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Title: Foraminifera Archaias angulatus and Amphistegina spp. as possible indicator species of ocean acidification and temperature increase.
Creator: Davis, Edward, Brooks, W. Randy, Graduate College
Date Issued: 2011-04-08
PURL: http://purl.flvc.org/fcla/dt/3172433
Subject Headings: Climatic changes, Marine fauna, Calcification
Format: Document (PDF)

Title: Three unprecedented chloro steroids from the Maui sponge Strongylacidon sp.: kiheisterones C, D, and E.
Creator: Carney, J. R., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
Date Issued: 1993
PURL: http://purl.flvc.org/FCLA/DT/3318958
Subject Headings: Sponges --Research, Marine metabolites, Steroids
Format: Document (PDF)

Title: 1,1-Dimethyl-5,6-dihydroxyindolinium chloride from a deep water marine sponge, Dercitus sp.
Creator: Kohmoto, S., McConnell, O. J., Wright, Amy E.
Date Issued: 1988
PURL: http://purl.flvc.org/fau/fd/FA00007184
Subject Headings: Sponges, Marine metabolites, Chemical structure
Format: Document (PDF)

Title: The potential for the marine biotechnology industry.
Creator: Pomponi, Shirley A.
Date Issued: 1999
PURL: http://purl.flvc.org/FCLA/DT/3343835
Subject Headings: Marine biotechnology, Biotechnology, Pharmaceutical biotechnology
Format: Document (PDF)

Title: Isolation and Semi-synthesis of Marine Diterpenoids.
Creator: Scesa, Paul D., West, Lyndon, Florida Atlantic University, Department of Chemistry and Biochemistry, Charles E. Schmidt College of Science
Abstract/Description: Natural products play a historical role in the discovery of medicine but present unique challenges for chemical isolation, identification and production. In this work we describe the identification of twenty novel diterpenoids. These were isolated by use of chromatography, and the structures determined by spectroscopic methods, primarily 1D and 2D NMR. Six of these possess unprecedented diterpenoid skeletons and two of them show significant growth inhibitory effects on cancer cell lines in...
Show moreNatural products play a historical role in the discovery of medicine but present unique challenges for chemical isolation, identification and production. In this work we describe the identification of twenty novel diterpenoids. These were isolated by use of chromatography, and the structures determined by spectroscopic methods, primarily 1D and 2D NMR. Six of these possess unprecedented diterpenoid skeletons and two of them show significant growth inhibitory effects on cancer cell lines in vitro (GI50 < 10 μM). The biomimetic semisynthesis of diterpendoids and analogues is also presented. Access to the bielschowskyane carbon skeleton by dearomatization of a furanocembranoid precursor is described. Highlights include a stereoselective alkene epoxidation, a novel kinetic furan dearomatization method, and an efficient [2+2] photochemical cycloaddition. The role of conformational steering was studied spectroscopically using VT 1H-NMR and NOESY as well as quantum chemical calculations at the DFT level of theory. We also disclose a biomimetic synthesis of providencin using a photochemical Norrish-Yang cyclization. This provided the absolute configuration by chemical correlation with the precursor bipinnatin E, the latter determined by x-ray diffraction. An unexpected, regioisomeric byproduct was observed and a possible mechanism is proposed. A biomimetic synthesis of the diterpene alkaloid aceropterine is also described, using an epoxidation-rearrangement cascade. This work led to a revised structure of aceropterine, formulated by spectroscopic methods. Finally, the isolation and structure elucidation of a novel, cyclic lipopeptide from Pseudomonas sp. is described. The compound was obtained using a unique antibiotic crowd sourcing approach and the structure determined by spectroscopic methods and advanced Marfey’s analysis.
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Date Issued: 2020
PURL: http://purl.flvc.org/fau/fd/FA00013539
Subject Headings: Marine natural products, Diterpenoids, Biomimetics
Format: Document (PDF)

Title: THE EFFECT OF TEMPERATURE, HYDROGEN ION AND CERTAIN GROWTH SUBSTRATES ON THE ACTIVITY OF THE CELLULOLYTIC ENZYME COMPLEX IN SELECTED MARINE FUNGI.
Creator: JENSEN, JAMES ROBERT, Florida Atlantic University, Sguros, Peter L., Charles E. Schmidt College of Science, Department of Biological Sciences
Abstract/Description: Halosphaeria mediosetigera and Culcitalna achraspora have been studied to elucidate the mechanism by which they degrade cellulosic materials in the sea. H. mediosetigera (700 LC 1), a C1-less variant, was also employed in this work. Standardized shake-cultures were grown on cellulose and cellulose derivatives supplemented with NH4N03, tris(hydroxymethyl)aminomethane and yeast extract in artificial sea water (Lyman and Fleming), pH 7.5, at 25 C. Induced C1 and Cx enzyme and cellobiase...
Show moreHalosphaeria mediosetigera and Culcitalna achraspora have been studied to elucidate the mechanism by which they degrade cellulosic materials in the sea. H. mediosetigera (700 LC 1), a C1-less variant, was also employed in this work. Standardized shake-cultures were grown on cellulose and cellulose derivatives supplemented with NH4N03, tris(hydroxymethyl)aminomethane and yeast extract in artificial sea water (Lyman and Fleming), pH 7.5, at 25 C. Induced C1 and Cx enzyme and cellobiase activities were determined calorimetrically by correlation with cotton fiber weight loss, by the formation of reducing sugars from carboxymethylcellulose and by Glucostat, respectively. Optimum pH values for both Cx enzyme and cellobiase of C. achraspora were 6.0 at 37 C while those for H. mediosetigera (700 LC 1) were 5.0 and 6.0, respectively, at 37 C. In both cultures, Cx enzymes had a variable optimum temperature ( 37-50 C) at pH 6.0, depending on the length of the incubation period, while cellobiases had the same optimum temperature (50 C) at pH 6.0. Thermostability observations on Cx enzyme and cellobiase of C. achraspora showed almost complete deactivation at 100 C in 15 min for the former and 50 C in 15 min for the latter. Thermostability observations on Cx enzyme and cellobiase of H. mediosetigera (700 LC 1) showed almost complete deactivation at 45 C in 15 min for the former and at 50 C in 15 min for the latter. Data indicate that at least three enzymatic functions are involved in cellulose breakdown by these cultures.
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Date Issued: 1971
PURL: http://purl.flvc.org/fcla/dt/13434
Subject Headings: Marine fungi, Cellulose--Biodegradation
Format: Document (PDF)

Title: Biosynthetic Studies of the Bryostatins, Anticancer Agents from the Marine Bryozoan Bugu/a neritina.
Creator: Lawry, Joseph, Kerr, Russell G., Florida Atlantic University, Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description: The bryostatins are a family of macrolide lactones isolated from the marine bryozoan Bugu/a neritina. Since its detection in 1968, bryostatin 1 has demonstrated remarkable anticancer, immunopotentiating, biomodulatory and radioprotective effects which result mainly from its ability to activate protein kinase C, a family of isozymes involved in cellular signal transduction. It is currently being tested in several phase I and phase II clinical trials as a potential anticancer drug for leukemia,...
Show moreThe bryostatins are a family of macrolide lactones isolated from the marine bryozoan Bugu/a neritina. Since its detection in 1968, bryostatin 1 has demonstrated remarkable anticancer, immunopotentiating, biomodulatory and radioprotective effects which result mainly from its ability to activate protein kinase C, a family of isozymes involved in cellular signal transduction. It is currently being tested in several phase I and phase II clinical trials as a potential anticancer drug for leukemia, melanoma and nephrotoma. A series of experiments was undertaken to elucidate the biosynthetic origins of bryostatin, using a fortified crude cell-free enzyme preparation and radiolabelled precursors. A regional characterization of Bugula neritina from Sicily, Italy and Daytona Beach, Florida is also described.
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Date Issued: 1997
PURL: http://purl.flvc.org/fau/fd/FA00000787
Subject Headings: Macrolide antibiotics, Bryozoa, Marine pharmacology
Format: Document (PDF)

Title: Biosynthetic studies of the antitumor ecteinascidins in the marine tunicate Ecteinascidia turbinata.
Creator: Miranda, Neil Fermino, Florida Atlantic University, Kerr, Russell G.
Abstract/Description: Ecteinascidin is a tetrahydroisoquinoline alkaloid isolated from the colonial ascidian Ecteinascidia turbinata. Ecteinascidin exhibits tremendous activity against P388 murine leukemia, however its yields from the tunicate are as low as 10^-4%. A biosynthetic investigation, using in vivo and in vitro methods, has resulted in the identification of the metabolic precursors of ecteinascidin as tyrosine, DOPA and cysteine. Reactive intermediates such as tyrosine and DOPA diketopiperazines have...
Show moreEcteinascidin is a tetrahydroisoquinoline alkaloid isolated from the colonial ascidian Ecteinascidia turbinata. Ecteinascidin exhibits tremendous activity against P388 murine leukemia, however its yields from the tunicate are as low as 10^-4%. A biosynthetic investigation, using in vivo and in vitro methods, has resulted in the identification of the metabolic precursors of ecteinascidin as tyrosine, DOPA and cysteine. Reactive intermediates such as tyrosine and DOPA diketopiperazines have also been identified. These preliminary experiments set the stage for subsequent protein isolation.
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Date Issued: 1996
PURL: http://purl.flvc.org/fcla/dt/15242
Subject Headings: Tunicata, Marine pharmacology, Biological assay
Format: Document (PDF)

Title: Identification of novel cytotoxic agents from the dinoflagellate symbiont of the gorgonian Erythropodium caribaeorum.
Creator: Wynter, Sherine, Florida Atlantic University, Kerr, Russell G.
Abstract/Description: Erythropodium caribaeorum is an octocoral known for its production of novel anticancer agents, such as eleutherobin and its analogs as well as for its complex association with symbiotic dinoflagellates (Zooxanthellae; genus Symbiodimum). With this in mind, two sets of experiments were conducted using the extracts of the symbiotic algal cells from Erythropodium caribaeorum: an isolation and characterization of a novel tri-hydroxy sterol and a bioassay-guided isolation of three additional...
Show moreErythropodium caribaeorum is an octocoral known for its production of novel anticancer agents, such as eleutherobin and its analogs as well as for its complex association with symbiotic dinoflagellates (Zooxanthellae; genus Symbiodimum). With this in mind, two sets of experiments were conducted using the extracts of the symbiotic algal cells from Erythropodium caribaeorum: an isolation and characterization of a novel tri-hydroxy sterol and a bioassay-guided isolation of three additional compounds. All compounds exhibit significant bioactivity against the following three cell lines: the human melanoma cell line M14P, the colon cancer cell line RKO and the breast cancer cell line MDA-MB-231. Importantly, this study reports the first isolation of a bioactive polyhydroxy sterol from a gorgonian's symbiont and further suggests that these algae represent a promising sustainable resource for drug discovery.
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Date Issued: 2004
PURL: http://purl.flvc.org/fcla/dt/13096
Subject Headings: Alcyonacea, Dinoflagellates, Zooxanthellales, Marine pharmacology
Format: Document (PDF)

Title: PRODUCTION, INDUCTION, AND RESOLUTION OF THE CELLULOLYTIC ENZYME COMPLEX IN SELECTED FILAMENTOUS MARINE FUNGI.
Creator: WHITE, JAMES L., JR., Florida Atlantic University
Abstract/Description: Cellulolytic enzymes were induced in the marine fungal isolates, Culcitalna achraspora, Halosphaeria mediosetigera, and Zalerion xylestrix by native cotton and related substrates. Marine environmental conditions were maintained in an artificial seawater medium. Induced c1 and ex enzymes and cellobiase were determined colorimetrically. Induction also occurred on cellobiose, but not on glucose and lactose. Permenter studies with glucose and with toilet tissue carbon sources gave close...
Show moreCellulolytic enzymes were induced in the marine fungal isolates, Culcitalna achraspora, Halosphaeria mediosetigera, and Zalerion xylestrix by native cotton and related substrates. Marine environmental conditions were maintained in an artificial seawater medium. Induced c1 and ex enzymes and cellobiase were determined colorimetrically. Induction also occurred on cellobiose, but not on glucose and lactose. Permenter studies with glucose and with toilet tissue carbon sources gave close correlations between mycelial dry weight, enzyme component activity, and cell nitrogen. In cotton substrate media, Tween 80 increased C1 activity by 148%, and Cx activity by 160%, on the average. Millipore ultrafiltration was the best technique for concentrating cellulase for Sephadex G-75 column chromatography, while conventional techniques were unsuccessful. Fractionation diagrams for all cultures were similar with 2 distinct peaks. The low molecular weight fraction contained mainly Cx enzyme activity, while the high molecular weight fraction contained C1 and Cx enzymes and cellobiase. These fungi possess a cellulase similar, but not identical, to that found in terrestrial species.
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Date Issued: 1972
PURL: http://purl.flvc.org/fcla/dt/13537
Subject Headings: Marine fungi, Cellulose--Biodegradation
Format: Document (PDF)

Title: ATTITUDE MEASURING SENSOR FOR A TOWED BODY.
Creator: Flitton, Garrett, Dhanak, Manhar, Florida Atlantic University, Department of Ocean and Mechanical Engineering, College of Engineering and Computer Science
Abstract/Description: The Design and Development of a remote attitude-measuring sensor package (RASP) for use onboard an underwater tow fish to analyze its dynamic movement while towing is described. The RASP will be used to determine the orientation, acceleration, and gyroscopic attitude of the tow fish. The collection of this data is important for understanding the trim of the tow fish under different towing conditions behind a manned surface vessel or unmanned underwater vehicle. The trim data acquired will...
Show moreThe Design and Development of a remote attitude-measuring sensor package (RASP) for use onboard an underwater tow fish to analyze its dynamic movement while towing is described. The RASP will be used to determine the orientation, acceleration, and gyroscopic attitude of the tow fish. The collection of this data is important for understanding the trim of the tow fish under different towing conditions behind a manned surface vessel or unmanned underwater vehicle. The trim data acquired will inform the extent to which post-processing of collected three-axis electromagnetic field data would be required. The RASP has been analyzed in the laboratory with a mechanical testing rig that was designed and built to validate the accuracy and performance of the entire sensor package system. The developed package will aid in the assessment of the performance of the tow fish in field operations with the sensor package implemented on the tow fish.
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Date Issued: 2024
PURL: http://purl.flvc.org/fau/fd/FA00014423
Subject Headings: Sensors, Marine towing, Electromagnetic fields
Format: Document (PDF)

Title: Transparency and visibility of gelatinous zooplankton from the northwestern Atlantic and Gulf of Mexico.
Creator: Johnsen, Sonke, Widder, Edith A., Harbor Branch Oceanographic Institute
Date Issued: 1998
PURL: http://purl.flvc.org/FCLA/DT/3171569
Subject Headings: Zooplankton, Zooplankton --Atlantic coast (U.S.), Marine zooplankton --Atlantic Ocean, Marine zooplankton --Greenland, Marine biology
Format: Document (PDF)

Title: First record of the sponge genera Crambe and Discorhabdella for the eastern Pacific, with description of three new species.
Creator: Maldonado, Manuel, Carmona, M. Carmen, Van Soest, Rob W. M., Pomponi, Shirley A.
Date Issued: 2001
PURL: http://purl.flvc.org/FCLA/DT/2795878
Subject Headings: Marine animals --Counting --Methodology, Marine animals --Geographical distribution, Marine animals --Pacific ocean, Tethyaster, Sponges --Classification
Format: Document (PDF)

Title: Isolation and Structural Elucidation of Novel Bioactive Natural Products from Marine Organisms of the Western Atlantic Ocean.
Creator: Zhang, Long, West, Lyndon, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description: The aim of this dissertation was to elaborate the exploration of biologically active secondary metabolites from the marine sponge Cacospongia cf. linteiformis collected from the Bahamas and the soft coral Briareum asbestinum collected from two different sites in Florida State, Boca Raton and Dry Tortugas. In chapter one, a review on previous chemical and biological studies of the marine sponge C. cf. linteiformis and soft coral B. asbestinum is provided. Particular attention is given to...
Show moreThe aim of this dissertation was to elaborate the exploration of biologically active secondary metabolites from the marine sponge Cacospongia cf. linteiformis collected from the Bahamas and the soft coral Briareum asbestinum collected from two different sites in Florida State, Boca Raton and Dry Tortugas. In chapter one, a review on previous chemical and biological studies of the marine sponge C. cf. linteiformis and soft coral B. asbestinum is provided. Particular attention is given to spongianolides and briarellins, two important classes of compounds isolated from C. cf. linteiformis and B. asbestinum, respectively, and their structural features and diverse bioactivities. In chapter two, the isolation and relative configuration determination of four epimeric sesterterpenoids, spongianolides E & F (18c, 18d, 19c, 19d) from C. cf. linteiformis collected from the Bahamas are discussed. Thanks to chemical modification (acetylation), diastereomeric 18c&18d and 19c&19d, respectively, were able to be isolated using chromatographic techniques for the first time, and then the relative configurations of 18c, 18d, 19c, 19d were determined based on NOESY NMR experiments. The bioactivity of mixture of compounds 18c, 18d, 19c, 19d were tested and it exhibited inhibition against Schnurri-3 (a regulator of postnatal bone mass). In chapter three, the isolation and structural elucidation of four new compounds, florellins A-D (49-52), from B. asbestinum collected off the coast of Boca Raton, FL are discussed. The molecular structures of these compounds were established by spectroscopic analysis. Compounds 49-52 are the first briarellins containing an acyl group at C-13, while 49 and 50 are the first briarellins possessing acylation at C-15. Florellins A–C (49-51) were screened and found cytotoxic against three human cell lines, BT474, WM266−4 and HEK293. In chapter four, the isolation and structural elucidation of four new compounds, florellins E-H (57-60), from B. asbestinum collected in Dry Tortugas, FL are discussed. The molecular structures of these compounds were established by spectroscopic analysis. Florellins F (58) and H (60) were screened against three human cell lines, BT474, WM266−4 and HEK293, but no cytotoxicity was exhibited. In chapter five, all the experimental procedures are described, including analytical instruments, animal materials, extraction and isolation processes, spectroscopic data and protocols of bioassays.
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Date Issued: 2017
PURL: http://purl.flvc.org/fau/fd/FA00004850, http://purl.flvc.org/fau/fd/FA00004850
Subject Headings: Pharmacognosy., Natural products--Analysis., Marine pharmacology., Marine biotechnology., Marine algae--Biotechnology., Bioactive compounds.
Format: Document (PDF)

Title: DESIGN, SIMULATION, AND TESTING OF A CVT BASED PTO AND CONTROLLER FOR A SMALL SCALE MHK-TURBINE IN LOW FLOW SPEED OPERATION.
Creator: Hall, Adam, Dhanak, Manhar, Florida Atlantic University, Department of Ocean and Mechanical Engineering, College of Engineering and Computer Science
Abstract/Description: The aim of this thesis project was to design, develop, and test, a continuously variable transmission (CVT)-based power take off (PTO) sub-system, and its controller, for a small scale marine hydrokinetic turbine (MHK) developed for low-speed tidal currents. In this thesis, a CVT based PTO and controller was developed for a predefined MHK and validated through simulations. A testing platform was subsequently developed including an emulation system to replicate the MHK for testing of the...
Show moreThe aim of this thesis project was to design, develop, and test, a continuously variable transmission (CVT)-based power take off (PTO) sub-system, and its controller, for a small scale marine hydrokinetic turbine (MHK) developed for low-speed tidal currents. In this thesis, a CVT based PTO and controller was developed for a predefined MHK and validated through simulations. A testing platform was subsequently developed including an emulation system to replicate the MHK for testing of the coupled MHK/PTO system. Laboratory testing of the emulation system, PTO component efficiencies, and full system with controls was then conducted. The results showed the mechanical PTO design to be a valid solution and the control methods to be marginally stable with adequate power conversion at low-speed current conditions. The results also identified future work in continued controller development, alternate PTO component testing, and continued testing in parallel with that being done on the MHK prototype.
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Date Issued: 2022
PURL: http://purl.flvc.org/fau/fd/FA00013977
Subject Headings: Marine turbines--Design and construction, Marine turbines--Transmission devices, Marine turbines--Testing
Format: Document (PDF)

Title: Oceans and human health: emerging public health risks in the marine environment.
Creator: Fleming, L.E., Broad, K., Clement, A., Dewailly, E., Elmir, S., Knap, A., Pomponi, Shirley A., Smith, S., Solo Gabriele, H., Walsh, P.
Date Issued: 2006
PURL: http://purl.flvc.org/FCLA/DT/1784217
Subject Headings: Marine resources conservation, Pollution marine, Pollution --Environmental aspects, Marine animals --Effect of water pollution on, Seafood --Contamination
Format: Document (PDF)

Title: Larval phototaxis in barnacles and snails associated with bathyal sea urchins.
Creator: Bingham, Brian L., Young, Craig M., Harbor Branch Oceanographic Institute
Date Issued: 1993
PURL: http://purl.flvc.org/FCLA/DT/3353878
Subject Headings: Phototaxis, Larvae--Behavior, Marine invertebrates
Format: Document (PDF)

Title: Ophirapstanol trisulfate, a new biologically active steroid sulfate from the deep water marine sponge Topsentia ophiraphidites.
Creator: Gunasekera, Sarath P., Sennett, Susan H., Kelly-Borges, M., Bryant, R. W., Harbor Branch Oceanographic Institute
Date Issued: 1994
PURL: http://purl.flvc.org/FCLA/DT/3319079
Subject Headings: Sponges --Research, Marine natural products, NMR spectroscopy
Format: Document (PDF)

Title: Five new Discodermolide analogues from the marine sponge Discodermia species.
Creator: Gunasekera, Sarath P., Paul, Gopal K., Longley, Ross E., Isbrucker, Richard A., Pomponi, Shirley A.
Date Issued: 2002
PURL: http://purl.flvc.org/FCLA/DT/3319106
Subject Headings: Sponges --Research, Cytotoxin, Marine natural products, Polyketides
Format: Document (PDF)

Title: Mechanisms of tri-n-butyltin bioaccumulation by marine phytoplankton.
Creator: Chiles, Thomas C., Pendoley, Peter D., Laughlin, R. B., Jr., Harbor Branch Oceanographic Institute
Date Issued: 1989
PURL: http://purl.flvc.org/FCLA/DT/3342231
Subject Headings: Tributyltin, Marine phytoplankton, Bioaccumulation, Trialkyltin Compounds
Format: Document (PDF)

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