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Pages
- Title
- Spongiatriol Inhibits Nuclear Factor Kappa B Activation and Induces Apoptosis in Pancreatic Cancer Cells.
- Creator
- Guzman, Esther A., Maher, Michael, Temkin, Alexis, Pitts, Tara P., Wright, Amy E.
- Date Issued
- 2013-04-02
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000178
- Format
- Citation
- Title
- Correction: Kallifatidis, G. et al. The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells. Mar. Drugs 2013, 11, 3500–3516.
- Creator
- Kallifatidis, Georgios, Hoepfner, Dominic, Jaeg, Tiphaine, Guzman, Esther A., Wright, Amy E.
- Abstract/Description
-
We found two errors in our previous published paper [1]. Figure 4A has a mistake in the units in the labels, where it shows mM instead of micromolar (μM). A correctly labeled Figure 4A ensues. In Figures 2 and 4, the size bar scale is micrometers (μm). We apologize for the inconvenience caused to our readers.
- Date Issued
- 2014-04-21
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000076
- Format
- Citation
- Title
- The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells.
- Creator
- Kallifatidis, Georgios, Hoepfner, Dominic, Jaeg, Tiphaine, Guzman, Esther A., Wright, Amy E.
- Abstract/Description
-
Manzamine A, a member of the manzamine alkaloids, was originally isolated from marine sponges of the genus Haliclona. It was recently shown to have activity against pancreatic cancer cells, but the precise mechanism of action remained unclear. To further our understanding of the mechanism of action of manzamine A, chemogenomic profiling in the yeast S. cerevisiae was performed, suggesting that manzamine A is an uncoupler of vacuolar ATPases. Fluorescence microscopy confirmed this effect on...
Show moreManzamine A, a member of the manzamine alkaloids, was originally isolated from marine sponges of the genus Haliclona. It was recently shown to have activity against pancreatic cancer cells, but the precise mechanism of action remained unclear. To further our understanding of the mechanism of action of manzamine A, chemogenomic profiling in the yeast S. cerevisiae was performed, suggesting that manzamine A is an uncoupler of vacuolar ATPases. Fluorescence microscopy confirmed this effect on yeast vacuoles, where manzamine A produced a phenotype very similar to that of the established v-ATPase inhibitor bafilomycin A1. In pancreatic cancer cells, 10 μM manzamine A affected vacuolar ATPase activity and significantly increased the level of autophagosome marker LC3-II and p62/SQSTM1 as observed by western blot analysis. Treatment with manzamine A in combination with bafilomycin A1 (inhibitor of autophagosome-lysosome fusion) did not change the levels of LC3-II when compared to cells treated with bafilomycin A1 alone, suggesting that manzamine A is a potential inhibitor of autophagy by preventing autophagosome turnover. As autophagy is essential for pancreatic tumor growth, blocking this pathway with manzamine A suggests a promising strategy for the treatment of pancreatic cancer.
Show less - Date Issued
- 2013-09-17
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000075
- Format
- Citation
- Title
- Natural Products from the Lithistida: A Review of the Literature since 2000.
- Creator
- Winder, Priscilla L., Pomponi, Shirley A., Wright, Amy E.
- Abstract/Description
-
Lithistid sponges are known to produce a diverse array of compounds ranging from polyketides, cyclic and linear peptides, alkaloids, pigments, lipids, and sterols. A majority of these structurally complex compounds have very potent and interesting biological activities. It has been a decade since a thorough review has been published that summarizes the literature on the natural products reported from this amazing sponge order. This review provides an update on the current taxonomic...
Show moreLithistid sponges are known to produce a diverse array of compounds ranging from polyketides, cyclic and linear peptides, alkaloids, pigments, lipids, and sterols. A majority of these structurally complex compounds have very potent and interesting biological activities. It has been a decade since a thorough review has been published that summarizes the literature on the natural products reported from this amazing sponge order. This review provides an update on the current taxonomic classification of the Lithistida, describes structures and biological activities of 131 new natural products, and discusses highlights from the total syntheses of 16 compounds from marine sponges of the Order Lithistida providing a compilation of the literature since the last review published in 2002.
Show less - Date Issued
- 2011-12-15
- PURL
- http://purl.flvc.org/fau/fd/FAUIR000059
- Format
- Citation
- Title
- Marine natural products.
- Creator
- Pomponi, Shirley A., Wright, Amy E., Reed, John K., McCarthy, Peter J.
- Date Issued
- 1999
- PURL
- http://purl.flvc.org/fau/fd/FA00007503
- Subject Headings
- Marine natural products
- Format
- Document (PDF)
- Title
- Total synthesis and biological evaluation of aseries of macrocyclic hybrids and analogues of the antimitotic natural products Dictyostatin,Discodermolide, and Taxol.
- Creator
- Paterson, Ian, Naylor, G. J., Gardner, Nicola M., Guzman, Esther A., Wright, Amy E.
- Date Issued
- 2011
- PURL
- http://purl.flvc.org/fau/fd/FA00007463
- Subject Headings
- Macrolides, Antimitotic Agents, Natural products, Tubulin
- Format
- Document (PDF)
- Title
- Leiodermatolide, a potent antimitotic macrolide from the marine sponge Leiodermatium sp.
- Creator
- Paterson, Ian, Dalby, S. M., Roberts, J. C., Naylor, G. J., Guzman, Esther A., Isbrucker, Richard A., Pitts, Tara P., Linley, P. A., Divlianska, D. B., Reed, John K., Wright, Amy E.
- Date Issued
- 2011
- PURL
- http://purl.flvc.org/fau/fd/FA00007465
- Subject Headings
- Antimitotic Agents, Macrolides, Sponges, Molecular structure, Nuclear Magnetic Resonance, Biomolecular, Cell lines
- Format
- Document (PDF)
- Title
- Isolation of marine natural products.
- Creator
- Wright, Amy E.
- Date Issued
- 1998
- PURL
- http://purl.flvc.org/fau/fd/FA00007419
- Subject Headings
- Marine natural products, Bioactive compounds--Biotechnology
- Format
- Document (PDF)
- Title
- Bioactivity of marine organisms: relationships with taxonomy, geography and depth.
- Creator
- Reed, John K., Sennett, Susan H., McCarthy, Peter J., Pitts, Tara P., Wright, Amy E., Pomponi, Shirley A.
- Date Issued
- 1998
- PURL
- http://purl.flvc.org/fau/fd/FA00007421
- Subject Headings
- Marine organisms, Bioactive compounds, Marine natural products
- Format
- Document (PDF)
- Title
- A new bicyclic guanidine alkaloid, Sch 575948, from amarine sponge, Ptilocaulis spiculifer.
- Creator
- Yang, Shu-Wei, Chan, Tze-Ming, Pomponi, Shirley A., Chen, Guodong, Wright, Amy E., Patel, Mahesh, Gullo, Vincent, Pramanik, B., Chu, Min
- Date Issued
- 2003
- PURL
- http://purl.flvc.org/fau/fd/FA00007361
- Subject Headings
- Sponges, Alkaloids, Guanidines, Antibacterial agents, Molecular structure
- Format
- Document (PDF)
- Title
- Cytotoxic peptides from marine sponges.
- Creator
- Gulavita, N. K., Wright, Amy E., McCarthy, Peter J., Pomponi, Shirley A., Longley, Ross E.
- Date Issued
- 1996
- PURL
- http://purl.flvc.org/fau/fd/FA00007341
- Subject Headings
- Sponges, Peptides, Cytotoxins, Stereochemistry
- Format
- Document (PDF)
- Title
- Development of techniques for in vitro production of bioactive natural products from marine sponges.
- Creator
- Pomponi, Shirley A., Willoughby, Robin, Kaighn, M. E., Wright, Amy E.
- Date Issued
- 1997
- PURL
- http://purl.flvc.org/fau/fd/FA00007344
- Subject Headings
- Sponges, Bioactive compounds, Marine natural products, Cell culture, Growth factors, Phytohemagglutinins, Cryopreservation
- Format
- Document (PDF)
- Title
- The discovery and characterization of an interleukin 6 cytokine familyantagonist protein from a marine sponge, Callyspongia sp.
- Creator
- Peppard, J. V., Loo, P., Sills, Matthew A., Wennogle, L., Wright, Amy E., Pomponi, Shirley A., Cueto, M.
- Date Issued
- 2001
- PURL
- http://purl.flvc.org/fau/fd/FA00007313
- Subject Headings
- Sponges, Interleukin-6, Cytokines--antagonists & inhibitors, Proteins--chemistry
- Format
- Document (PDF)
- Title
- Eryloside E from an Atlantic sponge Erylus goffrilleri.
- Creator
- Gulavita, N. K., Wright, Amy E., Kelly-Borges, M., Longley, Ross E., Yarwood, Donna, Sills, Matthew A.
- Date Issued
- 1994
- PURL
- http://purl.flvc.org/fau/fd/FA00007261
- Subject Headings
- Sponges, Terpenes, Glycosides, Chemical structure
- Format
- Document (PDF)
- Title
- Characterization of an interleukin 6 cytokinefamily antagonist protein from a marine sponge, Callyspongia sp.
- Creator
- Peppard, J. V., Loo, P., Sills, Matthew A., Munster, D., Pomponi, Shirley A., Wright, Amy E.
- Date Issued
- 1996
- PURL
- http://purl.flvc.org/fau/fd/FA00007266
- Subject Headings
- Sponges, Interleukin-6, Cytokines--antagonists & inhibitors
- Format
- Document (PDF)
- Title
- Antimicrobial constituent of the brown alga Sporochnus pedunculatus.
- Creator
- Gunasekera, L. S., Wright, Amy E., Gunasekera, Sarath P., McCarthy, Peter J., Reed, John K.
- Date Issued
- 1995
- PURL
- http://purl.flvc.org/fau/fd/FA00007231
- Subject Headings
- Brown algae, Antimicrobial agents, Nuclear magnetic resonance, Candida albicans, Bacillus subtilis
- Format
- Document (PDF)
- Title
- In vitro production of marine-derived antitumor compounds.
- Creator
- Pomponi, Shirley A., Willoughby, Robin, Wright, Amy E., Pecorella, C., Sennett, Susan H., Lopez, Jose V., Samples, Gail A.
- Date Issued
- 1998
- PURL
- http://purl.flvc.org/fau/fd/FA00007238
- Subject Headings
- Antineoplastic agents, Bioactive compounds, Marine natural products, In vitro, Antitumor agents
- Format
- Document (PDF)
- Title
- 1,1-Dimethyl-5,6-dihydroxyindolinium chloride from a deep water marine sponge, Dercitus sp.
- Creator
- Kohmoto, S., McConnell, O. J., Wright, Amy E.
- Date Issued
- 1988
- PURL
- http://purl.flvc.org/fau/fd/FA00007184
- Subject Headings
- Sponges, Marine metabolites, Chemical structure
- Format
- Document (PDF)
- Title
- Selective cytotoxic activity of the marine derivedbatzelline compounds against pancreatic cancer cell lines.
- Creator
- Guzman, Esther A., Johnson, J. D., Carrier, M. K., Meyer, C. I., Pitts, Tara P., Gunasekera, Sarath P., Wright, Amy E.
- Date Issued
- 2009
- PURL
- http://purl.flvc.org/fau/fd/FA00007114
- Subject Headings
- Pancreas--Cancer, Marine natural products, Drug Discovery, Sponges--Caribbean Sea, Mechanism of action (Biochemistry)
- Format
- Document (PDF)
- Title
- Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin.
- Creator
- Paterson, Ian, Naylor, G. J., Fujita, T., Guzman, Esther A., Wright, Amy E.
- Date Issued
- 2010
- PURL
- http://purl.flvc.org/fau/fd/FA00007065
- Subject Headings
- Antineoplastic agents, Paclitaxel, Polyketides, Microtubules, Tubulin Modulators, Marine natural products
- Format
- Document (PDF)