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Exploring Appropriate Offset Values for Pencil Beam and Monte Carlo Dose Optimization in Lung Stereotactic Body Radiotherapy Encompassing the Effects of Respiration and Tumor Location
Title
Exploring Appropriate Offset Values for Pencil Beam and Monte Carlo Dose Optimization in Lung Stereotactic Body Radiotherapy Encompassing the Effects of Respiration and Tumor Location.
Creator
Evans, Grant, Shang, Charles, Leventouri, Theodora, Graduate College
Abstract/Description
Purpose: To explore offset values in dose optimization with pencil beam (PB) algorithm to minimize dosimetric differences with plans calculated with Monte Carlo (MC) for lung cancer treatment with Stereotactic Body Radiotherapy (SBRT). Methods: 20 cases of Non-Small Cell Lung Cancer, treated with gated full motion range SBRT were selected. According to the proximity of the Gross Tumor Volume (GTV) to the chest wall, two groups are defined. Treatment plans were created on 4D average intensity...
Show morePurpose: To explore offset values in dose optimization with pencil beam (PB) algorithm to minimize dosimetric differences with plans calculated with Monte Carlo (MC) for lung cancer treatment with Stereotactic Body Radiotherapy (SBRT). Methods: 20 cases of Non-Small Cell Lung Cancer, treated with gated full motion range SBRT were selected. According to the proximity of the Gross Tumor Volume (GTV) to the chest wall, two groups are defined. Treatment plans were created on 4D average intensity projection (AIP) CT set with Brainlab iPlanDose® 4.1.2 planning system. The D97 of PTV was normalized to 50Gy using the fast PB and compared with MC. The optimized plan was then recomputed over each 4D respiratory phase, and compared with MC. Results: The mean difference in the PB and MC D97 of the ITV was 10.5% (±0.8%) of the prescription dose (50Gy). PB algorithm showed 2.3-2.4% less overestimation to the D97 of the ITV, when comparing to MC, in the maximum exhalation phase than in the maximal inhalation phase. Significantly smaller dose difference between PB and MC is also shown in plans for peripheral lesions (7.7 ± 0.7%) versus for central lesions (12.7±0.8%) (p< 0.01). Conclusions: The dosimetric differences between PB and MC can be reasonably predicted depending on the location of lesion in the lung, and may be used as offset value in dose optimization with PB. Caution is suggested when using the maximum inhalation phase for treatment planning.
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Date Issued
2014
PURL
http://purl.flvc.org/fau/fd/FA00005813
Format
Document (PDF)
Dosimetric and radiobiological comparison of CyberKnife M6(TM) InCise multileaf collimator over IRIS(TM) variable collimator in prostate stereotactic body radiation therapy
Title
Dosimetric and radiobiological comparison of CyberKnife M6(TM) InCise multileaf collimator over IRIS(TM) variable collimator in prostate stereotactic body radiation therapy.
Creator
Kathriarachchi, Vindu, Shang, Charles, Evans, Grant, Leventouri, Theodora, Kalantzis, Georgios
Date Issued
2016
PURL
http://purl.flvc.org/fau/fd/FAUIR000166
Format
Citation
Exploring appropriate offset values for pencil beam and Monte Carlo dose optimization in lung stereotactic body radiotherapy encompassing the effects of respiration and tumor location
Title
Exploring appropriate offset values for pencil beam and Monte Carlo dose optimization in lung stereotactic body radiotherapy encompassing the effects of respiration and tumor location.
Creator
Evans, Grant, Shang, Charles, Florida Atlantic University, Charles E. Schmidt College of Science, Department of Physics
Abstract/Description
Evaluation of dose optimization using the Pencil Beam (PB) and Monte Carlo (MC) algorithms may allow physicists to apply dosimetric offsets to account for inaccuracies of the PB algorithm for lung cancer treatment with Stereotactic Body Radiotherapy (SBRT). 20 cases of Non-Small Cell Lung Cancer (NSCLC) were selected. Treatment plans were created with Brainlab iPlanDose® 4.1.2. The D97 of the Planning Target Volume (PTV) was normalized to 50 Gy on the Average Intensity Projection (AIP) using...
Show moreEvaluation of dose optimization using the Pencil Beam (PB) and Monte Carlo (MC) algorithms may allow physicists to apply dosimetric offsets to account for inaccuracies of the PB algorithm for lung cancer treatment with Stereotactic Body Radiotherapy (SBRT). 20 cases of Non-Small Cell Lung Cancer (NSCLC) were selected. Treatment plans were created with Brainlab iPlanDose® 4.1.2. The D97 of the Planning Target Volume (PTV) was normalized to 50 Gy on the Average Intensity Projection (AIP) using the fast PB and compared with MC. This exact plan with the same beam Monitor Units (MUs) was recalculated over each respiratory phase. The results show that the PB algorithm has a 2.3-2.4% less overestimation at the maximum exhalation phase than the maximum inhalation phase when compared to MC. Significantly smaller dose difference between PB and MC is also shown in plans for peripheral lesions (7.7 ± 0.7%) versus central lesions (12.7±0.8%)(p< 0.01).
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Date Issued
2014
PURL
http://purl.flvc.org/fau/fd/FA00004105, http://purl.flvc.org/fau/fd/FA00004105
Subject Headings
Drug development -- Computer simulation, Image guided radiation therapy, Lung cancer -- Treatment, Monte Carlo method, Proton beams, Transport theory
Format
Document (PDF)