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Title: Secosteroids, and method for producing same.
Creator: Kerr, Russell G., Florida Atlantic University
Date Issued: 1998-06
PURL: http://purl.flvc.org/fcla/dt/15845
Format: Document (PDF)

Title: Pseudopterosin production.
Creator: Kerr, Russell G., Florida Atlantic University
Date Issued: 2005-05
PURL: http://purl.flvc.org/fcla/dt/15801
Format: Document (PDF)

Title: Method for producing marine-derived compounds and novel compounds produced therefrom.
Creator: Kerr, Russell G., Florida Atlantic University
Date Issued: 2000-04
PURL: http://purl.flvc.org/fcla/dt/15844
Format: Document (PDF)

Title: Isolation and production of bioactive marine products.
Creator: Kerr, Russell G., Florida Atlantic University
Date Issued: 2005-11
PURL: http://purl.flvc.org/fcla/dt/15803
Format: Document (PDF)

Title: Diterpene cyclase and methods of use.
Creator: Kerr, Russell G., Kohl, Amber, Florida Atlantic University
Date Issued: 2004-08
PURL: http://purl.flvc.org/fcla/dt/15815
Format: Document (PDF)

Title: Anti-inflammatory compounds derived from Pseudopterogorgia elisabethae.
Creator: Jacobs, Robert S., Kerr, Russell G., Florida Atlantic University
Date Issued: 2004-09
PURL: http://purl.flvc.org/fcla/dt/15811
Format: Document (PDF)

Title: Anti-inflammatory compounds derived from Pseudopterogorgia elisabethae.
Creator: Jacobs, Robert S., Kerr, Russell G., Florida Atlantic University
Date Issued: 2005-04
PURL: http://purl.flvc.org/fcla/dt/15805
Format: Document (PDF)

Title: Methods and compositions for cyclizing diterpenes.
Creator: Kerr, Russell G., Kohl, Amber, Florida Atlantic University
Date Issued: 2004-09
PURL: http://purl.flvc.org/fcla/dt/15812
Format: Document (PDF)

Title: The many faces of gene expression profiling: transcriptome analyses applied towardselucidating marine organismal interactions and metabolism.
Creator: Lopez, Jose V., Mouzon, B., McCarthy, Peter J., Kerr, Russell G.
Date Issued: 2009
PURL: http://purl.flvc.org/fau/fd/FA00007286
Subject Headings: Gene expression, Transcriptome, Molecular biotechnology, Marine ecology, Marine organisms
Format: Document (PDF)

Title: Biochemical and morphologicalheterogeneity in the Caribbean sponge Xestospongia muta (petrosida: Petrosiidae).
Creator: Kerr, Russell G., Kelly-Borges, M., Harbor Branch Oceanographic Institute
Date Issued: 1994
PURL: http://purl.flvc.org/fau/fd/FA00007380
Subject Headings: Sponges--Caribbean Sea, Morphology, Biochemistry, Sterols
Format: Document (PDF)

Title: Pseudopterosin compounds of Symbiodinium Spp isolated from Pseudopterogorgia elisabethae.
Creator: Jacobs, Robert S., Mydlarz, Laura, Kerr, Russell G., Florida Atlantic University
Date Issued: 2003-06
PURL: http://purl.flvc.org/fcla/dt/15824
Format: Document (PDF)

Title: Biosynthetic Studies of the Alkaloid, Stevensine, in a Cell Culture of the Marine Sponge Teichaxinella morchella.
Creator: Andrade, Paul, Willoughby, Robin, Pomponi, Shirley A., Kerr, Russell G.
Date Issued: 1999
PURL: http://purl.flvc.org/FCLA/DT/3158768
Subject Headings: Alkaloids, Sponges, Marine invertebrates, Amino acids, Biosynthetic Pathways
Format: Document (PDF)

Title: Chemoenzymatic synthesis of 9,11-secosteroids using an enzyme extract from a marine coral.
Creator: Rodriguez, Lesbeth Caridad., Florida Atlantic University, Kerr, Russell G.
Abstract/Description: 9,11-Secogorgosterol, a secondary metabolite from the gorgonian Pseudopterogorgia americana, exhibits inhibitory activity against protein kinase C, and potent anti-proliferative and anti-inflammatory activity. An efficient method for the production of 9,11-secogorgosterol has been developed and optimized using an enzyme extract from the gorgonian P. americana. The gorgonian also produces two other 9,11-secosteroids which have marked differences in their side chains and nuclei, which suggested...
Show more9,11-Secogorgosterol, a secondary metabolite from the gorgonian Pseudopterogorgia americana, exhibits inhibitory activity against protein kinase C, and potent anti-proliferative and anti-inflammatory activity. An efficient method for the production of 9,11-secogorgosterol has been developed and optimized using an enzyme extract from the gorgonian P. americana. The gorgonian also produces two other 9,11-secosteroids which have marked differences in their side chains and nuclei, which suggested that the enzymes responsible for their production were likely relatively nonspecific. Novel 9,11-secosteroids have been synthesized using the enzyme extract from the gorgonian.
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Date Issued: 1997
PURL: http://purl.flvc.org/fcla/dt/15431
Subject Headings: Steroids, Enzymes--Synthesis, Alcyonacea, Corals
Format: Document (PDF)

Title: Chemotaxonomy of the marine sponge Xestospongia muta.
Creator: Reddy, Manoj Kumar., Florida Atlantic University, Kerr, Russell G.
Abstract/Description: Chemical analysis of large number of specimens of the sponge Xestospongia muta have revealed the existence of three distinct sterol chemotypes. Since sponges are well known to contain a diverse array of all classes of lipids, the utility of fatty acid composition as a chemotaxonomic tool for Xestospongia muta has been addressed. Further the biosynthetic capabilities of the three chemotypes are being evaluated for possible taxonomic use. Further the utility of TLC and NMR as additional...
Show moreChemical analysis of large number of specimens of the sponge Xestospongia muta have revealed the existence of three distinct sterol chemotypes. Since sponges are well known to contain a diverse array of all classes of lipids, the utility of fatty acid composition as a chemotaxonomic tool for Xestospongia muta has been addressed. Further the biosynthetic capabilities of the three chemotypes are being evaluated for possible taxonomic use. Further the utility of TLC and NMR as additional taxonomic tools has also been evaluated.
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Date Issued: 1995
PURL: http://purl.flvc.org/fcla/dt/15167
Subject Headings: Chemotaxonomy, Sponges, Sterols
Format: Document (PDF)

Title: Characterization, biosynthetic studies and subcellular localization of sterols from the marine sponge Teichaxinella morchella.
Creator: Williams, Amanda Joy, Florida Atlantic University, Kerr, Russell G.
Abstract/Description: A-nor sterols have been isolated and characterized from the marine sponge Teichaxinella morchella using High Performance Liquid Chromatography, Nuclear Magnetic Resonance, and Mass Spectrometry. A cell free extract of T. morchella was used to determine the biosynthetic origin of the sterols. Incubation experiments with radiolabled Farnesyl Pyrophosphate and cholesterol showed that the sterols are coming from a dietary source. Subcellular localization studies showed that the sterols are part...
Show moreA-nor sterols have been isolated and characterized from the marine sponge Teichaxinella morchella using High Performance Liquid Chromatography, Nuclear Magnetic Resonance, and Mass Spectrometry. A cell free extract of T. morchella was used to determine the biosynthetic origin of the sterols. Incubation experiments with radiolabled Farnesyl Pyrophosphate and cholesterol showed that the sterols are coming from a dietary source. Subcellular localization studies showed that the sterols are part of the cell membrane.
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Date Issued: 2001
PURL: http://purl.flvc.org/fcla/dt/12865
Subject Headings: Sponges, Sterols
Format: Document (PDF)

Title: Aquaculture of Pseudopterogorgia elisabethae and induction of pseudopterosins.
Creator: Thornton, Renee S., Florida Atlantic University, Kerr, Russell G.
Abstract/Description: The pseudopterosins are a class of diterpene glycosides isolated from the Caribbean sea whip, Pseudopterogorgia elisabethae. Pseudopterosins A-D possess potent anti-inflammatory and analgesic properties (ED50 ca. 3.0 mg/kg). There is a large demand in the pharmaceutical and cosmetic industries for pseudopterosin derivatives and presently, the only source of these chemicals is from wild-collected gorgonians. Preliminary experiments were performed to develop a reliable, cost-effective...
Show moreThe pseudopterosins are a class of diterpene glycosides isolated from the Caribbean sea whip, Pseudopterogorgia elisabethae. Pseudopterosins A-D possess potent anti-inflammatory and analgesic properties (ED50 ca. 3.0 mg/kg). There is a large demand in the pharmaceutical and cosmetic industries for pseudopterosin derivatives and presently, the only source of these chemicals is from wild-collected gorgonians. Preliminary experiments were performed to develop a reliable, cost-effective production method of the pseudopterosins in order to avoid large-scale harvesting. We exposed the gorgonians to various forms of "stress" in an attempt to increase the amount of pseudopterosins produced. We have also evaluated the feasibility of raising Pseudopterogorgia elisabethae in an aquaculture setting by studying their growth rates in different environments. Our studies indicate that aquaculture used with some simple induction methods can allow for the commercialization of this important biochemical resource.
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Date Issued: 2000
PURL: http://purl.flvc.org/fcla/dt/12727
Subject Headings: Alcyonacea, Aquaculture, Marine pharmacology
Format: Document (PDF)

Title: Development of methods for the immobilization of enzymes used in 9,11-secosteroid biosynthesis.
Creator: Chen, Ying, Florida Atlantic University, Kerr, Russell G.
Abstract/Description: 9,11-Secosteroids exhibit novel biological activity and interesting pharmacological properties. A biosynthetic study of 9,11-secogorgosterol and other novel 9,11-secosteroids using an enzyme extract from the gorgonian Pseudopterogorgia americana demonstrated that this system is an efficient catalyst for a wide range 9,11-secosteroid production. Two methods to recover the enzyme from 9,11-secosteroid synthesis have been developed: (1) membrane-enclosed enzymatic catalysis, which combines...
Show more9,11-Secosteroids exhibit novel biological activity and interesting pharmacological properties. A biosynthetic study of 9,11-secogorgosterol and other novel 9,11-secosteroids using an enzyme extract from the gorgonian Pseudopterogorgia americana demonstrated that this system is an efficient catalyst for a wide range 9,11-secosteroid production. Two methods to recover the enzyme from 9,11-secosteroid synthesis have been developed: (1) membrane-enclosed enzymatic catalysis, which combines certain of the advantages of soluble enzymes and immobilized enzymes, shows high activity, simple recovery and at least 5 cycles or 23 days; (2) covalently bonded enzyme-agarose gel, attached by cyanogen bromide via the amino groups of enzymes, show 80% activity of free enzymes and at least 7 cycles or 46 days. Based on stability and kinetic studies of these immobilized enzymes in 9,11-secosteroid synthesis, a continuous flow column reactor for scale-up of 9,11-secosteroid production has been developed with great efficiency, which represents the first enzymatic production of a bioactive compound from a marine invertebrate on a large scale.
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Date Issued: 1998
PURL: http://purl.flvc.org/fcla/dt/15521
Subject Headings: Octocorallia, Enzymes--Synthesis, Steroids
Format: Document (PDF)

Title: Biosynthesis and enzymology of secosteroids from Pseudopterogorgia americana.
Creator: Head, Kevin, Florida Atlantic University, Kerr, Russell G.
Abstract/Description: 9,11-Secosteroids are biologically active secondary metabolites from the marine invertebrate, Pseudopterogorgia americana. They are produced in vitro through an incubation of the steroid substrate with a cell-free extract of P. americana containing the necessary enzymes. Further optimization of this incubation was attempted through adjustment of incubation reagents and cofactors. The enzymes responsible for secosteroid production were partially purified through chromatography in an effort to...
Show more9,11-Secosteroids are biologically active secondary metabolites from the marine invertebrate, Pseudopterogorgia americana. They are produced in vitro through an incubation of the steroid substrate with a cell-free extract of P. americana containing the necessary enzymes. Further optimization of this incubation was attempted through adjustment of incubation reagents and cofactors. The enzymes responsible for secosteroid production were partially purified through chromatography in an effort to isolate and purify these enzymes. Finally, experiments with radiolabeled gorgosterol led to the elucidation and isolation of a key secosteroid precursor, 9,11-dihydroxygorgosterol.
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Date Issued: 1999
PURL: http://purl.flvc.org/fcla/dt/15711
Subject Headings: Alcyonacea, Enzymes--Synthesis, Sterols
Format: Document (PDF)

Title: Biochemical and biosynthetic optimization of bryostatin 1 in Bugula neritina.
Creator: Vicchiarelli, Richard, Florida Atlantic University, Kerr, Russell G.
Abstract/Description: Bryostatin 1 is a macrocyclic lactone isolated from the marine bryozoan Bugula neritina. It is currently in clinical trials at the National Cancer Institute as a promising new antileukemic agent. Bryostatin 1 is found in Bugula neritina in poor yields (10^-4% dry weight). The focus of this research was to develop the biochemical and biosynthetic techniques that could be utilized to optimize the production of bryostatin 1 in Bugula neritina through aquaculture. To that end, the basic...
Show moreBryostatin 1 is a macrocyclic lactone isolated from the marine bryozoan Bugula neritina. It is currently in clinical trials at the National Cancer Institute as a promising new antileukemic agent. Bryostatin 1 is found in Bugula neritina in poor yields (10^-4% dry weight). The focus of this research was to develop the biochemical and biosynthetic techniques that could be utilized to optimize the production of bryostatin 1 in Bugula neritina through aquaculture. To that end, the basic biosynthetic pathway to bryostatin 1 in the marine bryozoan was evaluated by using radiolabeled precursors. Techniques for the incorporation of these precursors were also developed. Other experiments involved an analysis of the composition of a specific population of Bugula neritina in terms of its bryostatin and lipid content. A determination of which lipids are produced de novo and which are exogenous was also undertaken.
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Date Issued: 1993
PURL: http://purl.flvc.org/fcla/dt/14931
Subject Headings: Bryozoa, Aquaculture--Research
Format: Document (PDF)

Title: Biosynthetic studies of the antitumor ecteinascidins in the marine tunicate Ecteinascidia turbinata.
Creator: Miranda, Neil Fermino, Florida Atlantic University, Kerr, Russell G.
Abstract/Description: Ecteinascidin is a tetrahydroisoquinoline alkaloid isolated from the colonial ascidian Ecteinascidia turbinata. Ecteinascidin exhibits tremendous activity against P388 murine leukemia, however its yields from the tunicate are as low as 10^-4%. A biosynthetic investigation, using in vivo and in vitro methods, has resulted in the identification of the metabolic precursors of ecteinascidin as tyrosine, DOPA and cysteine. Reactive intermediates such as tyrosine and DOPA diketopiperazines have...
Show moreEcteinascidin is a tetrahydroisoquinoline alkaloid isolated from the colonial ascidian Ecteinascidia turbinata. Ecteinascidin exhibits tremendous activity against P388 murine leukemia, however its yields from the tunicate are as low as 10^-4%. A biosynthetic investigation, using in vivo and in vitro methods, has resulted in the identification of the metabolic precursors of ecteinascidin as tyrosine, DOPA and cysteine. Reactive intermediates such as tyrosine and DOPA diketopiperazines have also been identified. These preliminary experiments set the stage for subsequent protein isolation.
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Date Issued: 1996
PURL: http://purl.flvc.org/fcla/dt/15242
Subject Headings: Tunicata, Marine pharmacology, Biological assay
Format: Document (PDF)

FAU Theses and Dissertations (29)	+ -
Florida Atlantic University Patents (9)	+ -
HBOI Faculty Contributions (6)	+ -

Marine pharmacology (12)	+ -
Alcyonacea (7)	+ -
Sponges (5)	+ -
Anti-inflammatory agents (4)	+ -
Sterols (4)	+ -

Aquaculture (3)	+ -
Biosynthesis (3)	+ -
Bryozoa (3)	+ -
Enzymes--Synthesis (3)	+ -
Terpenes--Synthesis (3)	+ -
Tunicata (3)	+ -
Coral reef ecology (2)	+ -
Corals (2)	+ -
Diterpenes--Synthesis (2)	+ -
Fatty acids--Synthesis (2)	+ -
Marine invertebrates (2)	+ -
Natural products--Synthesis (2)	+ -
Octocorallia (2)	+ -
Pharmacognosy (2)	+ -
Sea squirts (2)	+ -
Steroids (2)	+ -
Symbiosis (2)	+ -
Alkaloids (1)	+ -
Alkaloids--Synthesis (1)	+ -
Amino acids (1)	+ -
Aquaculture--Research (1)	+ -
Bacterial diversity (1)	+ -
Bioactive compounds (1)	+ -
Biochemistry (1)	+ -
Biodiversity (1)	+ -

Electronic Thesis or Dissertation (29)	+ -
patent (9)	+ -
article (6)	+ -

Kerr, Russell G. (44)	+ -
Florida Atlantic University (38)	+ -
Charles E. Schmidt College of Science (9)	+ -
Department of Chemistry and Biochemistry (9)	+ -
McCarthy, Peter J. (4)	+ -

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