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Improving In Vivo Two Photon Microscopy Without Adaptive Optics
Title
Improving In Vivo Two Photon Microscopy Without Adaptive Optics.
Creator
Estrada, Gerardo, Beetle, Christopher, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
Abstract/Description
Two photon microscopy is one of the fastest growing methods of in-vivo imaging of the brain. It has the capability of imaging structures on the scale of 1μm. At this scale the wavelength of the imaging field (usually near infra-red), is comparable to the size of the structures being imaged, which makes the use of ray optics invalid. A better understanding is needed to predict the result of introducing different media into the light path. We use Wolf's integral, which is capable of fulfilling...
Show moreTwo photon microscopy is one of the fastest growing methods of in-vivo imaging of the brain. It has the capability of imaging structures on the scale of 1μm. At this scale the wavelength of the imaging field (usually near infra-red), is comparable to the size of the structures being imaged, which makes the use of ray optics invalid. A better understanding is needed to predict the result of introducing different media into the light path. We use Wolf's integral, which is capable of fulfilling these needs without the shortcomings of ray optics. We predict the effects of aberrating media introduced into the light path like glass cover-slips and then correct the aberration using the same method. We also create a method to predict aberrations when the interfaces of the media in the light-path are not aligned with the propagation direction of the wavefront.
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Date Issued
2015
PURL
http://purl.flvc.org/fau/fd/FA00004495
Subject Headings
Cellular signal transmission -- Measurement, Image analysis, Imaging systems in medicine, Membranes (Biology) -- Imaging, Neurons -- Imaging, Optics, Adaptive
Format
Document (PDF)
characterization of the LAP Aquarius Phantom for external LAP laser alignment and magnetic resonance geometric distortion verification for stereotactic radiation surgery patient simulation
Title
A characterization of the LAP Aquarius Phantom for external LAP laser alignment and magnetic resonance geometric distortion verification for stereotactic radiation surgery patient simulation.
Creator
Vergara, Daniel, Charles E. Schmidt College of Science, Department of Physics
Abstract/Description
The Thesis explores additional applications of LAP's Aquarius external laser alignment verification Phantom by examining geometric accuracy of magnetic resonance images commonly used for planning intracranial stereotactic radiation surgery (ICSRS) cases. The scans were performed with MRI protocols used for ICSRS, and head and neck diagnosis, and their images fused to computerized tomographic (CT) images. The geometric distortions (GDs) were measured against the CT in all axial, sagittal, and...
Show moreThe Thesis explores additional applications of LAP's Aquarius external laser alignment verification Phantom by examining geometric accuracy of magnetic resonance images commonly used for planning intracranial stereotactic radiation surgery (ICSRS) cases. The scans were performed with MRI protocols used for ICSRS, and head and neck diagnosis, and their images fused to computerized tomographic (CT) images. The geometric distortions (GDs) were measured against the CT in all axial, sagittal, and coronal directions at different levels. Using the Aquarius Phantom, one is able to detect GD in ICSRS planning MRI acquisitions, and align the external LAP patient alignment lasers, by following the LAP QA protocol. GDs up to about 2 mm are observed at the distal regions of the longitudinal axis in the SRS treatment planning MR images. Based on the results, one may recommend the use of the Aquarius Phantom to determine if margins should be included for SRS treatment planning.
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Date Issued
2012
PURL
http://purl.flvc.org/FAU/3352878
Subject Headings
Radiotherapy, Techniques, Medical physics, Imaging systems in medicine, Tomographic images, Computerized axial tomography
Format
Document (PDF)
An Algorithm for the Automated Interpretation of Cardiac Auscultation
Title
An Algorithm for the Automated Interpretation of Cardiac Auscultation.
Creator
Lieber, Claude, Erdol, Nurgun, Florida Atlantic University, College of Engineering and Computer Science, Department of Computer and Electrical Engineering and Computer Science
Abstract/Description
Cardiac auscultation, an important part of the physical examination, is difficult for many primary care providers. As a result, diagnoses are missed or auscultatory signs misinterpreted. A reliable, automated means of interpreting cardiac auscultation should be of benefit to both the primary care provider and to patients. This paper explores a novel approach to this problem and develops an algorithm that can be expanded to include all the necessary electronics and programming to develop such...
Show moreCardiac auscultation, an important part of the physical examination, is difficult for many primary care providers. As a result, diagnoses are missed or auscultatory signs misinterpreted. A reliable, automated means of interpreting cardiac auscultation should be of benefit to both the primary care provider and to patients. This paper explores a novel approach to this problem and develops an algorithm that can be expanded to include all the necessary electronics and programming to develop such a device. The algorithm is explained and its shortcomings exposed. The potential for further development is also expounded.
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Date Issued
2016
PURL
http://purl.flvc.org/fau/fd/FA00004609, http://purl.flvc.org/fau/fd/FA00004609
Subject Headings
Phonocardiography., Signal processing., Pattern recognition systems., Imaging systems in medicine., Decision support systems., Medicine--Data processing.
Format
Document (PDF)
Adaptive energy-aware real-time detection models for cardiac atrial fibrillation
Title
Adaptive energy-aware real-time detection models for cardiac atrial fibrillation.
Creator
Bouhenguel, Redjem., College of Engineering and Computer Science, Department of Computer and Electrical Engineering and Computer Science
Abstract/Description
Though several clinical monitoring ways exist and have been applied to detect cardiac atril fibrillation (A-Fib) and other arrhythmia, these medical interventions and the ensuing clinical treatments are after the fact and costly. Current portable healthcare monitoring systems come in the form of Ambulatory Event Monitors. They are small, battery-operated electrocardiograph devices used to record the heart's rhythm and activity. However, they are not energy-aware ; they are not personalized ;...
Show moreThough several clinical monitoring ways exist and have been applied to detect cardiac atril fibrillation (A-Fib) and other arrhythmia, these medical interventions and the ensuing clinical treatments are after the fact and costly. Current portable healthcare monitoring systems come in the form of Ambulatory Event Monitors. They are small, battery-operated electrocardiograph devices used to record the heart's rhythm and activity. However, they are not energy-aware ; they are not personalized ; they require long battery life, and ultimately fall short on delivering real-time continuous detection of arrhythmia and specifically progressive development of cardiac A-Fib. The focus of this dissertation is the design of a class of adaptive and efficient energy-aware real-time detection models for monitoring, early real-time detection and reporting of progressive development of cardiac A-Fib.... The design promises to have a greater positive public health impact from predicting A-Fib and providing a viable approach to meeting the energy needs of current and future real-time monitoring, detecting and reporting required in wearable computing healthcare applications that are constrained by scarce energy resources.
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Date Issued
2012
PURL
http://purl.flvc.org/FAU/3358332
Subject Headings
Medical informatics, Medicine, Data processing, Imaging systems in medicine, Design and construction, Cardiovascular system, Diseases, Diagnosis, Bioinformatics
Format
Document (PDF)
Dosimetric comparison of inverse planning by simulated annealing (IPSA) and dosepoints optimized treatment plans in high dose rate (HDR) brachytherapy of skin lesions using Freiburg flap applicator
Title
Dosimetric comparison of inverse planning by simulated annealing (IPSA) and dose points optimized treatment plans in high dose rate (HDR) brachytherapy of skin lesions using Freiburg flap applicator.
Creator
Ghebremichael, Bereket Tewolde, Ouhib, Zoubir, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
Abstract/Description
A detailed dosimetric comparison between Inverse Planning by Simulated Annealing (IPSA) and Dose Points (DP) optimized treatment plans has been performed for High Dose Rate (HDR) brachytherapy of skin lesions using Freiburg Flap applicator in order to find out whether or not IPSA offers better clinical dosimetric outcomes for lesions categorized into four different curvatures. Without compromising target coverage, IPSA reduced the volume of Planning Target Volume (lesion) that received at...
Show moreA detailed dosimetric comparison between Inverse Planning by Simulated Annealing (IPSA) and Dose Points (DP) optimized treatment plans has been performed for High Dose Rate (HDR) brachytherapy of skin lesions using Freiburg Flap applicator in order to find out whether or not IPSA offers better clinical dosimetric outcomes for lesions categorized into four different curvatures. Without compromising target coverage, IPSA reduced the volume of Planning Target Volume (lesion) that received at least 125% of the prescription dose on average by 41%. It also reduced the volume of the healthy skin surrounding the lesion that receives at least 100% of the prescription dose on average by 42%. IPSA did not show any advantage over DP in sparing normal structures underlying the lesions treated. Although DP optimization algorithm has been regularly used at Lynn Cancer Institute for HDR brachytherapy of skin lesions, recent upgrades in IPSA software have made IPSA more amenable to rapid treatment planning and therefore IPSA can be used either in place of DP or as its alternative.
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Date Issued
2014
PURL
http://purl.flvc.org/fau/fd/FA00004285
Subject Headings
Artificial intelligence -- Medical applications, Cancer -- Treatment, Computational intellingence, Imaging systems in medicine, Medical physics
Format
Document (PDF)
MCNP5 Monte Carlo based dosimetry for the Nucletron Iridium-192 high dose-rate brachytherapy source with tissue heterogeneity corrections
Title
MCNP5 Monte Carlo based dosimetry for the Nucletron Iridium-192 high dose-rate brachytherapy source with tissue heterogeneity corrections.
Creator
Herrera, Ramses, Charles E. Schmidt College of Science, Department of Physics
Abstract/Description
A Monte Carlo model has been developed using MCNP5 to simulate the Nucletron Ir-192 HDR source in order to investigate the influence of tissue heterogeneities on dose calculations compared to the dose in homogeneous water media, as it is typically calculated by brachytherapy Treatment Planning Systems (TPS). Validity of the simulation was verified in water medium in comparison with peer reviewed results using the dosimetric parameters recommended by AAPM, Task Group-43. The dose-rates in...
Show moreA Monte Carlo model has been developed using MCNP5 to simulate the Nucletron Ir-192 HDR source in order to investigate the influence of tissue heterogeneities on dose calculations compared to the dose in homogeneous water media, as it is typically calculated by brachytherapy Treatment Planning Systems (TPS). Validity of the simulation was verified in water medium in comparison with peer reviewed results using the dosimetric parameters recommended by AAPM, Task Group-43. The dose-rates in simulated prostate, bladder and rectum were compared to those obtained in the homogeneous water phantom. Based on the resulting dose differences, it is inferred that TPS algorithms for brachytherapy dose calculations overestimate the dose to tissues like prostate and bladder by up to 49%. A clinically relevant dose underestimation of 5.5% to the rectum was also found. We recommend that further investigation using actual patient CT data as input to the Monte Carlo simulation be performed.
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Date Issued
2012
PURL
http://purl.flvc.org/FAU/3355564
Subject Headings
Medical physics, Iridium, Therapeutic use, Imaging systems in medicine, Radioisotope brachytherapy
Format
Document (PDF)
The importance of immobilization and localization of gynecological applicators in high dose rate brachytherapy treatments
Title
The importance of immobilization and localization of gynecological applicators in high dose rate brachytherapy treatments.
Creator
Hyvärinen, Mikko, Pella, Silvia, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
Abstract/Description
Intracavitary high dose rate (HDR) brachytherapy is a form of radiation therapy generally in which a post-surgical tissue margin is treated. The dose gradient of HDR brachytherapy is very steep, and thus small displacements of the applicator, even as small as 1 mm, could potentially cause significant variations of dose which could result in undesired side effects such as overdose of a critical organ. In this retrospective dosimetric study, the variation of dose due to various small range...
Show moreIntracavitary high dose rate (HDR) brachytherapy is a form of radiation therapy generally in which a post-surgical tissue margin is treated. The dose gradient of HDR brachytherapy is very steep, and thus small displacements of the applicator, even as small as 1 mm, could potentially cause significant variations of dose which could result in undesired side effects such as overdose of a critical organ. In this retrospective dosimetric study, the variation of dose due to various small range motions of gynecological applicators is investigated. The results show that the implementation of additional immobilization and localization devices along with other safety measures needs to be further investigated.
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Date Issued
2015
PURL
http://purl.flvc.org/fau/fd/FA00004446
Subject Headings
Artificial intelligence -- Medical applications, Cancer -- Intraoperative radiotherapy, Generative organs, Female -- Cancer -- Treatment, Imaging systems in medicine, Medical physics, Radiosotope brachytherapy
Format
Document (PDF)