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Nonlinear properties of cardiac rhythm abnormalities
Title
Nonlinear properties of cardiac rhythm abnormalities.
Creator
Liebovitch, Larry S., Todorov, Angelo T., Zochowski, Michal, Scheurle, Daniela, Colgin, Laura, Wood, Mark A., Ellenbogen, Kenneth A., Herre, John M., Bernstein, Robert C.
Date Issued
1999-03
PURL
http://purl.flvc.org/fau/165473
Subject Headings
Biophysics--Research, Medicine-Mathematics, Arrythmia--therapy, Fractals, Nonlinear systems, Probabilities-Mathematical Models
Format
Document (PDF)
Migration induced epidemics: dynamics of flux-based multipatch models
Title
Migration induced epidemics: dynamics of flux-based multipatch models.
Creator
Liebovitch, Larry S., Schwartz, Ira B.
Date Issued
2004
PURL
http://purl.flvc.org/FAU/165227
Subject Headings
Communicable diseases--Epidemiology--Mathematical models, Emerging infectious diseases, Epidemiologic Methods, Epidemiology, Biomathematics, Medicine-Mathematics, Dynamics-Mathematical models
Format
Document (PDF)
Empirical beam angle optimization for lung cancer intensity modulated radiation therapy
Title
Empirical beam angle optimization for lung cancer intensity modulated radiation therapy.
Creator
Doozan, Brian, Pella, Silvia, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
Abstract/Description
Empirical methods of beam angle optimization (BAO) are tested against the BAO that is currently employed in Eclipse treatment planning software. Creating an improved BAO can decrease the amount of time a dosimetrist spends on making a treatment plan, improve the treatment quality and enhance the tools an inexperienced dosimetrist can use to develop planning techniques. Using empirical data created by experienced dosimetrists from 69 patients treated for lung cancer, the most frequently used...
Show moreEmpirical methods of beam angle optimization (BAO) are tested against the BAO that is currently employed in Eclipse treatment planning software. Creating an improved BAO can decrease the amount of time a dosimetrist spends on making a treatment plan, improve the treatment quality and enhance the tools an inexperienced dosimetrist can use to develop planning techniques. Using empirical data created by experienced dosimetrists from 69 patients treated for lung cancer, the most frequently used gantry angles were applied to four different regions in each lung to gather an optimal set of fields that could be used to treat future lung cancer patients. This method, given the moniker FAU BAO, is compared in 7 plans created with the Eclipse BAO choosing 5 fields and 9 fields. The results show that the conformality index improved by 30% or 3% when using the 5 and 9 fields. The conformation number was better by 12% from the 5 fields and 9% from the 9 fields. The organs at risk (OAR) were overall more protected to produce fewer nonstochastic effects from the radiation treatment with the FAU BAO.
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Date Issued
2014
PURL
http://purl.flvc.org/fau/fd/FA00004280, http://purl.flvc.org/fau/fd/FA00004280
Subject Headings
Cancer -- Radiotherapy, Image guided radiation therapy, Lung cancer -- Treatment, Medical physics, Medical radiology -- Data processing, Medicine -- Mathematical models
Format
Document (PDF)
The Advantages of Collimator Optimization for Intensity Modulated Radiation Therapy
Title
The Advantages of Collimator Optimization for Intensity Modulated Radiation Therapy.
Creator
Doozan, Brian, Leventouri, Theodora, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
Abstract/Description
The goal of this study was to improve dosimetry for pelvic, lung, head and neck, and other cancers sites with aspherical planning target volumes (PTV) using a new algorithm for collimator optimization for intensity modulated radiation therapy (IMRT) that minimizes the x-jaw gap (CAX) and the area of the jaws (CAA) for each treatment field. A retroactive study on the effects of collimator optimization of 20 patients was performed by comparing metric results for new collimator optimization...
Show moreThe goal of this study was to improve dosimetry for pelvic, lung, head and neck, and other cancers sites with aspherical planning target volumes (PTV) using a new algorithm for collimator optimization for intensity modulated radiation therapy (IMRT) that minimizes the x-jaw gap (CAX) and the area of the jaws (CAA) for each treatment field. A retroactive study on the effects of collimator optimization of 20 patients was performed by comparing metric results for new collimator optimization techniques in Eclipse version 11.0. Keeping all other parameters equal, multiple plans are created using four collimator techniques: CA0, all fields have collimators set to 0°, CAE, using the Eclipse collimator optimization, CAA, minimizing the area of the jaws around the PTV, and CAX, minimizing the x-jaw gap. The minimum area and the minimum x-jaw angles are found by evaluating each field beam’s eye view of the PTV with ImageJ and finding the desired parameters with a custom script. The evaluation of the plans included the monitor units (MU), the maximum dose of the plan, the maximum dose to organs at risk (OAR), the conformity index (CI) and the number of fields that are calculated to split. Compared to the CA0 plans, the monitor units decreased on average by 6% for the CAX method with a p-value of 0.01 from an ANOVA test. The average maximum dose remained within 1.1% difference between all four methods with the lowest given by CAX. The maximum dose to the most at risk organ was best spared by the CAA method, which decreased by 0.62% compared to the CA0. Minimizing the x-jaws significantly reduced the number of split fields from 61 to 37. In every metric tested the CAX optimization produced comparable or superior results compared to the other three techniques. For aspherical PTVs, CAX on average reduced the number of split fields, lowered the maximum dose, minimized the dose to the surrounding OAR, and decreased the monitor units. This is achieved while maintaining the same control of the PTV.
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Date Issued
2017
PURL
http://purl.flvc.org/fau/fd/FA00004804, http://purl.flvc.org/fau/fd/FA00004804
Subject Headings
Radiation--Dosage., Optical engineering., Medical physics., Image-guided radiation therapy., Cancer--Radiotherapy., Medical radiology--Data processing., Medicine--Mathematical models.
Format
Document (PDF)