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Reconstruction of Family-Level Phylogenetic Relationships within Demospongiae (Porifera) Using Nuclear Encoded Housekeeping Genes
Title
Reconstruction of Family-Level Phylogenetic Relationships within Demospongiae (Porifera) Using Nuclear Encoded Housekeeping Genes.
Creator
Hill, Malcolm S., Hill, April L., Lopez, Jose V., Peterson, Kevin J., Pomponi, Shirley A., Diaz, Maria Cristina, Thacker, Robert W., Adamska, Maja, Boury-Esnault, Nicole, Cárdenas, Paco, Chaves-Fonnegra, Andia, Danka, Elizabeth, De Laine, Bre-Onna, Formica, Dawn, Hajdu, Eduardo, Lobo-Hajdu, Gisele, Klontz, Sarah, Morrow, Christine C., Patel, Jignasa, Picton, Bernard, Pisani, Davide, Pohlmann, Deborah, Redmond, Niamh E., Reed, John K., Richey, Stacy, Riesgo, Ana, Rubin, Ewelina, Russell, Zach, Rützler, Klaus, Sperling, Erik A., di Stefano, Michael, Tarver, James E., Collins, Allen G., Lin, Senjie
Abstract/Description
Background: Demosponges are challenging for phylogenetic systematics because of their plastic and relatively simple morphologies and many deep divergences between major clades. To improve understanding of the phylogenetic relationships within Demospongiae, we sequenced and analyzed seven nuclear housekeeping genes involved in a variety of cellular functions from a diverse group of sponges. Methodology/Principal Findings: We generated data from each of the four sponge classes (i.e., Calcarea,...
Show moreBackground: Demosponges are challenging for phylogenetic systematics because of their plastic and relatively simple morphologies and many deep divergences between major clades. To improve understanding of the phylogenetic relationships within Demospongiae, we sequenced and analyzed seven nuclear housekeeping genes involved in a variety of cellular functions from a diverse group of sponges. Methodology/Principal Findings: We generated data from each of the four sponge classes (i.e., Calcarea, Demospongiae, Hexactinellida, and Homoscleromorpha), but focused on family-level relationships within demosponges. With data for 21 newly sampled families, our Maximum Likelihood and Bayesian-based approaches recovered previously phylogenetically defined taxa: Keratosap, Myxospongiaep, Spongillidap, Haploscleromorphap (the marine haplosclerids) and Democlaviap. We found conflicting results concerning the relationships of Keratosap and Myxospongiaep to the remaining demosponges, but our results strongly supported a clade of Haploscleromorphap+Spongillidap+Democlaviap. In contrast to hypotheses based on mitochondrial genome and ribosomal data, nuclear housekeeping gene data suggested that freshwater sponges (Spongillidap) are sister to Haploscleromorphap rather than part of Democlaviap. Within Keratosap, we found equivocal results as to the monophyly of Dictyoceratida. Within Myxospongiaep, Chondrosida and Verongida were monophyletic. A wellsupported clade within Democlaviap, Tetractinellidap, composed of all sampled members of Astrophorina and Spirophorina (including the only lithistid in our analysis), was consistently revealed as the sister group to all other members of Democlaviap. Within Tetractinellidap, we did not recover monophyletic Astrophorina or Spirophorina. Our results also reaffirmed the monophyly of order Poecilosclerida (excluding Desmacellidae and Raspailiidae), and polyphyly of Hadromerida and Halichondrida. Conclusions/Significance: These results, using an independent nuclear gene set, confirmed many hypotheses based on ribosomal and/or mitochondrial genes, and they also identified clades with low statistical support or clades that conflicted with traditional morphological classification. Our results will serve as a basis for future exploration of these outstanding questions using more taxon- and gene-rich datasets.
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Date Issued
2013-01-23
PURL
http://purl.flvc.org/fau/fd/FAUIR000044
Format
Citation
Satellite-Observed Black Water Events off Southwest Florida: Implications for Coral Reef Health in the Florida Keys National Marine Sanctuary
Title
Satellite-Observed Black Water Events off Southwest Florida: Implications for Coral Reef Health in the Florida Keys National Marine Sanctuary.
Creator
Zhao, Jun, Hu, Chuanmin, Lapointe, Brian E., Melo, Nelson, Johns, Elizabeth, Smith, Ryan
Abstract/Description
A “black water” event, as observed from satellites, occurred off southwest Florida in 2012. Satellite observations suggested that the event started in early January and ended in mid-April 2012. The black water patch formed off central west Florida and advected southward towards Florida Bay and the Florida Keys with the shelf circulation, which was confirmed by satellite-tracked surface drifter trajectories. Compared with a previous black water event in 2002, the 2012 event was weaker in terms...
Show moreA “black water” event, as observed from satellites, occurred off southwest Florida in 2012. Satellite observations suggested that the event started in early January and ended in mid-April 2012. The black water patch formed off central west Florida and advected southward towards Florida Bay and the Florida Keys with the shelf circulation, which was confirmed by satellite-tracked surface drifter trajectories. Compared with a previous black water event in 2002, the 2012 event was weaker in terms of spatial and temporal coverage. An in situ survey indicated that the 2012 black water patch contained toxic K. brevis and had relatively low CDOM (colored dissolved organic matter) and turbidity but high chlorophyll-a concentrations, while salinity was somewhat high compared with historical values. Further analysis revealed that the 2012 black water was formed by the K. brevis bloom initiated off central west Florida in late September 2011, while river runoff, Trichodesmium and possibly submarine groundwater discharge also played important roles in its formation. Black water patches can affect benthic coral reef communities by decreasing light availability at the bottom, and enhanced nutrient concentrations from black water patches support massive macroalgae growth that can overgrow coral reefs. It is thus important to continue the integrated observations where satellites provide synoptic and repeated observations of such adverse water quality events.
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Date Issued
2013-01-18
PURL
http://purl.flvc.org/fau/fd/FAUIR000032
Format
Citation
Separation and HPLC Analysis of Diastereomers and Rotational Isomers of.
Title
Separation and HPLC Analysis of Diastereomers and Rotational Isomers of.
Creator
Chamely-Wiik, Donna M., Carraher, Charles E., Kamel, George, Haky, Jerome E.
Date Issued
2006-06-10
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1080_10826070600757680_1521555358
Format
Citation
The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells
Title
The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells.
Creator
Kallifatidis, Georgios, Hoepfner, Dominic, Jaeg, Tiphaine, Guzman, Esther A., Wright, Amy E.
Abstract/Description
Manzamine A, a member of the manzamine alkaloids, was originally isolated from marine sponges of the genus Haliclona. It was recently shown to have activity against pancreatic cancer cells, but the precise mechanism of action remained unclear. To further our understanding of the mechanism of action of manzamine A, chemogenomic profiling in the yeast S. cerevisiae was performed, suggesting that manzamine A is an uncoupler of vacuolar ATPases. Fluorescence microscopy confirmed this effect on...
Show moreManzamine A, a member of the manzamine alkaloids, was originally isolated from marine sponges of the genus Haliclona. It was recently shown to have activity against pancreatic cancer cells, but the precise mechanism of action remained unclear. To further our understanding of the mechanism of action of manzamine A, chemogenomic profiling in the yeast S. cerevisiae was performed, suggesting that manzamine A is an uncoupler of vacuolar ATPases. Fluorescence microscopy confirmed this effect on yeast vacuoles, where manzamine A produced a phenotype very similar to that of the established v-ATPase inhibitor bafilomycin A1. In pancreatic cancer cells, 10 μM manzamine A affected vacuolar ATPase activity and significantly increased the level of autophagosome marker LC3-II and p62/SQSTM1 as observed by western blot analysis. Treatment with manzamine A in combination with bafilomycin A1 (inhibitor of autophagosome-lysosome fusion) did not change the levels of LC3-II when compared to cells treated with bafilomycin A1 alone, suggesting that manzamine A is a potential inhibitor of autophagy by preventing autophagosome turnover. As autophagy is essential for pancreatic tumor growth, blocking this pathway with manzamine A suggests a promising strategy for the treatment of pancreatic cancer.
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Date Issued
2013-09-17
PURL
http://purl.flvc.org/fau/fd/FAUIR000075
Format
Citation
Correction: Kallifatidis, G. et al. The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells. Mar. Drugs 2013, 11, 3500–3516
Title
Correction: Kallifatidis, G. et al. The Marine Natural Product Manzamine A Targets Vacuolar ATPases and Inhibits Autophagy in Pancreatic Cancer Cells. Mar. Drugs 2013, 11, 3500–3516.
Creator
Kallifatidis, Georgios, Hoepfner, Dominic, Jaeg, Tiphaine, Guzman, Esther A., Wright, Amy E.
Abstract/Description
We found two errors in our previous published paper [1]. Figure 4A has a mistake in the units in the labels, where it shows mM instead of micromolar (μM). A correctly labeled Figure 4A ensues. In Figures 2 and 4, the size bar scale is micrometers (μm). We apologize for the inconvenience caused to our readers.
Date Issued
2014-04-21
PURL
http://purl.flvc.org/fau/fd/FAUIR000076
Format
Citation
Spongiatriol Inhibits Nuclear Factor Kappa B Activation and Induces Apoptosis in Pancreatic Cancer Cells
Title
Spongiatriol Inhibits Nuclear Factor Kappa B Activation and Induces Apoptosis in Pancreatic Cancer Cells.
Creator
Guzman, Esther A., Maher, Michael, Temkin, Alexis, Pitts, Tara P., Wright, Amy E.
Date Issued
2013-04-02
PURL
http://purl.flvc.org/fau/fd/FAUIR000178
Format
Citation
Hair Mercury Concentrations and Fish Consumption Patterns in Florida Residents
Title
Hair Mercury Concentrations and Fish Consumption Patterns in Florida Residents.
Creator
Schaefer, Adam M., Jensen, Emily, Bossart, Gregory D., Reif, John S.
Date Issued
2014-06-26
PURL
http://purl.flvc.org/fau/fd/FAUIR000186
Format
Citation
Numerical simulations of a horizontal axis water turbine designed for underwater mooring platforms
Title
Numerical simulations of a horizontal axis water turbine designed for underwater mooring platforms.
Creator
Tian, Wenlong, Song, Baowei, VanZwieten, James H., Pyakurel, Parakram, Li, Yanjun
Date Issued
2016-01
PURL
http://purl.flvc.org/fau/fd/FAUIR000223
Format
Citation
Cuba's Mesophotic Coral Reefs Fish Photo Identification Guide
Title
Cuba's Mesophotic Coral Reefs Fish Photo Identification Guide.
Creator
David, Andrew, Cobián Rojas, Dorka, Drummond, Felicia, Garcia Rodriguez, Alain
Date Issued
2018
PURL
http://purl.flvc.org/fau/fd/FAUIR000354
Format
Citation
From Bhopal to Cold Fusion: A Case-Study Approach to Writing Assignments in Honors General Chemistry
Title
From Bhopal to Cold Fusion: A Case-Study Approach to Writing Assignments in Honors General Chemistry.
Creator
Chamely-Wiik, Donna M., Haky, Jerome E., Galin, Jeffrey R.
Date Issued
2012-03-13
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1021_ed101129v_1521555359
Format
Citation
Computational Fluid Dynamics Prediction of a Modified Savonius Wind Turbine with Novel Blade Shapes
Title
Computational Fluid Dynamics Prediction of a Modified Savonius Wind Turbine with Novel Blade Shapes.
Creator
Tian, Wenlong, Song, Baowei, VanZwieten, James H., Pyakurel, Parakram
Date Issued
2015-07-30
PURL
http://purl.flvc.org/fau/fd/FAUIR000195
Format
Citation
Number 1 and 2
Title
Broward legacy.: Volume 6 Issues 1 2.
Creator
Broward County Historical Commission
Date Issued
1976, 9999
PURL
http://purl.flvc.org/fau/fd/2416548
Subject Headings
History, Periodicals, History
Format
Serial component
Number 1 and 2
Title
Broward legacy.: Volume 5 Issues 3 4.
Creator
Broward County Historical Commission
Date Issued
1976, 9999
PURL
http://purl.flvc.org/fau/fd/2416433
Subject Headings
History, Periodicals, History
Format
Serial component
Number 3 and 4
Title
Broward legacy.: Volume 3 Issues 3 4.
Creator
Broward County Historical Commission
Date Issued
1976, 9999
PURL
http://purl.flvc.org/fau/fd/2416114
Subject Headings
History, Periodicals, History
Format
Serial component
Number 1 and 2
Title
Broward legacy.: Volume 3 Issues 1 2.
Creator
Broward County Historical Commission
Date Issued
1976, 9999
PURL
http://purl.flvc.org/fau/fd/2416013
Subject Headings
History, Periodicals, History
Format
Serial component
Number 1 and 2
Title
Broward legacy.: Volume 4 Issues 1 2.
Creator
Broward County Historical Commission
Date Issued
1976, 9999
PURL
http://purl.flvc.org/fau/fd/2416216
Subject Headings
History, Periodicals, History
Format
Serial component
Number 3 and 4
Title
Broward legacy.: Volume 4 Issues 3 4.
Creator
Broward County Historical Commission
Date Issued
1976, 9999
PURL
http://purl.flvc.org/fau/fd/2416324
Subject Headings
History, Periodicals, History
Format
Serial component
Number 1 and 2
Title
Broward legacy.: Volume 22 Numbers 1 and 2.
Creator
Broward County Historical Commission
Date Issued
1976, 9999
PURL
http://purl.flvc.org/fau/fd/2419877
Subject Headings
History, Periodicals, History
Format
Serial component
Number 3 and 4
Title
Broward legacy.: Volume 22 Numbers 3 and 4.
Creator
Broward County Historical Commission
Date Issued
1976, 9999
PURL
http://purl.flvc.org/fau/fd/2419982
Subject Headings
History, Periodicals, History
Format
Serial component
Number 2
Title
Broward legacy.: Volume 24 Number 2.
Creator
Broward County Historical Commission
Date Issued
1976, 9999
PURL
http://purl.flvc.org/fau/fd/2420285
Subject Headings
History, Periodicals, History
Format
Serial component

Pages