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Neural substrates of movement and music: An fMRI approach
| Title: | Neural substrates of movement and music: An fMRI approach. |
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| Name(s): |
Nair, Dinesh G. Florida Atlantic University, Degree Grantor Charles E. Schmidt College of Science Center for Complex Systems and Brain Sciences |
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| Type of Resource: | text | |
| Genre: | Electronic Thesis Or Dissertation | |
| Issuance: | monographic | |
| Date Issued: | 2004 | |
| Publisher: | Florida Atlantic University | |
| Place of Publication: | Boca Raton, Fla. | |
| Physical Form: | application/pdf | |
| Extent: | 212 p. | |
| Language(s): | English | |
| Summary: | In this dissertation, we examined the neural correlates of motor coordination and music perception using a set of four fMRI experiments. The neural correlates of goal-directed action were examined in a group of healthy adults in experiment I using execution and imagery of a unimanual and a bimanual finger-sequencing task. Similar neural networks were engaged for execution and imagination of movement sequences. Interestingly, we also found that the sensorimotor cortical and cerebellar areas are functionally decoupled from the task network when people imagine but do not actually execute sequential actions. In experiment 2, we used the same finger-sequencing paradigm to study recovery of function during recovery from stroke. It was observed that the wide spread neural activity during the initial session became more localized during the last session. In addition, using imagery tasks, we showed that hemiplegic patients retained the ability to activate neural pathways that are normally involved in executing goal-directed action sequences, despite the loss of ability to actually execute movements. In experiment 3, we examined brain activity when musicians and non-musicians listened to expressive and mechanical versions of a musical piece. The expressive performance activated the limbic areas more than the mechanical version in both groups of subjects suggesting perception of affect. The pattern of neural activity was also dictated by their experience and familiarity with the piece of music. In addition, we found activation of language related areas when musicians listened to the expressive version suggesting shared neural resources for language and music. The neural basis of sensorimotor coordination and timing in Parkinson's disease was investigated in the last experiment, using a synchronization-syncopation task and the continuation paradigm. Different neural areas subserved timing during the two different modes of coordination. However, these differences persisted during their respective continuation phases. In order to compensate for the functional deficiency in Parkinson's disease, patients recruited functionally segregated circuits that connect the striatum and association areas of the parietal, premotor and prefrontal cortices. | |
| Identifier: | 9780496673926 (isbn), 12082 (digitool), FADT12082 (IID), fau:8993 (fedora) | |
| Collection: | FAU Electronic Theses and Dissertations Collection | |
| Note(s): |
Advisers: J. A. Scott Kelso; Edward W. Large. Thesis (Ph.D.)--Florida Atlantic University, 2004. |
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| Subject(s): |
Biology, Neuroscience Psychology, Cognitive |
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| Held by: | Florida Atlantic University Libraries | |
| Persistent Link to This Record: | http://purl.flvc.org/fcla/dt/12082 | |
| Sublocation: | Digital Library | |
| Use and Reproduction: | Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder. | |
| Use and Reproduction: | http://rightsstatements.org/vocab/InC/1.0/ | |
| Host Institution: | FAU | |
| Is Part of Series: | Florida Atlantic University Digital Library Collections. |
