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Is dopamine transporter-mediated dopaminergic signaling in the retina a noninvasive biomarker for attention-deficit/ hyperactivity disorder? A study in a novel dopamine transporter variant Val559 transgenic mouse model
Title
Is dopamine transporter-mediated dopaminergic signaling in the retina a noninvasive biomarker for attention-deficit/ hyperactivity disorder? A study in a novel dopamine transporter variant Val559 transgenic mouse model.
Creator
Dai, Heng, Jackson, Chad R., Davis, Gwynne L., Blakely, Randy D., McMahon, Douglas G.
Date Issued
2017-12-28
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1186_s11689-017-9215-8_1634318373
Format
Citation
Analysis of neuroanatomical differences in mice with genetically modified serotonin transporters assessed by structural magnetic resonance imaging
Title
Analysis of neuroanatomical differences in mice with genetically modified serotonin transporters assessed by structural magnetic resonance imaging.
Creator
Ellegood, Jacob, Yee, Yohan, Kerr, Travis M., Muller, Christopher L., Blakely, Randy D., Henkelman, R. Mark, Veenstra-VanderWeele, Jeremy, Lerch, Jason P.
Date Issued
2018-12-10
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1186_s13229-018-0210-z_1634563542
Format
Citation
Glial loss of the metallo β-lactamase domain containing protein, SWIP-10, induces age- and glutamate-signaling dependent, dopamine neuron degeneration
Title
Glial loss of the metallo β-lactamase domain containing protein, SWIP-10, induces age- and glutamate-signaling dependent, dopamine neuron degeneration.
Creator
Gibson, Chelsea L., Balbona, Joseph T., Niedzwiecki, Ashlin, Rodriguez, Peter, Nguyen, Ken C. Q., Hall, David H., Blakely, Randy D., Bianchi, Laura
Date Issued
2018-03-28
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1371_journal.pgen.1007269_1634570797
Format
Citation
Elucidation of a Glial Copper Homeostasis Pathway Regulated by the Caenorhabditis elegans Gene swip-10 with Implications for Systemic Metabolism and Neurodegenerative Disease
Title
Elucidation of a Glial Copper Homeostasis Pathway Regulated by the Caenorhabditis elegans Gene swip-10 with Implications for Systemic Metabolism and Neurodegenerative Disease.
Creator
Rodriguez, Peter Jr., Blakely, Randy D., Florida Atlantic University, Department of Biomedical Science, Charles E. Schmidt College of Medicine
Abstract/Description
Using the Caenorhabditis elegans as a model we have employed forward genetic screens to uncover several novel genetic contributors to dopamine (DA) signaling(1). Follow-up characterization of some of these novel contributors have been detailed in published work from our lab(2), while follow-up studies on other pathways are still underway. Moreover, using the powerful Million Mutation Project library, we have uncovered an important link between primary cilium formation and the regulation of...
Show moreUsing the Caenorhabditis elegans as a model we have employed forward genetic screens to uncover several novel genetic contributors to dopamine (DA) signaling(1). Follow-up characterization of some of these novel contributors have been detailed in published work from our lab(2), while follow-up studies on other pathways are still underway. Moreover, using the powerful Million Mutation Project library, we have uncovered an important link between primary cilium formation and the regulation of the DA transporter dat-1(3). The focus of the body of work detailed in this manuscript is on a glial expressed gene, swip-10, uncovered from our original genetic screen(1, 4, 5). Unlike the other pathways uncovered from our genetic screening, swip-10 does not affect DA signaling via DAT-1 regulation, instead, loss of swip-10 produces excess DA signaling in a glutamate-signaling-dependent manner to cause swimming-induced paralysis (Swip)(4) as well as premature DA neuron degeneration(5). Specifically, the primary aim here was to uncover the molecular pathway by which swip-10 supports these phenotypes.
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Date Issued
2024
PURL
http://purl.flvc.org/fau/fd/FA00014511
Subject Headings
Neurodegenerative Diseases, Glial cells, Caenorhabditis elegans, Copper, Homeostasis
Format
Document (PDF)
p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse
Title
p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse.
Creator
Robson, Matthew J., Quinlan, Meagan A., Margolis, Kara Gross, Gajewski-Kurdziel, Paula A., Veenstra-VanderWeele, Jeremy, Gershon, Michael D., Watterson, D. Martin, Blakely, Randy D.
Date Issued
2018-10-08
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1073_pnas.1809137115_1634648319
Format
Citation
Pancreatic deletion of the interleukin-1 receptor disrupts whole body glucose homeostasis and promotes islet β-cell de-differentiation
Title
Pancreatic deletion of the interleukin-1 receptor disrupts whole body glucose homeostasis and promotes islet β-cell de-differentiation.
Creator
Burke, Susan J., Batdorf, Heidi M., Burk, David H., Martin, Thomas M., Mendoza, Tamra, Stadler, Krisztian, Alami, Wateen, Karlstad, Michael D., Robson, Matthew J., Blakely, Randy D., Mynatt, Randall L., Collier, J. Jason
Date Issued
2018-08
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1016_j.molmet.2018.06.003_1634579597
Format
Citation
Unresponsive Choline Transporter as a Trait Neuromarker and a Causal Mediator of Bottom-Up Attentional Biases
Title
Unresponsive Choline Transporter as a Trait Neuromarker and a Causal Mediator of Bottom-Up Attentional Biases.
Creator
Koshy Cherian, Ajeesh, Kucinski, Aaron, Pitchers, Kyle, Yegla, Brittney, Parikh, Vinay, Kim, Youngsoo, Valuskova, Paulina, Gurnani, Sarika, Lindsley, Craig W., Blakely, Randy D., Sarter, Martin
Date Issued
2017-02-13
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1523_JNEUROSCI.3499-16.2017_1634323040
Format
Citation
Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits
Title
Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits.
Creator
Muntean, Brian S., Zucca, Stefano, MacMullen, Courtney M., Dao, Maria T., Johnston, Caitlin, Iwamoto, Hideki, Blakely, Randy D., Davis, Ronald L., Martemyanov, Kirill A.
Date Issued
2018-01
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1016_j.celrep.2017.12.022_1634578549
Format
Citation
Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits
Title
Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits.
Creator
Brian S. Muntean, Stefano Zucca, Courtney M. MacMullen, Maria T. Dao, Caitlin Johnston, Hideki Iwamoto, Randy D. Blakely, Ronald L. Davis, Kirill A. Martemyanov
Abstract/Description
Modulation of neuronal circuits is key to information processing in the brain. The majority of neuromodulators exert their effects by activating G-proteincoupled receptors (GPCRs) that control the production of second messengers directly impacting cellular physiology. How numerous GPCRs integrate neuromodulatory inputs while accommodating diversity of incoming signals is poorly understood. In this study, we develop an in vivo tool and analytical suite for analyzing GPCR responses by...
Show moreModulation of neuronal circuits is key to information processing in the brain. The majority of neuromodulators exert their effects by activating G-proteincoupled receptors (GPCRs) that control the production of second messengers directly impacting cellular physiology. How numerous GPCRs integrate neuromodulatory inputs while accommodating diversity of incoming signals is poorly understood. In this study, we develop an in vivo tool and analytical suite for analyzing GPCR responses by monitoring the dynamics of a key second messenger, cyclic AMP (cAMP), with excellent quantitative and spatiotemporal resolution in various neurons. Using this imaging approach in combination with CRISPR/Cas9 editing and optogenetics, we interrogate neuromodulatory mechanisms of defined populations of neurons in an intact mesolimbic reward circuit and describe how individual inputs generate discrete second-messenger signatures in a cell- and receptor- specific fashion. This offers a resource for studying native neuronal GPCR signaling in real time.
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Date Issued
2018
PURL
http://purl.flvc.org/fau/fd/FAUIR000525
Format
Document (PDF)
Region-Specific Regulation of Presynaptic Dopamine Homeostasis by D 2 Autoreceptors Shapes the In Vivo Impact of the Neuropsychiatric Disease-Associated DAT Variant Val559
Title
Region-Specific Regulation of Presynaptic Dopamine Homeostasis by D 2 Autoreceptors Shapes the In Vivo Impact of the Neuropsychiatric Disease-Associated DAT Variant Val559.
Creator
Gowrishankar, Raajaram, Gresch, Paul J., Davis, Gwynne L., Katamish, Rania M., Riele, Justin R., Stewart, Adele M., Vaughan, Roxanne A., Hahn, Maureen K., Blakely, Randy D.
Date Issued
2018-05-08
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1523_JNEUROSCI.0055-18.2018_1634583255
Format
Citation
Truncating SLC5A7 mutations underlie a spectrum of dominant hereditary motor neuropathies
Title
Truncating SLC5A7 mutations underlie a spectrum of dominant hereditary motor neuropathies.
Creator
Salter, Claire G., Beijer, Danique, Hardy, Holly, Barwick, Katy E.S., Bower, Matthew, Mademan, Ines, De Jonghe, Peter, Deconinck, Tine, Russell, Mark A., McEntagart, Meriel M., Chioza, Barry A., Blakely, Randy D., Chilton, John K., De Bleecker, Jan, Baets, Jonathan, Baple, Emma L., Walk, David, Crosby, Andrew H.
Date Issued
2018-04-23
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1212_NXG.0000000000000222_1634649520
Format
Citation
Choline transporter mutations in severe congenital myasthenic syndrome disrupt transporter localization
Title
Choline transporter mutations in severe congenital myasthenic syndrome disrupt transporter localization.
Creator
Wang, Haicui, Salter, Claire G, Refai, Osama, Hardy, Holly, Barwick, Katy E S, Akpulat, Ugur, Kvarnung, Malin, Chioza, Barry A, Harlalka, Gaurav, Taylan, Fulya, Sejersen, Thomas, Wright, Jane, Zimmerman, Holly H, Karakaya, Mert, Stüve, Burkhardt, Weis, Joachim, Schara, Ulrike, Russell, Mark A, Abdul-Rahman, Omar A, Chilton, John, Blakely, Randy D, Baple, Emma L, Cirak, Sebahattin, Crosby, Andrew H
Date Issued
2017-10-27
PURL
http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1093_brain_awx249_1635361980
Format
Citation