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Combination of Sulindac and Metformin as a Therapeutic Target in Lung Cancer

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Date Issued:
2020
Abstract/Description:
Sulindac is an FDA approved, non-steroidal anti-inflammatory drug that exhibits anti-cancer properties. Metformin is and FDA approved, anti-diabetic drug that also has documented anti-cancer properties. The goal of this project was to explore if a dual-combination of sulindac and metformin in the presence of a chemical oxidizing agent is more effective in killing lung cancer cells while not inducing cell death in normal lung cells. Our data shows that a triple-drug combination of sulindac, metformin, and tert-butyl hydroperoxide induce significant cell death in lung cancer cells but did not induce significant cell death in normal lung cells.
Title: Combination of Sulindac and Metformin as a Therapeutic Target in Lung Cancer.
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Name(s): Butler, Heather , author
Trivigno, Catherine, Thesis advisor
Florida Atlantic University
Harriet L. Wilkes Honors College
Type of Resource: text
Genre: Thesis
Date Created: 2020
Date Issued: 2020
Publisher: Florida Atlantic University Digital Library
Place of Publication: Boca Raton, Fla.
Physical Form: online resource
Extent: 32 p.
Language(s): English
Abstract/Description: Sulindac is an FDA approved, non-steroidal anti-inflammatory drug that exhibits anti-cancer properties. Metformin is and FDA approved, anti-diabetic drug that also has documented anti-cancer properties. The goal of this project was to explore if a dual-combination of sulindac and metformin in the presence of a chemical oxidizing agent is more effective in killing lung cancer cells while not inducing cell death in normal lung cells. Our data shows that a triple-drug combination of sulindac, metformin, and tert-butyl hydroperoxide induce significant cell death in lung cancer cells but did not induce significant cell death in normal lung cells.
Identifier: FA00003700 (IID)
Degree granted: Thesis (B.A.)--Florida Atlantic University, Harriet L. Wilkes Honors College, 2020.
Collection: Florida Atlantic University Digital Library Collections
Note(s): Includes bibliography.
Persistent Link to This Record: http://purl.flvc.org/fau/fd/FA00003700
Use and Reproduction: Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder.
Use and Reproduction: http://rightsstatements.org/vocab/InC/1.0/
Host Institution: FAU

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