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Antitumor cyclic peroxides from the sponge Plakortis lita

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Date Issued:
Title: Antitumor cyclic peroxides from the sponge Plakortis lita.
Name(s): Sakemi, S., creator
Higa, T., creator
Anthoni, U., creator
Christophersen, C., creator
Harbor Branch Oceanographic Institute
Type of Resource: text
Genre: Article
Issuance: single unit
Date Issued: 1987
Publisher: Elsevier
Extent: 7 p.
Physical Description: pdf
Language(s): English
Identifier: 3353800 (digitool), FADT3353800 (IID), fau:6620 (fedora), 10.1016/S0040-4020(01)89953-1 (doi)
Note(s): Four new cyclic peroxides (5–8) along with known chondrillin (4) have been isolated as antitumor constituents of the sponge Plakortis lita. These are methyl-(3S*, 6S*)-3, 6-epidioxy- 6-methoxyoctadec-4-enoate (5), methyl( 3S*, 6S*, 16E)-3, 6-epidoxy- 6-methoxyoctadeca-4,16-dienoate (6), methyl( 3S*, 6S*, 14E, 16E)- 3, 6-epidioxy-6-methoxyoctadeca-4, 14, 16-trienoate (7), and methyl-( 3S*, 6S*, 16E, 18E)-3, 6-epidioxy-6-methoxyeicosa-4 ,16 ,18- trinoate (8). All of them are epimeric to 4 and exhibit higher antitumor potency than 4.
The final published version of this manuscript is available at and may be cited as: Sakemi, S., Higa, T., Anthoni, U., & Christophersen, C. (1987). Antitumor cyclic peroxides from the sponge Plakortis lita. Tetrahedron, 43(1), 263-268. doi:10.1016/S0040-4020(01)89953-1
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #577.
Subject(s): Antineoplastic agents
Marine metabolites
Persistent Link to This Record:
Restrictions on Access: ©1987 Elsevier Ltd.
Owner Institution: FAU