Current Search: Lung cancer -- Treatment (x)
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- Title
- Comparison of treatment plans calculated using ray tracing and Monte Carlo algorithms for lung cancer patients having undergone radiotherapy with cyberknife.
- Creator
- Pennington, Andreea, Selvaraj, Raj, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
- Abstract/Description
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The purpose of this research is to determine the feasibility of introducing the Monte Carlo (MC) dose calculation algorithm into the clinical practice. Unlike the Ray Tracing (RT) algorithm, the MC algorithm is not affected by the tissue inhomogeneities, which are significant inside the chest cavity. A retrospective study was completed for 102 plans calculated using both the RT and MC algorithms. The D95 of the PTV was 26% lower for the MC calculation. The first parameter of conformality, as...
Show moreThe purpose of this research is to determine the feasibility of introducing the Monte Carlo (MC) dose calculation algorithm into the clinical practice. Unlike the Ray Tracing (RT) algorithm, the MC algorithm is not affected by the tissue inhomogeneities, which are significant inside the chest cavity. A retrospective study was completed for 102 plans calculated using both the RT and MC algorithms. The D95 of the PTV was 26% lower for the MC calculation. The first parameter of conformality, as defined as the ratio of the Prescription Isodose Volume to the PTV Volume was on average 1.27 for RT and 0.67 for MC. The results confirm that the RT algorithm significantly overestimates the dosages delivered confirming previous analyses. Correlations indicate that these overestimates are largest for small PTV and/or when the ratio of the volume of lung tissue to the PTV approaches 1.
Show less - Date Issued
- 2014
- PURL
- http://purl.flvc.org/fau/fd/FA00004316
- Subject Headings
- Computer graphics, Diagnostic imaging, Image guided radiation therapy, Lung cancer -- Treatment, Lungs -- Cancer -- Radiotherapy, Monte Carlo method
- Format
- Document (PDF)
- Title
- A novel method to evaluate local control of lung cancer in stereotactic body radiation therapy (SBRT) treatment using 18f-Fdg positron emission tomography (PET).
- Creator
- Kathriarachchi, Vindu, Shang, Charles, Charles E. Schmidt College of Science, Department of Physics
- Abstract/Description
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An improved method is introduced for prediction of local tumor control following lung stereotactic body radiation therapy (SBRT) for early stage non-small cell lung cancer (NSCLC) patients using 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET). A normalized background-corrected tumor maximum Standard Uptake Value (SUVcmax) is introduced using the mean uptake of adjacent aorta (SUVref), instead of the maximum uptake of lung tumor (SUVmax). This method minimizes the variations...
Show moreAn improved method is introduced for prediction of local tumor control following lung stereotactic body radiation therapy (SBRT) for early stage non-small cell lung cancer (NSCLC) patients using 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET). A normalized background-corrected tumor maximum Standard Uptake Value (SUVcmax) is introduced using the mean uptake of adjacent aorta (SUVref), instead of the maximum uptake of lung tumor (SUVmax). This method minimizes the variations associated with SUVmax and objectively demonstrates a strong correlation between the low SUVcmax (< 2.5-3.0) and local control of post lung SBRT. The false positive rates of both SUVmax and SUVcmax increase with inclusion of early (<6 months) PET scans, therefore such inclusion is not recommended for assessing local tumor control of post lung SBRT.
Show less - Date Issued
- 2013
- PURL
- http://purl.flvc.org/fau/fd/FA0004029
- Subject Headings
- Cancer -- Radiotherapy, Image guided radiation therapy, Lung cancer -- Treatment, Radiopharmaceuticals, Tomography, Emission
- Format
- Document (PDF)
- Title
- Empirical beam angle optimization for lung cancer intensity modulated radiation therapy.
- Creator
- Doozan, Brian, Pella, Silvia, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
- Abstract/Description
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Empirical methods of beam angle optimization (BAO) are tested against the BAO that is currently employed in Eclipse treatment planning software. Creating an improved BAO can decrease the amount of time a dosimetrist spends on making a treatment plan, improve the treatment quality and enhance the tools an inexperienced dosimetrist can use to develop planning techniques. Using empirical data created by experienced dosimetrists from 69 patients treated for lung cancer, the most frequently used...
Show moreEmpirical methods of beam angle optimization (BAO) are tested against the BAO that is currently employed in Eclipse treatment planning software. Creating an improved BAO can decrease the amount of time a dosimetrist spends on making a treatment plan, improve the treatment quality and enhance the tools an inexperienced dosimetrist can use to develop planning techniques. Using empirical data created by experienced dosimetrists from 69 patients treated for lung cancer, the most frequently used gantry angles were applied to four different regions in each lung to gather an optimal set of fields that could be used to treat future lung cancer patients. This method, given the moniker FAU BAO, is compared in 7 plans created with the Eclipse BAO choosing 5 fields and 9 fields. The results show that the conformality index improved by 30% or 3% when using the 5 and 9 fields. The conformation number was better by 12% from the 5 fields and 9% from the 9 fields. The organs at risk (OAR) were overall more protected to produce fewer nonstochastic effects from the radiation treatment with the FAU BAO.
Show less - Date Issued
- 2014
- PURL
- http://purl.flvc.org/fau/fd/FA00004280, http://purl.flvc.org/fau/fd/FA00004280
- Subject Headings
- Cancer -- Radiotherapy, Image guided radiation therapy, Lung cancer -- Treatment, Medical physics, Medical radiology -- Data processing, Medicine -- Mathematical models
- Format
- Document (PDF)
- Title
- Exploring appropriate offset values for pencil beam and Monte Carlo dose optimization in lung stereotactic body radiotherapy encompassing the effects of respiration and tumor location.
- Creator
- Evans, Grant, Shang, Charles, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
- Abstract/Description
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Evaluation of dose optimization using the Pencil Beam (PB) and Monte Carlo (MC) algorithms may allow physicists to apply dosimetric offsets to account for inaccuracies of the PB algorithm for lung cancer treatment with Stereotactic Body Radiotherapy (SBRT). 20 cases of Non-Small Cell Lung Cancer (NSCLC) were selected. Treatment plans were created with Brainlab iPlanDose® 4.1.2. The D97 of the Planning Target Volume (PTV) was normalized to 50 Gy on the Average Intensity Projection (AIP) using...
Show moreEvaluation of dose optimization using the Pencil Beam (PB) and Monte Carlo (MC) algorithms may allow physicists to apply dosimetric offsets to account for inaccuracies of the PB algorithm for lung cancer treatment with Stereotactic Body Radiotherapy (SBRT). 20 cases of Non-Small Cell Lung Cancer (NSCLC) were selected. Treatment plans were created with Brainlab iPlanDose® 4.1.2. The D97 of the Planning Target Volume (PTV) was normalized to 50 Gy on the Average Intensity Projection (AIP) using the fast PB and compared with MC. This exact plan with the same beam Monitor Units (MUs) was recalculated over each respiratory phase. The results show that the PB algorithm has a 2.3-2.4% less overestimation at the maximum exhalation phase than the maximum inhalation phase when compared to MC. Significantly smaller dose difference between PB and MC is also shown in plans for peripheral lesions (7.7 ± 0.7%) versus central lesions (12.7±0.8%)(p< 0.01).
Show less - Date Issued
- 2014
- PURL
- http://purl.flvc.org/fau/fd/FA00004105, http://purl.flvc.org/fau/fd/FA00004105
- Subject Headings
- Drug development -- Computer simulation, Image guided radiation therapy, Lung cancer -- Treatment, Monte Carlo method, Proton beams, Transport theory
- Format
- Document (PDF)
- Title
- A dosimetric study of a heterogeneous phantom for lung stereotactic body radiation therapy comparing Monte Carlo and pencil beam calculations to dose distributions measured with a 2-d diode array.
- Creator
- Curley, Casey Michael, Ouhib, Zoubir, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
- Abstract/Description
-
Monte Carlo (MC) and Pencil Beam (PB) calculations are compared to their measured planar dose distributions using a 2-D diode array for lung Stereotactic Body Radiation Therapy (SBRT). The planar dose distributions were studied for two different phantom types: an in-house heterogeneous phantom and a homogeneous phantom. The motivation is to mimic the human anatomy during a lung SBRT treatment and incorporate heterogeneities into the pre-treatment Quality Assurance process, where measured and...
Show moreMonte Carlo (MC) and Pencil Beam (PB) calculations are compared to their measured planar dose distributions using a 2-D diode array for lung Stereotactic Body Radiation Therapy (SBRT). The planar dose distributions were studied for two different phantom types: an in-house heterogeneous phantom and a homogeneous phantom. The motivation is to mimic the human anatomy during a lung SBRT treatment and incorporate heterogeneities into the pre-treatment Quality Assurance process, where measured and calculated planar dose distributions are compared before the radiation treatment. Individual and combined field dosimetry has been performed for both fixed gantry angle (anterior to posterior) and planned gantry angle delivery. A gamma analysis has been performed for all beam arrangements. The measurements were obtained using the 2-D diode array MapCHECK 2™.
Show less - Date Issued
- 2015
- PURL
- http://purl.flvc.org/fau/fd/FA00004360
- Subject Headings
- Cancer -- Radiotherapy, Drug development -- Computer simulation, Image guided radiation therapy, Ion bombardment, Lung cancer -- Treatment, Medical physics, Monte Carlo method, Proton beams
- Format
- Document (PDF)
- Title
- Phantom Study Incorporating A Diode Array Into The Treatment Planning System For Patient-Specific Quality Assurance.
- Creator
- Curley, Casey Michael, Leventouri, Theodora, Ouhib, Zoubir, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
- Abstract/Description
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The purpose of this research is to accurately match the calculation environment, i.e. the treatment planning system (TPS) with the measurement environment (using a 2-D diode array) for lung Stereotactic Body Radiation Therapy (SBRT) patient-specific quality assurance (QA). Furthermore, a new phantom was studied in which the 2-D array and heterogeneities were incorporated into the patient-specific QA process for lung SBRT. Dual source dual energy computerized tomography (DSCT) and single...
Show moreThe purpose of this research is to accurately match the calculation environment, i.e. the treatment planning system (TPS) with the measurement environment (using a 2-D diode array) for lung Stereotactic Body Radiation Therapy (SBRT) patient-specific quality assurance (QA). Furthermore, a new phantom was studied in which the 2-D array and heterogeneities were incorporated into the patient-specific QA process for lung SBRT. Dual source dual energy computerized tomography (DSCT) and single energy computerized tomography (SECT) were used to model phantoms incorporating a 2-D diode array into the TPS. A water-equivalent and a heterogeneous phantom (simulating the thoracic region of a patient) were studied. Monte Carlo and pencil beam dose distributions were compared to the measured distributions. Composite and individual fields were analyzed for normally incident and planned gantry angle deliveries. The distributions were compared using γ-analysis for criteria 3% 3mm, 2% 2mm, and 1% 1mm. The Monte Carlo calculations for the DSCT modeled phantoms (incorporating the array) showed an increase in the passing percentage magnitude for 46.4 % of the fields at 3% 3mm, 85.7% at 2% 2mm, and 92.9% at 1% 1mm. The Monte Carlo calculations gave no agreement for the same γ-analysis criteria using the SECT. Pencil beam calculations resulted in lower passing percentages when the diode array was incorporated in the TPS. The DSCT modeled phantoms (incorporating the array) exhibited decrease in the passing percentage magnitude for 85.7% of the fields at 3% 3mm, 82.1% at 2% 2mm, and 71.4% at 1% 1mm. In SECT modeled phantoms (incorporating the array), a decrease in passing percentage magnitude were found for 92.9% of the fields at 3% 3mm, 89.3% at 2% 2mm, and 82.1% at 1% 1mm. In conclusion, this study demonstrates that including the diode array in the TPS results in increased passing percentages when using a DSCT system with a Monte Carlo algorithm for patient-specific lung SBRT QA. Furthermore, as recommended by task groups (e.g. TG 65, TG 101, TG 244) of the American Association of Physicists in Medicine (AAPM), pencil beam algorithms should be avoided in the presence of heterogeneous materials, including a diode array.
Show less - Date Issued
- 2016
- PURL
- http://purl.flvc.org/fau/fd/FA00004744, http://purl.flvc.org/fau/fd/FA00004744
- Subject Headings
- Cancer--Radiotherapy., Lungs--Cancer--Treatment., Monte Carlo method., Proton beams., Image-guided radiation therapy., Ion bombardment., Medical physics.
- Format
- Document (PDF)