Current Search: Aquaculture--Research (x)
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Title
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Biochemical and biosynthetic optimization of bryostatin 1 in Bugula neritina.
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Creator
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Vicchiarelli, Richard, Florida Atlantic University, Kerr, Russell G.
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Abstract/Description
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Bryostatin 1 is a macrocyclic lactone isolated from the marine bryozoan Bugula neritina. It is currently in clinical trials at the National Cancer Institute as a promising new antileukemic agent. Bryostatin 1 is found in Bugula neritina in poor yields (10^-4% dry weight). The focus of this research was to develop the biochemical and biosynthetic techniques that could be utilized to optimize the production of bryostatin 1 in Bugula neritina through aquaculture. To that end, the basic...
Show moreBryostatin 1 is a macrocyclic lactone isolated from the marine bryozoan Bugula neritina. It is currently in clinical trials at the National Cancer Institute as a promising new antileukemic agent. Bryostatin 1 is found in Bugula neritina in poor yields (10^-4% dry weight). The focus of this research was to develop the biochemical and biosynthetic techniques that could be utilized to optimize the production of bryostatin 1 in Bugula neritina through aquaculture. To that end, the basic biosynthetic pathway to bryostatin 1 in the marine bryozoan was evaluated by using radiolabeled precursors. Techniques for the incorporation of these precursors were also developed. Other experiments involved an analysis of the composition of a specific population of Bugula neritina in terms of its bryostatin and lipid content. A determination of which lipids are produced de novo and which are exogenous was also undertaken.
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Date Issued
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1993
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PURL
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http://purl.flvc.org/fcla/dt/14931
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Subject Headings
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Bryozoa, Aquaculture--Research
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Format
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Document (PDF)
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Title
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Evaluation of poultry by-product meal in commercial diets for hybrid striped bass (Morone chrysops ♀×M. saxatilis ♂)in recirculated tank production.
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Creator
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Rawles, S.D., Riche, Marty A., Gaylord, T.G., Webb, James, Freeman, D.W., Davis, Megan
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Date Issued
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2006
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PURL
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http://purl.flvc.org/FCLA/DT/1441116
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Subject Headings
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Aquaculture, Aquaculture --Research, Striped bass
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Format
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Document (PDF)
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Title
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A major target of a recirculation aquaculture system is maximum fish production without the use of large amounts of resources (land, energy, water) at a competitive cost. The objective of the study is to maximize the production of a basic RAS unit without the use of supplemental oxygenation.
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Creator
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Pfeiffer, Timothy J., Riley, Kenneth L., Harbor Branch Oceanographic Institute
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Date Issued
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2004
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PURL
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http://purl.flvc.org/FCLA/DT/3174239
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Subject Headings
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Aquaculture, Small-scale aquaculture, Aquaculture--Research
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Format
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Document (PDF)
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Title
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Comparative study of nozzle thrust for jet propulsion of a shallow water aquacultural research craft.
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Creator
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Holt, John K., Gangadharan, S., Clark, A. M., Sambandam, S., Harbor Branch Oceanographic Institute
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Date Issued
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1992
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PURL
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http://purl.flvc.org/fau/fd/FA00007500
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Subject Headings
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Aquaculture--Research, Research vessels, Propulsion systems, Nozzles
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Format
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Document (PDF)