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Marine natural products
Title
Marine natural products.
Creator
Pomponi, Shirley A., Wright, Amy E., Reed, John K., McCarthy, Peter J.
Date Issued
1999
PURL
http://purl.flvc.org/fau/fd/FA00007503
Subject Headings
Marine natural products
Format
Document (PDF)
A SHOTGUN METAGENOMIC APPROACH TO THE BIOSYNTHESIS OF MARINE NATURAL PRODUCTS
Title
A SHOTGUN METAGENOMIC APPROACH TO THE BIOSYNTHESIS OF MARINE NATURAL PRODUCTS.
Creator
Miller-Xavier, René Kathleen, Mincer, Tracy, Florida Atlantic University, Department of Biological Sciences, Charles E. Schmidt College of Science
Abstract/Description
Genomics has been revolutionized by improved sequencing technologies, allowing for the detailed exploration of microbial dark matter and complex microscopic ecosystems. The bottleneck in genomic workflows has shifted from high-throughput sequencing to data analysis. This dissertation developed the Florida Center for Coastal and Human Health Shotgun Metagenomics Workflow (FCHsm) that is easy to use and tailor to unique datasets. This work acts as the beta-testing for the workflow, as it...
Show moreGenomics has been revolutionized by improved sequencing technologies, allowing for the detailed exploration of microbial dark matter and complex microscopic ecosystems. The bottleneck in genomic workflows has shifted from high-throughput sequencing to data analysis. This dissertation developed the Florida Center for Coastal and Human Health Shotgun Metagenomics Workflow (FCHsm) that is easy to use and tailor to unique datasets. This work acts as the beta-testing for the workflow, as it analyzes disparate biomes (environmental and host microbiomes) at varying sequencing depths (shallow and deep). FCHsm was used to resolve molecular dynamics and mine trans-kingdom metagenomes for secondary metabolic biosynthetic gene clusters (BGCs) in two marine environments— Indian River Lagoon toxic harmful algal blooms (IRL HABs) and the medicinal Leiodermatium sponge holobiont. First, an in silico mock dataset was analyzed to benchmark the FCHsm workflow. Sourmash, coupled with the Genome Taxonomy Database, outcompeted the other taxonomic profilers by accurately predicting the size of the mock metagenome (450 genomes) and recalling the highest number of species (82 %) and strains (44 %). Nonpareil calculated the sequencing effort needed for 100 % coverage for all the datasets and correctly estimated the 75 Gbp of sequencing needed for almost 100 % coverage of the mock metagenomes (99.5 %). Next, the trans-kingdom metagenomes of the IRL were explored, and potential HAB biomarkers were identified.
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Date Issued
2023
PURL
http://purl.flvc.org/fau/fd/FA00014186
Subject Headings
Marine natural products, Metagenomics
Format
Document (PDF)
Marine biotechnology: realizing the potential
Title
Marine biotechnology: realizing the potential.
Creator
Pomponi, Shirley A., Baden, Daniel G., Zohar, Y.
Date Issued
2007
PURL
http://purl.flvc.org/FCLA/DT/3338530
Subject Headings
Marine biotechnology, Marine pharmacology, Marine natural products
Format
Document (PDF)
Antitumor activity and biochemical effects of topsentin
Title
Antitumor activity and biochemical effects of topsentin.
Creator
Burres, N. S., Barber, D. A., Gunasekera, Sarath P., Clement, J. J., Shen, L. L.
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3355144
Subject Headings
Marine natural products, Antitumor agents
Format
Document (PDF)
Two steroidal alkaloids from a sponge, Corticium sp.
Title
Two steroidal alkaloids from a sponge, Corticium sp.
Creator
Jurek, J., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
Date Issued
1994
PURL
http://purl.flvc.org/FCLA/DT/3319071
Subject Headings
Sponges --Research, Marine natural products
Format
Document (PDF)
Neopeltolide a new macrolide from a lithistid sponge of the family Neopeltidae
Title
Neopeltolide a new macrolide from a lithistid sponge of the family Neopeltidae.
Creator
Wright, Amy E., Botelho, J. C., Guzman, Esther A., Harmody, Dedra K., Linley, P. A., McCarthy, Peter J., Pitts, Tara P., Pomponi, Shirley A., Reed, John K.
Date Issued
2007
PURL
http://purl.flvc.org/FCLA/DT/3333011
Subject Headings
Sponges, Macrolides, Marine natural products
Format
Document (PDF)
A new sesterterpene, Sch 599473, from a marine sponge, Ircinia sp.
Title
A new sesterterpene, Sch 599473, from a marine sponge, Ircinia sp.
Creator
Yang, Shu-Wei, Chan, Tze-Ming, Pomponi, Shirley A., Gonsiorek, W., Chen, Guodong, Wright, Amy E., Hipkin, W., Patel, Mahesh, Gullo, Vincent, Pramanik, B., Zavodny, P., Chu, Min
Date Issued
2003
PURL
http://purl.flvc.org/FCLA/DT/3351980
Subject Headings
Sponges, Sesterterpenes, Marine natural products
Format
Document (PDF)
A brominated (aminoimidazolinyl) indole from the sponge Discodermia polydiscus
Title
A brominated (aminoimidazolinyl) indole from the sponge Discodermia polydiscus.
Creator
Sun, H. H., Sakemi, S., Harbor Branch Oceanographic Institute
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3332982
Subject Headings
Sponges, Indoles, Marine natural products
Format
Document (PDF)
8-hydroxymanzamine A, a β-Carboline alkaoid from a sponge, Pachypellina sp
Title
8-hydroxymanzamine A, a β-Carboline alkaoid from a sponge, Pachypellina sp.
Creator
Ichiba, T., Corgiat, J. M., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
Date Issued
1994
PURL
http://purl.flvc.org/FCLA/DT/3318972
Subject Headings
Sponges --Research, Marine natural products
Format
Document (PDF)
New sterol ester from a deep water marine sponge, Xestospongia sp.
Title
New sterol ester from a deep water marine sponge, Xestospongia sp.
Creator
Gunasekera, Sarath P., Cranick, S., Pomponi, Shirley A.
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3332980
Subject Headings
Sponges, Sterols, Marine natural products
Format
Document (PDF)
Isolation and Semi-synthesis of Marine Diterpenoids
Title
Isolation and Semi-synthesis of Marine Diterpenoids.
Creator
Scesa, Paul D., West, Lyndon, Florida Atlantic University, Department of Chemistry and Biochemistry, Charles E. Schmidt College of Science
Abstract/Description
Natural products play a historical role in the discovery of medicine but present unique challenges for chemical isolation, identification and production. In this work we describe the identification of twenty novel diterpenoids. These were isolated by use of chromatography, and the structures determined by spectroscopic methods, primarily 1D and 2D NMR. Six of these possess unprecedented diterpenoid skeletons and two of them show significant growth inhibitory effects on cancer cell lines in...
Show moreNatural products play a historical role in the discovery of medicine but present unique challenges for chemical isolation, identification and production. In this work we describe the identification of twenty novel diterpenoids. These were isolated by use of chromatography, and the structures determined by spectroscopic methods, primarily 1D and 2D NMR. Six of these possess unprecedented diterpenoid skeletons and two of them show significant growth inhibitory effects on cancer cell lines in vitro (GI50 < 10 μM). The biomimetic semisynthesis of diterpendoids and analogues is also presented. Access to the bielschowskyane carbon skeleton by dearomatization of a furanocembranoid precursor is described. Highlights include a stereoselective alkene epoxidation, a novel kinetic furan dearomatization method, and an efficient [2+2] photochemical cycloaddition. The role of conformational steering was studied spectroscopically using VT 1H-NMR and NOESY as well as quantum chemical calculations at the DFT level of theory. We also disclose a biomimetic synthesis of providencin using a photochemical Norrish-Yang cyclization. This provided the absolute configuration by chemical correlation with the precursor bipinnatin E, the latter determined by x-ray diffraction. An unexpected, regioisomeric byproduct was observed and a possible mechanism is proposed. A biomimetic synthesis of the diterpene alkaloid aceropterine is also described, using an epoxidation-rearrangement cascade. This work led to a revised structure of aceropterine, formulated by spectroscopic methods. Finally, the isolation and structure elucidation of a novel, cyclic lipopeptide from Pseudomonas sp. is described. The compound was obtained using a unique antibiotic crowd sourcing approach and the structure determined by spectroscopic methods and advanced Marfey’s analysis.
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Date Issued
2020
PURL
http://purl.flvc.org/fau/fd/FA00013539
Subject Headings
Marine natural products, Diterpenoids, Biomimetics
Format
Document (PDF)
A new bastadin from the sponge Psammaplysilla purpurea
Title
A new bastadin from the sponge Psammaplysilla purpurea.
Creator
Carney, J. R., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
Date Issued
1993
PURL
http://purl.flvc.org/FCLA/DT/3318955
Subject Headings
Sponges --Research, Marine metabolites, Marine natural products
Format
Document (PDF)
Bioactivity of marine organisms: relationships with taxonomy, geography and depth
Title
Bioactivity of marine organisms: relationships with taxonomy, geography and depth.
Creator
Reed, John K., Sennett, Susan H., McCarthy, Peter J., Pitts, Tara P., Wright, Amy E., Pomponi, Shirley A.
Date Issued
1998
PURL
http://purl.flvc.org/fau/fd/FA00007421
Subject Headings
Marine organisms, Bioactive compounds, Marine natural products
Format
Document (PDF)
Three new bromotyrosine derived metabolites of the sponge Psammaplysilla purpurea
Title
Three new bromotyrosine derived metabolites of the sponge Psammaplysilla purpurea.
Creator
Jurek, J., Yoshida, W. Y., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
Date Issued
1993
PURL
http://purl.flvc.org/FCLA/DT/3318965
Subject Headings
Marine natural products, Sponges --Research, Marine metabolites
Format
Document (PDF)
Marine organisms as a source of novel lead structures for drug development
Title
Marine organisms as a source of novel lead structures for drug development.
Creator
Wright, Amy E.
Date Issued
2000
PURL
http://purl.flvc.org/fau/fd/FA00007060
Subject Headings
Marine organisms, Marine natural products, Drug development
Format
Document (PDF)
The oceans and human health: the discovery and development of marine-derived drugs
Title
The oceans and human health: the discovery and development of marine-derived drugs.
Creator
Pomponi, Shirley A.
Date Issued
2001
PURL
http://purl.flvc.org/fau/fd/FA00007240
Subject Headings
Marine natural products, Marine pharmacology, Drug development
Format
Document (PDF)
Natural Product Studies of Marine Organisms from the Western Atlantic
Title
Natural Product Studies of Marine Organisms from the Western Atlantic.
Creator
Hall, Andrew, West, Lyndon, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
The projects described in this dissertation are focused on compounds derived from marine organisms collected from the western Atlantic marine environment. Chapter 1 provides an introduction to the study of natural products chemistry, marine natural products, and overview of the research undertaken from natural product chemists. Chapter 2 describes the isolation and structure elucidation of a series of rare diterpenoids from the gorgonian Briareum asbestinum, together with their conformational...
Show moreThe projects described in this dissertation are focused on compounds derived from marine organisms collected from the western Atlantic marine environment. Chapter 1 provides an introduction to the study of natural products chemistry, marine natural products, and overview of the research undertaken from natural product chemists. Chapter 2 describes the isolation and structure elucidation of a series of rare diterpenoids from the gorgonian Briareum asbestinum, together with their conformational analysis and biosynthetic interconversions. These rare diterpenes from Briareum asbestinum are linked by an unusual transannular oxa-6π electrocyclization which is described in detail and this work demonstates the biomimetic hemisynthesis of briareolate esters L (19) to B (22) achieved via an intermediary, briareolate ester G (2), through a controlled set of photoinduced isomerizations and a unique photochromic transannular oxa-6π electrocyclization. This work focuses largely on the mechanistic understanding of the photochemical production of these briarane diterpenoids and illustrates a unique UVA/UVC, photochromic switch which induces a transannular oxa- 6π electrocyclization. Chapter 3 describes the assay-guided isolation of marine antioxidants. This chapter focuses on the screening of marine organism extracts using the Ferric Reducing Antioxidant Power (FRAP) assay for antioxidant activity guided isolation of marine natural products. The chapter concludes with the activity guided isolation and structural elucidation of 1-O-palmitoyl-2-O-myristoyl-3-O-(6-sulfo-α-D-quinovopyranosyl)- glycerol (40) to show direct antioxidant potential through FRAP analysis. Chapter 4 describes the isolation, structural elucidation and pharmacological evaluation of the novel secondary metabolites iso-PsA(45), Iso-PsC (46), iso-PsD (47) as well as known Pseudopterosins A(41), B(42), C(43), D(44), K(48), K2’OAc(49), K2’OAc(50). These secondary metabolites were evaluated for both cytotoxicity. The chapter concludes with the screening of these compounds as αβ-amyloid fibril modulators utilizing atomic force microcopy (AFM).
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Date Issued
2016
PURL
http://purl.flvc.org/fau/fd/FA00004666
Subject Headings
Marine natural products., Diterpenes., Marine metabolites
Format
Document (PDF)
Ophirapstanol trisulfate, a new biologically active steroid sulfate from the deep water marine sponge Topsentia ophiraphidites
Title
Ophirapstanol trisulfate, a new biologically active steroid sulfate from the deep water marine sponge Topsentia ophiraphidites.
Creator
Gunasekera, Sarath P., Sennett, Susan H., Kelly-Borges, M., Bryant, R. W., Harbor Branch Oceanographic Institute
Date Issued
1994
PURL
http://purl.flvc.org/FCLA/DT/3319079
Subject Headings
Sponges --Research, Marine natural products, NMR spectroscopy
Format
Document (PDF)
Five new Discodermolide analogues from the marine sponge Discodermia species
Title
Five new Discodermolide analogues from the marine sponge Discodermia species.
Creator
Gunasekera, Sarath P., Paul, Gopal K., Longley, Ross E., Isbrucker, Richard A., Pomponi, Shirley A.
Date Issued
2002
PURL
http://purl.flvc.org/FCLA/DT/3319106
Subject Headings
Sponges --Research, Cytotoxin, Marine natural products, Polyketides
Format
Document (PDF)
Discodermide: a new bioactive macrocyclic lactam from the marine sponge Discodermia dissoluta
Title
Discodermide: a new bioactive macrocyclic lactam from the marine sponge Discodermia dissoluta.
Creator
Gunasekera, Sarath P., Gunasekera, M., McCarthy, Peter J.
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3332985
Subject Headings
Sponges, Lactams, Macrocyclic, Marine natural products
Format
Document (PDF)

Pages