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- Title
- Circulating Cell-free DNA and Interleukin-6 Expression Following Acute High-Intensity Interval Exercise in Obesity.
- Creator
- Ferrandi, Peter J., Huang, Chun-Jung, Florida Atlantic University, College of Education, Department of Exercise Science and Health Promotion
- Abstract/Description
-
The primary purpose of this study was to examine the impact of acute highintensity interval Exercise (HIIE) on plasma cfDNA and IL-6 responses in obese and normal-weight subjects. Fifteen subjects (8 obese and 7 normal-weight) were recruited to participate in an acute HIIE protocol. Our results demonstrated a significant elevation across time in plasma cfDNA and IL-6 immediately following acute HIIE, with no difference between obese and normal-weight subjects. Furthermore, cfDNA was not...
Show moreThe primary purpose of this study was to examine the impact of acute highintensity interval Exercise (HIIE) on plasma cfDNA and IL-6 responses in obese and normal-weight subjects. Fifteen subjects (8 obese and 7 normal-weight) were recruited to participate in an acute HIIE protocol. Our results demonstrated a significant elevation across time in plasma cfDNA and IL-6 immediately following acute HIIE, with no difference between obese and normal-weight subjects. Furthermore, cfDNA was not correlated with IL-6 in response to acute HIIE in either group. These findings indicate that the obese state does not further exacerbate the release of acute HIIE-induced inflammatory mediators (cfDNA and IL-6), which suggests that HIIE training may serve as a time-effective exercise strategy to improve obesity-associated inflammation.
Show less - Date Issued
- 2017
- PURL
- http://purl.flvc.org/fau/fd/FA00004929, http://purl.flvc.org/fau/fd/FA00004929
- Subject Headings
- Interval training--Physiological aspects., Exercise--Physiological aspects., Physical education and training--Measurement., Gene expression., Cellular control mechanisms.
- Format
- Document (PDF)
- Title
- Relationships of fibroblast growth factor 21 with inflammation and insulin resistance in response to acute exercise in obese individuals.
- Creator
- Slusher, Aaron L., Huang, Chun-Jung, Florida Atlantic University, College of Education, Department of Exercise Science and Health Promotion
- Abstract/Description
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Obesity is associated with elevated levels of the pro-inflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), contributing to systemic insulin resistance. Fibroblast growth factor 21 (FGF21) is a vital metabolic and inflammatory regulator, however circulating FGF21 concentrations are elevated in obese individuals. Acute aerobic exercise increases systemic FGF21 in normal-weight individuals, however the effect of acute aerobic exercise on plasma FGF21 response and...
Show moreObesity is associated with elevated levels of the pro-inflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), contributing to systemic insulin resistance. Fibroblast growth factor 21 (FGF21) is a vital metabolic and inflammatory regulator, however circulating FGF21 concentrations are elevated in obese individuals. Acute aerobic exercise increases systemic FGF21 in normal-weight individuals, however the effect of acute aerobic exercise on plasma FGF21 response and the relationships with inflammation (IL-6 and TNF-α), insulin resistance, and energy expenditure in obese individuals is unknown. Following 30 minutes of treadmill running at 75% VO2max, plasma FGF21 response, as indicated by area-under-the-curve “with respect to increase” (AUCi) analyses, was attenuated in 12 obese compared to 12 normalweight subjects. Additionally, FGF21 AUCi positively correlated with glucose AUCi, total relative energy expenditure, and relative VO2max, suggesting that cardiorespiratory fitness levels may predict FGF21 response, contributing to the enhanced regulation of glucose and energy metabolism.
Show less - Date Issued
- 2014
- PURL
- http://purl.flvc.org/fau/fd/FA00004229, http://purl.flvc.org/fau/fd/FA00004229
- Subject Headings
- Fibroblast growth factor., Cell differentiation., Cellular signal transduction., Obesity--Health aspects., Metabolic syndrome--Pathophysiology.
- Format
- Document (PDF)
- Title
- The Comparison of High-Intensity Interval Exercise vs. Continuous Moderate Exercise on C1q/TNF-Related Protein-9 Expression and Flow-Mediated Vasodilation.
- Creator
- Fico, Brandon G., Huang, Chun-Jung, Florida Atlantic University, College of Education, Department of Exercise Science and Health Promotion
- Abstract/Description
-
The primary purpose of this study was to investigate the effect of acute high-intensity interval exercise (HIIE) vs. continuous moderate-intensity exercise (CME) on serum CTRP9 and brachial FMD responses in obese and normal-weight subjects. Sixteen participants (9 obese and 7 normal-weight) completed HIIE and CME in a randomized fashion. Our results showed a significant time effect for CTRP9 immediately following acute HIIE and CME in both groups. Furthermore, both significant treatment by...
Show moreThe primary purpose of this study was to investigate the effect of acute high-intensity interval exercise (HIIE) vs. continuous moderate-intensity exercise (CME) on serum CTRP9 and brachial FMD responses in obese and normal-weight subjects. Sixteen participants (9 obese and 7 normal-weight) completed HIIE and CME in a randomized fashion. Our results showed a significant time effect for CTRP9 immediately following acute HIIE and CME in both groups. Furthermore, both significant treatment by time and group by time interactions for FMD were observed following both exercise protocols, with greater CME-induced FMD response in obese subjects than normal-weight subjects. Additionally, a positive correlation in percent change (baseline to peak) between CTRP9 and FMD was observed following acute CME. These findings support acute CME for improvement of endothelial function in obesity. Furthermore, the novel results from this study provide a foundation for additional examination of the mechanisms of exercise-mediated CTRP9 on endothelial function.
Show less - Date Issued
- 2017
- PURL
- http://purl.flvc.org/fau/fd/FA00004915, http://purl.flvc.org/fau/fd/FA00004915
- Subject Headings
- Cardiovascular system--Physiology., Biological transport., Exercise--Physiological aspects., Interval training--Physiological aspects., Bioinformatics., Exercise--Health aspects., Lifestyles--Health aspects., Gene expression.
- Format
- Document (PDF)
- Title
- The Impact of Obesity on Plasma Calprotectin in Response to Acute Aerobic Exercise.
- Creator
- Fico, Brandon G., Slusher, Aaron L., Whitehurst, Michael, Maharaj, Arun, Huang, Chun-Jung, College of Education
- Abstract/Description
-
The secular issue of obesity has been linked to increased inflammatory mediators, such as calprotectin (S100A8/A9). This study examined the effect of acute aerobic exercise on plasma calprotectin response in obese and normal-weight subjects and its relationship with inflammatory cytokine (IL-6). All subjects (11 obese and 10 normal-weight) performed 30 minutes of treadmill exercise at 75% maximal oxygen consumption (VO2max). Blood samples were collected prior to, immediately following...
Show moreThe secular issue of obesity has been linked to increased inflammatory mediators, such as calprotectin (S100A8/A9). This study examined the effect of acute aerobic exercise on plasma calprotectin response in obese and normal-weight subjects and its relationship with inflammatory cytokine (IL-6). All subjects (11 obese and 10 normal-weight) performed 30 minutes of treadmill exercise at 75% maximal oxygen consumption (VO2max). Blood samples were collected prior to, immediately following exercise, and one hour after exercise. Our results showed higher baseline levels of calprotectin in obese subjects than normal-weight subjects. While acute aerobic exercise increased an elevation in calprotectin and IL-6, no difference was found between two groups. Furthermore, a positive relationship was observed between calprotectin area-under-the curve “with respect to increase” (AUCi) and IL-6 AUCi, even after controlling for cardiorespiratory fitness (VO2max). Our results support previous finding that IL-6 may potentially regulate calprotectin expression in skeletal muscle during exercise.
Show less - Date Issued
- 2015
- PURL
- http://purl.flvc.org/fau/fd/FA00005187
- Subject Headings
- College students --Research --United States.
- Format
- Document (PDF)