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Discorhabdin D, an antitumor alkaloid from the sponges Latrunculia brevis and Prianos sp.
Title
Discorhabdin D, an antitumor alkaloid from the sponges Latrunculia brevis and Prianos sp.
Creator
Perry, N. B., Blunt, J. W., Munro, M. H. G., Higa, T., Sakai, R., Harbor Branch Oceanographic Institute
Date Issued
1988
PURL
http://purl.flvc.org/FCLA/DT/3332949
Subject Headings
Sponges, Alkaloids, Antineoplastic agents, Alkaloids--Structure
Format
Document (PDF)
Manzamine B and C, two novel alkaloids from the sponge Haliciona sp
Title
Manzamine B and C, two novel alkaloids from the sponge Haliciona sp.
Creator
Sakai, R., Kohmoto, S., Higa, T., Jefford, C. W., Bernardinelli, G., Harbor Branch Oceanographic Institute
Date Issued
1987
PURL
http://purl.flvc.org/FCLA/DT/3353812
Subject Headings
Indole Alkaloids, Sponges, Carbolines
Format
Document (PDF)
New cytotoxic acridine alkaloids from two deep water marine sponges of the family Pachastrellidae
Title
New cytotoxic acridine alkaloids from two deep water marine sponges of the family Pachastrellidae.
Creator
Gunawardana, G. P., Kohmoto, S., Burres, N. S., Harbor Branch Oceanographic Institute
Date Issued
1989
PURL
http://purl.flvc.org/FCLA/DT/3353842
Subject Headings
Sponges, Acridines, Alkaloids, Cytotoxins
Format
Document (PDF)
Xestamines A, B, and C, three new long-chain methoxylamine pyridines from the sponge Xestospongia wiedenmayeri
Title
Xestamines A, B, and C, three new long-chain methoxylamine pyridines from the sponge Xestospongia wiedenmayeri.
Creator
Sakemi, S., Totton, L. E., Sun, H. H., Harbor Branch Oceanographic Institute
Date Issued
1990
PURL
http://purl.flvc.org/FCLA/DT/3332968
Subject Headings
Sponges, Pyridines, Alkaloids, Haplosclerida
Format
Document (PDF)
New manzamine alkaloids from a sponge of the genus xestospongia
Title
New manzamine alkaloids from a sponge of the genus xestospongia.
Creator
Ichiba, T., Sakai, R., Kohmoto, S., Saucy, G., Higa, T., Harbor Branch Oceanographic Institute
Date Issued
1988
PURL
http://purl.flvc.org/FCLA/DT/3353822
Subject Headings
Alkaloids, Indole Alkaloids, Sponges, Cytotoxin, Carbazoles, Chemical structure
Format
Document (PDF)
Dercitin, a new biologically active acridine alkaloid from a deep water marine sponge, Dercitus sp.
Title
Dercitin, a new biologically active acridine alkaloid from a deep water marine sponge, Dercitus sp.
Creator
Gunawardana, G. P., Kohmoto, S., Gunasekera, Sarath P., McConnell, O. J., Koehn, F. E., Harbor Branch Oceanographic Institute
Date Issued
1988
PURL
http://purl.flvc.org/FCLA/DT/3332948
Subject Headings
Sponges, Alkaloids, Acridine, Marine toxins
Format
Document (PDF)
Manzamine A, a novel antitumor alkaloid from a sponge
Title
Manzamine A, a novel antitumor alkaloid from a sponge.
Creator
Sakai, R., Higa, T., Jefford, C. W., Bernardinelli, G., Harbor Branch Oceanographic Institute
Date Issued
1986
PURL
http://purl.flvc.org/FCLA/DT/3332936
Subject Headings
Alkaloids, Antineoplastic agents, Carbazoles, Sponges
Format
Document (PDF)
Pyridoacridine alkaloids from deep-water marine sponges of the family Pachastrellidae: structure revision of dercitin and related compounds and correlation with the kuanoniamines
Title
Pyridoacridine alkaloids from deep-water marine sponges of the family Pachastrellidae: structure revision of dercitin and related compounds and correlation with the kuanoniamines.
Creator
Gunawardana, G. P., Koehn, F. E., Lee, A. Y., Clardy, J., He, H-y., Faulkner, D. J., Harbor Branch Oceanographic Institute
Date Issued
1992
PURL
http://purl.flvc.org/FCLA/DT/3333000
Subject Headings
Sponges, Acridines, Alkaloids, Chemical structure
Format
Document (PDF)
A new bicyclic guanidine alkaloid, Sch 575948, from amarine sponge, Ptilocaulis spiculifer
Title
A new bicyclic guanidine alkaloid, Sch 575948, from amarine sponge, Ptilocaulis spiculifer.
Creator
Yang, Shu-Wei, Chan, Tze-Ming, Pomponi, Shirley A., Chen, Guodong, Wright, Amy E., Patel, Mahesh, Gullo, Vincent, Pramanik, B., Chu, Min
Date Issued
2003
PURL
http://purl.flvc.org/fau/fd/FA00007361
Subject Headings
Sponges, Alkaloids, Guanidines, Antibacterial agents, Molecular structure
Format
Document (PDF)
Antitumor tetrahydroisoquinoline alkaloids from the colonial ascidian Ecteinascidia turbinata
Title
Antitumor tetrahydroisoquinoline alkaloids from the colonial ascidian Ecteinascidia turbinata.
Creator
Wright, Amy E., Forleo, D. A., Gunawardana, G. P., Gunasekera, Sarath P., Koehn, F. E., McConnell, O. J.
Date Issued
1990
PURL
http://purl.flvc.org/FCLA/DT/3332974
Subject Headings
Ascidians, Perophoridae (Tunicata), Tetrahydroisoquinolines, Alkaloids, Antineoplastic agents
Format
Document (PDF)
Kauluamine: an unprecedented manzamine dimer from an Indonesian marine sponge, Prianos sp
Title
Kauluamine: an unprecedented manzamine dimer from an Indonesian marine sponge, Prianos sp.
Creator
Ohtani, I. I., Ichiba, T., Isobe, M., Kelly-Borges, M., Scheuer, P. J., Harbor Branch Oceanographic Institute
Date Issued
1995
PURL
http://purl.flvc.org/FCLA/DT/3319093
Subject Headings
Sponges, Sponges --Research, Marine natural products, Alkaloids
Format
Document (PDF)
Antifungal activity of meridine, a natural product from the marine sponge Corticium sp.
Title
Antifungal activity of meridine, a natural product from the marine sponge Corticium sp.
Creator
McCarthy, Peter J., Pitts, Tara P., Gunawardana, G. P., Kelly-Borges, M., Pomponi, Shirley A.
Date Issued
1992
PURL
http://purl.flvc.org/FCLA/DT/3333005
Subject Headings
Sponges, Alkaloids, Marine natural products, Antifungal agents
Format
Document (PDF)
Nortopsentins A, B, and C. Cytotoxic and antifungal imidazolediylbis [indoles] from the sponge Spongosorites ruetzleri
Title
Nortopsentins A, B, and C. Cytotoxic and antifungal imidazolediylbis [indoles] from the sponge Spongosorites ruetzleri.
Creator
Sakemi, S., Sun, H. H., Harbor Branch Oceanographic Institute
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3332983
Subject Headings
Sponges, Indole Alkaloids, Marine natural products
Format
Document (PDF)
A new bis-(indole) alkaloid from a deep-water marine sponge of the genus Spongosorites
Title
A new bis-(indole) alkaloid from a deep-water marine sponge of the genus Spongosorites.
Creator
Wright, Amy E., Pomponi, Shirley A., Cross, S. S., McCarthy, Peter J.
Date Issued
1992
PURL
http://purl.flvc.org/FCLA/DT/3333002
Subject Headings
Sponges, Indole alkaloids, Marine natural products
Format
Document (PDF)
Inhibition of larval settlement by natural products from the ascidian, Eudistoma olivaceum (Van Name)
Title
Inhibition of larval settlement by natural products from the ascidian, Eudistoma olivaceum (Van Name).
Creator
Davis, A. R., Wright, Amy E.
Date Issued
1990
PURL
http://purl.flvc.org/FCLA/DT/3333148
Subject Headings
Ascidians, Carbolines, Marine natural products, Alkaloids, Fouling
Format
Document (PDF)
Kapakahine B, a cyclic hexapeptide with an alpha-carboline ring system from the marine sponge Cribrochalina olemda
Title
Kapakahine B, a cyclic hexapeptide with an alpha-carboline ring system from the marine sponge Cribrochalina olemda.
Creator
Nakao, Y., Yeung, Bryan K. S., Yoshida, W. Y., Scheuer, P. J., Kelly-Borges, M., Harbor Branch Oceanographic Institute
Date Issued
1995
PURL
http://purl.flvc.org/FCLA/DT/3319086
Subject Headings
Indole alkaloids, Sponges --Research, Carbolines, Cyclic peptides
Format
Document (PDF)
biosynthetic production of marine-derived anti-tumor ecteinascidins and the aquaculture of the marine tunicate Ecteinascidia turbinata
Title
The biosynthetic production of marine-derived anti-tumor ecteinascidins and the aquaculture of the marine tunicate Ecteinascidia turbinata.
Creator
Krenisky, Joann Mary, Florida Atlantic University, Kerr, Russell G., Charles E. Schmidt College of Science, Department of Chemistry and Biochemistry
Abstract/Description
A family of tetrahydroisoquinoline alkaloids, the ecteinascidins, are a group of biologically active secondary metabolites produced by the marine tunicate Ecteinascidia turbinata. Ecteinascidins have shown in vivo anti-tumor activity against P388 lymphoma, B16 melanoma, M5076 ovarian sarcoma, Lewis lung carcinoma, and LX-1 human lung and MX-1 human mammary carcinoma xenografts in laboratory mice. Because ecteinascidins are produced in low yields, 1x10^-4%, supply for clinical development is a...
Show moreA family of tetrahydroisoquinoline alkaloids, the ecteinascidins, are a group of biologically active secondary metabolites produced by the marine tunicate Ecteinascidia turbinata. Ecteinascidins have shown in vivo anti-tumor activity against P388 lymphoma, B16 melanoma, M5076 ovarian sarcoma, Lewis lung carcinoma, and LX-1 human lung and MX-1 human mammary carcinoma xenografts in laboratory mice. Because ecteinascidins are produced in low yields, 1x10^-4%, supply for clinical development is a significant problem. The ultimate goal of this study is to develop an enzyme-based synthesis of the ecteinascidins. In this regard, the biosynthesis of these alkaloids has been investigated. Optimal conditions for in vitro ecteinascidin biosynthesis were found. The origin of the C22-C1 two-carbon unit was identified as pyruvate and the tyrosine and DOPA diketopiperazines were identified as key intermediates. Methods were developed for an in-the-sea aquaculture of the colonal marine ascidian Ecteinascidia turbinata.
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Date Issued
1997
PURL
http://purl.flvc.org/fcla/dt/15454
Subject Headings
Sea squirts, Tetrahydroisoquinolines, Alkaloids--Synthesis
Format
Document (PDF)
Hamacanthins A and B. New antifungal bis indole alkaloids from the deep-water marine sponge, Hamacantha sp
Title
Hamacanthins A and B. New antifungal bis indole alkaloids from the deep-water marine sponge, Hamacantha sp.
Creator
Gunasekera, Sarath P., McCarthy, Peter J., Kelly-Borges, M.
Date Issued
1994
PURL
http://purl.flvc.org/FCLA/DT/3319078
Subject Headings
Sponges --Research, Indole alkaloids, Marine natural products, Antifungal agents
Format
Document (PDF)
Alkaloids and ascidian chemical defense: evidence for the ecological role of natural products from Eudistoma olivaceum
Title
Alkaloids and ascidian chemical defense: evidence for the ecological role of natural products from Eudistoma olivaceum.
Creator
Davis, A. R., Harbor Branch Oceanographic Institute
Date Issued
1991
PURL
http://purl.flvc.org/FCLA/DT/3351175
Subject Headings
Sea squirts, Ascidians, Alkaloids, Animal chemical defenses, Fouling organisms
Format
Document (PDF)
Antitumor activity and nucleic acid binding properties of Dercitin, a new acridinealkaloid isolated from a marine dercitus species sponge
Title
Antitumor activity and nucleic acid binding properties of Dercitin, a new acridinealkaloid isolated from a marine dercitus species sponge.
Creator
Burres, N. S., Sazesh, S., Gunawardana, G. P., Clement, J. J., Harbor Branch Oceanographic Institute
Date Issued
1989
PURL
http://purl.flvc.org/fau/fd/FA00007199
Subject Headings
Alkaloids, Acridines, Sponges, Antineoplastic agents, Cytotoxins, Marine natural products
Format
Document (PDF)

Pages