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Potential mechanism of phytochemical-induced apoptosis in human prostate adenocarcinoma cells: Therapeutic synergy in genistein and β-lapachone combination treatment
Title
Potential mechanism of phytochemical-induced apoptosis in human prostate adenocarcinoma cells: Therapeutic synergy in genistein and β-lapachone combination treatment.
Creator
Kumi-Diaka, James, Saddler, Shawnette Simone, Aller, Alex, Brown, Jayann Marie
Date Issued
2004-08-17
PURL
http://purl.flvc.org/fcla/dt/3327156
Format
Document (PDF)
Anti-cancer activity of pomegranate (Punica granatum ) extracts in testicular cancer
Title
Anti-cancer activity of pomegranate (Punica granatum ) extracts in testicular cancer.
Creator
Brown, Jayann Marie, Florida Atlantic University, Kumi-Diaka, James
Abstract/Description
Recent advancement in chemotherapy has resulted in higher and longer survival rates of testicular cancer patients. However the use of chemotherapeutic agents are not without serious, sometimes fatal side effects. This study investigated the potential therapeutic efficacy of pomegranate extracts in testis cancer cells, GC1-spg, in vitro. A battery of assays was used to determine the chemosensitivity of GC1-spg cells to two pomegranate extracts, S (seed) and P (pericarp), in single and...
Show moreRecent advancement in chemotherapy has resulted in higher and longer survival rates of testicular cancer patients. However the use of chemotherapeutic agents are not without serious, sometimes fatal side effects. This study investigated the potential therapeutic efficacy of pomegranate extracts in testis cancer cells, GC1-spg, in vitro. A battery of assays was used to determine the chemosensitivity of GC1-spg cells to two pomegranate extracts, S (seed) and P (pericarp), in single and combination treatments: MTS and LDH to determine post-treatment survival rate (growth inhibition) and cytotoxicity respectively; Acridine Orange/Ethidium Bromide fluorescent dye to assess treatment-induced apoptosis/necrosis; Annexin V-FITC and TUNEL assays for early and late apoptosis respectively. Results from the obtained data indicated that both extracts have significant cytotoxic effect on testicular cancer cells (GC1-spg) in single and combination treatments. The data revealed a dose and time dependency of chemosensitivity to both extracts; and that apoptosis was the major mechanism treatment-induced cell death. Synergism was also indicated in growth inhibition by combination treatment. These findings offer strong justification for further studies with pomegranate as potential phytotherapy.
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Date Issued
2004
PURL
http://purl.flvc.org/fcla/dt/13154
Subject Headings
Testis--Cancer--Treatment, Generative organs, Male--Diseases--Treatment, Phytochemicals--Physiological effect, Cancer--Adjuvant treatment, Apoptosis--Molecular aspects
Format
Document (PDF)
CytoregR inhibits growth and proliferation of human adenocarcinoma cells via induction of apoptosis
Title
CytoregR inhibits growth and proliferation of human adenocarcinoma cells via induction of apoptosis.
Creator
Kumi-Diaka, James, Hassanhi, M., Brown, Jayann Marie, Merchant, Kendra T., Garcia, C., Jimenez, W.
Date Issued
2006-01-09
PURL
http://purl.flvc.org/fcla/dt/3327155
Format
Document (PDF)