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(1 - 4 of 4)
- Title
- Attention deficit caused by MDMA ('ecstasy').
- Creator
- Rudacille, Mary C., Tao, Rui
- Date Issued
- 2013-04-05
- PURL
- http://purl.flvc.org/fcla/dt/3361175
- Subject Headings
- Ecstasy (Drug), MDMA (Drug), Attention deficit disorder
- Format
- Document (PDF)
- Title
- The effects of 3.4 methylenedioxymethamphetamine (MDMA) on mnemonic and executive measures and serotonergic neurotoxicity using interspecies effects scaling.
- Creator
- Linley, Stephanie Brooke., Charles E. Schmidt College of Science, Department of Psychology
- Abstract/Description
-
3,4-methlenedioxymethamphetamine (MDMA), the main constituent of Ecstasy, is a ring-substituted amphetamine commonly abused in recreational users. High doses of MDMA determined by allometric scaling produce serotonin (5-HT) axon deneveration. Studies suggest that this interspecies scaling does not reflect human use. An 'effects' scale comparing similar behavioral and physiological effects between species has been postulated as more accurate for translational studies. Experiment 1 examined the...
Show more3,4-methlenedioxymethamphetamine (MDMA), the main constituent of Ecstasy, is a ring-substituted amphetamine commonly abused in recreational users. High doses of MDMA determined by allometric scaling produce serotonin (5-HT) axon deneveration. Studies suggest that this interspecies scaling does not reflect human use. An 'effects' scale comparing similar behavioral and physiological effects between species has been postulated as more accurate for translational studies. Experiment 1 examined the effects of MDMA on serotonergic forebrain innervation using immunohistochemical labeling targeting the serotonin transporter protein (SERT). Experiments 2 and 3 examined low and high doses of MDMA on spatial memory, prefrontal functioning, and serotonergic neurotoxicity using 'effects' scaling. Long Evans rats were given MDMA regimens of: chronic low dose (daily injections of 1.5 mg/kg for 10 days); binge low dose (2 days of 4 x 1.5 mg/kg spaced 2 hours apart), binge high dose (2 x 7.5 mg/kg sp aced 2 hours apart). Acquisition, retention, and spatial reversal (SR) were measured in a water maze task. A 2.0 mg/kg MDMA drug challenge was then given prior to a serial spatial reversal (SSR) task to assess performance while under the effect of the drug. Attentional set shifting and behavioral flexibility were assessed in an intradimensional extradimensionl (IED) task using odor/texture discriminations. MDMA chronic and binge low doses did not impair water maze or IED performance and produced no reductions in SERT expression. MDMA binge high dose resulted in significant reductions of SERT density in the prefrontal cortex, striatum, cortical mantle, hippocampus, amygdala, and many thalamic nuclei. Despite prominent 5-HT denervation, water maze performance was unaffected. Selective impairment in behavioral flexibility on the IED test was found., This suggests that low doses of MDMA do not produce long-term deleterious effects. But, high doses of MDMA taken in 'binges' produces widespread loss of forebrain SERT fiber innervation and significant impairments in reversal learning, while leaving attentional set shifting and spatial navigation unscathed.
Show less - Date Issued
- 2011
- PURL
- http://purl.flvc.org/FAU/3171679
- Subject Headings
- MDMA (Drug), Ecstasy (Drug), Psychological effect, Psychopharmacology, Methamphetamine abuse, Brain, Effect of drugs on, Psychotropic drugs, Side effects
- Format
- Document (PDF)
- Title
- Effect of MDMA abuse on axonal transportation of serotonergic nervous system in the rat brain.
- Creator
- Adams, Herbert D., Ma, Zhiyuan, Tao, Rui
- Date Issued
- 2012-04-06
- PURL
- http://purl.flvc.org/fcla/dt/3348609
- Subject Headings
- N-Methyl-3,4-methylenedioxyamphetamine, Ecstasy, Receptors, Serotonin - drug effects, Serotonergic nervous system, Substance-related disorders, Methamphetamine --adverse effects, Serotonin --pharmacokinetics
- Format
- Document (PDF)
- Title
- Measurement of Cognitive Function using the CANT AB Neuropsychological Battery in Current and Previous Human Ecstasy (MDMA) Users: A Polydrug Control Study.
- Creator
- Paz, Andres L., Hughes, Katherine M., Florida Atlantic University
- Abstract/Description
-
Widespread use of the illicit drug ecstasy (MDMA or 3,4- Methylenedioxymethamphetarnine) and the possible neurological damage caused by its abuse is disconcerting. This study examined possible cognitive impairments in ecstasy users while controlling for polydrug use. The CANT AB neuropsychological tests was used to test working memory capacity, immediate and delayed perceptual matching, shifting of attention, episodic memory, and learning in current and previous ecstasy users compared to non...
Show moreWidespread use of the illicit drug ecstasy (MDMA or 3,4- Methylenedioxymethamphetarnine) and the possible neurological damage caused by its abuse is disconcerting. This study examined possible cognitive impairments in ecstasy users while controlling for polydrug use. The CANT AB neuropsychological tests was used to test working memory capacity, immediate and delayed perceptual matching, shifting of attention, episodic memory, and learning in current and previous ecstasy users compared to non-ecstasy polydrug users. The prediction that current and heavy previous ecstasy users would perform worse on the neuropsychological tests, when compared to polydrug control group, denoting neurological damage was not confirmed. The previous light ecstasy users' performance was also equivalent to the poly drug control group, suggesting that excessive ecstasy use is required to reveal cognitive impairments .. The results suggest that the amount of ecstasy consumed by the participants did not lead to cognitive impairments in the brain regions investigated and supports a 'moderation idea'.
Show less - Date Issued
- 2006
- PURL
- http://purl.flvc.org/fau/fd/FA00000805
- Subject Headings
- Ecstasy (Drug)--Psychological effect, Designer drugs--Physiological effect, Drugs of abuse--Physiological effect, Attachment behavior--Case studies
- Format
- Document (PDF)
