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Effects of low salinity on metamorphosis in estuarine colonial ascidians
Title
Effects of low salinity on metamorphosis in estuarine colonial ascidians.
Creator
Vazquez, Elsa, Young, Craig M., Harbor Branch Oceanographic Institute
Date Issued
2000
PURL
http://purl.flvc.org/FCLA/DT/3174093
Subject Headings
Sea squirts
Format
Document (PDF)
Synthesis and testing the intermediacy of diketopiperazines in the biosynthesis of ecteinascidins
Title
Synthesis and testing the intermediacy of diketopiperazines in the biosynthesis of ecteinascidins.
Creator
Jeedigunta, Shanti, Florida Atlantic University, Kerr, Russell G., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
Ecteinascidin 743 is a trace secondary metabolite isolated from the marine tunicate, Ecteinascidia turbinata. Ecteinacidin 743 a most potent antitumor agent, is currently in Phase II clinical trials in Europe and in the USA. A cell-free extract of Ecteinascidia turbinata was used to investigate the biogenetic origin of the ecteinascidins. Incubation experiments with radiolabeled diketopiperazines indicated that the diketopiperazine of tyrosine is the first committed intermediate in the...
Show moreEcteinascidin 743 is a trace secondary metabolite isolated from the marine tunicate, Ecteinascidia turbinata. Ecteinacidin 743 a most potent antitumor agent, is currently in Phase II clinical trials in Europe and in the USA. A cell-free extract of Ecteinascidia turbinata was used to investigate the biogenetic origin of the ecteinascidins. Incubation experiments with radiolabeled diketopiperazines indicated that the diketopiperazine of tyrosine is the first committed intermediate in the biosynthesis of ecteinascidins. Phenylalanine diketopiperazine was not transformed into the ecteinascidins indicating that this cyclic dipeptide is not an intermediate in the biosynthesis of ecteinascidins. The diketopiperazine of DOPA was used as a cold carrier demonstrating that the diketopiperazine of tyrosine is oxidized to DOPA diketopiperazine and then further transformed to the ecteinascidins.
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Date Issued
2000
PURL
http://purl.flvc.org/fcla/dt/15754
Subject Headings
Sea squirts, Dopa, Tunicata
Format
Document (PDF)
Morphology, larval development and distribution of Bathypera feminalba n. sp. (Ascidiacea: Pyuridae), a deep-water ascidian from the fjords and sounds of British Columbia
Title
Morphology, larval development and distribution of Bathypera feminalba n. sp. (Ascidiacea: Pyuridae), a deep-water ascidian from the fjords and sounds of British Columbia.
Creator
Young, Craig M., Vazquez, Elsa, Harbor Branch Oceanographic Institute
Date Issued
1995
PURL
http://purl.flvc.org/FCLA/DT/3327213
Subject Headings
Pyuridae, Ascidians, Sea squirts--Canada, Sea squirts--Embryology
Format
Document (PDF)
Etzionin, a new antifungal metabolite from a Red Sea tunicate
Title
Etzionin, a new antifungal metabolite from a Red Sea tunicate.
Creator
Hirsch, S., Miroz, A., McCarthy, Peter J., Kashman, Y.
Date Issued
1989
PURL
http://purl.flvc.org/FCLA/DT/3353854
Subject Headings
Tunicates, Sea squirts, Antifungal agents
Format
Document (PDF)
Distributional consequences of adhesive eggs and anural development in the ascidian Molgula pacifica (Huntsman, 1912)
Title
Distributional consequences of adhesive eggs and anural development in the ascidian Molgula pacifica (Huntsman, 1912).
Creator
Young, Craig M., Gowan, Richard F., Dalby, James E., Jr., Pennachetti, Catherine A., Gagliardi, David, Harbor Branch Oceanographic Institute
Date Issued
1988
PURL
http://purl.flvc.org/FCLA/DT/3171588
Subject Headings
Sea squirts --Eggs, Sea squirts --Development, Sea squirts --Canada, Marine ecology, Larvae
Format
Document (PDF)
Agnezia monnioti and Styela gagetyleri, new deep-sea ascidians specialized for life within and below the oxygen minimum layer in the Arabian Sea
Title
Agnezia monnioti and Styela gagetyleri, new deep-sea ascidians specialized for life within and below the oxygen minimum layer in the Arabian Sea.
Creator
Young, Craig M., Vazquez, Elsa
Date Issued
1997
PURL
http://purl.flvc.org/FCLA/DT/3174083
Subject Headings
Sea squirts, Arabian Sea, Biological invasions
Format
Document (PDF)
Larval behavior of the ascidian Ecteinascidia turbinata Herdman; an in situ experimental study of the effects of swimming on dispersal
Title
Larval behavior of the ascidian Ecteinascidia turbinata Herdman; an in situ experimental study of the effects of swimming on dispersal.
Creator
Bingham, Brian L., Young, Craig M., Harbor Branch Oceanographic Institute
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3353858
Subject Headings
Ascidians, Sea squirts, Larvae--Dispersal
Format
Document (PDF)
Responses of compound ascidian larvae to haloclines
Title
Responses of compound ascidian larvae to haloclines.
Creator
Vázquez, E., Young, Craig M., Harbor Branch Oceanographic Institute
Date Issued
1996
PURL
http://purl.flvc.org/FCLA/DT/3350876
Subject Headings
Ascidians, Sea squirts, Larvae--Behavior, Salinity
Format
Document (PDF)
Larval depletion by ascidians has little effect on settlement of epifauna
Title
Larval depletion by ascidians has little effect on settlement of epifauna.
Creator
Young, Craig M., Harbor Branch Oceanographic Institute
Date Issued
1989
PURL
http://purl.flvc.org/FCLA/DT/3333142
Subject Headings
Ascidians, Larvae, Benthic animals, Sea squirts
Format
Document (PDF)
Sensory structures in tadpole larvae of the ascidians Microcosmus exasperatus Heller and Herdmania momus (Savigny)
Title
Sensory structures in tadpole larvae of the ascidians Microcosmus exasperatus Heller and Herdmania momus (Savigny).
Creator
Svane, Ib, Young, Craig M., Harbor Branch Oceanographic Institute
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3342304
Subject Headings
Ascidians, Sea squirts, Pyuridae, Larvae, Morphology
Format
Document (PDF)
Rhopalaea cloneyi (Ascidiacea, Cionidae), a new deep-water ascidian from the coastal waters of British Columbia
Title
Rhopalaea cloneyi (Ascidiacea, Cionidae), a new deep-water ascidian from the coastal waters of British Columbia.
Creator
Vazquez, Elsa, Young, Craig M., Harbor Branch Oceanographic Institute
Date Issued
1996
PURL
http://purl.flvc.org/FCLA/DT/3327216
Subject Headings
Cionidae, Ascidians, Sea squirts--Canada
Format
Document (PDF)
Additions to the inventory of eastern tropical Atlantic ascidians; arrival of cosmopolitan species
Title
Additions to the inventory of eastern tropical Atlantic ascidians; arrival of cosmopolitan species.
Creator
Monniot, Claude, Monniot, Françoise, Harbor Branch Oceanographic Institute
Date Issued
1994
PURL
http://purl.flvc.org/FCLA/DT/3172865
Subject Headings
Sea squirts, Ascidia, Tunicata, Scuba apparatus, Biochemistry
Format
Document (PDF)
biosynthetic production of marine-derived anti-tumor ecteinascidins and the aquaculture of the marine tunicate Ecteinascidia turbinata
Title
The biosynthetic production of marine-derived anti-tumor ecteinascidins and the aquaculture of the marine tunicate Ecteinascidia turbinata.
Creator
Krenisky, Joann Mary, Florida Atlantic University, Kerr, Russell G., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
A family of tetrahydroisoquinoline alkaloids, the ecteinascidins, are a group of biologically active secondary metabolites produced by the marine tunicate Ecteinascidia turbinata. Ecteinascidins have shown in vivo anti-tumor activity against P388 lymphoma, B16 melanoma, M5076 ovarian sarcoma, Lewis lung carcinoma, and LX-1 human lung and MX-1 human mammary carcinoma xenografts in laboratory mice. Because ecteinascidins are produced in low yields, 1x10^-4%, supply for clinical development is a...
Show moreA family of tetrahydroisoquinoline alkaloids, the ecteinascidins, are a group of biologically active secondary metabolites produced by the marine tunicate Ecteinascidia turbinata. Ecteinascidins have shown in vivo anti-tumor activity against P388 lymphoma, B16 melanoma, M5076 ovarian sarcoma, Lewis lung carcinoma, and LX-1 human lung and MX-1 human mammary carcinoma xenografts in laboratory mice. Because ecteinascidins are produced in low yields, 1x10^-4%, supply for clinical development is a significant problem. The ultimate goal of this study is to develop an enzyme-based synthesis of the ecteinascidins. In this regard, the biosynthesis of these alkaloids has been investigated. Optimal conditions for in vitro ecteinascidin biosynthesis were found. The origin of the C22-C1 two-carbon unit was identified as pyruvate and the tyrosine and DOPA diketopiperazines were identified as key intermediates. Methods were developed for an in-the-sea aquaculture of the colonal marine ascidian Ecteinascidia turbinata.
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Date Issued
1997
PURL
http://purl.flvc.org/fcla/dt/15454
Subject Headings
Sea squirts, Tetrahydroisoquinolines, Alkaloids--Synthesis
Format
Document (PDF)
Ascidian cannibalism correlates with larval behavior and adult distribution
Title
Ascidian cannibalism correlates with larval behavior and adult distribution.
Creator
Young, Craig M., Harbor Branch Oceanographic Institute
Date Issued
1988
PURL
http://purl.flvc.org/FCLA/DT/3353805
Subject Headings
Ascidians, Sea squirts, Cannibalism in animals, Larvae--Behavior
Format
Document (PDF)
Biogeographic and bathymetric ranges of Atlantic deep-sea echinoderms and ascidians: the role of larval dispersal
Title
Biogeographic and bathymetric ranges of Atlantic deep-sea echinoderms and ascidians: the role of larval dispersal.
Creator
Young, Craig M., Sewell, Mary A., Tyler, Paul A., Metaxas, Anna, Harbor Branch Oceanographic Institute
Date Issued
1997
PURL
http://purl.flvc.org/FCLA/DT/3318893
Subject Headings
Echinodermata --Atlantic Ocean, Sea squirts, Larvae--Dispersal
Format
Document (PDF)
Role of early post-settlement mortality in setting the upper limit of ascidians in Florida epifaunal communities
Title
Role of early post-settlement mortality in setting the upper limit of ascidians in Florida epifaunal communities.
Creator
Dalby, James E., Jr., Young, Craig M., Harbor Branch Oceanographic Institute
Date Issued
1992
PURL
http://purl.flvc.org/FCLA/DT/3350866
Subject Headings
Sea squirts, Oysters, American oyster, Predation (Biology), Mortality
Format
Document (PDF)
The ecology and behaviour of ascidian larvae
Title
The ecology and behaviour of ascidian larvae.
Creator
Svane, Ib, Young, Craig M., Harbor Branch Oceanographic Institute
Date Issued
1989
PURL
http://purl.flvc.org/FCLA/DT/3352919
Subject Headings
Sea squirts, Ascidians, Larvae--Ecology, Larvae--Behavior
Format
Document (PDF)
Direct observations of larval dispersal in the colonial ascidian Podoclavella moluccensis Sluiter: evidence for closed populations
Title
Direct observations of larval dispersal in the colonial ascidian Podoclavella moluccensis Sluiter: evidence for closed populations.
Creator
Davis, A. R., Butler, A. J., Harbor Branch Oceanographic Institute
Date Issued
1989
PURL
http://purl.flvc.org/FCLA/DT/3353828
Subject Headings
Ascidians, Sea squirts--Australia, Polycitoridae, Aplousobranchia, Larvae--Dispersal
Format
Document (PDF)
Colony regeneration following damage and size-dependent mortality in the Australian ascidian Podoclavella moluccensis Sluiter
Title
Colony regeneration following damage and size-dependent mortality in the Australian ascidian Podoclavella moluccensis Sluiter.
Creator
Davis, A. R., Harbor Branch Oceanographic Institute
Date Issued
1988
PURL
http://purl.flvc.org/FCLA/DT/3353826
Subject Headings
Ascidians, Sea squirts--Australia, Predation (Biology), Mortality, Animal colonies
Format
Document (PDF)
Alkaloids and ascidian chemical defense: evidence for the ecological role of natural products from Eudistoma olivaceum
Title
Alkaloids and ascidian chemical defense: evidence for the ecological role of natural products from Eudistoma olivaceum.
Creator
Davis, A. R., Harbor Branch Oceanographic Institute
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3351175
Subject Headings
Sea squirts, Ascidians, Alkaloids, Animal chemical defenses, Fouling organisms
Format
Document (PDF)

Pages