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Fistularin 3 and 11-Ketofistularin 3. Feline leukemia virus active bromotyrosine metabolites from the marine sponge Aplysina archeri
Title
Fistularin 3 and 11-Ketofistularin 3. Feline leukemia virus active bromotyrosine metabolites from the marine sponge Aplysina archeri.
Creator
Gunasekera, Sarath P., Cross, S. S., Harbor Branch Oceanographic Institute
Date Issued
1992
PURL
http://purl.flvc.org/FCLA/DT/3332993
Subject Headings
Sponges, Tyrosine, Marine metabolites
Format
Document (PDF)
3-amino-1-(2-aminoimidazolyl)-prop-i-ene from the marine sponges Teichaxinella morchella and Ptilocaulis walpersi
Title
3-amino-1-(2-aminoimidazolyl)-prop-i-ene from the marine sponges Teichaxinella morchella and Ptilocaulis walpersi.
Creator
Wright, Amy E., Chiles, S. A., Cross, S. S.
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3332990
Subject Headings
Sponges, Marine metabolites, Pyrroles
Format
Document (PDF)
Isolation of Latrunculin A, 6,7-Epoxylatrunculin A, Fijianolide A, and Euryfuran from a new genus of the family Thorectidae
Title
Isolation of Latrunculin A, 6,7-Epoxylatrunculin A, Fijianolide A, and Euryfuran from a new genus of the family Thorectidae.
Creator
Gulavita, N. K., Gunasekera, Sarath P., Pomponi, Shirley A.
Date Issued
1992
PURL
http://purl.flvc.org/FCLA/DT/3332996
Subject Headings
Sponges, Marine toxins, Marine metabolites
Format
Document (PDF)
Farming sponges for chemicals with pharmaceutical potential
Title
Farming sponges for chemicals with pharmaceutical potential.
Creator
Duckworth, Alan R., Harbor Branch Oceanographic Institute
Date Issued
2001
PURL
http://purl.flvc.org/FCLA/DT/3352965
Subject Headings
Sponges, Metabolites, Sponges--Biotechnology, Marine metabolites, Marine pharmacology
Format
Document (PDF)
Immunosuppressive compounds from a deep water marine sponge, Agelas flabelliformis
Title
Immunosuppressive compounds from a deep water marine sponge, Agelas flabelliformis.
Creator
Gunasekera, Sarath P., Cranick, S., Longley, Ross E., Harbor Branch Oceanographic Institute
Date Issued
1989
PURL
http://purl.flvc.org/FCLA/DT/3332960
Subject Headings
Sponges, Immunosuppressive agents, Marine metabolites
Format
Document (PDF)
Three unprecedented chloro steroids from the Maui sponge Strongylacidon sp.: kiheisterones C, D, and E
Title
Three unprecedented chloro steroids from the Maui sponge Strongylacidon sp.: kiheisterones C, D, and E.
Creator
Carney, J. R., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
Date Issued
1993
PURL
http://purl.flvc.org/FCLA/DT/3318958
Subject Headings
Sponges --Research, Marine metabolites, Steroids
Format
Document (PDF)
1,1-Dimethyl-5,6-dihydroxyindolinium chloride from a deep water marine sponge, Dercitus sp.
Title
1,1-Dimethyl-5,6-dihydroxyindolinium chloride from a deep water marine sponge, Dercitus sp.
Creator
Kohmoto, S., McConnell, O. J., Wright, Amy E.
Date Issued
1988
PURL
http://purl.flvc.org/fau/fd/FA00007184
Subject Headings
Sponges, Marine metabolites, Chemical structure
Format
Document (PDF)
A new bastadin from the sponge Psammaplysilla purpurea
Title
A new bastadin from the sponge Psammaplysilla purpurea.
Creator
Carney, J. R., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
Date Issued
1993
PURL
http://purl.flvc.org/FCLA/DT/3318955
Subject Headings
Sponges --Research, Marine metabolites, Marine natural products
Format
Document (PDF)
Isolation and structure elucidation of onnamide a, a new bioactive metabolite of a marine sponge, Theonella sp.
Title
Isolation and structure elucidation of onnamide a, a new bioactive metabolite of a marine sponge, Theonella sp.
Creator
Sakemi, S., Ichiba, T., Kohmoto, S., Saucy, G., Higa, T., Harbor Branch Oceanographic Institute
Date Issued
1988
PURL
http://purl.flvc.org/FCLA/DT/3332945
Subject Headings
Sponges, Bioactive compounds, Marine metabolites, Marine Toxins
Format
Document (PDF)
Three new bromotyrosine derived metabolites of the sponge Psammaplysilla purpurea
Title
Three new bromotyrosine derived metabolites of the sponge Psammaplysilla purpurea.
Creator
Jurek, J., Yoshida, W. Y., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
Date Issued
1993
PURL
http://purl.flvc.org/FCLA/DT/3318965
Subject Headings
Marine natural products, Sponges --Research, Marine metabolites
Format
Document (PDF)
Natural Product Studies of Marine Organisms from the Western Atlantic
Title
Natural Product Studies of Marine Organisms from the Western Atlantic.
Creator
Hall, Andrew, West, Lyndon, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
The projects described in this dissertation are focused on compounds derived from marine organisms collected from the western Atlantic marine environment. Chapter 1 provides an introduction to the study of natural products chemistry, marine natural products, and overview of the research undertaken from natural product chemists. Chapter 2 describes the isolation and structure elucidation of a series of rare diterpenoids from the gorgonian Briareum asbestinum, together with their conformational...
Show moreThe projects described in this dissertation are focused on compounds derived from marine organisms collected from the western Atlantic marine environment. Chapter 1 provides an introduction to the study of natural products chemistry, marine natural products, and overview of the research undertaken from natural product chemists. Chapter 2 describes the isolation and structure elucidation of a series of rare diterpenoids from the gorgonian Briareum asbestinum, together with their conformational analysis and biosynthetic interconversions. These rare diterpenes from Briareum asbestinum are linked by an unusual transannular oxa-6π electrocyclization which is described in detail and this work demonstates the biomimetic hemisynthesis of briareolate esters L (19) to B (22) achieved via an intermediary, briareolate ester G (2), through a controlled set of photoinduced isomerizations and a unique photochromic transannular oxa-6π electrocyclization. This work focuses largely on the mechanistic understanding of the photochemical production of these briarane diterpenoids and illustrates a unique UVA/UVC, photochromic switch which induces a transannular oxa- 6π electrocyclization. Chapter 3 describes the assay-guided isolation of marine antioxidants. This chapter focuses on the screening of marine organism extracts using the Ferric Reducing Antioxidant Power (FRAP) assay for antioxidant activity guided isolation of marine natural products. The chapter concludes with the activity guided isolation and structural elucidation of 1-O-palmitoyl-2-O-myristoyl-3-O-(6-sulfo-α-D-quinovopyranosyl)- glycerol (40) to show direct antioxidant potential through FRAP analysis. Chapter 4 describes the isolation, structural elucidation and pharmacological evaluation of the novel secondary metabolites iso-PsA(45), Iso-PsC (46), iso-PsD (47) as well as known Pseudopterosins A(41), B(42), C(43), D(44), K(48), K2’OAc(49), K2’OAc(50). These secondary metabolites were evaluated for both cytotoxicity. The chapter concludes with the screening of these compounds as αβ-amyloid fibril modulators utilizing atomic force microcopy (AFM).
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Date Issued
2016
PURL
http://purl.flvc.org/fau/fd/FA00004666
Subject Headings
Marine natural products., Diterpenes., Marine metabolites
Format
Document (PDF)
Reiswigins A and B, novel antiviral diterpenes from a deepwater sponge
Title
Reiswigins A and B, novel antiviral diterpenes from a deepwater sponge.
Creator
Kashman, Y., Hirsch, S., Koehn, F. E., Cross, S. S., Harbor Branch Oceanographic Institute
Date Issued
1987
PURL
http://purl.flvc.org/FCLA/DT/3353808
Subject Headings
Antiviral agents, Diterpenes, Sponges, Marine metabolites
Format
Document (PDF)
Antitumor cyclic peroxides from the sponge Plakortis lita
Title
Antitumor cyclic peroxides from the sponge Plakortis lita.
Creator
Sakemi, S., Higa, T., Anthoni, U., Christophersen, C., Harbor Branch Oceanographic Institute
Date Issued
1987
PURL
http://purl.flvc.org/FCLA/DT/3353800
Subject Headings
Antineoplastic agents, Sponges, Peroxides, Marine metabolites
Format
Document (PDF)
Diterpene metabolites from two chemotypes of the marine sponge Myrmekioderma styx
Title
Diterpene metabolites from two chemotypes of the marine sponge Myrmekioderma styx.
Creator
Sennett, Susan H., Pomponi, Shirley A., Wright, Amy E.
Date Issued
1992
PURL
http://purl.flvc.org/FCLA/DT/3333004
Subject Headings
Sponges, Diterpenes, Marine metabolites, Chemical structure
Format
Document (PDF)
Venustatriol. A new, anti-viral, triterpene tetracyclic ether from Laurencia venusta
Title
Venustatriol. A new, anti-viral, triterpene tetracyclic ether from Laurencia venusta.
Creator
Sakemi, S., Higa, T., Jefford, C. W., Bernardinelli, G., Harbor Branch Oceanographic Institute
Date Issued
1986
PURL
http://purl.flvc.org/FCLA/DT/3353796
Subject Headings
Triterpenes, Laurencia, Squalene, Marine metabolites, Antiviral agents
Format
Document (PDF)
(+)-Curcuphenol and (+)-Curcudiol, sesquiterpene phenols from shallow and deep water collections of the marine sponge Didiscus Flavus
Title
(+)-Curcuphenol and (+)-Curcudiol, sesquiterpene phenols from shallow and deep water collections of the marine sponge Didiscus Flavus.
Creator
Wright, Amy E., Pomponi, Shirley A., McConnell, O. J., Kohmoto, S., McCarthy, Peter J.
Date Issued
1987
PURL
http://purl.flvc.org/FCLA/DT/3332940
Subject Headings
Sponges, Sesquiterpenes, Antifungal agents, Marine metabolites
Format
Document (PDF)
Sterols of the marine sponge Petrosia weinbergi: implications for the absolute configurations of the antiviral orthoesterols and weinbersterols
Title
Sterols of the marine sponge Petrosia weinbergi: implications for the absolute configurations of the antiviral orthoesterols and weinbersterols.
Creator
Giner, José-Luis, Gunasekera, Sarath P., Pomponi, Shirley A.
Date Issued
1999
PURL
http://purl.flvc.org/FCLA/DT/3158771
Subject Headings
Sponges, Sterols --Analysis, Steroids, Biosynthesis, Marine metabolites
Format
Document (PDF)
Dysidiolide: a novel protein phosphatase inhibitor from the Caribbean sponge Dysidea etheria de Laubenfels
Title
Dysidiolide: a novel protein phosphatase inhibitor from the Caribbean sponge Dysidea etheria de Laubenfels.
Creator
Gunasekera, Sarath P., McCarthy, Peter J., Kelly-Borges, M., Lobkovsky, E., Clardy, J.
Date Issued
1996
PURL
http://purl.flvc.org/FCLA/DT/3319096
Subject Headings
Sponges --Research, Dysidiolide, Marine metabolites, Marine natural products, Protein phosphatases
Format
Document (PDF)
Isolation, synthesis, and biological activity of Aphrocallistin, an adenine-substituted bromotyramine metabolite from the hexactinellida sponge Aphrocallistes beatrix
Title
Isolation, synthesis, and biological activity of Aphrocallistin, an adenine-substituted bromotyramine metabolite from the hexactinellida sponge Aphrocallistes beatrix.
Creator
Wright, Amy E., Roth, G. P., Hoffman, J. K., Divlianska, D. B., Pechter, D., Sennett, Susan H., Guzman, Esther A., Linley, P. A., McCarthy, Peter J., Pitts, Tara P., Pomponi, Shirley A., Reed, John K.
Date Issued
2009
PURL
http://purl.flvc.org/FCLA/DT/3319109
Subject Headings
Sponges --Research, Marine metabolites, Marine natural products, Hexactinellida
Format
Document (PDF)
Biogenetically diverse, bioactive constituents of a sponge, order Verongida: bromotyramines and sesquiterpene-shikimate derived metabolites
Title
Biogenetically diverse, bioactive constituents of a sponge, order Verongida: bromotyramines and sesquiterpene-shikimate derived metabolites.
Creator
Hamann, Mark T., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
Date Issued
1993
PURL
http://purl.flvc.org/FCLA/DT/3318968
Subject Headings
Sponges --Research, Marine metabolites, Sesquiterpenes, Marine natural products
Format
Document (PDF)

Pages