,Discodermolide, and Taxol.
-
Creator
-
Paterson, Ian, Naylor, G. J., Gardner, Nicola M., Guzman, Esther A., Wright, Amy E.
-
Date Issued
-
2011
-
PURL
-
http://purl.flvc.org/fau/fd/FA00007463
-
Subject Headings
-
Macrolides, Antimitotic Agents, Natural products, Tubulin
-
Format
-
Document (PDF)
-
-
Title
-
Three new peroxides from the sponge Plakinastrella species.
-
Creator
-
Chen, Ying, Killday, K. B., McCarthy, Peter J., Schimoler, Rebecca, Chilson, Katherine, Selitrennikoff, Claude, Pomponi, Shirley A., Wright, Amy E.
-
Date Issued
-
2001
-
PURL
-
http://purl.flvc.org/FCLA/DT/3319103
-
Subject Headings
-
Sponges --Research, Spectral analysis, Marine natural products, Peroxides, Antifungal agents
-
Format
-
Document (PDF)
-
-
Title
-
The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells.
-
Creator
-
Kallifatidis, Georgios, Hoepfner, Dominic, Jaeg, Tiphaine, Guzman, Esther A., Wright, Amy E.
-
Abstract/Description
-
Manzamine A, a member of the manzamine alkaloids, was originally isolated from marine sponges of the genus Haliclona. It was recently shown to have activity against pancreatic cancer cells, but the precise mechanism of action remained unclear. To further our understanding of the mechanism of action of manzamine A, chemogenomic profiling in the yeast S. cerevisiae was performed, suggesting that manzamine A is an uncoupler of vacuolar ATPases. Fluorescence microscopy confirmed this effect on...
Show moreManzamine A, a member of the manzamine alkaloids, was originally isolated from marine sponges of the genus Haliclona. It was recently shown to have activity against pancreatic cancer cells, but the precise mechanism of action remained unclear. To further our understanding of the mechanism of action of manzamine A, chemogenomic profiling in the yeast S. cerevisiae was performed, suggesting that manzamine A is an uncoupler of vacuolar ATPases. Fluorescence microscopy confirmed this effect on yeast vacuoles, where manzamine A produced a phenotype very similar to that of the established v-ATPase inhibitor bafilomycin A1. In pancreatic cancer cells, 10 μM manzamine A affected vacuolar ATPase activity and significantly increased the level of autophagosome marker LC3-II and p62/SQSTM1 as observed by western blot analysis. Treatment with manzamine A in combination with bafilomycin A1 (inhibitor of autophagosome-lysosome fusion) did not change the levels of LC3-II when compared to cells treated with bafilomycin A1 alone, suggesting that manzamine A is a potential inhibitor of autophagy by preventing autophagosome turnover. As autophagy is essential for pancreatic tumor growth, blocking this pathway with manzamine A suggests a promising strategy for the treatment of pancreatic cancer.
Show less
-
Date Issued
-
2013-09-17
-
PURL
-
http://purl.flvc.org/fau/fd/FAUIR000075
-
Format
-
Citation
-
-
Title
-
The Lithistida: important sources of compounds useful in biomedical research.
-
Creator
-
Wright, Amy E.
-
Date Issued
-
2010
-
PURL
-
http://purl.flvc.org/FCLA/DT/3331940
-
Subject Headings
-
Sponges, Biomedical research, Marine natural products, Bioactive compounds
-
Format
-
Document (PDF)
-
-
Title
-
The discovery and characterization of an interleukin 6 cytokine familyantagonist protein from a marine sponge, Callyspongia sp.
-
Creator
-
Peppard, J. V., Loo, P., Sills, Matthew A., Wennogle, L., Wright, Amy E., Pomponi, Shirley A., Cueto, M.
-
Date Issued
-
2001
-
PURL
-
http://purl.flvc.org/fau/fd/FA00007313
-
Subject Headings
-
Sponges, Interleukin-6, Cytokines--antagonists & inhibitors, Proteins--chemistry
-
Format
-
Document (PDF)
-
-
Title
-
Synthetic Analogues of the Microtubule-Stabilizing Agent (+)-Discodermolide: Preparation and Biological Activity.
-
Creator
-
Gunasekera, Sarath P., Mickel, Stuart J., Daeffler, Robert, Niederer, Daniel, Wright, Amy E., Linley, P. A., Pitts, Tara P.
-
Date Issued
-
2004
-
PURL
-
http://purl.flvc.org/FCLA/DT/3164107
-
Subject Headings
-
Microtubules, Cancer --Research, Biopharmaceutics, Molecular biology, Stereochemistry
-
Format
-
Document (PDF)
-
-
Title
-
Synthesis and biological evaluation of novel analogues of dictyostatin.
-
Creator
-
Paterson, Ian, Gardner, Nicola M., Poullennec, Karine G., Wright, Amy E.
-
Date Issued
-
2007
-
PURL
-
http://purl.flvc.org/FCLA/DT/2763290
-
Subject Headings
-
Microtubules --Research--Methodology, Microtubules
-
Format
-
Document (PDF)
-
-
Title
-
Synthesis and biological evaluation of 10, 11-Dihydrodictyostatin, a potent analogue of the marine anticancer agent dictyostatin.
-
Creator
-
Paterson, Ian, Gardner, Nicola M., Poullennec, Karine G., Wright, Amy E.
-
Date Issued
-
2008
-
PURL
-
http://purl.flvc.org/FCLA/DT/3333013
-
Subject Headings
-
Macrolides, Antineoplastic agents, Biological evaluation, Synthesis, Antimitotic agents
-
Format
-
Document (PDF)
-
-
Title
-
Sulfircin: a new sesterterpene sulfate from a deep-water sponge of the genus Ircinia.
-
Creator
-
Wright, Amy E., McCarthy, Peter J., Schulte, G. K.
-
Date Issued
-
1989
-
PURL
-
http://purl.flvc.org/FCLA/DT/3332962
-
Subject Headings
-
Sponges, Sulfates, Sesterterpenes, Antifungal agents, Marine natural products
-
Format
-
Document (PDF)
-
-
Title
-
Submersible and scuba collections in the coastal waters of the Bahama Islands and Florida's oculina coral banks: Biomedical and biodiversity research of the benthic communities with emphasis on porifera and gorgonacea.
-
Creator
-
Pomponi, Shirley A., Reed, John K., Wright, Amy E., Janda, Kathleen E., Willoughby, Robin, Sennett, Susan H., Kelly-Borges, M., McInerney, James O., Adams, Christi L., Kelly-Borges, Klaus, Myles, David
-
Date Issued
-
1997-01-23
-
PURL
-
http://purl.flvc.org/fcla/dt/3359258
-
Subject Headings
-
Biomedical research, Sponges--Research, Biodiversity--Research, Gorgonacea, Benthos
-
Format
-
Document (PDF)
-
-
Title
-
Stereochemical determination of dictyostatin, a novel microtubule-stabilising macrolide from the marine sponge Corallistidae sp.
-
Creator
-
Paterson, Ian, Britton, R., Delgado, Oscar, Wright, Amy E.
-
Date Issued
-
2004
-
PURL
-
http://purl.flvc.org/fau/fd/FA00007061
-
Subject Headings
-
Macrolides, Sponges, Tubulin Modulators, Stereochemistry, Microtubules, Polyketides, Antimitotic Agents
-
Format
-
Document (PDF)
-
-
Title
-
Spongiatriol Inhibits Nuclear Factor Kappa B Activation and Induces Apoptosis in Pancreatic Cancer Cells.
-
Creator
-
Guzman, Esther A., Maher, Michael, Temkin, Alexis, Pitts, Tara P., Wright, Amy E.
-
Date Issued
-
2013-04-02
-
PURL
-
http://purl.flvc.org/fau/fd/FAUIR000178
-
Format
-
Citation
Pages