Current Search: Department of Biomedical Science (x)
Pages
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Title
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Pharmacological protection of retinal pigmented epithelial cells by sulindac involves PPAR-α.
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Creator
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Sur, Arunodoy, Kesaraju, Shailaja, Prentice, Howard, Ayyanathan, Kasirajan, Baronas-Lowell, Diane, Zhu, Danhong, Hinton, David R., Blanks, Janet, Weissbach, Herbert
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Date Issued
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2014-11-10
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PURL
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http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1073_pnas.1419576111_1631807081
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Format
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Citation
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Title
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Planar Cell Polarity Signaling Pathway in Congenital Heart Diseases.
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Creator
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Wu, Gang, Ge, Jiao, Huang, Xupei, Hua, Yimin, Mu, Dezhi
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Date Issued
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2011
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PURL
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http://purl.flvc.org/fau/fd/FAUIR000155
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Format
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Citation
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Title
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Gold Nanoparticles as a Probe for Amyloid-β Oligomer and Amyloid Formation.
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Creator
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Esmail A. Elbassal, Clifford Morris, Thomas W. Kent, Thomas W. Kent, Bimlesh Ojha, Ewa P. Wojcikiewicz, Deguo Du
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Abstract/Description
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The process of amyloid-β (Aβ) amyloid formation is pathologically linked to Alzheimer’s disease (AD). The identification of Aβ amyloids and intermediates that are crucial players in the pathology of AD is critical for exploring the underlying mechanism of Aβ aggregation and the diagnosis of the disease. Herein, we performed a gold nanoparticle (AuNP)-based study to detect the formation of Aβ amyloid fibrils and oligomers. Our results demonstrate that the intensity of the surface plasmon...
Show moreThe process of amyloid-β (Aβ) amyloid formation is pathologically linked to Alzheimer’s disease (AD). The identification of Aβ amyloids and intermediates that are crucial players in the pathology of AD is critical for exploring the underlying mechanism of Aβ aggregation and the diagnosis of the disease. Herein, we performed a gold nanoparticle (AuNP)-based study to detect the formation of Aβ amyloid fibrils and oligomers. Our results demonstrate that the intensity of the surface plasmon resonance (SPR) absorption band of the AuNPs is sensitive to the quantity of Aβ40 amyloids. This allows the SPR assay to be used for detection and semi-quantification of Aβ40 amyloids, and characterization of the kinetics of Aβ amyloid formation. Furthermore, our study demonstrates that the SPR band intensity of the AuNPs is sensitive to the presence of oligomers of both Aβ40 and an Aβ40 mutant, which forms more stable oligomers. The kinetics of the stable oligomer formation of the Aβ40 mutant can also be monitored following the SPR band intensity change of AuNPs. Our results indicate that this nanoparticle based method can be used for mechanistic studies of early protein self-assembly and fibrillogenesis.
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Date Issued
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2017
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PURL
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http://purl.flvc.org/fau/fd/FAUIR000499
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Format
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Document (PDF)
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Title
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Analysis of neuroanatomical differences in mice with genetically modified serotonin transporters assessed by structural magnetic resonance imaging.
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Creator
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Ellegood, Jacob, Yee, Yohan, Kerr, Travis M., Muller, Christopher L., Blakely, Randy D., Henkelman, R. Mark, Veenstra-VanderWeele, Jeremy, Lerch, Jason P.
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Date Issued
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2018-12-10
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PURL
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http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1186_s13229-018-0210-z_1634563542
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Format
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Citation
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Title
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Glial loss of the metallo β-lactamase domain containing protein, SWIP-10, induces age- and glutamate-signaling dependent, dopamine neuron degeneration.
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Creator
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Gibson, Chelsea L., Balbona, Joseph T., Niedzwiecki, Ashlin, Rodriguez, Peter, Nguyen, Ken C. Q., Hall, David H., Blakely, Randy D., Bianchi, Laura
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Date Issued
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2018-03-28
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PURL
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http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1371_journal.pgen.1007269_1634570797
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Format
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Citation
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Title
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Characterization of Human Angiogenin Variants Implicated in Amyotrophic Lateral Sclerosis.
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Creator
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Crabtree, Benedict, Thiyagarajan, Nethaji, Prior, Stephen H., Wilson, Peter, Iyer, Shalini, Ferns, Tyrone, Shapiro, Robert, Brew, Keith, Subramanian, Vasanta, Acharya, K. Ravi
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Date Issued
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2007-10-01
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PURL
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http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1021_bi701333h_1638203835
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Format
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Document (PDF)
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Title
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Inactivation of N-TIMP-1 by N-terminal acetylation when expressed in bacteria.
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Creator
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Van Doren, Steven R., Wei, Shuo, Gao, Guanghua, DaGue, Beverly B., Palmier, Mark O., Bahudhanapati, Harinath, Brew, Keith
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Date Issued
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2008-11
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PURL
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http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1002_bip.21043_1638215239
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Format
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Document (PDF)
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Title
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Engineered Sarafotoxins as Tissue Inhibitor of Metalloproteinases-like Matrix Metalloproteinase Inhibitors.
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Creator
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Lauer-Fields, Janelle L., Cudic, Mare, Wei, Shuo, Mari, Frank, Fields, Gregg B., Brew, Keith
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Date Issued
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2007-09
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PURL
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http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1074_jbc.M611612200_1638212835
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Format
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Document (PDF)
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Title
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A New Role for TIMP-1 in Modulating Neurite Outgrowth and Morphology of Cortical Neurons.
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Creator
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Ould-yahoui, Adlane, Tremblay, Evelyne, Sbai, Oualid, Ferhat, Lotfi, Bernard, Anne, Charrat, Eliane, Gueye, Yatma, Lim, Ngee Han, Brew, Keith, Risso, Jean-Jacques, Dive, Vincent, Khrestchatisky, Michel, Rivera, Santiago, Chédotal, Alain
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Date Issued
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2009-12-14
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PURL
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http://purl.flvc.org/fau/fd/FAUIR000096
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Format
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Citation
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Title
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Unresponsive Choline Transporter as a Trait Neuromarker and a Causal Mediator of Bottom-Up Attentional Biases.
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Creator
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Koshy Cherian, Ajeesh, Kucinski, Aaron, Pitchers, Kyle, Yegla, Brittney, Parikh, Vinay, Kim, Youngsoo, Valuskova, Paulina, Gurnani, Sarika, Lindsley, Craig W., Blakely, Randy D., Sarter, Martin
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Date Issued
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2017-02-13
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PURL
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http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1523_JNEUROSCI.3499-16.2017_1634323040
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Format
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Citation
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Title
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Pancreatic deletion of the interleukin-1 receptor disrupts whole body glucose homeostasis and promotes islet β-cell de-differentiation.
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Creator
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Burke, Susan J., Batdorf, Heidi M., Burk, David H., Martin, Thomas M., Mendoza, Tamra, Stadler, Krisztian, Alami, Wateen, Karlstad, Michael D., Robson, Matthew J., Blakely, Randy D., Mynatt, Randall L., Collier, J. Jason
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Date Issued
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2018-08
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PURL
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http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1016_j.molmet.2018.06.003_1634579597
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Format
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Citation
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Title
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The Roles of Substrate Thermal Stability and P2 and P1′ Subsite Identity on Matrix Metalloproteinase Triple-helical Peptidase Activity and Collagen Specificity.
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Creator
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Minond, Dmitriy, Lauer-Fields, Janelle L., Cudic, Mare, Overall, Christopher M., Pei, Duanqing, Brew, Keith, Visse, Robert, Nagase, Hideaki, Fields, Gregg B.
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Date Issued
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2006-12
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PURL
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http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1074_jbc.M606004200_1638203001
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Format
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Document (PDF)
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Title
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Choline transporter mutations in severe congenital myasthenic syndrome disrupt transporter localization.
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Creator
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Wang, Haicui, Salter, Claire G, Refai, Osama, Hardy, Holly, Barwick, Katy E S, Akpulat, Ugur, Kvarnung, Malin, Chioza, Barry A, Harlalka, Gaurav, Taylan, Fulya, Sejersen, Thomas, Wright, Jane, Zimmerman, Holly H, Karakaya, Mert, Stüve, Burkhardt, Weis, Joachim, Schara, Ulrike, Russell, Mark A, Abdul-Rahman, Omar A, Chilton, John, Blakely, Randy D, Baple, Emma L, Cirak, Sebahattin, Crosby, Andrew H
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Date Issued
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2017-10-27
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PURL
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http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1093_brain_awx249_1635361980
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Format
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Citation
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Title
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Truncating SLC5A7 mutations underlie a spectrum of dominant hereditary motor neuropathies.
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Creator
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Salter, Claire G., Beijer, Danique, Hardy, Holly, Barwick, Katy E.S., Bower, Matthew, Mademan, Ines, De Jonghe, Peter, Deconinck, Tine, Russell, Mark A., McEntagart, Meriel M., Chioza, Barry A., Blakely, Randy D., Chilton, John K., De Bleecker, Jan, Baets, Jonathan, Baple, Emma L., Walk, David, Crosby, Andrew H.
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Date Issued
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2018-04-23
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PURL
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http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1212_NXG.0000000000000222_1634649520
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Format
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Citation
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Title
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Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications.
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Creator
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Lim, Ngee H., Kashiwagi, Masahide, Visse, Robert, Jones, Jonathan, Enghild, Jan J., Brew, Keith, Nagase, Hideaki
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Date Issued
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2010-10-01
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PURL
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http://purl.flvc.org/fau/flvc_fau_islandoraimporter_10.1042_BJ20100725_1638297790
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Format
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Document (PDF)
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