Current Search: Pyruvic acid--Synthesis (x)
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Title
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An efficient preparation of beta-mercaptopyruvic acid, a putative intermediate in ecteinascidin biosynthesis.
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Creator
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Fawehinmi, Hafusat Abosede, Florida Atlantic University, Kerr, Russell G.
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Abstract/Description
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The ecteinascidins are a family of marine derived alkaloids with potent antitumor activity. Ecteinascidins 743 and 729 are the prime targets due to their superior antitumor activity. beta-Mercaptopyruvic acid is a proposed intermediate in the biosynthesis of ecteinascidins 743/729. A novel synthesis of beta-mercaptopyruvic acid using an enzymatic system was achieved. This was accomplished by trapping the equilibrium between beta-mercaptopyruvic acid and 2,5-dihydroxy-1,4-dithiane-2,5...
Show moreThe ecteinascidins are a family of marine derived alkaloids with potent antitumor activity. Ecteinascidins 743 and 729 are the prime targets due to their superior antitumor activity. beta-Mercaptopyruvic acid is a proposed intermediate in the biosynthesis of ecteinascidins 743/729. A novel synthesis of beta-mercaptopyruvic acid using an enzymatic system was achieved. This was accomplished by trapping the equilibrium between beta-mercaptopyruvic acid and 2,5-dihydroxy-1,4-dithiane-2,5-dicarboxylate using oxidative deamination of cysteine by amino acid oxidase.
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Date Issued
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1999
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PURL
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http://purl.flvc.org/fcla/dt/15725
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Subject Headings
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Tunicata, Pyruvic acid--Synthesis
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Format
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Document (PDF)