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Novel steroidal saponins, Sch 725737 and Sch 725739, from a marine starfish, Novodinia antillensis
Title
Novel steroidal saponins, Sch 725737 and Sch 725739, from a marine starfish, Novodinia antillensis.
Creator
Yang, Shu-Wei, Chan, Tze-Ming, Buevich, Alexei, Priestley, T., Crona, J., Reed, John K., Wright, Amy E., Patel, Mahesh, Gullo, Vincent, Chen, Guodong, Pramanik, B., Chu, Min
Date Issued
2007
PURL
http://purl.flvc.org/FCLA/DT/3343845
Subject Headings
Steroid saponins, Starfishes
Format
Document (PDF)
Three unprecedented chloro steroids from the Maui sponge Strongylacidon sp.: kiheisterones C, D, and E
Title
Three unprecedented chloro steroids from the Maui sponge Strongylacidon sp.: kiheisterones C, D, and E.
Creator
Carney, J. R., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
Date Issued
1993
PURL
http://purl.flvc.org/FCLA/DT/3318958
Subject Headings
Sponges --Research, Marine metabolites, Steroids
Format
Document (PDF)
Development of methods for the immobilization of enzymes used in 9,11-secosteroid biosynthesis
Title
Development of methods for the immobilization of enzymes used in 9,11-secosteroid biosynthesis.
Creator
Chen, Ying, Florida Atlantic University, Kerr, Russell G.
Abstract/Description
9,11-Secosteroids exhibit novel biological activity and interesting pharmacological properties. A biosynthetic study of 9,11-secogorgosterol and other novel 9,11-secosteroids using an enzyme extract from the gorgonian Pseudopterogorgia americana demonstrated that this system is an efficient catalyst for a wide range 9,11-secosteroid production. Two methods to recover the enzyme from 9,11-secosteroid synthesis have been developed: (1) membrane-enclosed enzymatic catalysis, which combines...
Show more9,11-Secosteroids exhibit novel biological activity and interesting pharmacological properties. A biosynthetic study of 9,11-secogorgosterol and other novel 9,11-secosteroids using an enzyme extract from the gorgonian Pseudopterogorgia americana demonstrated that this system is an efficient catalyst for a wide range 9,11-secosteroid production. Two methods to recover the enzyme from 9,11-secosteroid synthesis have been developed: (1) membrane-enclosed enzymatic catalysis, which combines certain of the advantages of soluble enzymes and immobilized enzymes, shows high activity, simple recovery and at least 5 cycles or 23 days; (2) covalently bonded enzyme-agarose gel, attached by cyanogen bromide via the amino groups of enzymes, show 80% activity of free enzymes and at least 7 cycles or 46 days. Based on stability and kinetic studies of these immobilized enzymes in 9,11-secosteroid synthesis, a continuous flow column reactor for scale-up of 9,11-secosteroid production has been developed with great efficiency, which represents the first enzymatic production of a bioactive compound from a marine invertebrate on a large scale.
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Date Issued
1998
PURL
http://purl.flvc.org/fcla/dt/15521
Subject Headings
Octocorallia, Enzymes--Synthesis, Steroids
Format
Document (PDF)
Sterols of the marine sponge Petrosia weinbergi: implications for the absolute configurations of the antiviral orthoesterols and weinbersterols
Title
Sterols of the marine sponge Petrosia weinbergi: implications for the absolute configurations of the antiviral orthoesterols and weinbersterols.
Creator
Giner, José-Luis, Gunasekera, Sarath P., Pomponi, Shirley A.
Date Issued
1999
PURL
http://purl.flvc.org/FCLA/DT/3158771
Subject Headings
Sponges, Sterols --Analysis, Steroids, Biosynthesis, Marine metabolites
Format
Document (PDF)
Chemoenzymatic synthesis of 9,11-secosteroids using an enzyme extract from a marine coral
Title
Chemoenzymatic synthesis of 9,11-secosteroids using an enzyme extract from a marine coral.
Creator
Rodriguez, Lesbeth Caridad., Florida Atlantic University, Kerr, Russell G.
Abstract/Description
9,11-Secogorgosterol, a secondary metabolite from the gorgonian Pseudopterogorgia americana, exhibits inhibitory activity against protein kinase C, and potent anti-proliferative and anti-inflammatory activity. An efficient method for the production of 9,11-secogorgosterol has been developed and optimized using an enzyme extract from the gorgonian P. americana. The gorgonian also produces two other 9,11-secosteroids which have marked differences in their side chains and nuclei, which suggested...
Show more9,11-Secogorgosterol, a secondary metabolite from the gorgonian Pseudopterogorgia americana, exhibits inhibitory activity against protein kinase C, and potent anti-proliferative and anti-inflammatory activity. An efficient method for the production of 9,11-secogorgosterol has been developed and optimized using an enzyme extract from the gorgonian P. americana. The gorgonian also produces two other 9,11-secosteroids which have marked differences in their side chains and nuclei, which suggested that the enzymes responsible for their production were likely relatively nonspecific. Novel 9,11-secosteroids have been synthesized using the enzyme extract from the gorgonian.
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Date Issued
1997
PURL
http://purl.flvc.org/fcla/dt/15431
Subject Headings
Steroids, Enzymes--Synthesis, Alcyonacea, Corals
Format
Document (PDF)
Eryloside F, a Novel Penasterol Disaccharide Possessing Potent Thrombin Receptor Antagonist Activity
Title
Eryloside F, a Novel Penasterol Disaccharide Possessing Potent Thrombin Receptor Antagonist Activity.
Creator
Stead, Paul, Hiscox, Steve, Robinson, Phil S., Pike, Nicholas B., Sidebottom, Philip J., Roberts, Andrew D., Taylor, Nicholas L., Wright, Amy E., Pomponi, Shirley A., Langley, David
Date Issued
2000
PURL
http://purl.flvc.org/FCLA/DT/2848300
Subject Headings
Disaccharides --Conformations, Peptide drugs, Hepatocyte growth factor --Receptors, Sponges, Steroid harmone metabolism
Format
Document (PDF)