Current Search: Merritt, Mckenzie D. (x)
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Title
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Using C. elegans as a Model System to Discover Antiepileptic Drugs.
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Creator
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Merritt, Mckenzie D., Wetterer, James K., Harriet L. Wilkes Honors College
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Abstract/Description
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Novel antiepileptic drugs (AEDs) are commonly tested using rats and mice as model systems. These animals, however, require a great deal of time, money, and lab space to maintain. In contrast, the nematode Caenorhabditis elegans (C. elegans) potentially can provide a faster, and less expensive model system for testing AEDs. C. elegans are simple to maintain and have a very short generation time, allowing high throughput assays to screen for new AEDs. For my thesis research, I used C. elegans...
Show moreNovel antiepileptic drugs (AEDs) are commonly tested using rats and mice as model systems. These animals, however, require a great deal of time, money, and lab space to maintain. In contrast, the nematode Caenorhabditis elegans (C. elegans) potentially can provide a faster, and less expensive model system for testing AEDs. C. elegans are simple to maintain and have a very short generation time, allowing high throughput assays to screen for new AEDs. For my thesis research, I used C. elegans to test FDA approved AEDs. My tests support the contention that C. elegans can be a useful model system for AED discovery.
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Date Issued
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2016
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PURL
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http://purl.flvc.org/fau/fd/FA00003682
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Format
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Document (PDF)
