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Manzamine A, a novel antitumor alkaloid from a sponge
Title
Manzamine A, a novel antitumor alkaloid from a sponge.
Creator
Sakai, R., Higa, T., Jefford, C. W., Bernardinelli, G., Harbor Branch Oceanographic Institute
Date Issued
1986
PURL
http://purl.flvc.org/FCLA/DT/3332936
Subject Headings
Alkaloids, Antineoplastic agents, Carbazoles, Sponges
Format
Document (PDF)
Antitumor tetrahydroisoquinoline alkaloids from the colonial ascidian Ecteinascidia turbinata
Title
Antitumor tetrahydroisoquinoline alkaloids from the colonial ascidian Ecteinascidia turbinata.
Creator
Wright, Amy E., Forleo, D. A., Gunawardana, G. P., Gunasekera, Sarath P., Koehn, F. E., McConnell, O. J.
Date Issued
1990
PURL
http://purl.flvc.org/FCLA/DT/3332974
Subject Headings
Ascidians, Perophoridae (Tunicata), Tetrahydroisoquinolines, Alkaloids, Antineoplastic agents
Format
Document (PDF)
Discorhabdin D, an antitumor alkaloid from the sponges Latrunculia brevis and Prianos sp.
Title
Discorhabdin D, an antitumor alkaloid from the sponges Latrunculia brevis and Prianos sp.
Creator
Perry, N. B., Blunt, J. W., Munro, M. H. G., Higa, T., Sakai, R., Harbor Branch Oceanographic Institute
Date Issued
1988
PURL
http://purl.flvc.org/FCLA/DT/3332949
Subject Headings
Sponges, Alkaloids, Antineoplastic agents, Alkaloids--Structure
Format
Document (PDF)
Antitumor cyclic peroxides from the sponge Plakortis lita
Title
Antitumor cyclic peroxides from the sponge Plakortis lita.
Creator
Sakemi, S., Higa, T., Anthoni, U., Christophersen, C., Harbor Branch Oceanographic Institute
Date Issued
1987
PURL
http://purl.flvc.org/FCLA/DT/3353800
Subject Headings
Antineoplastic agents, Sponges, Peroxides, Marine metabolites
Format
Document (PDF)
A cembranolide diterpene farnesyl protein transferase inhibitor from the marine soft coral Lobophytum cristagalli
Title
A cembranolide diterpene farnesyl protein transferase inhibitor from the marine soft coral Lobophytum cristagalli.
Creator
Coval, S. J., Patton, R. W., Petrin, J. M., James, L., Rothofsky, M. L., Lin, S. L., Patel, Mahesh, Reed, John K., McPhail, A. T., Bishop, W. R.
Date Issued
1996
PURL
http://purl.flvc.org/FCLA/DT/3331913
Subject Headings
Corals, Alcyoniidae, Ras proteins, Diterpenes, Antineoplastic agents
Format
Document (PDF)
analysis of the effectiveness of dichloroacetate as an anti-cancer agent
Title
An analysis of the effectiveness of dichloroacetate as an anti-cancer agent.
Creator
Flint, Valerie., Harriet L. Wilkes Honors College
Abstract/Description
Dichloroacetate (DCA) is a chemical with potential to be a cancer therapy due to its ability to treat mitochondrial metabolic disorders. Previous studies have affirmed DCA's ability to target cancer cells, leaving healthy cells unharmed (Bonnet et al., 2007). Javonia Washington continued research that Bonnet et al. began by testing DCA's effectson a greater number of cell types (Washington, 2008). This project collects and analyzes the data generated by Washington's research using the...
Show moreDichloroacetate (DCA) is a chemical with potential to be a cancer therapy due to its ability to treat mitochondrial metabolic disorders. Previous studies have affirmed DCA's ability to target cancer cells, leaving healthy cells unharmed (Bonnet et al., 2007). Javonia Washington continued research that Bonnet et al. began by testing DCA's effectson a greater number of cell types (Washington, 2008). This project collects and analyzes the data generated by Washington's research using the computer programs Excel and SPSS. The analysis shows that DCA concentration is vital when considering the chemical as an anti-cancer drug ; it had a significant effect on the cancerous cells from 0.5mM and higher, but both cancerous and non-cancerous cells died at similar rates when the concentration reached 10mM. Further, DCA affects some cancer cells more quickly than others, which could increase the risk of harming surrounding healthy cells if used improperly as a cancer treatment.
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Date Issued
2010
PURL
http://purl.flvc.org/FAU/3335018
Subject Headings
Chloroacetic acids, Therapeutic use, Antineoplastic agents, Apoptosis
Format
Document (PDF)
Synthesis and Characterization of Organotin Polyamine Esters from Diglycine
Title
Synthesis and Characterization of Organotin Polyamine Esters from Diglycine.
Creator
Slawek, Paul Peter, Carraher, Charles E., Haky, Jerome E., Florida Atlantic University, Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
This research is part of a long-term project aimed at elucidating important structural features, of both ligands and metals, that are needed to produce effective anti-cancer agents. The specific goal is the synthesis of organotin polymers containing amino acids, in this case the diamino acid diglycine. The desired materials were synthesized with percent yields ranging from 32-99%. The products were synthesized employing the interfacial polymerization technique. The polymers were then...
Show moreThis research is part of a long-term project aimed at elucidating important structural features, of both ligands and metals, that are needed to produce effective anti-cancer agents. The specific goal is the synthesis of organotin polymers containing amino acids, in this case the diamino acid diglycine. The desired materials were synthesized with percent yields ranging from 32-99%. The products were synthesized employing the interfacial polymerization technique. The polymers were then characterized utilizing the following physical characterization techniques: light scattering photometry (LS), Infrared spectroscopy (IR), nuclear magnetic resonance spectroscopy (NMR), and matrix assisted laser desorption mass spectroscopy (MALDI). Physical characterization showed evidence of formation of desired adducts in addition to data that was consistent with the formation of materials containing multiple repeat units. The materials were then analyzed for biological activity. The synthesized materials displayed the ability to inhibit tested cancer cell lines.
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Date Issued
2018
PURL
http://purl.flvc.org/fau/fd/FA00013158
Subject Headings
Organotin Compounds, Glycylglycine, Antineoplastic agents--Development
Format
Document (PDF)
Synthesis and biological evaluation of 10, 11-Dihydrodictyostatin, a potent analogue of the marine anticancer agent dictyostatin
Title
Synthesis and biological evaluation of 10, 11-Dihydrodictyostatin, a potent analogue of the marine anticancer agent dictyostatin.
Creator
Paterson, Ian, Gardner, Nicola M., Poullennec, Karine G., Wright, Amy E.
Date Issued
2008
PURL
http://purl.flvc.org/FCLA/DT/3333013
Subject Headings
Macrolides, Antineoplastic agents, Biological evaluation, Synthesis, Antimitotic agents
Format
Document (PDF)
2,3-Dihydrolinderazulene, a new bioactiveazulene pigment from the gorgonian Acalycigorgia sp.
Title
2,3-Dihydrolinderazulene, a new bioactiveazulene pigment from the gorgonian Acalycigorgia sp.
Creator
Sakemi, S., Higa, T., Harbor Branch Oceanographic Institute
Date Issued
1987
PURL
http://purl.flvc.org/fau/fd/FA00007179
Subject Headings
Azulene, Gorgonacea, Bioactive compounds, Pigments, Antineoplastic agents, Antifungal agents
Format
Document (PDF)
Antimicrobial and antineoplastic activity in some South Florida seaweeds.
Title
Antimicrobial and antineoplastic activity in some South Florida seaweeds.
Creator
Hodgson, L. M., Harbor Branch Oceanographic Institute
Date Issued
1984
PURL
http://purl.flvc.org/fau/fd/FA00007020
Subject Headings
Marine algae--Florida, Antineoplastic agents, Antimicrobial agents, Seaweeds
Format
Document (PDF)
Topsentin, bromotopsentin, and dihydrodeoxybromotopsentin; antiviral and antitumor bis(indolyl)imidazoles from Caribbean deep-sea sponges of the family Halichondriidae. Structural and synthetic studies
Title
Topsentin, bromotopsentin, and dihydrodeoxybromotopsentin; antiviral and antitumor bis(indolyl)imidazoles from Caribbean deep-sea sponges of the family Halichondriidae. Structural and synthetic studies.
Creator
Tsujii, S., Rinehart, Kenneth L., Gunasekera, Sarath P., Kashman, Y., Cross, S. S., Lui, M. S., Pomponi, Shirley A., Diaz, Maria Cristina
Date Issued
1988
PURL
http://purl.flvc.org/FCLA/DT/3332952
Subject Headings
Sponges--Caribbean Sea, Imidazoles, Indoles, Antiviral agents, Antineoplastic agents
Format
Document (PDF)
A mammalian cell agar-diffusion assay for the detection of toxic compounds
Title
A mammalian cell agar-diffusion assay for the detection of toxic compounds.
Creator
Burres, N. S., Hunter, J. E., Wright, Amy E.
Date Issued
1989
PURL
http://purl.flvc.org/FCLA/DT/3332955
Subject Headings
Antineoplastic agents, Toxins, Chromatographic analysis, Thin layer chromatography
Format
Document (PDF)
Lasonolide A, a new cytotoxic macrolide from the marine sponge Forcepia sp.
Title
Lasonolide A, a new cytotoxic macrolide from the marine sponge Forcepia sp.
Creator
Horton, P. A., Koehn, F. E., Longley, Ross E., McConnell, O. J., Harbor Branch Oceanographic Institute
Date Issued
1994
PURL
http://purl.flvc.org/FCLA/DT/3319075
Subject Headings
Sponges --Research, Antineoplastic agents, Marine natural products, Macrolides
Format
Document (PDF)
Puupehenone, a cytotoxic metabolite from a deep water marine sponge, Stronglyophora hartmani
Title
Puupehenone, a cytotoxic metabolite from a deep water marine sponge, Stronglyophora hartmani.
Creator
Kohmoto, S., McConnell, O. J., Wright, Amy E., Koehn, F. E., Thompson, W., Lui, M. S., Snader, K. M.
Date Issued
1987
PURL
http://purl.flvc.org/FCLA/DT/3332938
Subject Headings
Sponges, Sesquiterpenes, Cytotoxin, Antineoplastic agents, Marine natural products
Format
Document (PDF)
Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide.
Title
Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide.
Creator
Paterson, Ian, Naylor, G. J., Wright, Amy E.
Date Issued
2008
PURL
http://purl.flvc.org/fau/fd/FA00007062
Subject Headings
Antineoplastic agents, Macrolides, Polyketides, Tubulin Modulators, Marine natural products, Sponges
Format
Document (PDF)
Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin
Title
Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin.
Creator
Paterson, Ian, Naylor, G. J., Fujita, T., Guzman, Esther A., Wright, Amy E.
Date Issued
2010
PURL
http://purl.flvc.org/fau/fd/FA00007065
Subject Headings
Antineoplastic agents, Paclitaxel, Polyketides, Microtubules, Tubulin Modulators, Marine natural products
Format
Document (PDF)
Makaluvamine G, a cytotoxic pigment from an Indonesian sponge Histodermella sp.
Title
Makaluvamine G, a cytotoxic pigment from an Indonesian sponge Histodermella sp.
Creator
Carney, J. R., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
Date Issued
1993
PURL
http://purl.flvc.org/FCLA/DT/3331874
Subject Headings
Sponges, Cytotoxin, Tryptamine--Derivatives--Synthesis, Tyramine, Antineoplastic agents
Format
Document (PDF)
Antitumor activity and nucleic acid binding properties of Dercitin, a new acridinealkaloid isolated from a marine dercitus species sponge
Title
Antitumor activity and nucleic acid binding properties of Dercitin, a new acridinealkaloid isolated from a marine dercitus species sponge.
Creator
Burres, N. S., Sazesh, S., Gunawardana, G. P., Clement, J. J., Harbor Branch Oceanographic Institute
Date Issued
1989
PURL
http://purl.flvc.org/fau/fd/FA00007199
Subject Headings
Alkaloids, Acridines, Sponges, Antineoplastic agents, Cytotoxins, Marine natural products
Format
Document (PDF)
Antitumor macrodiolides isolated from a marine sponge Theonella sp.: structure revision of misakinolide A
Title
Antitumor macrodiolides isolated from a marine sponge Theonella sp.: structure revision of misakinolide A.
Creator
Kato, Y., Fusetani, N., Matsunaga, S., Hashimoto, K., Sakai, R., Higa, T., Kashman, Y., Harbor Branch Oceanographic Institute
Date Issued
1987
PURL
http://purl.flvc.org/FCLA/DT/3353820
Subject Headings
Sponges, Antineoplastic agents, Macrolides, Chemical structure, Marine natural products
Format
Document (PDF)
Discorhabdins S, T, and U, New Cytotoxic Pyrroloiminoquinones from a Deep‐Water Caribbean Sponge of the Genus Batzella
Title
Discorhabdins S, T, and U, New Cytotoxic Pyrroloiminoquinones from a Deep‐Water Caribbean Sponge of the Genus Batzella.
Creator
Gunasekera, Sarath P., Zuleta, Ignacio A., Longley, Ross E, Wright, Amy E., Pomponi, Shirley A.
Date Issued
2003
PURL
http://purl.flvc.org/FCLA/DT/3164103
Subject Headings
Sponges, Nuclear magnetic resonance spectroscopy, Antineoplastic agents, Mass spectrometry, Pharmacognosy
Format
Document (PDF)

Pages