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Should we use RapidArc (VMAT) for breast radiotherapy? A Dosimetric comparison of IMRT versus VMAT optimization
Title
Should we use RapidArc (VMAT) for breast radiotherapy? A Dosimetric comparison of IMRT versus VMAT optimization.
Creator
Moshiri Sedeh, Nader, Pella, Silvia, Leventouri, Theodora, Graduate College
Abstract/Description
Purpose: The purpose of this study is to compare the dose-volumetric results of intensity modulated radiation therapy (IMRT) with RapidArc (RA Varian Medical Systems, Palo Alto, CA) for whole breast irradiation. Methods: 25 patients previously treated for whole left breast (either RapidArc plan or IMRT) were the subjects of this planning study. Eclipse v 11.0.47 was used to make all retrospective plans using the same contours, energy, machine and normalization. Prescription dose to the...
Show morePurpose: The purpose of this study is to compare the dose-volumetric results of intensity modulated radiation therapy (IMRT) with RapidArc (RA Varian Medical Systems, Palo Alto, CA) for whole breast irradiation. Methods: 25 patients previously treated for whole left breast (either RapidArc plan or IMRT) were the subjects of this planning study. Eclipse v 11.0.47 was used to make all retrospective plans using the same contours, energy, machine and normalization. Prescription dose to the planning target volume was 5000 Gy in 25 fractions. All plans were normalized such that 100% covered 95% of planning target volume (PTV). Results: V10, V20 and Dmean Gy of left lung significantly differed between the two plans (p-value <0.0001, =0.0473 and <0.0001 respectively), but V30 Gy did not (p-value 0.463). V25, D33 and Dmean Gy of heart significantly differed between the two plans (p-value =0.034, <0.0001 and 0.01 respectively), but V10 Gy did not (p-value 0.058). V5 of both right breast and right lung significantly differed between the two plans (p-value <0.0007 and =0.0112, respectively). Also Dmean of both right breast and right lung significantly differed between the two plans (p-value <0.0001 for both). The mean conformity index did not significantly differ, p-value 0.142. There was a significant difference between the mean MUs of the two plans as well, p-value <0.0001.
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Date Issued
2015
PURL
http://purl.flvc.org/fau/fd/FA00005901
Format
Document (PDF)
COMPARATIVE PHARMACOKINETICS, BIODISTRIBUTION AND DOSIMETRY OF 212Pb (ALPHA-EMITTER) LABELED ANTIBODY VS PEPTIDE VS SMALL MOLECULE
Title
COMPARATIVE PHARMACOKINETICS, BIODISTRIBUTION AND DOSIMETRY OF 212Pb (ALPHA-EMITTER) LABELED ANTIBODY VS PEPTIDE VS SMALL MOLECULE.
Creator
Moshiri, Nader Sedeh, Leventouri, Theodora, Florida Atlantic University, Department of Physics, Charles E. Schmidt College of Science
Abstract/Description
With the advent of newly and more reliably designed targeted therapy methods in the past several years, targeted radionuclide therapy has attracted more attentions around the world as a more reliable treatment modality in combination with other well established traditional cancer treatments i.e., external beam radiotherapy and chemotherapy. Alpha particles have a high relative biological effectiveness (RBE) due to their high linear energy transfer (LET). However, to utilize them for...
Show moreWith the advent of newly and more reliably designed targeted therapy methods in the past several years, targeted radionuclide therapy has attracted more attentions around the world as a more reliable treatment modality in combination with other well established traditional cancer treatments i.e., external beam radiotherapy and chemotherapy. Alpha particles have a high relative biological effectiveness (RBE) due to their high linear energy transfer (LET). However, to utilize them for therapeutic purposes, precise human body dosimetry calculation is required. The measurement of their uptake and biodistribution can be quite challenging. Also, due to the complex biology of different types of cells, their shapes and functions, there is not a simple and clear understanding of the mechanism of action that fits all. This study aims to estimate and compare the human organ dosimetry of the alpha emitter, 212Pb, from animal data assuming that it is conjugated with three different types of commonly used targeting nanoparticles. For this purpose, the pre-published animal data of three different radionuclide labeled peptide, antibody, and small molecule carriers were selected and converted to human data. Then a compartmental model was designed for each of them to fit the model to the human data with 212Pb, half-life of 10.64 hours. Once each model reached the desired fit, the area under the curves were extracted then the estimated human organ dosimetry calculations took place via the MIRD scheme. The organ dosimetry results for 212Pb + three different carriers are presented in Tables 14, 17, and 20.
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Date Issued
2023
PURL
http://purl.flvc.org/fau/fd/FA00014215
Subject Headings
Cancer--Treatment, Lead-212, Nuclear Medicine
Format
Document (PDF)
Dosimetric and Radiobiological Comparison of Forward Tangent Intensity Modulated Radiation Therapy (FT-IMRT) and Volumetric Modulated Arc Therapy (VMAT) for Early Stage Whole Breast Cancer
Title
Dosimetric and Radiobiological Comparison of Forward Tangent Intensity Modulated Radiation Therapy (FT-IMRT) and Volumetric Modulated Arc Therapy (VMAT) for Early Stage Whole Breast Cancer.
Creator
Moshiri Sedeh, Nader, Pella, Silvia, Leventouri, Theodora, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
Abstract/Description
Intensity Modulated Radiation Therapy (IMRT) is a well-known type of external beam radiation therapy. The advancement in technology has had an inevitable influence in radiation oncology as well that has led to a newer and faster dose delivery technique called Volumetric Modulated Arc Therapy (VMAT). Since the presence of the VMAT modality in clinics in the late 2000, there have been many studies in order to compare the results of the VMAT modality with the current popular modality IMRT for...
Show moreIntensity Modulated Radiation Therapy (IMRT) is a well-known type of external beam radiation therapy. The advancement in technology has had an inevitable influence in radiation oncology as well that has led to a newer and faster dose delivery technique called Volumetric Modulated Arc Therapy (VMAT). Since the presence of the VMAT modality in clinics in the late 2000, there have been many studies in order to compare the results of the VMAT modality with the current popular modality IMRT for various tumor sites in the body such as brain, prostate, head and neck, cervix and anal carcinoma. This is the first study to compare VMAT with IMRT for breast cancer. The results show that the RapidArc technique in Eclipse version 11 does not improve all aspects of the treatment plans for the breast cases automatically and easily, but it needs to be manipulated by extra techniques to create acceptable plans thus further research is needed.
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Date Issued
2015
PURL
http://purl.flvc.org/fau/fd/FA00004526, http://purl.flvc.org/fau/fd/FA00004526
Subject Headings
Breast -- Cancer -- Treatment, Cancer -- Radiation therapy, Image guided radiation therapy, Radiation dosimetry, Radiotherapy -- Technological innovations
Format
Document (PDF)