Current Search: Drug development -- Computer simulation (x)
-
-
Title
-
Exploring appropriate offset values for pencil beam and Monte Carlo dose optimization in lung stereotactic body radiotherapy encompassing the effects of respiration and tumor location.
-
Creator
-
Evans, Grant, Shang, Charles, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
-
Abstract/Description
-
Evaluation of dose optimization using the Pencil Beam (PB) and Monte Carlo (MC) algorithms may allow physicists to apply dosimetric offsets to account for inaccuracies of the PB algorithm for lung cancer treatment with Stereotactic Body Radiotherapy (SBRT). 20 cases of Non-Small Cell Lung Cancer (NSCLC) were selected. Treatment plans were created with Brainlab iPlanDose® 4.1.2. The D97 of the Planning Target Volume (PTV) was normalized to 50 Gy on the Average Intensity Projection (AIP) using...
Show moreEvaluation of dose optimization using the Pencil Beam (PB) and Monte Carlo (MC) algorithms may allow physicists to apply dosimetric offsets to account for inaccuracies of the PB algorithm for lung cancer treatment with Stereotactic Body Radiotherapy (SBRT). 20 cases of Non-Small Cell Lung Cancer (NSCLC) were selected. Treatment plans were created with Brainlab iPlanDose® 4.1.2. The D97 of the Planning Target Volume (PTV) was normalized to 50 Gy on the Average Intensity Projection (AIP) using the fast PB and compared with MC. This exact plan with the same beam Monitor Units (MUs) was recalculated over each respiratory phase. The results show that the PB algorithm has a 2.3-2.4% less overestimation at the maximum exhalation phase than the maximum inhalation phase when compared to MC. Significantly smaller dose difference between PB and MC is also shown in plans for peripheral lesions (7.7 ± 0.7%) versus central lesions (12.7±0.8%)(p< 0.01).
Show less
-
Date Issued
-
2014
-
PURL
-
http://purl.flvc.org/fau/fd/FA00004105, http://purl.flvc.org/fau/fd/FA00004105
-
Subject Headings
-
Drug development -- Computer simulation, Image guided radiation therapy, Lung cancer -- Treatment, Monte Carlo method, Proton beams, Transport theory
-
Format
-
Document (PDF)
-
-
Title
-
A dosimetric study of a heterogeneous phantom for lung stereotactic body radiation therapy comparing Monte Carlo and pencil beam calculations to dose distributions measured with a 2-d diode array.
-
Creator
-
Curley, Casey Michael, Ouhib, Zoubir, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
-
Abstract/Description
-
Monte Carlo (MC) and Pencil Beam (PB) calculations are compared to their measured planar dose distributions using a 2-D diode array for lung Stereotactic Body Radiation Therapy (SBRT). The planar dose distributions were studied for two different phantom types: an in-house heterogeneous phantom and a homogeneous phantom. The motivation is to mimic the human anatomy during a lung SBRT treatment and incorporate heterogeneities into the pre-treatment Quality Assurance process, where measured and...
Show moreMonte Carlo (MC) and Pencil Beam (PB) calculations are compared to their measured planar dose distributions using a 2-D diode array for lung Stereotactic Body Radiation Therapy (SBRT). The planar dose distributions were studied for two different phantom types: an in-house heterogeneous phantom and a homogeneous phantom. The motivation is to mimic the human anatomy during a lung SBRT treatment and incorporate heterogeneities into the pre-treatment Quality Assurance process, where measured and calculated planar dose distributions are compared before the radiation treatment. Individual and combined field dosimetry has been performed for both fixed gantry angle (anterior to posterior) and planned gantry angle delivery. A gamma analysis has been performed for all beam arrangements. The measurements were obtained using the 2-D diode array MapCHECK 2™.
Show less
-
Date Issued
-
2015
-
PURL
-
http://purl.flvc.org/fau/fd/FA00004360
-
Subject Headings
-
Cancer -- Radiotherapy, Drug development -- Computer simulation, Image guided radiation therapy, Ion bombardment, Lung cancer -- Treatment, Medical physics, Monte Carlo method, Proton beams
-
Format
-
Document (PDF)
