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A brominated (aminoimidazolinyl) indole from the sponge Discodermia polydiscus
Title
A brominated (aminoimidazolinyl) indole from the sponge Discodermia polydiscus.
Creator
Sun, H. H., Sakemi, S., Harbor Branch Oceanographic Institute
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3332982
Subject Headings
Sponges, Indoles, Marine natural products
Format
Document (PDF)
A new bis-(indole) alkaloid from a deep-water marine sponge of the genus Spongosorites
Title
A new bis-(indole) alkaloid from a deep-water marine sponge of the genus Spongosorites.
Creator
Wright, Amy E., Pomponi, Shirley A., Cross, S. S., McCarthy, Peter J.
Date Issued
1992
PURL
http://purl.flvc.org/FCLA/DT/3333002
Subject Headings
Sponges, Indole alkaloids, Marine natural products
Format
Document (PDF)
A new sesterterpene, Sch 599473, from a marine sponge, Ircinia sp.
Title
A new sesterterpene, Sch 599473, from a marine sponge, Ircinia sp.
Creator
Yang, Shu-Wei, Chan, Tze-Ming, Pomponi, Shirley A., Gonsiorek, W., Chen, Guodong, Wright, Amy E., Hipkin, W., Patel, Mahesh, Gullo, Vincent, Pramanik, B., Zavodny, P., Chu, Min
Date Issued
2003
PURL
http://purl.flvc.org/FCLA/DT/3351980
Subject Headings
Sponges, Sesterterpenes, Marine natural products
Format
Document (PDF)
An antiviral sesquiterpene hydroquinone from the marine sponge Strongylophora hartmani
Title
An antiviral sesquiterpene hydroquinone from the marine sponge Strongylophora hartmani.
Creator
Wright, Amy E., Rueth, S. A., Cross, S. S.
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3332987
Subject Headings
Sponges, Sesquiterpenes, Marine natural products, Spectroscopy
Format
Document (PDF)
Antifungal activity of meridine, a natural product from the marine sponge Corticium sp.
Title
Antifungal activity of meridine, a natural product from the marine sponge Corticium sp.
Creator
McCarthy, Peter J., Pitts, Tara P., Gunawardana, G. P., Kelly-Borges, M., Pomponi, Shirley A.
Date Issued
1992
PURL
http://purl.flvc.org/FCLA/DT/3333005
Subject Headings
Sponges, Alkaloids, Marine natural products, Antifungal agents
Format
Document (PDF)
Antitumor activity and nucleic acid binding properties of Dercitin, a new acridinealkaloid isolated from a marine dercitus species sponge
Title
Antitumor activity and nucleic acid binding properties of Dercitin, a new acridinealkaloid isolated from a marine dercitus species sponge.
Creator
Burres, N. S., Sazesh, S., Gunawardana, G. P., Clement, J. J., Harbor Branch Oceanographic Institute
Date Issued
1989
PURL
http://purl.flvc.org/fau/fd/FA00007199
Subject Headings
Alkaloids, Acridines, Sponges, Antineoplastic agents, Cytotoxins, Marine natural products
Format
Document (PDF)
Antitumor macrodiolides isolated from a marine sponge Theonella sp.: structure revision of misakinolide A
Title
Antitumor macrodiolides isolated from a marine sponge Theonella sp.: structure revision of misakinolide A.
Creator
Kato, Y., Fusetani, N., Matsunaga, S., Hashimoto, K., Sakai, R., Higa, T., Kashman, Y., Harbor Branch Oceanographic Institute
Date Issued
1987
PURL
http://purl.flvc.org/FCLA/DT/3353820
Subject Headings
Sponges, Antineoplastic agents, Macrolides, Chemical structure, Marine natural products
Format
Document (PDF)
Collections of marine organisms for research on natural products chemistry and biodiversity: A survey of the benthic communities with emphasis on porifera, octocorals, and algae from the reefs and grassbeds of Bootless Bay, Papua New Guinea
Title
Collections of marine organisms for research on natural products chemistry and biodiversity: A survey of the benthic communities with emphasis on porifera, octocorals, and algae from the reefs and grassbeds of Bootless Bay, Papua New Guinea.
Creator
Reed, John K., Kelly-Borges, M., Janda, Kathleen E., Reed, Sherry A.
Date Issued
1997-03-25
PURL
http://purl.flvc.org/fcla/dt/3359854
Subject Headings
Biomedical research, Biodiversity--Research, New Guinea, Octocorallia, Porifera, Sponges, Algae, Marine natural products
Format
Document (PDF)
Development of techniques for in vitro production of bioactive natural products from marine sponges
Title
Development of techniques for in vitro production of bioactive natural products from marine sponges.
Creator
Pomponi, Shirley A., Willoughby, Robin, Kaighn, M. E., Wright, Amy E.
Date Issued
1997
PURL
http://purl.flvc.org/fau/fd/FA00007344
Subject Headings
Sponges, Bioactive compounds, Marine natural products, Cell culture, Growth factors, Phytohemagglutinins, Cryopreservation
Format
Document (PDF)
Discobahamins A and B, new peptides from the Bahamian deep water marine sponge Discodermia sp.
Title
Discobahamins A and B, new peptides from the Bahamian deep water marine sponge Discodermia sp.
Creator
Gunasekera, Sarath P., Pomponi, Shirley A., McCarthy, Peter J.
Date Issued
1994
PURL
http://purl.flvc.org/FCLA/DT/3333010
Subject Headings
Sponges, Peptides, Marine natural products, Chemical structure
Format
Document (PDF)
Discodermide: a new bioactive macrocyclic lactam from the marine sponge Discodermia dissoluta
Title
Discodermide: a new bioactive macrocyclic lactam from the marine sponge Discodermia dissoluta.
Creator
Gunasekera, Sarath P., Gunasekera, M., McCarthy, Peter J.
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3332985
Subject Headings
Sponges, Lactams, Macrocyclic, Marine natural products
Format
Document (PDF)
Diversity and bioactivity of marine sponges of the Caribbean: the Turks and Caicos Islands
Title
Diversity and bioactivity of marine sponges of the Caribbean: the Turks and Caicos Islands.
Creator
Pomponi, Shirley A., Reed, John K., Wright, Amy E., McCarthy, Peter J.
Date Issued
1996
PURL
http://purl.flvc.org/FCLA/DT/3351966
Subject Headings
Sponges--Turks and Caicos Islands, Bioactive compounds, Marine natural products, Sponges, Demospongiae
Format
Document (PDF)
Duryne, a new cytotoxic agent from the marine sponge Cribrochalina dura
Title
Duryne, a new cytotoxic agent from the marine sponge Cribrochalina dura.
Creator
Wright, Amy E., McConnell, O. J., Kohmoto, S., Lui, M. S., Thompson, W., Snader, K. M.
Date Issued
1987
PURL
http://purl.flvc.org/FCLA/DT/3353798
Subject Headings
Cytotoxin, Sponges, Marine natural products, Polyacetylenes
Format
Document (PDF)
Early effects of Lasonolide A on pancreatic cancer cells
Title
Early effects of Lasonolide A on pancreatic cancer cells.
Creator
Isbrucker, Richard A., Guzman, Esther A., Pitts, Tara P., Wright, Amy E.
Date Issued
2000
PURL
http://purl.flvc.org/fau/fd/FA00007053
Subject Headings
Macrolides, Sponges, Marine natural products, Pancreatic Neoplasms, Pancreas--Cancer
Format
Document (PDF)
Elenic acid, an inhibitor of Topoisomerase II, from a sponge, Plakinastrella sp.
Title
Elenic acid, an inhibitor of Topoisomerase II, from a sponge, Plakinastrella sp.
Creator
Juagdan, E. G., Kalidindi, R. S., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
Date Issued
1995
PURL
http://purl.flvc.org/FCLA/DT/3331894
Subject Headings
Sponges, Topoisomerase II Inhibitors, Marine natural products
Format
Document (PDF)
ESTABLISHING A SPONGE HYBRIDOMA FOR THE IN VITRO PRODUCTION OF A MARINE NATURAL PRODUCT
Title
ESTABLISHING A SPONGE HYBRIDOMA FOR THE IN VITRO PRODUCTION OF A MARINE NATURAL PRODUCT.
Creator
Dougan, Cassady, Pomponi, Shirley A., Florida Atlantic University, Department of Marine Science and Oceanography, Charles E. Schmidt College of Science
Abstract/Description
Marine sponges are one of the most prolific sources of chemical compounds with pharmaceutical importance. To establish a supply of such compounds large enough for clinical development, in vitro production methodology was investigated. Since all sponge cells do not divide in culture, it was hypothesized that the fusion of rapidly dividing cells of a sponge that does not produce any compounds of interest with cells of a nondividing but compound-producing sponge would result in a hybridoma that...
Show moreMarine sponges are one of the most prolific sources of chemical compounds with pharmaceutical importance. To establish a supply of such compounds large enough for clinical development, in vitro production methodology was investigated. Since all sponge cells do not divide in culture, it was hypothesized that the fusion of rapidly dividing cells of a sponge that does not produce any compounds of interest with cells of a nondividing but compound-producing sponge would result in a hybridoma that produces the compound of interest. In this study, hybridomas have been produced with cells of two marine sponges, Axinella corrugata, which produces the antitumor compound stevensine, and Geodia neptuni, which divides rapidly in a nutrient medium optimized for sponge cell culture. Successful hybridization and subsequent cell division and in vitro stevensine production may unlock the potential for sustainable mass production of other sponge-derived compounds.
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Date Issued
2022
PURL
http://purl.flvc.org/fau/fd/FA00014024
Subject Headings
Marine natural products, Sponges, Hybridomas, In vitro
Format
Document (PDF)
Isolation and structure elucidation of 34-sulfatobastadin 13, an inhibitor of the endothelin A receptor, from a marine sponge of the genus Ianthella
Title
Isolation and structure elucidation of 34-sulfatobastadin 13, an inhibitor of the endothelin A receptor, from a marine sponge of the genus Ianthella.
Creator
Gulavita, N. K., Wright, Amy E., McCarthy, Peter J., Pomponi, Shirley A., Kelly-Borges, M., Chin, M., Sills, Matthew A.
Date Issued
1993
PURL
http://purl.flvc.org/FCLA/DT/3333007
Subject Headings
Sponges, Receptor, Endothelin A, Marine natural products, Anti-Infective Agents
Format
Document (PDF)
Kauluamine: an unprecedented manzamine dimer from an Indonesian marine sponge, Prianos sp
Title
Kauluamine: an unprecedented manzamine dimer from an Indonesian marine sponge, Prianos sp.
Creator
Ohtani, I. I., Ichiba, T., Isobe, M., Kelly-Borges, M., Scheuer, P. J., Harbor Branch Oceanographic Institute
Date Issued
1995
PURL
http://purl.flvc.org/FCLA/DT/3319093
Subject Headings
Sponges, Sponges --Research, Marine natural products, Alkaloids
Format
Document (PDF)
Neopeltolide a new macrolide from a lithistid sponge of the family Neopeltidae
Title
Neopeltolide a new macrolide from a lithistid sponge of the family Neopeltidae.
Creator
Wright, Amy E., Botelho, J. C., Guzman, Esther A., Harmody, Dedra K., Linley, P. A., McCarthy, Peter J., Pitts, Tara P., Pomponi, Shirley A., Reed, John K.
Date Issued
2007
PURL
http://purl.flvc.org/FCLA/DT/3333011
Subject Headings
Sponges, Macrolides, Marine natural products
Format
Document (PDF)
New antiviral sterol disulfate ortho esters from the marine sponge Petrosia weinbergi
Title
New antiviral sterol disulfate ortho esters from the marine sponge Petrosia weinbergi.
Creator
Koehn, F. E., Gunasekera, M., Cross, S. S., Harbor Branch Oceanographic Institute
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3332977
Subject Headings
Sponges, Sterols, Marine natural products, Antiviral agents
Format
Document (PDF)

Pages