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Dependence of spectroscopic and electrochemical properties of dimolybdenum multiimine complexes on ligand structure
Title
Dependence of spectroscopic and electrochemical properties of dimolybdenum multiimine complexes on ligand structure.
Creator
Yang, Fengli, Florida Atlantic University, Baird, Donald M.
Abstract/Description
The complexes MoX4(Multiimine)2, where X = Cl, Br, I and Multiimine = dimethyl-bipyridine, bipyridine, phenanthroline, bipyrazine, bipyridazine and bipyrimidine, have been prepared. The product complexes apparently contain non-bridged quadruple molybdenum-molybdenum bonds. Each molybdenum is coordinated to a bidentate diimine and two halogen atoms. An electronic absorption study reveals an important trend that the intensity of the delta-->delta* transition increases with decreasing energy....
Show moreThe complexes MoX4(Multiimine)2, where X = Cl, Br, I and Multiimine = dimethyl-bipyridine, bipyridine, phenanthroline, bipyrazine, bipyridazine and bipyrimidine, have been prepared. The product complexes apparently contain non-bridged quadruple molybdenum-molybdenum bonds. Each molybdenum is coordinated to a bidentate diimine and two halogen atoms. An electronic absorption study reveals an important trend that the intensity of the delta-->delta* transition increases with decreasing energy. This shows the energy of this band is determined by mixing of this transition with a metal-to-ligand charge transfer transition. An EEC type mechanism is proposed for the redox behavior of these compounds on the basis of an electrochemical study and some consistent results are obtained by correlating the oxidation potentials with the delta-->delta* transition energies. Also, fairly good correlations of both the delta-->delta* transition energies and the oxidation potentials with pk(a) of L are obtained.
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Date Issued
1991
PURL
http://purl.flvc.org/fcla/dt/14724
Subject Headings
Molybdenum, Diffusion bonding (Metals), Ligand binding (Biochemistry)
Format
Document (PDF)
Chitin Microparticles (CMPs) Induce M1 Macrophage Activation via Intracellular TLR2 Signaling Mechanism
Title
Chitin Microparticles (CMPs) Induce M1 Macrophage Activation via Intracellular TLR2 Signaling Mechanism.
Creator
Davis, Spring, Shibata, Yoshimi, Florida Atlantic University, Charles E. Schmidt College of Medicine, Department of Biological Sciences
Abstract/Description
Chitin Microparticles (CMPs, 1-10um), a special form of the ubiquitous and nontoxic polysaccharide Chitin (GlcNAc), is capable of inducing a switch in macrophages from the wound-healing M2 phenotype to the classically activated pro-inflammatory M1 phenotype; which has therapeutic implications in allergy and cancer. We hypothesized that TLR2 forms a complex with CMPs and Chitin-Binding Proteins (CBPs) at the surface of peritoneal macrophages and remains with that complex after internalization...
Show moreChitin Microparticles (CMPs, 1-10um), a special form of the ubiquitous and nontoxic polysaccharide Chitin (GlcNAc), is capable of inducing a switch in macrophages from the wound-healing M2 phenotype to the classically activated pro-inflammatory M1 phenotype; which has therapeutic implications in allergy and cancer. We hypothesized that TLR2 forms a complex with CMPs and Chitin-Binding Proteins (CBPs) at the surface of peritoneal macrophages and remains with that complex after internalization to initiate downstream signaling events, leading to the production of the M1 cytokine, TNFalpha. Our results from experiments performed in RAW 264.7 cells show that TLR2 and TLR1, but not TLR6, are associated with the CMP binding fraction, and that both TLR1 and TLR2 might be important for M1 activation as a result of CMP phagocytosis. This project sheds light on CMP as a potential therapeutic agent and provides more evidence for a phagocytosis-dependent TLR2 signaling pathway.
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Date Issued
2016
PURL
http://purl.flvc.org/fau/fd/FA00004762, http://purl.flvc.org/fau/fd/FA00004762
Subject Headings
Biopharmaceutics., Macrophages., Cell receptors., Ligands (Biochemistry), High performance processors.
Format
Document (PDF)
synthesis of bis(dimolybdenum)-1,3,5,7-tetrakis(2-pyridylimino) benzodipyrrole as a precursor for an inorganic, quadruple bond containing polymer
Title
The synthesis of bis(dimolybdenum)-1,3,5,7-tetrakis(2-pyridylimino) benzodipyrrole as a precursor for an inorganic, quadruple bond containing polymer.
Creator
Kavanaugh, David John, Florida Atlantic University, Baird, Donald M., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
The planar, dinuclear, tridentate ligands, 1,3,5,7-tetrakis(2-pyridylimino)benzodipyrrole (TAII) and 1,3,5,7-tetrakis(4,6-dimethyl-2-pyridylimino)benzodipyrrole (DiMeTAII) were synthesized and characterized as were all intermediates characterized by both infrared and 1H-NMR spectra. Evidence is presented for the formation of Mo4(OAc)6-(DiMeTAII) (I), the dinuclear analog of Mo2(OAc)3-BAII using UV/Vis to show the delta--->delta* transition typical of the quadruple bond and for the...
Show moreThe planar, dinuclear, tridentate ligands, 1,3,5,7-tetrakis(2-pyridylimino)benzodipyrrole (TAII) and 1,3,5,7-tetrakis(4,6-dimethyl-2-pyridylimino)benzodipyrrole (DiMeTAII) were synthesized and characterized as were all intermediates characterized by both infrared and 1H-NMR spectra. Evidence is presented for the formation of Mo4(OAc)6-(DiMeTAII) (I), the dinuclear analog of Mo2(OAc)3-BAII using UV/Vis to show the delta--->delta* transition typical of the quadruple bond and for the determination of percent molybdenum which is consistent with the proposed structure. A review of recent studies into the field of quadruply bonded metal containing polymers will be discussed along with application of compound (I) in this field.
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Date Issued
1993
PURL
http://purl.flvc.org/fcla/dt/14950
Subject Headings
Ligands (Biochemistry), Metal-metal bonds, Diffusion bonding (Metals)
Format
Document (PDF)
Marine sponge Bis(Indole) alkaloids that displace ligand binding to α1 adrenergic receptors
Title
Marine sponge Bis(Indole) alkaloids that displace ligand binding to α1 adrenergic receptors.
Creator
Phife, D. W., Ramos, R. A., Feng, M., King, I., Gunasekera, Sarath P., Wright, Amy E., Patel, Mahesh, Pachter, J. A., Coval, S. J.
Date Issued
1996
PURL
http://purl.flvc.org/FCLA/DT/3331919
Subject Headings
Sponges, Indole alkaloids, Adrenergic alpha blockers, Alpha adrenoceptors, Ligand binding (Biochemistry)
Format
Document (PDF)