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Florida Atlantic Undergraduate Research Journal 2020.
Title
Florida Atlantic Undergraduate Research Journal 2020.
Creator
Council for Scholarship and Inquiry
Abstract/Description
The FAURJ is an interdisciplinary, peer-reviewed journal that is published annually. FAURJ is published online as well as in print and its mission is to showcase high quality undergraduate research in all fields, supply undergraduates with an idea of the standard of research, and promote inquiry-based activities at Florida Atlantic University.
Date Issued
2020
PURL
http://purl.flvc.org/fau/fd/FAUIR000381
Subject Headings
College students--Research--Periodicals., Florida Atlantic University--Research., Research--Periodicals., College students--Research.
Format
Document (PDF)
Cuba's Mesophotic Coral Reefs Fish Photo Identification Guide
Title
Cuba's Mesophotic Coral Reefs Fish Photo Identification Guide.
Creator
David, Andrew, Cobián Rojas, Dorka, Drummond, Felicia, Garcia Rodriguez, Alain
Date Issued
2018
PURL
http://purl.flvc.org/fau/fd/FAUIR000354
Format
Citation
Cumulative Trauma Among Mayas Living in Southeast Florida
Title
Cumulative Trauma Among Mayas Living in Southeast Florida.
Creator
Millender, Eugenia I., Lowe, John
Date Issued
2017-06-04
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1007_s10903-015-0337-3_1570552393
Format
Citation
The effect of rater accountability on performance ratings: A meta-analytic review
Title
The effect of rater accountability on performance ratings: A meta-analytic review.
Creator
Harari, Michael B., Rudolph, Cort W.
Date Issued
2017-03
PURL
http://purl.flvc.org/fau/fd/faudoi0000001
Format
Citation
Green tea extract catechin improves internal cardiac muscle relaxation in RCM mice
Title
Green tea extract catechin improves internal cardiac muscle relaxation in RCM mice.
Creator
Wang, Xiaoqin, Zhang, Zhengyu, Wu, Gang, Nan, Changlong, Shen, Wen, Hua, Yimin, Huang, Xupei
Date Issued
2016-12-28
PURL
http://purl.flvc.org/fau/fd/FAUIR000199
Format
Citation
The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration
Title
The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration.
Creator
Grill, Brock, Murphey, Rodney K., Borgen, Melissa A.
Abstract/Description
During development, a coordinated and integrated series of events must be accomplished in order to generate functional neural circuits. Axons must navigate toward target cells, build synaptic connections, and terminate outgrowth. The PHR proteins (consisting of mammalian Phr1/MYCBP2, Drosophila Highwire and C. elegans RPM-1) function in each of these events in development. Here, we review PHR function across species, as well as the myriad of signaling pathways PHR proteins regulate. These...
Show moreDuring development, a coordinated and integrated series of events must be accomplished in order to generate functional neural circuits. Axons must navigate toward target cells, build synaptic connections, and terminate outgrowth. The PHR proteins (consisting of mammalian Phr1/MYCBP2, Drosophila Highwire and C. elegans RPM-1) function in each of these events in development. Here, we review PHR function across species, as well as the myriad of signaling pathways PHR proteins regulate. These findings collectively suggest that the PHR proteins are intracellular signaling hubs, a concept we explore in depth. Consistent with prominent developmental functions, genetic links have begun to emerge between PHR signaling networks and neurodevelopmental disorders, such as autism, schizophrenia and intellectual disability. Finally, we discuss the recent and important finding that PHR proteins regulate axon degeneration, which has further heightened interest in this fascinating group of molecules.
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Date Issued
2016-12-23
PURL
http://purl.flvc.org/fau/fd/FAUIR000039
Format
Citation
Plant expression of cocaine hydrolase-Fc fusion protein for treatment of cocaine abuse
Title
Plant expression of cocaine hydrolase-Fc fusion protein for treatment of cocaine abuse.
Creator
Wang, Guojun, Zhang, Ting, Huang, Haifeng, Hou, Shurong, Chen, Xiabin, Zheng, Fang, Zhan, Chang-Guo
Date Issued
2016-12-19
PURL
http://purl.flvc.org/fau/fd/FAUIR000197
Format
Citation
A survey of compliance issues in cloud computing
Title
A survey of compliance issues in cloud computing.
Creator
Yimam, Dereje, Fernandez, Eduardo B.
Date Issued
2016-12-10
PURL
http://purl.flvc.org/fau/fd/FAUIR000139
Format
Citation
Motion Alters Color Appearance
Title
Motion Alters Color Appearance.
Creator
Hong, Sang Wook, Kang, Min-Suk
Abstract/Description
Chromatic induction compellingly demonstrates that chromatic context as well as spectral lights reflected from an object determines its color appearance. Here, we show that when one colored object moves around an identical stationary object, the perceived saturation of the stationary object decreases dramatically whereas the saturation of the moving object increases. These color appearance shifts in the opposite directions suggest that normalization induced by the object’s motion may mediate...
Show moreChromatic induction compellingly demonstrates that chromatic context as well as spectral lights reflected from an object determines its color appearance. Here, we show that when one colored object moves around an identical stationary object, the perceived saturation of the stationary object decreases dramatically whereas the saturation of the moving object increases. These color appearance shifts in the opposite directions suggest that normalization induced by the object’s motion may mediate the shift in color appearance. We ruled out other plausible alternatives such as local adaptation, attention, and transient neural responses that could explain the color shift without assuming interaction between color and motion processing. These results demonstrate that the motion of an object affects both its own color appearance and the color appearance of a nearby object, suggesting a tight coupling between color and motion processing.
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Date Issued
2016-12-08
PURL
http://purl.flvc.org/fau/fd/FAUIR000022
Format
Citation
Class-specific discriminant time-frequency analysis using novel jointly learnt non-negative matrix factorization
Title
Class-specific discriminant time-frequency analysis using novel jointly learnt non-negative matrix factorization.
Creator
Ghoraani, Behnaz
Date Issued
2016-12-07
PURL
http://purl.flvc.org/fau/fd/FAUIR000143
Format
Citation
Antibodies elicited by the first non-viral prophylactic cancer vaccine show tumor-specificity and immunotherapeutic potential
Title
Antibodies elicited by the first non-viral prophylactic cancer vaccine show tumor-specificity and immunotherapeutic potential.
Creator
Lohmueller, Jason J., Sato, Shuji, Popova, Lana, Chu, Isabel M., Tucker, Meghan A., Barberena, Roberto, Innocenti, Gregory M., Cudic, Mare, Ham, James D., Cheung, Wan Cheung, Polakiewicz, Roberto D., Finn, Olivera J.
Abstract/Description
MUC1 is a shared tumor antigen expressed on >80% of human cancers. We completed the first prophylactic cancer vaccine clinical trial based on a non-viral antigen, MUC1, in healthy individuals at-risk for colon cancer. This trial provided a unique source of potentially effective and safe immunotherapeutic drugs, fully-human antibodies affinity-matured in a healthy host to a tumor antigen. We purified, cloned, and characterized 13 IgGs specific for several tumor-associated MUC1 epitopes with a...
Show moreMUC1 is a shared tumor antigen expressed on >80% of human cancers. We completed the first prophylactic cancer vaccine clinical trial based on a non-viral antigen, MUC1, in healthy individuals at-risk for colon cancer. This trial provided a unique source of potentially effective and safe immunotherapeutic drugs, fully-human antibodies affinity-matured in a healthy host to a tumor antigen. We purified, cloned, and characterized 13 IgGs specific for several tumor-associated MUC1 epitopes with a wide range of binding affinities. These antibodies bind hypoglycosylated MUC1 on human cancer cell lines and tumor tissues but show no reactivity against fully-glycosylated MUC1 on normal cells and tissues. We found that several antibodies activate complement-mediated cytotoxicity and that T cells carrying chimeric antigen receptors with the antibody variable regions kill MUC1+ target cells, express activation markers, and produce interferon gamma. Fully-human and tumor-specific, these antibodies are candidates for further testing and development as immunotherapeutic drugs.
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Date Issued
2016-10-22
PURL
http://purl.flvc.org/fau/fd/FAUIR000012
Format
Citation
cGMP-Dependent Protein Kinase Inhibition Extends the Upper Temperature Limit of Stimulus-Evoked Calcium Responses in Motoneuronal Boutons of Drosophila melanogaster Larvae
Title
cGMP-Dependent Protein Kinase Inhibition Extends the Upper Temperature Limit of Stimulus-Evoked Calcium Responses in Motoneuronal Boutons of Drosophila melanogaster Larvae.
Creator
Krill, Jennifer L., Dawson-Scully, Ken, McCabe, Brian D.
Abstract/Description
While the mammalian brain functions within a very narrow range of oxygen concentrations and temperatures, the fruit fly, Drosophila melanogaster, has employed strategies to deal with a much wider range of acute environmental stressors. The foraging (for) gene encodes the cGMP-dependent protein kinase (PKG), has been shown to regulate thermotolerance in many stress-adapted species, including Drosophila, and could be a potential therapeutic target in the treatment of hyperthermia in mammals....
Show moreWhile the mammalian brain functions within a very narrow range of oxygen concentrations and temperatures, the fruit fly, Drosophila melanogaster, has employed strategies to deal with a much wider range of acute environmental stressors. The foraging (for) gene encodes the cGMP-dependent protein kinase (PKG), has been shown to regulate thermotolerance in many stress-adapted species, including Drosophila, and could be a potential therapeutic target in the treatment of hyperthermia in mammals. Whereas previous thermotolerance studies have looked at the effects of PKG variation on Drosophila behavior or excitatory postsynaptic potentials at the neuromuscular junction (NMJ), little is known about PKG effects on presynaptic mechanisms. In this study, we characterize presynaptic calcium ([Ca^2+]i) dynamics at the Drosophila larval NMJ to determine the effects of high temperature stress on synaptic transmission. We investigated the neuroprotective role of PKG modulation both genetically using RNA interference (RNAi), and pharmacologically, to determine if and how PKG affects presynaptic [Ca^2+]i dynamics during hyperthermia. We found that PKG activity modulates presynaptic neuronal Ca^2+ responses during acute hyperthermia, where PKG activation makes neurons more sensitive to temperatureinduced failure of Ca^2+ flux and PKG inhibition confers thermotolerance and maintains normal Ca^2+ dynamics under the same conditions. Targeted motoneuronal knockdown of PKG using RNAi demonstrated that decreased PKG expression was sufficient to confer thermoprotection. These results demonstrate that the PKG pathway regulates presynaptic motoneuronal Ca^2+ signaling to influence thermotolerance of presynaptic function during acute hyperthermia.
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Date Issued
2016-10-06
PURL
http://purl.flvc.org/fau/fd/FAUIR000079
Format
Citation
Modulating Behavior in C. elegans Using Electroshock and Antiepileptic Drugs
Title
Modulating Behavior in C. elegans Using Electroshock and Antiepileptic Drugs.
Creator
Risley, Monica G., Kelly, Stephanie P., Jia, Kailiang, Grill, Brock, Dawson-Scully, Ken, Dupuy, Denis
Abstract/Description
The microscopic nematode Caenorhabditis elegans has emerged as a valuable model for understanding the molecular and cellular basis of neurological disorders. The worm offers important physiological similarities to mammalian models such as conserved neuron morphology, ion channels, and neurotransmitters. While a wide-array of behavioral assays are available in C. elegans, an assay for electroshock/electroconvulsion remains absent. Here, we have developed a quantitative behavioral method to...
Show moreThe microscopic nematode Caenorhabditis elegans has emerged as a valuable model for understanding the molecular and cellular basis of neurological disorders. The worm offers important physiological similarities to mammalian models such as conserved neuron morphology, ion channels, and neurotransmitters. While a wide-array of behavioral assays are available in C. elegans, an assay for electroshock/electroconvulsion remains absent. Here, we have developed a quantitative behavioral method to assess the locomotor response following electric shock in C. elegans. Electric shock impairs normal locomotion, and induces paralysis and muscle twitching; after a brief recovery period, shocked animals resume normal locomotion. We tested electric shock responses in loss-of-function mutants for unc-25, which encodes the GABA biosynthetic enzyme GAD, and unc-49, which encodes the GABAA receptor. unc-25 and unc-49 mutants have decreased inhibitory GABAergic transmission to muscles, and take significantly more time to recover normal locomotion following electric shock compared to wild-type. Importantly, increased sensitivity of unc-25 and unc- 49 mutants to electric shock is rescued by treatment with antiepileptic drugs, such as retigabine. Additionally, we show that pentylenetetrazol (PTZ), a GABAA receptor antagonist and proconvulsant in mammalian and C. elegans seizure models, increases susceptibility of worms to electric shock.
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Date Issued
2016-09-26
PURL
http://purl.flvc.org/fau/fd/FAUIR000085
Format
Citation
Coordination Dynamics in Cognitive Neuroscience
Title
Coordination Dynamics in Cognitive Neuroscience.
Creator
Bressler, Steven L., Kelso, J. A. Scott
Date Issued
2016-09-15
PURL
http://purl.flvc.org/fau/fd/FAUIR000128
Format
Citation
Bilayer Membrane Modulation of Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Structure and Proteolytic Activity
Title
Bilayer Membrane Modulation of Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Structure and Proteolytic Activity.
Creator
Cerofolini, Linda, Amar, Sabrina, Lauer, Janelle L., Martelli, Tommaso, Fragai, Marco, Luchinat, Claudio, Fields, Gregg B.
Abstract/Description
Cell surface proteolysis is an integral yet poorly understood physiological process. The present study has examined how the pericellular collagenase membrane-type 1 matrix metalloproteinase (MT1-MMP) and membrane-mimicking environments interplay in substrate binding and processing. NMR derived structural models indicate that MT1-MMP transiently associates with bicelles and cells through distinct residues in blades III and IV of its hemopexin-like domain, while binding of collagen-like triple...
Show moreCell surface proteolysis is an integral yet poorly understood physiological process. The present study has examined how the pericellular collagenase membrane-type 1 matrix metalloproteinase (MT1-MMP) and membrane-mimicking environments interplay in substrate binding and processing. NMR derived structural models indicate that MT1-MMP transiently associates with bicelles and cells through distinct residues in blades III and IV of its hemopexin-like domain, while binding of collagen-like triple-helices occurs within blades I and II of this domain. Examination of simultaneous membrane interaction and triple-helix binding revealed a possible regulation of proteolysis due to steric effects of the membrane. At bicelle concentrations of 1%, enzymatic activity towards triple-helices was increased 1.5-fold. A single mutation in the putative membrane interaction region of MT1-MMP (Ser466Pro) resulted in lower enzyme activation by bicelles. An initial structural framework has thus been developed to define the role(s) of cell membranes in modulating proteolysis.
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Date Issued
2016-09-13
PURL
http://purl.flvc.org/fau/fd/FAUIR0000004
Format
Citation
Life Cycle Characteristics of Warm-Season Severe Thunderstorms in Central United States from 2010 to 2014
Title
Life Cycle Characteristics of Warm-Season Severe Thunderstorms in Central United States from 2010 to 2014.
Creator
Liu, Weibo, Li, Xingong
Date Issued
2016-09-08
PURL
http://purl.flvc.org/fau/fd/FAUIR000167
Format
Citation
Infectious Disease and Hospital Surge Capacity Impacts on Urban Transportation
Title
Infectious Disease and Hospital Surge Capacity Impacts on Urban Transportation.
Creator
Kaisar, Evangelos I., Coolahan, James E., Koomullil, Roy P., Averkiou, Peter A.
Date Issued
2016-08-31
PURL
http://purl.flvc.org/fau/fd/fauir00003
Format
Citation
Contribution to Accident Prediction Models Development for Rural Two-Lane Roads in Serbia
Title
Contribution to Accident Prediction Models Development for Rural Two-Lane Roads in Serbia.
Creator
Glavić, Draženko, Mladenović, Miloš, Stevanovic, Aleksandar, Tubić, Vladan, Milenković, Marina, Vidas, Marijo
Abstract/Description
Over the last three decades numerous research efforts have been conducted worldwide to determine the relationship between traffic accidents and traffic and road characteristics. So far, the mentioned studies have not been carried out in Serbia and in the region. This paper represents one of the first attempts to develop accident prediction models in Serbia. The paper provides a comprehensive literature review, describes procedures for collection and analysis of the traffic accident data, as...
Show moreOver the last three decades numerous research efforts have been conducted worldwide to determine the relationship between traffic accidents and traffic and road characteristics. So far, the mentioned studies have not been carried out in Serbia and in the region. This paper represents one of the first attempts to develop accident prediction models in Serbia. The paper provides a comprehensive literature review, describes procedures for collection and analysis of the traffic accident data, as well as the methodology used to develop the accident prediction models. The paper presents models obtained by both univariate and multivariate regression analyses. The obtained results are compared to the results of other studies and comparisons are discussed. Finally, the paper presents conclusions and important points for future research. The results of this research can find theoretical as well as practical application.
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Date Issued
2016-08-31
PURL
http://purl.flvc.org/fau/fd/FAUIR000051
Format
Citation
Identification and Ultrastructural Characterization of a Novel Nuclear Degradation Complex in Differentiating Lens Fiber Cells
Title
Identification and Ultrastructural Characterization of a Novel Nuclear Degradation Complex in Differentiating Lens Fiber Cells.
Creator
Costello, M. Joseph, Brennan, Lisa A., Mohamed, Ashik, Gilliland, Kurt O., Johnsen, Sonke, Kantorow, Marc, Nagaraj, Ram
Date Issued
2016-08-18
PURL
http://purl.flvc.org/fau/fd/FAUIR000093
Format
Citation
Engineering long shelf life multi-layer biologically active surfaces on microfluidic devices for point of care applications
Title
Engineering long shelf life multi-layer biologically active surfaces on microfluidic devices for point of care applications.
Creator
Asghar, Waseem, Yuksekkaya, Mehmet, Shafiee, Hadi, Zhang, Michael, Ozen, Mehmet O., Inci, Fatih, Kocakulak, Mustafa, Demirci, Utkan
Date Issued
2016-08-17
PURL
http://purl.flvc.org/fau/fd/FAUIR000118
Format
Citation

Pages