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A new sesterterpene, Sch 599473, from a marine sponge, Ircinia sp.

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Date Issued:
Title: A new sesterterpene, Sch 599473, from a marine sponge, Ircinia sp.
Name(s): Yang, Shu-Wei, creator
Chan, Tze-Ming, creator
Pomponi, Shirley A., creator
Gonsiorek, W., creator
Chen, Guodong, creator
Wright, Amy E., creator
Hipkin, W., creator
Patel, Mahesh, creator
Gullo, Vincent, creator
Pramanik, B., creator
Zavodny, P., creator
Chu, Min, creator
Type of Resource: text
Genre: Article
Issuance: single unit
Date Issued: 2003
Publisher: Nature Publishing Group
Extent: 5 p.
Physical Description: pdf
Language(s): English
Identifier: 3351980 (digitool), FADT3351980 (IID), fau:6526 (fedora), 10.7164/antibiotics.56.783 (doi)
Note(s): Marine organisms are an excellent source of structurally diverse molecules which are potentially useful for drug discovery. Several marine natural products have been discovered as lead compounds in various therapeutic areas, and some of them are currently in clinical studies. In our marine natural product research program, we have built a marine fraction library (MFL) for high throughput screening (HTS) for a variety of biological targets. The active fractions are followed up using bioassay-guided fractionation to identify the active compounds. Isolation and identification of CCR7 receptor binding inhibitors from the marine sponge lrcinia sp. are described in this paper.
This manuscript is an author version with the final publication available at and may be cited as: Yang, S.-W., Chan, T.-M., Pomponi, S. A., Gonsiorek, W., Chen, G., Wright, A. E., Hipkin, W., Patel, M., Gullo, V., Pramanik, B., Zavodny, P., & Chu, M. (2003). A new sesterterpene, Sch 599473, from a marine sponge, Ircinia sp. The Journal of Antibiotics, 56(9), 783-786. doi:10.7164/antibiotics.56.783
Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1540.
Subject(s): Sponges
Marine natural products
Persistent Link to This Record:
Restrictions on Access: ©2003 Nature Publishing Group
Owner Institution: FAU