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A new sesterterpene, Sch 599473, from a marine sponge, Ircinia sp.
| Title: | A new sesterterpene, Sch 599473, from a marine sponge, Ircinia sp. |
 140 views 26 downloads |
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| Name(s): |
Yang, Shu-Wei, creator Chan, Tze-Ming, creator Pomponi, Shirley A., creator Gonsiorek, W., creator Chen, Guodong, creator Wright, Amy E., creator Hipkin, W., creator Patel, Mahesh, creator Gullo, Vincent, creator Pramanik, B., creator Zavodny, P., creator Chu, Min, creator |
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| Type of Resource: | text | |
| Genre: | Article | |
| Issuance: | single unit | |
| Date Issued: | 2003 | |
| Publisher: | Nature Publishing Group | |
| Extent: | 5 p. | |
| Physical Description: | ||
| Language(s): | English | |
| Identifier: | 3351980 (digitool), FADT3351980 (IID), fau:6526 (fedora), 10.7164/antibiotics.56.783 (doi) | |
| Note(s): |
Marine organisms are an excellent source of structurally diverse molecules which are potentially useful for drug discovery. Several marine natural products have been discovered as lead compounds in various therapeutic areas, and some of them are currently in clinical studies. In our marine natural product research program, we have built a marine fraction library (MFL) for high throughput screening (HTS) for a variety of biological targets. The active fractions are followed up using bioassay-guided fractionation to identify the active compounds. Isolation and identification of CCR7 receptor binding inhibitors from the marine sponge lrcinia sp. are described in this paper. This manuscript is an author version with the final publication available at http://www.nature.com/ja/index.html and may be cited as: Yang, S.-W., Chan, T.-M., Pomponi, S. A., Gonsiorek, W., Chen, G., Wright, A. E., Hipkin, W., Patel, M., Gullo, V., Pramanik, B., Zavodny, P., & Chu, M. (2003). A new sesterterpene, Sch 599473, from a marine sponge, Ircinia sp. The Journal of Antibiotics, 56(9), 783-786. doi:10.7164/antibiotics.56.783 Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1540. |
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| Subject(s): |
Sponges Sesterterpenes Marine natural products |
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| Persistent Link to This Record: | http://purl.flvc.org/FCLA/DT/3351980 | |
| Links: | http://doi.org/10.7164/antibiotics.56.783 | |
| Restrictions on Access: | ©2003 Nature Publishing Group | |
| Host Institution: | FAU |
