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The effects of leptin on glucocorticoid sensitivity of peripheral blood mononuclear cells in non-obese and obese subjects
Title
The effects of leptin on glucocorticoid sensitivity of peripheral blood mononuclear cells in non-obese and obese subjects.
Creator
Randazzo, Christopher, Huang, Chun-Jung, Shibata, Yoshimi
Date Issued
2012-04-06
PURL
http://purl.flvc.org/fcla/dt/3349045
Subject Headings
Leptin, Glucocorticoid sensitivity, Obesity --epidemiology, Leptin-induced cytokine production, Peripheral blood mononuclear cells (PBMCs)
Format
Document (PDF)
The synergistic effects of concurrent stress on the inflammatory response in healthy individuals
Title
The synergistic effects of concurrent stress on the inflammatory response in healthy individuals.
Creator
McAlpine, David, Huang, Chun-Jung
Date Issued
2012-04-06
PURL
http://purl.flvc.org/fcla/dt/3349030
Subject Headings
Pentraxin 3, Inflammation, PTX3 protein, Vascular Diseases, Blood Vessels, C-Reactive Protein, Inflammation --blod, Parasympathetic Nervous System, Stress --psychological
Format
Document (PDF)
The Impact of Obesity on Plasma Calprotectin in Response to Acute Aerobic Exercise
Title
The Impact of Obesity on Plasma Calprotectin in Response to Acute Aerobic Exercise.
Creator
Fico, Brandon G., Slusher, Aaron L., Whitehurst, Michael, Maharaj, Arun, Huang, Chun-Jung, College of Education
Abstract/Description
The secular issue of obesity has been linked to increased inflammatory mediators, such as calprotectin (S100A8/A9). This study examined the effect of acute aerobic exercise on plasma calprotectin response in obese and normal-weight subjects and its relationship with inflammatory cytokine (IL-6). All subjects (11 obese and 10 normal-weight) performed 30 minutes of treadmill exercise at 75% maximal oxygen consumption (VO2max). Blood samples were collected prior to, immediately following...
Show moreThe secular issue of obesity has been linked to increased inflammatory mediators, such as calprotectin (S100A8/A9). This study examined the effect of acute aerobic exercise on plasma calprotectin response in obese and normal-weight subjects and its relationship with inflammatory cytokine (IL-6). All subjects (11 obese and 10 normal-weight) performed 30 minutes of treadmill exercise at 75% maximal oxygen consumption (VO2max). Blood samples were collected prior to, immediately following exercise, and one hour after exercise. Our results showed higher baseline levels of calprotectin in obese subjects than normal-weight subjects. While acute aerobic exercise increased an elevation in calprotectin and IL-6, no difference was found between two groups. Furthermore, a positive relationship was observed between calprotectin area-under-the curve “with respect to increase” (AUCi) and IL-6 AUCi, even after controlling for cardiorespiratory fitness (VO2max). Our results support previous finding that IL-6 may potentially regulate calprotectin expression in skeletal muscle during exercise.
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Date Issued
2015
PURL
http://purl.flvc.org/fau/fd/FA00005187
Subject Headings
College students --Research --United States.
Format
Document (PDF)
LPS-activated obese human PBMCs produce a BDNF and IL-6 associative response
Title
LPS-activated obese human PBMCs produce a BDNF and IL-6 associative response.
Creator
Wilson, Alan, Mari, David, Shibata, Yoshimi, Huang, Chun-Jung
Date Issued
2013-04-05
PURL
http://purl.flvc.org/fcla/dt/3361231
Subject Headings
Lipopolysaccharides, Obesity, Neurodegenerative diseases, IL-6 (Biomolecule)
Format
Document (PDF)
Enhanced ticket-based QoS routing protocols in ad hoc networks
Title
Enhanced ticket-based QoS routing protocols in ad hoc networks.
Creator
Huang, Chun-Jung, Florida Atlantic University, Wu, Jie
Abstract/Description
This thesis describes QoS routing techniques in ad hoc networks. QoS routing is to find paths between given source and destinations that fulfill a set of QoS requirements. QoS routing in ad hoc networks is a challenging problem due to the dynamical nature of ad hoc networks and the complexity of the QoS routing problem. Ticket-based probing scheme (TBP) is a creative approach to solve QoS routing problem, however, its proactive nature makes it deficient and unscalable. In this thesis, we...
Show moreThis thesis describes QoS routing techniques in ad hoc networks. QoS routing is to find paths between given source and destinations that fulfill a set of QoS requirements. QoS routing in ad hoc networks is a challenging problem due to the dynamical nature of ad hoc networks and the complexity of the QoS routing problem. Ticket-based probing scheme (TBP) is a creative approach to solve QoS routing problem, however, its proactive nature makes it deficient and unscalable. In this thesis, we first present the adaptive ticket-based routing protocol (ATBR), a proactive protocol enhanced from TBP, by introducing a new imprecise QoS state model. We then present the location-aided, ticket-based routing protocol (LTBR), an integration of locate-based routing and ticket-based routing, where tickets are dynamically generated and guided by location and QoS metric. Our simulations show that, in networks under any density, LTBR achieves close performances to flooding with considerably lower routing overhead.
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Date Issued
2003
PURL
http://purl.flvc.org/fcla/dt/13060, http://purl.flvc.org/fau/fd/FADT13060
Subject Headings
Computer network protocols, Mobile computing, Wireless communication systems, Routers (Computer networks)
Format
Document (PDF)
Pentraxin 3 Reactivity to Acute Exercise in Obese Individuals
Title
Pentraxin 3 Reactivity to Acute Exercise in Obese Individuals.
Creator
Maharaj, Arun, Urtula, Alyssa M., Slusher, Aaron L., Mock, J. Thomas, Fisher, Craig B., Huang, Chun-Jung
Abstract/Description
Pentraxin 3 (PTX3) has been demonstrated as a vital biomarker for chronic inflammatory diseases. Decreased plasma PTX3 has been observed in obese populations. However, no studies have examined the impact of obesity on PTX3 reactivity to exercise. Therefore, our study sought to investigate PTX3 plasma response to maximal exercise in obese and normal-weight subjects, and its relationship with insulin sensitivity. Twenty-one subjects (9 obese and 12 normal-weight) were recruited. Plasma PTX3,...
Show morePentraxin 3 (PTX3) has been demonstrated as a vital biomarker for chronic inflammatory diseases. Decreased plasma PTX3 has been observed in obese populations. However, no studies have examined the impact of obesity on PTX3 reactivity to exercise. Therefore, our study sought to investigate PTX3 plasma response to maximal exercise in obese and normal-weight subjects, and its relationship with insulin sensitivity. Twenty-one subjects (9 obese and 12 normal-weight) were recruited. Plasma PTX3, insulin, and glucose levels were measured before and following exercise. While our results showed lower resting PTX3 levels in obese subjects, exercise elicited similar elevations in PTX3 and insulin sensitivity in both groups. Furthermore, PTX3 area-under-curve (AUC) was correlated with glucose AUC, even when controlled for body mass index and fitness level. These findings suggest that glucose may potentially regulate PTX3 response to exercise. Further investigation is needed to verify the impact of substrate utilization on exercise-induced PTX3 elevation.
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Date Issued
2014
PURL
http://purl.flvc.org/fau/fd/FA0005028
Subject Headings
College students --Research --United States.
Format
Document (PDF)
Cardiovascular reactivity, stress, and physical activity
Title
Cardiovascular reactivity, stress, and physical activity.
Creator
Huang, Chun-Jung, Webb, Heather E., Zourdos, Michael C., Acevedo, Edmund O.
Date Issued
2013
PURL
http://purl.flvc.org/fau/fd/FAUIR000156
Format
Citation
Circulating Cell-free DNA and Interleukin-6 Expression Following Acute High-Intensity Interval Exercise in Obesity
Title
Circulating Cell-free DNA and Interleukin-6 Expression Following Acute High-Intensity Interval Exercise in Obesity.
Creator
Ferrandi, Peter J., Huang, Chun-Jung, Florida Atlantic University, College of Education, Department of Exercise Science and Health Promotion
Abstract/Description
The primary purpose of this study was to examine the impact of acute highintensity interval Exercise (HIIE) on plasma cfDNA and IL-6 responses in obese and normal-weight subjects. Fifteen subjects (8 obese and 7 normal-weight) were recruited to participate in an acute HIIE protocol. Our results demonstrated a significant elevation across time in plasma cfDNA and IL-6 immediately following acute HIIE, with no difference between obese and normal-weight subjects. Furthermore, cfDNA was not...
Show moreThe primary purpose of this study was to examine the impact of acute highintensity interval Exercise (HIIE) on plasma cfDNA and IL-6 responses in obese and normal-weight subjects. Fifteen subjects (8 obese and 7 normal-weight) were recruited to participate in an acute HIIE protocol. Our results demonstrated a significant elevation across time in plasma cfDNA and IL-6 immediately following acute HIIE, with no difference between obese and normal-weight subjects. Furthermore, cfDNA was not correlated with IL-6 in response to acute HIIE in either group. These findings indicate that the obese state does not further exacerbate the release of acute HIIE-induced inflammatory mediators (cfDNA and IL-6), which suggests that HIIE training may serve as a time-effective exercise strategy to improve obesity-associated inflammation.
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Date Issued
2017
PURL
http://purl.flvc.org/fau/fd/FA00004929, http://purl.flvc.org/fau/fd/FA00004929
Subject Headings
Interval training--Physiological aspects., Exercise--Physiological aspects., Physical education and training--Measurement., Gene expression., Cellular control mechanisms.
Format
Document (PDF)
The Comparison of High-Intensity Interval Exercise vs. Continuous Moderate Exercise on C1q/TNF-Related Protein-9 Expression and Flow-Mediated Vasodilation
Title
The Comparison of High-Intensity Interval Exercise vs. Continuous Moderate Exercise on C1q/TNF-Related Protein-9 Expression and Flow-Mediated Vasodilation.
Creator
Fico, Brandon G., Huang, Chun-Jung, Florida Atlantic University, College of Education, Department of Exercise Science and Health Promotion
Abstract/Description
The primary purpose of this study was to investigate the effect of acute high-intensity interval exercise (HIIE) vs. continuous moderate-intensity exercise (CME) on serum CTRP9 and brachial FMD responses in obese and normal-weight subjects. Sixteen participants (9 obese and 7 normal-weight) completed HIIE and CME in a randomized fashion. Our results showed a significant time effect for CTRP9 immediately following acute HIIE and CME in both groups. Furthermore, both significant treatment by...
Show moreThe primary purpose of this study was to investigate the effect of acute high-intensity interval exercise (HIIE) vs. continuous moderate-intensity exercise (CME) on serum CTRP9 and brachial FMD responses in obese and normal-weight subjects. Sixteen participants (9 obese and 7 normal-weight) completed HIIE and CME in a randomized fashion. Our results showed a significant time effect for CTRP9 immediately following acute HIIE and CME in both groups. Furthermore, both significant treatment by time and group by time interactions for FMD were observed following both exercise protocols, with greater CME-induced FMD response in obese subjects than normal-weight subjects. Additionally, a positive correlation in percent change (baseline to peak) between CTRP9 and FMD was observed following acute CME. These findings support acute CME for improvement of endothelial function in obesity. Furthermore, the novel results from this study provide a foundation for additional examination of the mechanisms of exercise-mediated CTRP9 on endothelial function.
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Date Issued
2017
PURL
http://purl.flvc.org/fau/fd/FA00004915, http://purl.flvc.org/fau/fd/FA00004915
Subject Headings
Cardiovascular system--Physiology., Biological transport., Exercise--Physiological aspects., Interval training--Physiological aspects., Bioinformatics., Exercise--Health aspects., Lifestyles--Health aspects., Gene expression.
Format
Document (PDF)
Relationships of fibroblast growth factor 21 with inflammation and insulin resistance in response to acute exercise in obese individuals
Title
Relationships of fibroblast growth factor 21 with inflammation and insulin resistance in response to acute exercise in obese individuals.
Creator
Slusher, Aaron L., Huang, Chun-Jung, Florida Atlantic University, College of Education, Department of Exercise Science and Health Promotion
Abstract/Description
Obesity is associated with elevated levels of the pro-inflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), contributing to systemic insulin resistance. Fibroblast growth factor 21 (FGF21) is a vital metabolic and inflammatory regulator, however circulating FGF21 concentrations are elevated in obese individuals. Acute aerobic exercise increases systemic FGF21 in normal-weight individuals, however the effect of acute aerobic exercise on plasma FGF21 response and...
Show moreObesity is associated with elevated levels of the pro-inflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), contributing to systemic insulin resistance. Fibroblast growth factor 21 (FGF21) is a vital metabolic and inflammatory regulator, however circulating FGF21 concentrations are elevated in obese individuals. Acute aerobic exercise increases systemic FGF21 in normal-weight individuals, however the effect of acute aerobic exercise on plasma FGF21 response and the relationships with inflammation (IL-6 and TNF-α), insulin resistance, and energy expenditure in obese individuals is unknown. Following 30 minutes of treadmill running at 75% VO2max, plasma FGF21 response, as indicated by area-under-the-curve “with respect to increase” (AUCi) analyses, was attenuated in 12 obese compared to 12 normalweight subjects. Additionally, FGF21 AUCi positively correlated with glucose AUCi, total relative energy expenditure, and relative VO2max, suggesting that cardiorespiratory fitness levels may predict FGF21 response, contributing to the enhanced regulation of glucose and energy metabolism.
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Date Issued
2014
PURL
http://purl.flvc.org/fau/fd/FA00004229, http://purl.flvc.org/fau/fd/FA00004229
Subject Headings
Fibroblast growth factor., Cell differentiation., Cellular signal transduction., Obesity--Health aspects., Metabolic syndrome--Pathophysiology.
Format
Document (PDF)
Influence of Physical Activity and Nutrition on Obesity-Related Immune Function
Title
Influence of Physical Activity and Nutrition on Obesity-Related Immune Function.
Creator
Huang, Chun-Jung, Zourdos, Michael C., Jo, Edward, Ormsbee, Michael J.
Abstract/Description
Research examining immune function during obesity suggests that excessive adiposity is linked to impaired immune responses leading to pathology.Thedeleterious effects of obesity on immunity have been associated with the systemic proinflammatory profile generated by the secretory molecules derived from adipose cells. These include inflammatory peptides, such as TNF-𝛼, CRP, and IL-6. Consequently, obesity is now characterized as a state of chronic low-grade systemic inflammation, a condition...
Show moreResearch examining immune function during obesity suggests that excessive adiposity is linked to impaired immune responses leading to pathology.Thedeleterious effects of obesity on immunity have been associated with the systemic proinflammatory profile generated by the secretory molecules derived from adipose cells. These include inflammatory peptides, such as TNF-𝛼, CRP, and IL-6. Consequently, obesity is now characterized as a state of chronic low-grade systemic inflammation, a condition considerably linked to the development of comorbidity. Given the critical role of adipose tissue in the inflammatory process, especially in obese individuals, it becomes an important clinical objective to identify lifestyle factors that may affect the obesity-immune system relationship. For instance, stress, physical activity, and nutrition have each shown to be a significant lifestyle factor influencing the inflammatory profile associated with the state of obesity.Therefore, the purpose of this review is to comprehensively evaluate the impact of lifestyle factors, in particular psychological stress, physical activity, and nutrition, on obesity-related immune function with specific focus on inflammation.
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Date Issued
2013
PURL
http://purl.flvc.org/fau/fd/FAUIR000023
Format
Citation