Current Search: Tetrahydroisoquinolines (x)
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Title
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Antitumor tetrahydroisoquinoline alkaloids from the colonial ascidian Ecteinascidia turbinata.
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Creator
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Wright, Amy E., Forleo, D. A., Gunawardana, G. P., Gunasekera, Sarath P., Koehn, F. E., McConnell, O. J.
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Date Issued
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1990
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PURL
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http://purl.flvc.org/FCLA/DT/3332974
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Subject Headings
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Ascidians, Perophoridae (Tunicata), Tetrahydroisoquinolines, Alkaloids, Antineoplastic agents
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Format
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Document (PDF)
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Title
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The biosynthetic production of marine-derived anti-tumor ecteinascidins and the aquaculture of the marine tunicate Ecteinascidia turbinata.
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Creator
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Krenisky, Joann Mary, Florida Atlantic University, Kerr, Russell G., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
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Abstract/Description
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A family of tetrahydroisoquinoline alkaloids, the ecteinascidins, are a group of biologically active secondary metabolites produced by the marine tunicate Ecteinascidia turbinata. Ecteinascidins have shown in vivo anti-tumor activity against P388 lymphoma, B16 melanoma, M5076 ovarian sarcoma, Lewis lung carcinoma, and LX-1 human lung and MX-1 human mammary carcinoma xenografts in laboratory mice. Because ecteinascidins are produced in low yields, 1x10^-4%, supply for clinical development is a...
Show moreA family of tetrahydroisoquinoline alkaloids, the ecteinascidins, are a group of biologically active secondary metabolites produced by the marine tunicate Ecteinascidia turbinata. Ecteinascidins have shown in vivo anti-tumor activity against P388 lymphoma, B16 melanoma, M5076 ovarian sarcoma, Lewis lung carcinoma, and LX-1 human lung and MX-1 human mammary carcinoma xenografts in laboratory mice. Because ecteinascidins are produced in low yields, 1x10^-4%, supply for clinical development is a significant problem. The ultimate goal of this study is to develop an enzyme-based synthesis of the ecteinascidins. In this regard, the biosynthesis of these alkaloids has been investigated. Optimal conditions for in vitro ecteinascidin biosynthesis were found. The origin of the C22-C1 two-carbon unit was identified as pyruvate and the tyrosine and DOPA diketopiperazines were identified as key intermediates. Methods were developed for an in-the-sea aquaculture of the colonal marine ascidian Ecteinascidia turbinata.
Show less
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Date Issued
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1997
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PURL
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http://purl.flvc.org/fcla/dt/15454
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Subject Headings
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Sea squirts, Tetrahydroisoquinolines, Alkaloids--Synthesis
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Format
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Document (PDF)