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Acute and temporal responses of brain–derived neurotrophic factor and Interleukin-6 to high and low repetition resistance training programs
Title
Acute and temporal responses of brain–derived neurotrophic factor and Interleukin-6 to high and low repetition resistance training programs.
Creator
Quiles, Justin M., Zourdos, Michael C., Florida Atlantic University, College of Education, Department of Exercise Science and Health Promotion
Abstract/Description
The purpose of this study was to determine if resistance exercise altered peripheral BDNF concentration. Eighteen trained male subjects were split into two groups performing varied repetition ranges. DUP-HR and DUP-LR groups trained 3x/week for 8 weeks, and were equated for total volume (repetitions X sets X intensity). Plasma BDNF and interleukin-6 (IL-6) levels were measured prior to and immediately following the first exercise session of weeks 1, 2, 4 and 6. Pre-exercise levels were also...
Show moreThe purpose of this study was to determine if resistance exercise altered peripheral BDNF concentration. Eighteen trained male subjects were split into two groups performing varied repetition ranges. DUP-HR and DUP-LR groups trained 3x/week for 8 weeks, and were equated for total volume (repetitions X sets X intensity). Plasma BDNF and interleukin-6 (IL-6) levels were measured prior to and immediately following the first exercise session of weeks 1, 2, 4 and 6. Pre-exercise levels were also assessed prior to the second and third sessions of week 1 and 6. Lastly, resting levels were measured before and after training intervention. No group differences (p>0.05) were detected for either biomarker. An acute BDNF elevation (p=0.018) was detected only in the final week of training. IL-6 elevations were detected at all acute measurements (p<0.01). BDNF and IL-6 percentage change correlated significantly (p<0.05) in week-1. No chronic alterations were observed (p>0.05).
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Date Issued
2015
PURL
http://purl.flvc.org/fau/fd/FA00004461, http://purl.flvc.org/fau/fd/FA00004461
Subject Headings
Bioenergetics, Cognitive science, Exercise -- Physiological aspects, Kinesiology, Metabolic syndrome -- Pathophysiology, Neurons -- Physiology, Neurophysiology, Neurotrophic functions
Format
Document (PDF)
The effect of acute moderate-intensity continuous and high intensity interval exercise on serum brain-derived neurotrophic factor in recreationally trained males
Title
The effect of acute moderate-intensity continuous and high intensity interval exercise on serum brain-derived neurotrophic factor in recreationally trained males.
Creator
Mock, Thomas J., Whitehurst, Michael, Florida Atlantic University, College of Education, Department of Exercise Science and Health Promotion
Abstract/Description
BDNF is a neurotrophin that enhances neural health and is increased by exercise. PURPOSE: To compare moderate continuous (MCE) and high-intensity interval exercise (HIE) effects on serum BDNF levels, and examine the relationship between BDNF and lactate. METHODS: Seven males completed a VO2peak test and two protocols on separate days, (MCE) 28 min at 60% Workrate max (WRmax) and (HIE) 28 min of intervals at 90%WRmax (10- 1 min intervals separated by 2 min of rest). Serum BDNF and lactate were...
Show moreBDNF is a neurotrophin that enhances neural health and is increased by exercise. PURPOSE: To compare moderate continuous (MCE) and high-intensity interval exercise (HIE) effects on serum BDNF levels, and examine the relationship between BDNF and lactate. METHODS: Seven males completed a VO2peak test and two protocols on separate days, (MCE) 28 min at 60% Workrate max (WRmax) and (HIE) 28 min of intervals at 90%WRmax (10- 1 min intervals separated by 2 min of rest). Serum BDNF and lactate were determined prior, during, and following both protocols. RESULTS: BDNF levels (pg/mL) increased from baseline during HIE and MCE (p<.05). The BDNF response to HIE correlated with lactate for area under the curve (AUC) (r=0.901; P<0.05). CONCLUSION: HIE is an effective alternative to MCE at increasing BDNF. Additionally, lactate may act as a measure of intensity or a mediator of the BDNF response to exercise.
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Date Issued
2014
PURL
http://purl.flvc.org/fau/fd/FA00004219, http://purl.flvc.org/fau/fd/FA00004219
Subject Headings
Biochemical markers., Neurons--Physiology., Cell aging--Physiology., Neurotrophic function., Metabolic syndrome--Pathophysiology.
Format
Document (PDF)
Adult olfactory neuron turnover and the asscociation between fractalkine and microglia
Title
Adult olfactory neuron turnover and the asscociation between fractalkine and microglia.
Creator
Mello, Rebecca Femandes, Guthrie, Kathleen M.
Date Issued
2013-04-05
PURL
http://purl.flvc.org/fcla/dt/3361154
Subject Headings
Olfactory Receptor Neurons, Olfactory Bulb--physiology, Cell death, Microglia, Chemokines
Format
Document (PDF)
VISUALIZING NANO-SCALE SYNAPTIC CHANGES DURING SINGLE DENDRITIC SPINE LONG-TERM POTENTIATION BY CORRELATIVE LIGHT AND ELECTRON MICROSCOPY
Title
VISUALIZING NANO-SCALE SYNAPTIC CHANGES DURING SINGLE DENDRITIC SPINE LONG-TERM POTENTIATION BY CORRELATIVE LIGHT AND ELECTRON MICROSCOPY.
Creator
Sun, Ye, Yasuda, Ryohei, Florida Atlantic University, Department of Biological Sciences, Charles E. Schmidt College of Science
Abstract/Description
Dendritic spines are the major sites for receiving excitatory synaptic inputs and play important roles in neuronal signal transduction, memory storage and neuronal circuit organization. Structural plasticity of dendritic spines is correlated with functional plasticity, and is critical for learning and memory. Visualization of the changes of dendritic spines at the ultrastructural level that specifically correlated with their function changes in high throughput would shed light on detailed...
Show moreDendritic spines are the major sites for receiving excitatory synaptic inputs and play important roles in neuronal signal transduction, memory storage and neuronal circuit organization. Structural plasticity of dendritic spines is correlated with functional plasticity, and is critical for learning and memory. Visualization of the changes of dendritic spines at the ultrastructural level that specifically correlated with their function changes in high throughput would shed light on detailed mechanisms of synaptic plasticity. Here we developed a correlative light and electron microscopy workflow which combines two-photon MNI-glutamate uncaging, pre-embedding immunolabeling, Automatic Tape-collecting Ultramicrotome sectioning and scanning electron microscopy imaging. This method bridges two different visualization platforms, directly linking ultrastructure and function at the level of individual synapses. With this method, we successfully relocated single dendritic spines that underwent long-term potentiation (LTP) induced by two-photon MNI-glutamate uncaging, and visualized their ultrastructures and AMPA receptors distribution at different phases of LTP in high throughput.
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Date Issued
2020
PURL
http://purl.flvc.org/fau/fd/FA00013433
Subject Headings
Dendritic Spines, Neuroplasticity, Visualization, Microscopy, Long-Term Potentiation--physiology, Neurons--ultrastructure
Format
Document (PDF)