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Effect of MDMA abuse on axonal transportation of serotonergic nervous system in the rat brain
Title
Effect of MDMA abuse on axonal transportation of serotonergic nervous system in the rat brain.
Creator
Adams, Herbert D., Ma, Zhiyuan, Tao, Rui
Date Issued
2012-04-06
PURL
http://purl.flvc.org/fcla/dt/3348609
Subject Headings
N-Methyl-3,4-methylenedioxyamphetamine, Ecstasy, Receptors, Serotonin - drug effects, Serotonergic nervous system, Substance-related disorders, Methamphetamine --adverse effects, Serotonin --pharmacokinetics
Format
Document (PDF)
Attention deficit caused by MDMA ('ecstasy')
Title
Attention deficit caused by MDMA ('ecstasy').
Creator
Rudacille, Mary C., Tao, Rui
Date Issued
2013-04-05
PURL
http://purl.flvc.org/fcla/dt/3361175
Subject Headings
Ecstasy (Drug), MDMA (Drug), Attention deficit disorder
Format
Document (PDF)
New in-situ hybridization method measuring serotonin 2A (5-HT2A) receptor mRNA levels in rats exposed to MDMA
Title
New in-situ hybridization method measuring serotonin 2A (5-HT2A) receptor mRNA levels in rats exposed to MDMA.
Creator
Sousa, John, Shokry, Ibrahim M., Callanan, John J., Tao, Rui, Charles E. Schmidt College of Medicine
Abstract/Description
This study aimed to identify changes in the expression of serotonin (5-hydroxytryptamine; 5-HT) receptor 5-HT2a mRNA in paraformaldehyde prefixed rat brain tissue after exposure to 3, 4 methylenedioxymethamphetamine (MDMA). Rather than use traditional, time-consuming methods that were highly prone to error, such as the use of radioactive riboprobes, we used recent advancements in the development of rapid in-situ hybridization to our advantage. The use of rapid in-situ hybridization (such as...
Show moreThis study aimed to identify changes in the expression of serotonin (5-hydroxytryptamine; 5-HT) receptor 5-HT2a mRNA in paraformaldehyde prefixed rat brain tissue after exposure to 3, 4 methylenedioxymethamphetamine (MDMA). Rather than use traditional, time-consuming methods that were highly prone to error, such as the use of radioactive riboprobes, we used recent advancements in the development of rapid in-situ hybridization to our advantage. The use of rapid in-situ hybridization (such as the RNAscope assay) has allowed us to use paraformaldehyde prefixed brain tissue sections, which are more widely available and easier to use, instead of fresh frozen tissue. Here we describe the results from the use of the RNAscope assay to measure the amount of dapB (a bacterial gene), ppiB (a eukaryotic housekeeping gene), and htr2a (a eukaryotic gene coding for 5-HT2A receptors) mRNA.
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Date Issued
2015
PURL
http://purl.flvc.org/fau/fd/FA00005211
Subject Headings
College students --Research --United States.
Format
Document (PDF)
New Insights on Different Response of MDMA-Elicited Serotonin Syndrome to Systemic and Intracranial Administrations in the Rat Brain
Title
New Insights on Different Response of MDMA-Elicited Serotonin Syndrome to Systemic and Intracranial Administrations in the Rat Brain.
Creator
Shokry, Ibrahim M., Callanan, John J., Sousa, John, Tao, Rui, Dominguez, Juan M
Date Issued
2016-05-18
PURL
http://purl.flvc.org/fau/fd/FAUIR000112
Format
Citation
Calpain Cleavage of Brain Glutamic Acid Decarboxylase 65 Is Pathological and Impairs GABA Neurotransmission
Title
Calpain Cleavage of Brain Glutamic Acid Decarboxylase 65 Is Pathological and Impairs GABA Neurotransmission.
Creator
Buddhala, Chandana, Suarez, Marjorie, Modi, Jigar P., Prentice, Howard, Ma, Zhiyuan, Tao, Rui, Wu, Jang-Yen, Smalheiser, Neil R.
Date Issued
2012-03-12
PURL
http://purl.flvc.org/fau/fd/FAUIR000097
Format
Citation
EEG Topographic Changes in Opioid Use Disorder
Title
EEG Topographic Changes in Opioid Use Disorder.
Creator
Minnerly, Christopher, Tao, Rui, Florida Atlantic University, Department of Biomedical Science, Charles E. Schmidt College of Medicine
Abstract/Description
The present study aimed at quantifying the topographic distribution of spectral power as measured with electroencephalogram (EEG) in patients with opioid use disorder (OUD) across five broad band frequencies (δ, θ, α, β, and γ). Through comparative groups of healthy controls, patients with methamphetamine use disorder, and patients with alcohol use disorder, it was determined that OUD EEG spectral power was globally increased in the δ frequency, and more region-specific in others (frontal...
Show moreThe present study aimed at quantifying the topographic distribution of spectral power as measured with electroencephalogram (EEG) in patients with opioid use disorder (OUD) across five broad band frequencies (δ, θ, α, β, and γ). Through comparative groups of healthy controls, patients with methamphetamine use disorder, and patients with alcohol use disorder, it was determined that OUD EEG spectral power was globally increased in the δ frequency, and more region-specific in others (frontal lobes in θ and β frequencies). α frequency was reduced in occipital lobes in OUD. The observed changes are discussed in terms of the microcircuit-level changes in the cortex. Based on these findings, EEG may prove to be a valuable tool for diagnostic and prognostic evaluation of OUD.
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Date Issued
2020
PURL
http://purl.flvc.org/fau/fd/FA00013488
Subject Headings
Opioid-Related Disorders, Electroencephalography, Brain Mapping
Format
Document (PDF)
Effect of amyloid beta on nutrient uptake and ATP in the brain cells
Title
Effect of amyloid beta on nutrient uptake and ATP in the brain cells.
Creator
To, William, Tao, Rui, Florida Atlantic University, Department of Biomedical Science, Charles E. Schmidt College of Medicine
Abstract/Description
Unintentional weight loss in older adults often precedes Alzheimer’s disease (AD). Positron emission tomography (PET) scan reveals that AD patients exhibit reduced uptake of fluorodeoxyglucose into brain cells, defined as ‘hypometabolism’. However, cellular mechanisms underlying weight loss and hypometabolism have not received much attention. The primary goal of the study was to test the hypothesis that cells become starved in confrontation with amyloid beta proteins (Aβ), which are...
Show moreUnintentional weight loss in older adults often precedes Alzheimer’s disease (AD). Positron emission tomography (PET) scan reveals that AD patients exhibit reduced uptake of fluorodeoxyglucose into brain cells, defined as ‘hypometabolism’. However, cellular mechanisms underlying weight loss and hypometabolism have not received much attention. The primary goal of the study was to test the hypothesis that cells become starved in confrontation with amyloid beta proteins (Aβ), which are increasingly aggregated in the AD brain. Cellular ATP is known as a biomarker indicating for cell starvation. We found that Aβ caused a dose-dependent reduction in ATP of astrocytes. This effect was similar to those of cells being deprived from nutrients (i.e., glucose, pyruvate and glutamine). Together, the data of the present study support the hypothesis that cell starvation is likely associated with weight loss and hypometabolism in AD patients.
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Date Issued
2022
PURL
http://purl.flvc.org/fau/fd/FA00013941
Subject Headings
Alzheimer Disease, Amyloid, Amyloid beta-Peptides, Adenosine Triphosphate
Format
Document (PDF)