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A Comparative Analysis of Monte Carlo and Collapsed Cone Dose Calculation Algorithms for Monaco 3D Treatment Plans
Title
A Comparative Analysis of Monte Carlo and Collapsed Cone Dose Calculation Algorithms for Monaco 3D Treatment Plans.
Creator
Pereira, Shakeel, Kyriacou, Andreas, Florida Atlantic University, Department of Physics, Charles E. Schmidt College of Science
Abstract/Description
The Monaco treatment planning system offers three different dose calculation algorithms for use in calculating 3D treatment plans. These include Monte Carlo (MC), Collapsed Cone (CC) and the pencil beam algorithms. The aim of this study is an in-depth analysis of Monte Carlo and Collapsed Cone dose calculation methods to find the optimal parameters for clinical use for both algorithms. An end-to-end phantom with inhomogeneities was scanned and the DICOM images were imported into Monaco for...
Show moreThe Monaco treatment planning system offers three different dose calculation algorithms for use in calculating 3D treatment plans. These include Monte Carlo (MC), Collapsed Cone (CC) and the pencil beam algorithms. The aim of this study is an in-depth analysis of Monte Carlo and Collapsed Cone dose calculation methods to find the optimal parameters for clinical use for both algorithms. An end-to-end phantom with inhomogeneities was scanned and the DICOM images were imported into Monaco for contouring and planning. Treatment plans were then created in Monaco for both MC and CC using different permutations of variables for approximately 400 plans. These variables include CT Slice thickness, grid size, statistical uncertainty, and beam energy. Following planning the end-to-end phantom was then irradiated on an Elekta Linac and plans for each beam energy were created. Clinical beam data was then compared to the computed plans for each dose calculation method.
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Date Issued
2022
PURL
http://purl.flvc.org/fau/fd/FA00014019
Subject Headings
Radiotherapy, Radiotherapy Dosage, Radiation dosimetry
Format
Document (PDF)
Development of a Monte Carlo Simulation Model for Varian ProBeam Compact Single-Room Proton Therapy System using GEANT4
Title
Development of a Monte Carlo Simulation Model for Varian ProBeam Compact Single-Room Proton Therapy System using GEANT4.
Creator
String, Shawn, Muhammad, Wazir, Shang, Charles, Florida Atlantic University, Department of Physics, Charles E. Schmidt College of Science
Abstract/Description
Proton therapy with pencil beam scanning technique is a novel technique to treat cancer patients due to its unique biophysical properties. However, a small error in dose calculation may lead towards undesired greater uncertainties in planed doses. This project aims to create a simulation model of Varian ProBeam Compact using the GEANT4 Monte Carlo simulation tool kit. Experimental data from the first clinical ProBeam Compact system at South Florida Proton Therapy Institute was used to...
Show moreProton therapy with pencil beam scanning technique is a novel technique to treat cancer patients due to its unique biophysical properties. However, a small error in dose calculation may lead towards undesired greater uncertainties in planed doses. This project aims to create a simulation model of Varian ProBeam Compact using the GEANT4 Monte Carlo simulation tool kit. Experimental data from the first clinical ProBeam Compact system at South Florida Proton Therapy Institute was used to validate the simulation model. A comparison was made between the experimental and simulated Integrated Depth-Dose curves using a 2%/2mm gamma index test with 100% of points passing. The beam spot standard deviation sizes (s!) were compared using percent deviation. All simulated s! matched the experimental s! within 2.5%, except 70 and 80 MeV. The model can be used to develop a more comprehensive model as an independent dose verification tool and further investigate dose distribution.
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Date Issued
2020
PURL
http://purl.flvc.org/fau/fd/FA00013547
Subject Headings
Proton Therapy, Monte-Carlo-Simulation, Radiotherapy Dosage
Format
Document (PDF)
Dose Validation for Partial Accelerated Breast Irradiation treated with the SAVI Applicator
Title
Dose Validation for Partial Accelerated Breast Irradiation treated with the SAVI Applicator.
Creator
Pinder, Janeil K., Pella, Silvia, Leventouri, Theodora, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
Abstract/Description
The purpose of this study is to verify and validate the dose at various points of interest in accelerated partial breast irradiation (APBI) treated with the Strut Adjusted Volume Implant (SAVI) applicator using Thermoluminescent Dosimeters (TLDs). A set of CT images were selected from a patient’s data who had received APBI using the SAVI applicator. The images were used to make 3D models. TLDs were calibrated for Brachytherapy. Various points of interest were marked out and slots were carved...
Show moreThe purpose of this study is to verify and validate the dose at various points of interest in accelerated partial breast irradiation (APBI) treated with the Strut Adjusted Volume Implant (SAVI) applicator using Thermoluminescent Dosimeters (TLDs). A set of CT images were selected from a patient’s data who had received APBI using the SAVI applicator. The images were used to make 3D models. TLDs were calibrated for Brachytherapy. Various points of interest were marked out and slots were carved in the 3D models to fit the TLDs. CT scans were taken of the 3D models with expanded SAVI applicator inserted. A plan was made following B-39 protocol. The TLDs were read and the absorbed doses were calculated and compared to the delivered doses. The results of this study show that the overall average reading of the TLDs is within expected value. The TPS shows overestimated dose calculations for brachytherapy.
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Date Issued
2017
PURL
http://purl.flvc.org/fau/fd/FA00005942
Subject Headings
Dissertations, Academic -- Florida Atlantic University, Thermoluminescence dosimetry., Brachytherapy., Radiotherapy Dosage., Breast--Cancer--Radiotherapy.
Format
Document (PDF)
Manufacturing of 3D Printed Boluses for Use In Electron Radiation Therapy
Title
Manufacturing of 3D Printed Boluses for Use In Electron Radiation Therapy.
Creator
Gibbard, Grant, Kalantzis, Georgios, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
Abstract/Description
This research demonstrates that a 3D printed bolus can be customized for electron radiation therapy. Both extruder and powder based printers were used, along with, paraffin wax, super stuff, and H20. The plan dose coverage and conformity for the planning target volume (PTV), was such that the distal side of the PTV was covered by the 90% isodose line. The structure is read, and converted into an STL file. The file is sent to a slicer to print. The object was filled with parafin wax,...
Show moreThis research demonstrates that a 3D printed bolus can be customized for electron radiation therapy. Both extruder and powder based printers were used, along with, paraffin wax, super stuff, and H20. The plan dose coverage and conformity for the planning target volume (PTV), was such that the distal side of the PTV was covered by the 90% isodose line. The structure is read, and converted into an STL file. The file is sent to a slicer to print. The object was filled with parafin wax, superstuff or water and sealed. Materials Hounsfield units were analyzed, along with the structure stability. This method is evaluated by scanning the 3D printed bolus. The dose conformity is improved compared to that with no bolus. By generating a patient specific 3D printed bolus there is an in improvement in conformity of the prescription isodose surface while sparing immediately adjacent normal tissues.
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Date Issued
2017
PURL
http://purl.flvc.org/fau/fd/FA00005943
Subject Headings
Dissertations, Academic -- Florida Atlantic University, Radiotherapy Dosage., Skin--Cancer., Radiotherapy--methods
Format
Document (PDF)
New method of collecting output factors for commissioming linear accelerators with special emphasis on small fields and intensity modualted readiation therapy
Title
New method of collecting output factors for commissioming linear accelerators with special emphasis on small fields and intensity modualted readiation therapy.
Creator
Smith, Cindy, Pella, Silvia, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
Abstract/Description
Common methods for commissioning linear accelerators often neglect beam data for small fields. Examining the methods of beam data collection and modeling for commissioning linear accelerators revealed little to no discussion of the protocols for fields smaller than 4 cm x 4 cm. This leads to decreased confidence levels in the dose calculations and associated monitor units (MUs) for Intensity Modulated Radiation Therapy (IMRT). The parameters of commissioning the Novalis linear accelerator ...
Show moreCommon methods for commissioning linear accelerators often neglect beam data for small fields. Examining the methods of beam data collection and modeling for commissioning linear accelerators revealed little to no discussion of the protocols for fields smaller than 4 cm x 4 cm. This leads to decreased confidence levels in the dose calculations and associated monitor units (MUs) for Intensity Modulated Radiation Therapy (IMRT). The parameters of commissioning the Novalis linear accelerator (linac) on the Eclipse Treatment Planning System (TPS) led to the study of challenges collecting data for very small fields. The focus of this thesis is the examination of the protocols for output factor collection and their impact on dose calculations by the TPS for IMRT treatment plans. Improving output factor collection methods, led to significant improvement in absolute dose calculations which correlated with the complexity of the plans.
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Date Issued
2014
PURL
http://purl.flvc.org/fau/fd/FA00004161
Subject Headings
Coherence (Nuclear physics), Linear accelerators in medicine, Medical physics, Nuclear medicine, Particle beams, Radiation -- Dosage, Radiotherapy -- Positioning
Format
Document (PDF)
The Advantages of Collimator Optimization for Intensity Modulated Radiation Therapy
Title
The Advantages of Collimator Optimization for Intensity Modulated Radiation Therapy.
Creator
Doozan, Brian, Leventouri, Theodora, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
Abstract/Description
The goal of this study was to improve dosimetry for pelvic, lung, head and neck, and other cancers sites with aspherical planning target volumes (PTV) using a new algorithm for collimator optimization for intensity modulated radiation therapy (IMRT) that minimizes the x-jaw gap (CAX) and the area of the jaws (CAA) for each treatment field. A retroactive study on the effects of collimator optimization of 20 patients was performed by comparing metric results for new collimator optimization...
Show moreThe goal of this study was to improve dosimetry for pelvic, lung, head and neck, and other cancers sites with aspherical planning target volumes (PTV) using a new algorithm for collimator optimization for intensity modulated radiation therapy (IMRT) that minimizes the x-jaw gap (CAX) and the area of the jaws (CAA) for each treatment field. A retroactive study on the effects of collimator optimization of 20 patients was performed by comparing metric results for new collimator optimization techniques in Eclipse version 11.0. Keeping all other parameters equal, multiple plans are created using four collimator techniques: CA0, all fields have collimators set to 0°, CAE, using the Eclipse collimator optimization, CAA, minimizing the area of the jaws around the PTV, and CAX, minimizing the x-jaw gap. The minimum area and the minimum x-jaw angles are found by evaluating each field beam’s eye view of the PTV with ImageJ and finding the desired parameters with a custom script. The evaluation of the plans included the monitor units (MU), the maximum dose of the plan, the maximum dose to organs at risk (OAR), the conformity index (CI) and the number of fields that are calculated to split. Compared to the CA0 plans, the monitor units decreased on average by 6% for the CAX method with a p-value of 0.01 from an ANOVA test. The average maximum dose remained within 1.1% difference between all four methods with the lowest given by CAX. The maximum dose to the most at risk organ was best spared by the CAA method, which decreased by 0.62% compared to the CA0. Minimizing the x-jaws significantly reduced the number of split fields from 61 to 37. In every metric tested the CAX optimization produced comparable or superior results compared to the other three techniques. For aspherical PTVs, CAX on average reduced the number of split fields, lowered the maximum dose, minimized the dose to the surrounding OAR, and decreased the monitor units. This is achieved while maintaining the same control of the PTV.
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Date Issued
2017
PURL
http://purl.flvc.org/fau/fd/FA00004804, http://purl.flvc.org/fau/fd/FA00004804
Subject Headings
Radiation--Dosage., Optical engineering., Medical physics., Image-guided radiation therapy., Cancer--Radiotherapy., Medical radiology--Data processing., Medicine--Mathematical models.
Format
Document (PDF)